Lynch Syndrome
What's New
Last Posted: Jun 13, 2024
- Population-Level Identification of Patients With Lynch Syndrome for Clinical Care, Quality Improvement, and Research.
Ravi N Sharaf et al. JCO Clin Cancer Inform 2024 8e2300157 - Targeted sequencing for hereditary breast and ovarian cancer in BRCA1/2-negative families from the Lynch Memorial Biobank reveals complex genetic architecture and phenocopies.
Jocelyn N Plowman et al. HGG Adv 2024 100306 - ChatGPT accurately performs genetic counseling for gynecologic cancers.
Jharna M Patel et al. Gynecol Oncol 2024 183115-119 - National Experiences from 30 Years of Provider-Mediated Cascade Testing in Lynch Syndrome Families-The Danish Model.
Lars Joachim Lindberg et al. Cancers (Basel) 2024 16(8) - No Racial Disparities Observed Using Point-of-Care Genetic Counseling and Testing for Endometrial and Ovarian Cancer in a Diverse Patient Population: A Retrospective Cohort Study.
Michael Kim et al. Cancers (Basel) 2024 16(8) - The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Lauren Gima et al. Clin Colon Rectal Surg 2024 37(3) 133-139 - Hereditary Cancer Syndrome Carriers: Feeling Left in the Corner.
Celia Diez de Los Rios de la Serna et al. Semin Oncol Nurs 2024 151624 - Challenges and opportunities for Lynch syndrome cascade testing in the United States.
Lauren E Passero et al. Fam Cancer 2024 3 - What to Know About Lynch Syndrome
ThedaCare Genetic Counseling, March 2024 - Codesign of Lynch Choices : Using implementation science to create a clinically deliverable patient decision support website to transform cancer genetics care pathways.
Kelly Kohut et al. Psychooncology 2024 33(3) e6330 - Lynch Syndrome Ups Risk for Colorectal, Other Cancers
E Herlache, Cancer Care, March 2024 - Cascade screening in HBOC and Lynch syndrome: guidelines and procedures in a UK centre.
D Gareth Evans et al. Fam Cancer 2024 - [Return of Individual Genomic Results to Germline Pathogenic Variant Carriers of Hereditary Cancer in Population Based Cohort Study].
Kinuko Ohneda et al. Gan To Kagaku Ryoho 2024 51(3) 231-236 - The comprehensive English National Lynch Syndrome Registry: development and description of a new genomics data resource.
Catherine Huntley et al. EClinicalMedicine 2024 69102465 - Identification of people with Lynch syndrome from those presenting with colorectal cancer in England: baseline analysis of the diagnostic pathway
FE McRonald et al, EJHG, February 15, 2024 - Real-World Data on Institutional Implementation of Screening for Mismatch Repair Deficiency and Lynch Syndrome in Endometrial Cancer Patients.
Carmen Joder et al. Cancers (Basel) 2024 16(3) - Combined population genomic screening for three high-risk conditions in Australia: a modelling study.
Paul Lacaze et al. EClinicalMedicine 2024 66102297 - Counselling and management of women with genetic predisposition to gynaecological cancers.
Naushabah Malik et al. Eur J Obstet Gynecol Reprod Biol 2024 29444-48 - Remembering My Brother Who Died of Cancer January 11, 2024 Georgia Hurst Blog Article
G Hurst, Cure, January 11, 2024 - Streamlining the diagnostic pathway for Lynch syndrome in colorectal cancer patients: a 10-year experience in a single Italian Cancer Center.
Alberto Puccini et al. Eur J Cancer Prev 2024 - Experiences of patients and family members with follow-up care, information needs and provider support after identification of Lynch Syndrome.
Ryan Mooney et al. Hered Cancer Clin Pract 2023 21(1) 28 - Prevalence of Variants of Uncertain Significance in Patients Undergoing Genetic Testing for Hereditary Breast and Ovarian Cancer and Lynch Syndrome.
Pavlina Chrysafi et al. Cancers (Basel) 2023 15(24) - Secondary (additional) findings from the 100,000 Genomes Project: disease manifestation, healthcare outcomes and costs of disclosure.
Joshua Nolan et al. Genet Med 2023 101051 - How Holiday Conversations About Cancer Can Save Lives
G Hurst, Cure, December 13, 2023 - Co-design of patient information leaflets for germline predisposition to cancer: recommendations for clinical practice from the UK Cancer Genetics Group (UKCGG), Cancer Research UK (CRUK) funded CanGene-CanVar Programme and the Association of Genetic Nurse Counsellors (AGNC).
Kelly Kohut et al. J Med Genet 2023 - [Providing Opportunities for Close Examination of Lynch Syndrome after Microsatellite Instability Testing in a Hospital Setting].
Misako Kaido et al. Gan To Kagaku Ryoho 2023 50(10) 1069-1072 - "Go ahead and screen" - advice to healthcare systems for routine lynch syndrome screening from interviews with newly diagnosed colorectal cancer patients.
Jennifer L Schneider et al. Hered Cancer Clin Pract 2023 21(1) 24 - Referral, Uptake, and Outcome of Genetic Counseling and Testing in Patients With Early-Onset Colorectal Cancer.
Hareem Syed et al. J Natl Compr Canc Netw 2023 21(11) 1156-1163.e5 - Influence of family history on penetrance of hereditary cancers in a population setting.
Leigh Jackson et al. EClinicalMedicine 2023 11 102159 - Screening and testing practices for Lynch syndrome in Nova Scotians with endometrial cancer: a descriptive study.
