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| NAT2 and CYP2E1 polymorphisms and antituberculosis drug-induced hepatotoxicity in Peruvian patients. Molecular genetics & genomic medicine 2022 Jun e1987. Jaramillo-Valverde Luis, Levano Kelly S, Tarazona David D, Capristano Silvia, Zegarra-Chapoñan Roberto, Sanchez Cesar, Yufra-Picardo Velia M, Tarazona-Santos Eduardo, Ugarte-Gil Cesar, Guio Heinn |
| Clinical and Genetic Risk Factors for Drug-Induced Liver Injury Associated with Anti-Tuberculosis Treatment-A Study from Patients of Portuguese Health Centers. Journal of personalized medicine 2022 May 12 (5): . Cavaco Maria João, Alcobia Celeste, Oliveiros Bárbara, Mesquita Luís Alcides, Carvalho Aurora, Matos Fernando, Carvalho José Miguel, Villar Miguel, Duarte Raquel, Mendes João, Ribeiro Carolina, Cordeiro Carlos Robalo, Regateiro Fernando, Silva Henriqueta Coimb |
| GSTT1/GSTM1 Genotype and Anti-Tuberculosis Drug-Induced Hepatotoxicity in Peruvian Patients. International journal of molecular sciences 2022 10 23 (19): . Jaramillo-Valverde Luis, Levano Kelly S, Tarazona David D, Vasquez-Dominguez Andres, Toledo-Nauto Anel, Capristano Silvia, Sanchez Cesar, Tarazona-Santos Eduardo, Ugarte-Gil Cesar, Guio Heinn |
| Homozygotes NAT2*5B slow acetylators are highly associated with hepatotoxicity induced by anti-tuberculosis drugs. Memorias do Instituto Oswaldo Cruz 2022 117 e210328. El-Jaick Kenia Balbi, Ribeiro-Alves Marcelo, Soares Marcos Vinícius Guimarães, Araujo Gabriela Eduardo França de, Pereira Gabriel Rodrigues Coutinho, Rolla Valeria Cavalcanti, Mesquita Joelma Freire De, De Castro Lia |
| Influence of N-acetyltransferase 2 (NAT2) genotype/single nucleotide polymorphisms on clearance of isoniazid in tuberculosis patients: a systematic review of population pharmacokinetic models. European journal of clinical pharmacology 2022 7 78 (10): 1535-1553. Thomas Levin, Raju Arun Prasath, Chaithra , M Sonal Sekhar, Varma Muralidhar, Saravu Kavitha, Banerjee Mithu, Sv Chidananda Sanju, Mallayasamy Surulivelrajan, Rao Mahad |
| Influence of NAT2 Genotype and Maturation on Isoniazid Exposure in Low-Birth-Weight and Preterm Infants With or Without Human Immunodeficiency Virus (HIV) Exposure. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 2 75 (6): 1037-1045. Béranger Agathe, Bekker Adrie, Solans Belén P, Cotton Mark F, Mirochnick Mark, Violari Avy, Wang Jiajia, Cababasay Mae, Wiesner Lubbe, Browning Renee, Moye Jack, Capparelli Edmund V, Savic Radojka |
| NAT2 polymorphism and clinical factors that increase antituberculosis drug-induced hepatotoxicity. Pharmacogenomics 2022 5 23 (9): 531-541. Mohamed Noor Nur Farhana, Salleh Mohd Zaki, Mohd Zim Mohd Arif, Bakar Zamzurina Abu, Fakhruzzaman Noorizhab Mohd Nur, Zakaria Noor Izyani, Lailanor Muhammad Imran, Teh Lay K |
| Pharmacogenetic testing for NAT2 genotypes in a Tanzanian population across the lifespan to guide future personalized isoniazid dosing. Tuberculosis (Edinburgh, Scotland) 2022 8 136 102246. Masiphephethu Maano V, Sariko Margaretha, Walongo Thomas, Maro Athanasia, Mduma Dorcus, Gratz Jean, Alshaer Mohammad, Peloquin Charles A, Mduma Estomih, Mpagama Stellah G, Thomas Tania, Houpt Eric R, Traore Afsatou, Bessong Pascal, Heysell Scott K, Operario Darwin |
| Population Pharmacokinetics and Pharmacodynamics of Isoniazid and its Metabolite Acetylisoniazid in Chinese Population. Frontiers in pharmacology 2022 8 13 932686. Chen Bing, Shi Hao-Qiang, Feng Meihua Rose, Wang Xi-Han, Cao Xiao-Mei, Cai Wei-M |
| Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity. Xenobiotica; the fate of foreign compounds in biological systems 2022 6 52 (5): 520-526. Wang Ning, Guo Shaochen, Liu Haiting, Ding Yangming, Yao Rong, Liu Zhongquan, Zhu Hui, Chen Xi, Yang Xinting, Chen Xiaoyou, Lu |
| A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment. American journal of respiratory and critical care medicine 2021 Aug . Verma Renu, Patil Sunita, Zhang Nan, Moreira Flora M F, Vitorio Marize T, Santos Andrea da S, Wallace Ellen, Gnanashanmugam Devasena, Persing David H, Savic Rada M, Croda Julio, Andrews Jason |
| Pharmacogenetics of interaction between depot medroxyprogesterone acetate and efavirenz, rifampicin, and isoniazid during treatment of HIV and tuberculosis. Pharmacogenetics and genomics 2021 Aug . Haas David W, Mngqibisa Rosie, Francis Jose, McIlleron Helen, Robinson Jennifer A, Kendall Michelle A, Baker Paxton, Mawlana Sajeeda, Badal-Faesen Sharlaa, Angira Francis, Omoz-Oarhe Ayotunde, Samaneka Wadzanai P, Denti Paolo, Cohn Susan E, |
| Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients. Molecular genetics & genomic medicine 2021 9 9 (10): e1764. Levano Kelly S, Jaramillo-Valverde Luis, Tarazona David D, Sanchez Cesar, Capristano Silvia, Vásquez-Loarte Tania, Solari Lely, Mendoza-Ticona Alberto, Soto Alonso, Rojas Christian, Zegarra-Chapoñan Roberto, Guio Heinn |
| Genetic characterization of N-acetyltransferase 2 variants in acquired multidrug-resistant tuberculosis in Indonesia. Pharmacogenomics 2021 1 22 (3): 157-163. Yuliwulandari Rika, Prayuni Kinasih, Razari Intan, Susilowati Retno W, Zulhamidah Yenni, Soedarsono Soedarsono, Sofro Abdul Salam M, Tokunaga Katsus |
| NAT2 Gene rs1041983 is Associated with Anti-Tuberculosis Drug Induced Hepatotoxicity Among Pediatric Tuberculosis in Bandung, Indonesia. The application of clinical genetics 2021 14 297-303. Headriawan Achmad, Pramono Alvinsyah Adhityo, Sukadi Abdurachman, Chairulfatah Alex, Maskoen Ani Melani, Nataprawira Heda Melin |
| NAT2 polymorphisms associated with the development of hepatotoxicity after first-line tuberculosis treatment in Mexican patients: From genotype to molecular structure characterization. Clinica chimica acta; international journal of clinical chemistry 2021 5 519 153-162. Herrera-Rodulfo Aldo, Carrillo-Tripp Mauricio, Laura Yeverino-Gutierrez Myrna, Peñuelas-Urquides Katia, Adiene González-Escalante Laura, Bermúdez de León Mario, Silva-Ramirez Beatr |
| PBPK Analysis to Study the Impact of Genetic Polymorphism of NAT2 on Drug-Drug Interaction Potential of Isoniazid. Pharmaceutical research 2021 9 38 (9): 1485-1496. Balhara Ankit, Singh Saranj |
| Population pharmacokinetic model of isoniazid in patients with tuberculosis in Tunisia. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2021 1 104 562-567. Fredj N Ben, Romdhane H Ben, Woillard J B, Chickaid M, Fadhel N Ben, Chadly Z, Chaabane A, Boughattas N, Aouam |
| Validation of PHASE for deriving N-acetyltransferase 2 haplotypes in the Western Cape mixed ancestry population. African journal of laboratory medicine 2021 1 9 (1): 988. Swart Celeste, Meldau Surita, Centner Chad M, Marais Adrian D, Omar Fierd |
| A Systematic Review and Meta-analysis of Isoniazid Pharmacokinetics in Healthy Volunteers and Patients with Tuberculosis. Clinical therapeutics 2020 Oct . Hong Boi-Lam, D'Cunha Ronilda, Li Peizhi, Al-Shaer Mohammad H, Alghamdi Wael A, An Guohua, Peloquin Charl |
