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Last Posted: Jan 30, 2024
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Multiomic Analysis of Neuroinflammation and Occult Infection in Sudden Infant Death Syndrome.
Prashanth S Ramachandran et al. JAMA Neurol 2024 1

From the abstract: "In this case-control study, postmortem serum and/or cerebrospinal fluid (CSF) samples from 71 sudden infant death syndrome (SIDS) cases and 20 controls were screened for inflammatory markers. A subset of SIDS cases showed elevated levels of CSF neopterin; metagenomic next-generation sequencing identified human parechovirus 3 (HPeV3) in 1 case, and single-nucleus RNA sequencing revealed cell type–specific molecular signatures of brainstem neuroinflammation associated with HPeV3. Postmortem application of next-generation molecular approaches can reveal undiagnosed neuroinflammation, occult infection, and novel insights into pathophysiology in infants dying suddenly and unexpectedly. "

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