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Last Posted: Jan 30, 2024
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Predictive evidence of the relevance of epigenetics to PTSD.
Leon Mutesa et al. Nat Rev Genet 2023 8

Post-traumatic stress disorder (PTSD) is a complex mental health condition that can occur after a life-threatening or otherwise traumatic event. Although its molecular causes are unclear, its development is thought to involve a range of biological, psychological and environmental factors. In 2009, Yehuda and Bierer posited that epigenetic modifications, such as DNA methylation, may occur in response to environmental influences such as trauma exposure, thus altering the functional expression of genes. These mechanisms may explain the intergenerational transmission of PTSD across affected families.

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