Apr 08, 2020
Last Posted: Apr-08-2020 15:09:37
How many people are infected with Covid-19? Sewage suggests that number is much higher than officially confirmed
Medium, April 8, 2020
Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal
L Wynants et al, BMJ, April 7, 2020
This review critically appraises published and preprint reports of prediction models for diagnosing coronavirus disease 2019 (covid-19) in patients with suspected infection, for prognosis of patients with covid-19, and for detecting people in the general population at risk of being admitted to hospital for covid-19 pneumonia.
Hunt Is on for Genetic Clues to Why Coronavirus Impact Varies
AD Marcus, WSJ, April 7, 2020
Scientists around the world are pooling their knowledge and resources to determine whether gene variations make people more susceptible to serious Covid-19 infection, hoping to learn why some patients’ coronavirus symptoms are quite mild while others’ are severe.
How Many Adults Are at Risk of Serious Illness If Infected with Coronavirus? Updated Data
W Koma et al, Global Health Policy, KFF, April 7, 2020
Meta-Analysis of Vaginal Microbiome Data Provides New Insights Into Preterm Birth
I Kosti et al, Front Micro, April 8, 2020
We integrated raw longitudinal 16S rRNA vaginal microbiome data from five independent studies across 3,201 samples and were able to gain new insights into the vaginal microbiome state in women who deliver preterm. We found that women who deliver prematurely show higher within-sample variance in vaginal microbiome abundance, mostly during the first trimester.
Rights, interests and expectations: Indigenous perspectives on unrestricted access to genomic data
M Hudson et al, Nat Rev Genetics, April 7, 2020
Although Indigenous experiences with genetic research have been shaped by negative interactions, there is increasing recognition that equitable benefits can only be realized through greater participation of Indigenous communities. Issues of trust, accountability and equity underpin Indigenous critiques of genetic research and the sharing of genomic data.
Recent advances in understanding inherited deficiencies in immunity to infections
GM Constantine et al, F1000, April 7, 2020
Inherited immunodeficiencies that manifest with susceptibility to bacterial, viral, and/or fungal infections have provided fundamental insights into the indispensable contribution of key immune pathways in host defense against various pathogens. In this mini-review, we summarize the findings from recent publications on inherited immunodeficiencies.
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