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Hot Topics of the Day|PHGKB
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12/24/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Direct RNA nanopore sequencing of SARS-CoV-2 extracted from critical material from swabs
D Vacca et al, MEDRXIV, December 23, 2020

Digital proximity tracing app notifications lead to faster quarantine in non-household contacts: results from the Zurich SARS-CoV-2 Cohort Study
T Ballouz et al MEDRXIV, December 23, 2020

Automated processing of thermal imaging to detect COVID-19
RY Brzeinski et al, MEDRXIV, December 24, 2020

Predicting the Evolution of COVID-19 Mortality Risk: a Recurrent Neural Network Approach
M Villegas et al, MEDRXIV, December 24, 2020

THE SEARCH FOR AN ASSOCIATION OF HLA ALLELES AND COVID-19 RELATED MORTALITY IN THE RUSSIAN POPULATION
V Cheranev et al, MEDRXIV< December 24, 2020

On an optimal testing strategy for workplace settings operating during the COVID-19 pandemic
X Hernandez et al, MEDRXIV, December 24, 2020

Analysis of genome characteristics and transmission of SARS-CoV-2 strains in North-East of Romania during the first COVID-19 outbreak
A Lobiuc et al, MEDRXIV, December 24, 2020

Identifying communities at risk for COVID-19-related burden across 500 U.S. Cities and within New York City
CJ Patel et al MEDRXIV, December 24, 2020

We develop a COVID-19 Community Risk Score (C-19 Risk Score) that summarizes the complex disease co-occurrences for individual census tracts with unsupervised learning. We mapped the C19 Risk Score onto neighborhoods in New York City and associated the score with C-19 related death. The C-19 Risk Score describes 85% of variation in co-occurrence of 15 diseases that are risk factors for COVID complications among 26K census tract neighborhoods.

Toward a COVID-19 testing policy: where and how to test when the purpose is to isolate silent spreaders
AL Rivas et al, MEDRXIV, December 24, 2020

Coronavirus GenBrowser for monitoring adaptive evolution and transmission of SARS-CoV-2
D Yu et al, MEDRXIV, December 24, 2020

Patterns of SARS-CoV-2 testing preferences in a national cohort in the United States
ML Romo et al, MEDRXIV, December 24, 2020

Unravelling the early warning capability of wastewater surveillance for COVID-19: A temporal study on SARS-CoV-2 RNA detection and need for the escalation
M Kumar et al, MEDRXIV, December 24, 2020

https://www.medrxiv.org/content/10.1101/2020.12.23.20248725v1
LT Nguyen et al, MEDRXIV, December 24, 2020

COVID-19 Published Science and Research
CDC, December 22, 2020 Brand

CDC is responding to the COVID-19 pandemic by learning more about how the disease spreads and affects people and communities. CDC’s MMWR publishes the results of COVID-19 outbreak investigations. CDC’s scientific journal Emerging Infectious Diseases has published dozens of studies by researchers studying COVID-19 since the pandemic began.

Pandemic Spotlights In-home Colon Cancer Screening Tests
MC Jaclevic, JAMA, December 23, 2020

Long overshadowed by colonoscopy, stool-based screening tests that patients perform at home are getting a boost as hospitals halted and then curtailed nonemergency procedures in an effort to preserve resources and prevent novel coronavirus transmission. One type of test, multitarget stool DNA detects cancer biomarkers and blood in the stools.

A Genomic-Pathologic Annotated Risk Model to Predict Recurrence in Early-Stage Lung Adenocarcinoma
GD Jones et al JAMA SUregery, December 23, 2020

In this observational study of 426 patients with LUAD, alterations in SMARCA4 and TP53 and fraction of genome altered were independently associated with relapse-free survival. By integrating genomic and clinicopathologic factors, this prediction model outperformed the TNM-based model (concordance probability estimate, 0.73 vs 0.61) for prediction of relapse-free survival and was externally validated using The Cancer Genome Atlas data set.

Association of the V122I Transthyretin Amyloidosis Genetic Variant With Cardiac Structure and Function in Middle-aged Black Adults - Coronary Artery Risk Development in Young Adults (CARDIA) Study
A Sinha et al, JAMA Cardiology, December 23, 2020

In this population-based cohort study of 875 Black adults, there was a significant association of the TTR V122I variant with worse left ventricular structure and cardiac mechanics at a mean age of 54 years. Earlier screening with echocardiography may inform use of novel therapies and intensification of risk factor modification to prevent heart failure.


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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