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Hot Topics of the Day|PHGKB
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10/01/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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The Human Genome Project turns the big 3-0!
P Ganguly, NHGRI, September 29, 2020 Brand

Genomics — now a household word — was greatly elevated in stature in October 1990 with the worldwide launch of the Human Genome Project. This month marks the 30th anniversary of the endeavor, biology's audacious odyssey that deciphered the first sequence of the 3 billion DNA letters making up the human genetic blueprint — the human genome.

Genome UK: a new National Genomics Healthcare Strategy
P Brice, PHG Foundation, September 26, 2020

The much-anticipated National Genomics Healthcare Strategy, has now landed. GENOME UK: The future of healthcare sets out plans to use genomics to drive improvements in diagnosis and personalized medicine; disease prevention; and research. All to be achieved by building on existing major institutions, funding streams and infrastructure.

Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area
S Wesley et al, MEDRXIV, September 29, 2020

Preliminary analysis of scRNA sequencing of children's lung tissues excludes the expression of SARS-CoV-2 entry related genes as the key reason for the milder syndromes of COVID-19 in children
Y Tao et al, MEDRXIV, September 29, 2020

Functional immunoparalysis characterized by elevated Interleukin-10 and Interleukin-10-to-Lymphocyte Count Ratio is associated with severe disease and poor outcomes in coronavirus disease 2019 (COVID-19)
BM Henry et al, MEDRXIV, September 29, 2020

Coding Complete Genome Sequences of Twenty-three SARS-CoV-2 Strains Isolated in the Philippines
JS Velasco et al, MEDRXIV, September 29, 2020

DeepCOVID: An Operational Deep Learning-driven Framework for Explainable Real-time COVID-19 Forecasting
A Rodriguez et al, MEDRXIV, September 29, 2020

Artificial intelligence to predict the risk of mortality from COVID-19: Insights from a Canadian Application
B Snider et al, MEDRXIV, September 30, 2020

Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia.
Logunov Denis Y et al. Lancet (London, England) 2020 09 (10255) 887-897

In this small study involving older adults, adverse events associated with the mRNA-1273 vaccine were mainly mild or moderate. The 100-µg dose induced higher binding- and neutralizing-antibody titers than the 25-µg dose, which supports the use of the 100-µg dose in a phase 3 vaccine trial.

Rethinking Covid-19 Test Sensitivity - A Strategy for Containment.
Mina Michael J et al. The New England journal of medicine 2020 Sep

It’s time to change how we think about the sensitivity of testing for Covid-19. The Food and Drug Administration (FDA) and the scientific community are currently almost exclusively focused on test sensitivity. Critically, this measure neglects the context of how the test is being used. Yet when it comes to broad screening, context is fundamental.

From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer.
Wray Naomi R et al. JAMA psychiatry 2020 Sep

Utility of polygenic risk scores in clinical medicine and ethical issues related to their use should be evaluated in the context of realistic expectations of what PRS can and cannot deliver. For different diseases, PRS could have utility in community settings or could contribute to clinical decision-making for those presenting with symptoms but where formal diagnosis is unclear. More data are needed to allow development of PRS in practice.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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