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Last Posted: Mar 14, 2024
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Personalized Medicine in Kidney Disease
G Gembilo et al, JPM, October 16, 2023

From the abstract: "Personalized medicine uses the phenotypes and genotypes of individuals to tailor the best therapeutic approach for each patient at the appropriate time, to identify a person’s propensity for disease, and/or to provide timely and targeted prevention. In the context of kidney diseases, it has the potential to completely transform patient care on the basis of individual traits and needs. In particular, personalized medicine approaches in chronic kidney disease (CKD) aim to tailor treatment strategies based on underlying causes, genetic factors, the rate of disease progression, and other personalized factors. "

CKD Risk Factors
CDC, June 2023 Brand

Diabetes and high blood pressure are the more common causes of CKD in most adults. Other risk factors include heart disease, obesity, a family history of CKD, inherited kidney disorders, past damage to the kidneys, and older age.

Non-invasive chronic kidney disease risk stratification tool derived from retina-based deep learning and clinical factors.
Young Su Joo et al. NPJ Digit Med 2023 6 (1) 114

Despite the importance of preventing chronic kidney disease (CKD), predicting high-risk patients who require active intervention is challenging, especially in people with preserved kidney function. In this study, a predictive risk score for CKD (Reti-CKD score) was derived from a deep learning algorithm using retinal photographs. The performance of the Reti-CKD score was verified using two longitudinal cohorts of the UK Biobank and Korean Diabetic Cohort.

Biomarkers and personalised medicine in paediatric kidney disease
BL Neuen, The Lancet Ped Adol Med, June 2023

The concept of precision medicine for children and adults with chronic kidney disease has gained considerable attention in the past decade, with improvements in our understanding of the genetic, molecular, and other mechanisms that drive disease predisposition and progression. A notable example is the US National Institute of Diabetes and Digestive and Kidney Diseases' Kidney Precision Medicine Project,

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Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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