Marianne Levesque et al. CMAJ Open 2023 11(5) E1012-E1019 - DNA Mismatch Repair Gene Variant Classification: Evaluating the Utility of Somatic Mutations and Mismatch Repair Deficient Colonic Crypts and Endometrial Glands.
Romy Walker et al. Cancers (Basel) 2023 15(20) - Hereditary cancer testing in a diverse sample across three breast imaging centers.
Laura Westbrook et al. Breast Cancer Res Treat 2023 - Less is more: rethinking colorectal cancer resection strategies in Lynch syndrome.
Bryson W Katona et al. Lancet Gastroenterol Hepatol 2023 - Province-Wide Ascertainment of Lynch Syndrome in Manitoba.
Heidi Rothenmund et al. Clin Gastroenterol Hepatol 2023 - Tumor Testing and Genetic Analysis to Identify Lynch Syndrome Patients in an Italian Colorectal Cancer Cohort.
Antonino Pantaleo et al. Cancers (Basel) 2023 15(20) - Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade.
Emily C Harrold et al. Nat Med 2023 10 (10) 2458-2463 - Use of a multi-phased approach to identify and address facilitators and barriers to the implementation of a population-wide genomic screening program.
Caitlin G Allen et al. Implement Sci Commun 2023 4(1) 122 - Risk-stratified faecal immunochemical testing (FIT) for urgent colonoscopy in Lynch syndrome during the COVID-19 pandemic.
Anne G Lincoln et al. BJS Open 2023 7(5) - Lynch syndrome-associated upper tract urothelial carcinoma frequently occurs in patients older than 60 years: an opportunity to revisit urology clinical guidelines.
Kristyna Pivovarcikova et al. Virchows Arch 2023 - A retrospective study of consistency between immunohistochemistry and polymerase chain reaction of microsatellite instability in endometrial cancer.
Cheng Wang et al. PeerJ 2023 11e15920 - From diagnosis of colorectal cancer to diagnosis of Lynch syndrome: The RM Partners quality improvement project.
Laura Monje-Garcia et al. Colorectal Dis 2023 - PREMM5 distinguishes sporadic from Lynch syndrome-associated MMR-deficient/MSI-high colorectal cancer.
Renata L Sandoval et al. Fam Cancer 2023 - Lynch Syndrome Biopathology and Treatment: The Potential Role of microRNAs in Clinical Practice.
Serena Ascrizzi et al. Cancers (Basel) 2023 15(15) - Prevalence and genetic spectrum associated with hereditary colorectal cancer syndromes, the need to improve cancer risk awareness, and family cascade testing in Vietnam.
Huu-Thinh Nguyen et al. Fam Cancer 2023 - Using a multistep approach with multidisciplinary team to increase the diagnosis rate of Lynch syndrome-associated colorectal cancer after universal screening: a single-center study in Japan.
Kyota Tatsuta et al. Hered Cancer Clin Pract 2023 21(1) 14 - "Lynch Syndrome"-From Healer to a Vulnerable Patient: A Transformative Odyssey.
Aisha Khalid et al. J Patient Exp 2023 1023743735231189348 - Public attitudes challenge clinical practice on genetic risk disclosure in favour of healthcare-provided direct dissemination to relatives
A Rosen et al, EJHG, July 20, 2023 - The English National Lynch Syndrome Transformation Project
Brit Soc Gastro, July 14, 2023 - The Promise of Population-based Genomic Screening for Selected Hereditary Conditions: Contributions of Cost-Effectiveness Analysis
ND Rao et al, CDC Blog Post, July 14, 2023 - Molecular testing of endometrial carcinoma in real-world clinical practice.
M Bednaríková et al. Klin Onkol 2023 36(3) 215-223 - Clinical Multigene Panel Testing Identifies Racial and Ethnic Differences in Germline Pathogenic Variants Among Patients With Early-Onset Colorectal Cancer.
Hannah M Seagle et al. J Clin Oncol 2023 JCO2202378 - A mainstreaming oncogenomics model: improving the identification of Lynch syndrome.
Rosie O'Shea et al. Front Oncol 2023 131140135 - Current chemoprevention approaches in Lynch syndrome and Familial adenomatous polyposis: a global clinical practice survey.
Kathryn A Mraz et al. Front Oncol 2023 131141810 - Improving genetic testing following abnormal mismatch repair immunohistochemistry results in endometrial cancer.
Hannah C Karpel et al. Gynecol Oncol 2023 17520-24 - The Impact of Germline Alterations in Appendiceal Adenocarcinoma.
Michael B Foote et al. Clin Cancer Res 2023 OF1-OF7 - Mismatch Repair Deficiency and Lynch Syndrome Among Adult Patients With Glioma.
Patrick R Benusiglio et al. JCO Precis Oncol 2023 7e2200525 - Summary for Patients: Population Genomic Screening for Three Common Hereditary Conditions.
et al. Ann Intern Med 2023 5 (5) I19 - Privacy and utility of genetic testing in families with hereditary cancer syndromes living in three countries: the international cascade genetic screening experience.
Sivia Barnoy et al. Front Genet 2023 141109431 - Risk of Syndrome-Associated Cancers Among First-Degree Relatives of Patients With Pancreatic Ductal Adenocarcinoma With Pathogenic or Likely Pathogenic Germline Variants.
Xuan Chen et al. JAMA Oncol 2023 - Screening for 3 Genetic Conditions Is Cost-effective in Younger People.
Emily Harris et al. JAMA 2023 5
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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
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