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Implementation Science PHGKB

Specific PHGKB|Implementation Science PHGKB|Public Health Genomics and Precision Health Knowledge Base (PHGKB)

Last Posted: May 11, 2024
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Family cascade screening for equitable identification of familial hypercholesterolemia: study protocol for a hybrid effectiveness-implementation type III randomized controlled trial
(Posted Apr 19, 2024 10AM)

From the abstract: " Familial hypercholesterolemia (FH) is a heritable disorder affecting 1.3 million individuals in the USA. Eighty percent of people with FH are undiagnosed, particularly minoritized populations including Black or African American people, Asian or Asian American people, and women across racial groups. Family cascade screening is an evidence-based practice that can increase diagnosis and improve health outcomes but is rarely implemented in routine practice, representing an important care gap. In pilot work, we leveraged best practices from behavioral economics and implementation science—including mixed-methods contextual inquiry with clinicians, patients, and health system constituents—to co-design two patient-facing implementation strategies to address this care gap..."

Training Institute for Dissemination and Implementation Research in Genomics and Precision Public Health (TIDR-GPPH)
UNC Precision Public Health Network, March 2024 (Posted Mar 20, 2024 7AM)

From the website: "This facilitated course is intended to provide participants with a thorough grounding in conducting dissemination and implementation (D&I) research with a specific focus on genomics and precision public health.is. TIDIR-GPPH will be a hybrid course including training through open access Training Institute for Dissemination and Implementation Research in Cancer (TIDIRC) with assigned reading material and office hours and a 2-day in-person event. Faculty and guest lecturers consist of leading experts in D&I theories, models, and frameworks; intervention fidelity and adaptation; stakeholder engagement and partnership for D&I; research methods and study designs for D&I; and measures and outcomes for D&I. "

To warrant clinical adoption AI models require a multi-faceted implementation evaluation
D van De Sande et al, NPJ Digital Medicine, March 6, 2024 (Posted Mar 06, 2024 9AM)

From the abstract: "Despite artificial intelligence (AI) technology progresses at unprecedented rate, our ability to translate these advancements into clinical value and adoption at the bedside remains comparatively limited. This paper reviews the current use of implementation outcomes in randomized controlled trials evaluating AI-based clinical decision support and found limited adoption. To advance trust and clinical adoption of AI, there is a need to bridge the gap between traditional quantitative metrics and implementation outcomes to better grasp the reasons behind the success or failure of AI systems and improve their translation into clinical value. "

Using implementation science to evaluate a population-wide genomic screening program: Findings from the first 20,000 In Our DNA SC participants.
Caitlin G Allen et al. Am J Hum Genet 2024 2 (Posted Feb 03, 2024 9AM)

From the abstract: "Over 14 months, 20,478 participants enrolled, and 14,053 samples were collected. The majority selected at-home sample collection followed by clinical sample collection and collection at community events. Participants were predominately female, White (self-identified), non-Hispanic, and between the ages of 40-49. Participants enrolled through community events were the most racially diverse and the youngest. Half of those enrolled completed the program. We identified 137 individuals with pathogenic or likely pathogenic variants for CDC Tier 1 conditions. The majority (77.4%) agreed to genetic counseling, and of those that agreed, 80.2% completed counseling. "


news Latest News and Publications
Implementation of AZD7442 (Tixagevimab/Cilgavimab) COVID-19 Pre-exposure Prophylaxis (PrEP) in the Largest Health Maintenance Organization in Israel: Real-world Uptake and Sociodemographic and Clinical Characteristics Across Immunocompromised Patient Groups. External Web Site Icon
Hayek Samah, et al. Infectious diseases and therapy 2024 0 0.
Factors impacting the adoption of big data in healthcare: A systematic literature review. External Web Site Icon
Abeer Saleh Al Teneiji et al. Int J Med Inform 2024 187105460
Applying Machine Learning Techniques to Implementation Science. External Web Site Icon
Nathalie Huguet et al. Online J Public Health Inform 2024 16e50201
Family cascade screening for equitable identification of familial hypercholesterolemia: study protocol for a hybrid effectiveness-implementation type III randomized controlled trial. External Web Site Icon
Christina Johnson et al. Implement Sci 2024 19(1) 30
Genetically guided precision medicine clinical decision support tools: a systematic review. External Web Site Icon
Darren Johnson et al. J Am Med Inform Assoc 2024
Validation of a Multivariable Model to Predict Suicide Attempt in a Mental Health Intake Sample. External Web Site Icon
Santiago Papini et al. JAMA Psychiatry 2024
Codesign of Lynch Choices : Using implementation science to create a clinically deliverable patient decision support website to transform cancer genetics care pathways. External Web Site Icon
Kelly Kohut et al. Psychooncology 2024 33(3) e6330
The Science of Precision Prevention: Research Opportunities and Clinical Applications to Reduce Cardiovascular Health Disparities. External Web Site Icon
Thomas A Pearson et al. JACC Adv 2024 3(1)
Implementation of rapid genomic sequencing in safety-net neonatal intensive care units: protocol for the VIrtual GenOme CenteR (VIGOR) proof-of-concept study. External Web Site Icon
Alissa M D'Gama et al. BMJ Open 2024 14(2) e080529
Publics' knowledge of, attitude to and motivation towards health-related genomics: a scoping review. External Web Site Icon
Angela Pearce et al. Eur J Hum Genet 2024

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About Implementation Science PHGKB

Implementation Science PHGKB is an online, continuously updated, searchable database of information and publications relevant to the role of implementation science to accelerate the translation of genomics and precision health applications into practice and programs. The ultimate success of these applications will depend on the incorporation of implementation science tools and methods in research. This research is relevant at the global, national, state, community and health systems level.

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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