Twins with Covid Help Scientists Untangle the Disease’s Genetic Roots
“I want to know,” one twin said, “why did she have Covid worse than me?”
KJ Wu, NY Times, January 18, 2021
‘A bloody mess’: Confusion reigns over naming of new COVID variants
As more lineages emerge, researchers are struggling with a patchwork of nomenclature.
E Callaway, Nature News, January 15, 2021
Alarming COVID variants show vital role of genomic surveillance
D Cyranoski, Nature News, January 15, 2021
The pandemic has ushered in an era of genomic surveillance in which scientists are tracking genomic changes to a virus at a speed and scale never seen before. But surveillance is patchy globally. Scientists warn that worrying variants are probably spreading undetected in these regions.
The challenges of containing SARS-CoV-2 via test-trace-and-isolate
S Contreras et al, Nat Comm, January 15, 2021
Without a cure, vaccine, or proven long-term immunity against SARS-CoV-2, test-trace-and-isolate (TTI) strategies present a promising tool to contain its spread. For any TTI strategy, however, mitigation is challenged by pre- and asymptomatic transmission. Our modeling suggests that TTI alone is insufficient to contain an otherwise unhindered spread of SARS-CoV-2.
Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hotspots, Functional Crosstalk and Regulatory Interactions in SARS-CoV-2
V Gupta et al, BIORXIV, January 15, 2021
Correlation of Computerized Tomography (CT) Severity Score for COVID-19 pneumonia with Clinical Outcomes
K Hilal et al, BIORXIV, January 15, 2021
Metabolic markers distinguish COVID-19 from other intensive care patients and show potential to stratify for disease risk
F Schmelter et al, MEDRXIV, January 16, 2021
Coronavirus-19 and coagulopathy: A Systematic Review [COVID-COAG]
SG Lee et al, MEDRXIV, January 16, 2021
The microbiota in pneumonia: From protection to predisposition.
Thibeault Charlotte et al. Science translational medicine 2021 Jan (576)
The normal upper respiratory tract and gut microbiota protects against pneumonia by impeding colonization by potentially pathogenic bacteria and by regulating immune responses. However, antimicrobial therapy and critical care procedures perturb the microbiota, thus compromising its function and predisposing to lung infections. Interindividual variations and age-related alterations in the microbiota also affect vulnerability to pneumonia.
Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses.
Sun Luanluan et al. PLoS medicine 2021 Jan (1) e1003498
We quantified the incremental predictive gain with polygenic risk scores on top of conventional risk factors using data on 306,654 individuals from UK Biobank.?Addition of PRSs to conventional risk factors provided modest improvement in prediction of first-onset CVD. even moderate improvements could translate into meaningful clinical benefit if applied at scale, and lead to the prevention of 7% more CVD events than conventional risk factors alone.