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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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24 hot topic(s) found with the query "Chronic fatigue syndrome"

Understanding myalgic encephalomyelitis.
Marshall-Gradisnik Sonya et al. Science (New York, N.Y.) 2022 9 (6611) 1150-1151 (Posted: Sep 10, 2022 10AM)

An important research challenge is the lack of a validated biomarker, laboratory-based test, and animal model, likely attributed to inconsistency in protocols, such as cell isolation, sample type, and technique. These challenges provide important lessons for research of Long Covid. By developing interdisciplinary and consistent research protocols, the pathomechanism of ME/CFS and Long Covid can be elucidated.

Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis
S Das et al, MEDRXIV, September 9, 2022 (Posted: Sep 10, 2022 10AM)

We applied both GWAS and the PrecisionLife combinatorial analytics platform to analyze ME/CFS cohorts from UK Biobank, including the Pain Questionnaire cohort, in a case-control design with 1,000 cycles of fully random permutation. The results from this study were supported by a series of replication and cohort comparison experiments, including use of a disjoint Verbal Interview cohort also derived from UK Biobank, and results compared for reproducibility. Results: Combinatorial analysis revealed 199 SNPs mapping to 14 genes, that were significantly associated with 91% of the cases in the ME/CFS population.

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome
BD Paul et al, PNAS, August 24, 2021 (Posted: Aug 23, 2021 11AM)

We summarize the evidence that people with acute COVID-19 and with ME/CFS have biological abnormalities including redox imbalance, systemic inflammation and neuroinflammation, an impaired ability to generate adenosine triphosphate, and a general hypometabolic state. We also examine the bidirectional relationship between redox imbalance, inflammation, energy metabolic deficits, and a hypometabolic state. We speculate as to what may be causing these abnormalities. Thus, understanding the molecular underpinnings of both PASC and ME/CFS may lead to the development of novel therapeutics.

The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: analysis of high-throughput epigenetic and gene expression studies
J Malato et al, MEDRXIV, April 8, 2021 (Posted: Apr 09, 2021 7AM)

Long COVID: let patients help define long-lasting COVID symptoms
Nature editorial, October 7, 2020 (Posted: Oct 07, 2020 1PM)

In deciding how to act on long COVID, we must take heed of what happened in the case of myalgic encephalomyelitis, also called chronic fatigue syndrome (ME/CFS). The condition shares some of the symptoms of long COVID, and people with ME/CFS struggled for years to be recognized as having a serious medical condition that needed specialized treatment and research.

Biomarker Test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
J Abbasi, JAMA, July 9, 2019 (Posted: Jul 11, 2019 8AM)

Researchers recently described a new nanoelectronics assay designed to measure immune cells? response to an osmotic stressor?in this case a dose of salt, a common way researchers stress cells in the lab. The idea was to mimic postexertional malaise, the cardinal feature of chronic fatigue syndrome, on a cellular level.

Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome.
Komaroff Anthony L et al. JAMA 2019 Jul (Posted: Jul 08, 2019 8AM)

Major advances have occurred in understanding the pathophysiology of chronic fatigue syndrome. However, to date, we have no reliable diagnostic test and no approved treatment.

Information for Healthcare Providers
Brand (Posted: Jul 17, 2018 0PM)

Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?
Newberry Fiona et al. Clinical science (London, England : 1979) 2018 Mar (5) 523-542 (Posted: Jul 17, 2018 10AM)

May 12 is ME/CFS and Fibromyalgia International Awareness Day
Brand (Posted: May 12, 2018 10AM)

CDC Information: Chronic Fatigue Syndrome Awareness Day
Brand (Posted: May 10, 2016 1PM)

Chronic Fatigue Syndrome: Advancing Research and Clinical Education
Brand (Posted: Feb 12, 2016 1PM)

Chronic Fatigue Syndrome Research Gains Funding, And Controversy
National Public Radio, November 4, 2015 (Posted: Nov 04, 2015 5PM)

Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome.
Rajeevan Mangalathu S et al. Human immunology 2015 Aug (8) 553-60 (Posted: Nov 04, 2015 9AM)

Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region: Associations With HPA Axis Hypofunction and Childhood Trauma.
Vangeel Elise et al. Psychosomatic medicine 2015 Oct (8) 853-62 (Posted: Nov 04, 2015 9AM)

NIH takes action to bolster research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
NIH News, October 29, 2015 Brand (Posted: Nov 04, 2015 9AM)

Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome.
Brown Audrey E et al. PLoS ONE 2015 (4) e0122982 (Posted: May 12, 2015 7AM)

Identification of a MicroRNA Signature for the Diagnosis of Fibromyalgia.
Cerdá-Olmedo Germán et al. PLoS ONE 2015 (3) e0121903 (Posted: May 12, 2015 7AM)

CDC information: Chronic fatigue syndrome is a debilitating and complex disorder
CFS is characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity Brand (Posted: Feb 25, 2015 0PM)

Chronic Fatigue syndrome gets a new name
David Tuller, New York Times, February 10, 2015 (Posted: Feb 12, 2015 8AM)

What genes have been reported in relation to risk and outcomes of chronic Fatigue syndrome?
Check out the HuGE Navigator (Posted: Feb 12, 2015 8AM)

Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome.
Smith Alicia K et al. Neuropsychobiology 2011 (4) 183-94 (Posted: Feb 12, 2015 8AM)

Genome-wide analysis of single nucleotide polymorphisms and copy number variants in fibromyalgia suggest a role for the central nervous system.
Docampo Elisa et al. Pain 2014 Jun (6) 1102-9 (Posted: Feb 12, 2015 8AM)

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an illness [PDF 373.58 KB]
Institute of Medicine Report, February 2015 (Posted: Jan 01, 2014 0AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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