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Infectious Disease PHGKB

Specific PHGKB|Infectious Diseases PHGKB|PHGKB
Last Posted: Dec 02, 2023
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Neighborhood Deprivation Measures and DNA Methylation Clocks-Understanding the Real Needs of Each Person.
Benjamin D Horne et al. JAMA Netw Open 2023 11 (11) e2344688 (Posted Dec 02, 2023 9AM)

From the article: " A recent study reports a unique and powerful approach for finding neighborhood factors marking risks of early death and disease.4 Measurement of racial segregation using spatial clustering methods and separating that from economic deprivation (and education) aid in clarifying the sources of health concerns. The study uses methylation patterns which can be remodeled by many factors such as smoking, physical activity, diet, infection, and stressors from the childhood environment (eg, lack of loving adult support, malnutrition), adverse living conditions (eg, noise pollution, particulate matter air pollution), and poor interactions with others (eg, emotional or physical abuse). "

A medical multimodal large language model for future pandemics
Liu et al, NPJ Digital Medicine, December 2, 2023 (Posted Dec 02, 2023 8AM)

From the paper: "With the goal of quick deployment of tools for rapid response to rare diseases, we present the medical multimodal large language model (Med-MLLM) framework. We evaluate the effectiveness of Med-MLLM using the COVID-19 pandemic “in replay”, showing that Med-MLLM is able to accomplish accurate COVID-19 decision-support tasks with limited labelled data. In contrast, existing efforts usually require thousands, or even more, labelled data to achieve similar performance. "

Notes from the Field: The National Wastewater Surveillance System's Centers of Excellence Contributions to Public Health Action During the Respiratory Virus Season - Four U.S. Jurisdictions, 2022-23.
Diana Valencia et al. MMWR Morb Mortal Wkly Rep 2023 11 (48) 1309-1312 (Posted Dec 01, 2023 7AM)

From the article: "NWSS Centers of Excellence have reported correlation between WWS data and clinical surveillance with WWS allowing localized, timely coverage, and in some situations, valuable lead time notification. In Wisconsin, WWS detected increases in influenza and RSV weeks before increases in related emergency department visits were observed. NWSS data, together with clinical surveillance data, have guided jurisdictional partner decisions regarding allocation of resources, deployment of vaccination clinics, updating clinical guidance, and sending respiratory disease notifications and alerts when trends exceed baseline thresholds. During the 2022–23 respiratory disease season, NWSS Centers of Excellence translated WWS data into real-time public health action for multiple respiratory pathogens, highlighting the contribution of WWS in monitoring disease circulation and helping guide public health response. "

'Treasure trove' of new CRISPR systems holds promise for genome editing.
Sara Reardon et al. Nature 2023 11 (Posted Nov 27, 2023 10AM)

From the paper: "CRISPR–Cas9 is best known as a laboratory tool for editing DNA, but its natural function is as part of the immune system that helps certain microorganisms to fight off viruses. Now, researchers have used an algorithm to sort through millions of genomes to find new, rare types of CRISPR system that could eventually be adapted into genome-editing tools. "

news Latest News and Publications
A medical multimodal large language model for future pandemics External Web Site Icon
Liu et al, NPJ Digital Medicine, December 2, 2023
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance. External Web Site Icon
Lee Audrey, et al. Nature immunology 2023 0 0.
Broadcast health: Leveraging YouTube for community health education. External Web Site Icon
Neely Sara Bynon, et al. Public health nursing (Boston, Mass.) 2023 0 0.
Clinical characteristics and outcomes of COVID-19 infection in Chinese patients with hematologic malignancies in the Omicron era. External Web Site Icon
Li Xian, et al. Hematology (Amsterdam, Netherlands) 2023 0 0. (1) 2288477
Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host. External Web Site Icon
Schami Alyssa, et al. Frontiers in cellular and infection microbiology 2023 0 0. 1274175
Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections. External Web Site Icon
Parums Dinah V, et al. Medical science monitor : international medical journal of experimental and clinical research 2023 0 0. e943312
Engineered immunogens to elicit antibodies against conserved coronavirus epitopes. External Web Site Icon
Kapingidza A Brenda, et al. Nature communications 2023 0 0. (1) 7897
Examining the potential risk factors for variable airflow limitation in patients recovering from SARS-CoV-2 Omicron variant infection: A case-control study. External Web Site Icon
Zhao Lihong, et al. American journal of infection control 2023 0 0.
Harnessing synthetic biology for advancing RNA therapeutics and vaccine design. External Web Site Icon
Pfeifer Blaine A, et al. NPJ systems biology and applications 2023 0 0. (1) 60
How do Twitter users feel about telehealth? A mixed-methods analysis of experiences, perceptions and expectations. External Web Site Icon
Sazon Hannah, et al. Health expectations : an international journal of public participation in health care and health policy 2023 0 0.


Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.