What Is Prediabetes?
J Jin, JAMA Patient Corner, December 1, 2023
From the article: " Prediabetes affects approximately 1 in 3 US adults and about 720 million individuals worldwide. People with prediabetes often have no symptoms, so most people with prediabetes do not know they have it. Risk Factors for Prediabetes include: Being older than 45 years; Being overweight or obese; Being physically active less than 3 times a week; Eating an unhealthy diet; Having a parent or sibling with type 2 diabetes; Having a history of diabetes during pregnancy (gestational diabetes) or giving birth to an infant weighing more than 9 pounds; Having polycystic ovary syndrome."
Digital Technology for Diabetes
MS Hughes et al, NEJM, November 29, 2023
From the article: "It is not unreasonable to forecast that developments in diabetes technology will continue to improve glycemic control while decreasing the burdens for patients in managing diabetes. If widely adopted, these types of technology have the potential to improve the lives of both patients with type 1, type 2, and other forms of diabetes. The onus lies with the medical profession to help achieve greater and more equitable use of these methods. "
Including diverse populations enhances the discovery of type 2 diabetes loci
S Fatumo, Nat Rev Genetics, November 22, 2023
From the paper: "A recent multi-ancestry GWAS meta-analysis greatly advances our understanding of the genetic basis of T2D by encompassing a broad range of populations. The insights gained from this research provide a foundation for future functional investigations, therapeutic development and the translation of GWAS findings to improve global health outcomes for all, regardless of genetic background. "
Association Between a First-Degree Family History and Self-Reported Personal History of Obesity, Diabetes, and Heart and Blood Conditions: Results From the All of Us Research Program.
Danielle Rasooly et al. J Am Heart Assoc 2023 11 e030779
From the abstract: "We assessed the association between a self-reported family history of ODHBs and their risk in the adult population (age =20 years) of the AoU (All of Us) Research Program, a longitudinal cohort study of diverse participants across the United States. We conducted a family history-wide association study to systematically assess the association of a first-degree family history of 15 ODHBs in AoU. We use the FamWAS method to estimate 225 familial associations among 15 ODHBs. The results include overlapping associations between family history of different types of cardiometabolic conditions (such as type 2 diabetes and coronary artery disease), and their risk factors (obesity, hypertension), where adults with a family history of 1 ODHB exhibited 1.1 to 5.6 times (1.5, on average) the odds of having a different ODHB. "