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Hot Topics of the Day|PHGKB
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12/25/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

SARS-CoV-2 Genomic Surveillance in Costa Rica: Evidence of a Divergent Population and an Increased Detection of a Spike T1117I Mutation
JAM Mora et al, BIORXIV, December 2020

Evolutionary tracking of SARS-CoV-2 genetic variants highlights intricate balance of stabilizing and destabilizing mutations
JJ Jacob et al, BIORXIV, December 22, 2020

Patterns of within-host genetic diversity in SARS-CoV-2
GT Hill et al, BIORXIV, December 25, 2020

DeepCOVID: An Operational Deep Learning-driven Framework for Explainable Real-time COVID-19 Forecasting
A Rodriguez et al MEDRXIV, December 24, 2020

A Neanderthal OAS1 Isoform Protects Against COVID-19 Susceptibility and Severity: Results from Mendelian Randomization and Case-Control Studies
S Zhou et al, MEDRXIV, December 24, 2020

Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections
J Hellewell et al, MEDRXIV, December 24, 2020

HLA-C* 04:01 is a Genetic Risk Allele for Severe Course of COVID-19
J Weiner et al, MEDRXIV, December 24, 2020

We analyzed a total of 332 samples. First, we enrolled 233 patients in Germany, Spain, and Switzerland for HLA and whole exome sequencing. We identified HLA-C* 04:01 as a novel genetic predictor for severe clinical course in COVID-19. Carriers of HLA-C* 04:01 had twice the risk of intubation when infected with SARS-CoV-2 (hazard ratio 2.1, adjusted p-value=0.0036). Importantly, these findings were successfully replicated in an independent data set.

Prioritizing Risk Groups for SARS-CoV-2 Vaccination "By the Numbers"
CJ MacDonald et al, MEDRXIV, December 24, 2020


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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