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Hot Topics of the Day|PHGKB
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Jul 20, 2019

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Last Posted: Jul-20-2019 16:33:49

Genomic knowledge in the contextstic exome sequencing: changes over time, persistent subgroup differences, and associations with psychological sequencing outcomes.
Rini Christine et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Jul

People undergoing diagnostic genome-scale sequencing are expected to have better psychological outcomes when they can incorporate and act on accurate, relevant knowledge that supports informed decision making. The NCGENES study of diagnostic exome sequencing to evaluate associations between factual genomic knowledge and sequencing outcomes.

Comparison of Postmarketing Findings vs the Initial Clinical Validation Findings of a Thyroid Nodule Gene Expression Classifier: A Systematic Review and Meta-analysis.
Valderrabano Pablo et al. JAMA otolaryngology-- head & neck surgery 2019 Jul

Is the diagnostic performance of a common thyroid nodule gene expression classifier in the initial validation study consistent with results of postmarketing studies? Find out what this systematic review and meta-analysis of 19 studies involving 2568 cytologically indeterminate thyroid nodules found.

Molecular Testing for Indeterminate Thyroid Nodules-When the Rubber Meets the Road.
Marti Jennifer L et al. JAMA otolaryngology-- head & neck surgery 2019 Jul

Comparison of adopted and non-adopted individuals reveals gene-environment interplay for education in the UK Biobank
R Cheesman et al, BioRXIV preprints, July 18, 2019

The study uses information from 6311 individuals in the UK Biobank who were adopted in childhood to compare genetic influence on education between adoptees and non-adopted individuals. The study provides another kind of evidence for the influence of parental behavior on offspring education.

Prediction and Prevention Using Deep Learning.
Tsega Surafel et al. JAMA network open 2019 Jul (7) e197447

Medicine finds itself in an age of data. From electronic medical records to wearables, the capturing, storing, and synthesizing of data are becoming an important part in the changing landscape. Deep learning uses computer modeling, known as artificial neural networks, to identify complex relationships, and to apply this knowledge to newly added data.

It Is Now Time to Focus on Risk Before Age 40.
Gidding Samuel S et al. Journal of the American College of Cardiology 2019 Jul (3) 342-345


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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