| The role of NAT2 polymorphism and methylation in anti-tuberculosis drug-induced liver injury in Mongolian tuberculosis patients. Journal of clinical pharmacy and therapeutics 2020 Jun 45 (3): 561-569. Zhang Dong, Hao Jinqi, Hou Ruili, Yu Yanqin, Hu Baocui, Wei Liq |
| [Association of rs1495741 Single Nucleotide Polymorphism with Susceptibility of Anti-tuberculosis Drug-induced Hepatotoxicity]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2020 7 49 (6): 910-913. Wang Ming-Gui, Zhang Yao-Zhi, Zhang Meng, He Jian-Qi |
| A pilot study to investigate the utility of NAT2 genotype-guided isoniazid monotherapy regimens in NAT2 slow acetylators. Pharmacogenetics and genomics 2020 11 31 (3): 68-73. Yoo Hyounggyoon, Chun Ji Sang, Cho Joo-Youn, Kim Sang-Heon, Yoon Jihoon G, Goo Lee Min, Yu Kyung-Sang, Jang In-Jin, Oh Jaeseo |
| N-Acetyltransferase 2 Genotypes among Zulu-Speaking South Africans and Isoniazid and N-Acetyl-Isoniazid Pharmacokinetics during Antituberculosis Treatment. Antimicrobial agents and chemotherapy 2020 1 64 (4): . Mthiyane Thuli, Millard James, Adamson John, Balakrishna Yusentha, Connolly Cathy, Owen Andrew, Rustomjee Roxana, Dheda Keertan, McIlleron Helen, Pym Alexander |
| The Influence of NAT2 Genotypes on Isoniazid Plasma Concentration of Pulmonary Tuberculosis Patients in Southern Thailand. Tuberculosis and respiratory diseases 2020 11 83 (Supple 1): S55-S62. Ungcharoen Usanee, Sriplung Hutcha, Mahasirimongkol Surakameth, Chusri Saranyou, Wichukchinda Nuanjun, Mokmued Phongpan, Wattanapokayakit Sukanya, Chongsuvivatwong Virasak |
| Association of Drug Metabolic Enzyme Genetic Polymorphisms and Adverse Drug Reactions in Patients Receiving Rifapentine and Isoniazid Therapy for Latent Tuberculosis. International journal of environmental research and public health 2019 Dec 17 (1): . Yu Ya-Yen, Tsao Shih-Ming, Yang Wen-Ta, Huang Wei-Chang, Lin Ching-Hsiung, Chen Wei-Wen, Yang Shun-Fa, Chiou Hui-Ling, Huang Yi-W |
| Hepatotoxicity during TB treatment in people with HIV/AIDS related to NAT2 polymorphisms in Pernambuco, Northeast Brazil. Annals of hepatology 2019 Oct . Araujo-Mariz Carolline, Militão de Albuquerque Maria de Fátima P, Lopes Edmundo P, Ximenes Ricardo A A, Lacerda Heloísa R, Miranda-Filho Demócrito B, Lustosa-Martins Brena B, Pastor André Filipe P, Acioli-Santos Bartolom |
| Association of genetic polymorphisms of CYP2E1, NAT2, GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis. BMJ open 2019 Aug 9 (8): e027940. Yang Seungwon, Hwang Se Jung, Park Jung Yun, Chung Eun Kyoung, Lee Jangik |
Genomewide Association Study Confirming the Association of NAT2 with Susceptibility to Antituberculosis Drug-Induced Liver Injury in Thai Patients.
Antimicrobial agents and chemotherapy 2019 Aug 63 (8): . Suvichapanich Supharat, Wattanapokayakit Sukanya, Mushiroda Taisei, Yanai Hideki, Chuchottawon Charoen, Kantima Tassawan, Nedsuwan Supalert, Suwankesawong Wimon, Sonsupap Cholticha, Pannarunothai Roongkarn, Tumpattanakul Sukanya, Bamrungram Warawut, Chaiwong Achara, Mahasirimongkol Surakameth, Mameechai Sasithorn, Panthong Weerapat, Klungtes Nantawan, Munsoo Amara, Chauychana Udomrat, Maneerat Molrudee, Fukunaga Koya, Omae Yosuke, Tokunaga Katsus |
| Association of Nat2 Gene Polymorphism with Antitubercular Drug-induced Hepatotoxicity in the Eastern Uttar Pradesh Population. Cureus 2019 Apr 11 (4): e4425. Yadav Divya, Kumar Rahul, Dixit Rakesh K, Kant Surya, Verma Ajay, Srivastava Kanchan, Singh S K, Singh Sarve |
- Page last reviewed:Feb 1, 2023
- Page last updated:Mar 20, 2023
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