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Hot Topics of the Day|PHGKB
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Apr 08, 2020

Last Posted: Apr-08-2020 15:09:37

How many people are infected with Covid-19? Sewage suggests that number is much higher than officially confirmed
Medium, April 8, 2020

Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal
L Wynants et al, BMJ, April 7, 2020

This review critically appraises published and preprint reports of prediction models for diagnosing coronavirus disease 2019 (covid-19) in patients with suspected infection, for prognosis of patients with covid-19, and for detecting people in the general population at risk of being admitted to hospital for covid-19 pneumonia.

Hunt Is on for Genetic Clues to Why Coronavirus Impact Varies
AD Marcus, WSJ, April 7, 2020

Scientists around the world are pooling their knowledge and resources to determine whether gene variations make people more susceptible to serious Covid-19 infection, hoping to learn why some patients’ coronavirus symptoms are quite mild while others’ are severe.

How Many Adults Are at Risk of Serious Illness If Infected with Coronavirus? Updated Data
W Koma et al, Global Health Policy, KFF, April 7, 2020

Meta-Analysis of Vaginal Microbiome Data Provides New Insights Into Preterm Birth
I Kosti et al, Front Micro, April 8, 2020

We integrated raw longitudinal 16S rRNA vaginal microbiome data from five independent studies across 3,201 samples and were able to gain new insights into the vaginal microbiome state in women who deliver preterm. We found that women who deliver prematurely show higher within-sample variance in vaginal microbiome abundance, mostly during the first trimester.

Associations Between Mutations in MSH6 and PMS2 and Risk of Surveillance-detected Colorectal Cancer.
Lamba Mehul et al. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020 Mar

The need for a system view to regulate artificial intelligence/machine learning-based software as medical device
S Gerke et al, NPJ Digital Medicine, April 7, 2020

A shift in perspective—from a product view to a system view—is central to maximizing the safety and efficacy of AI/ML in health care, but it also poses significant challenges for agencies who are used to regulating products, not systems. We offer several suggestions for regulators to make this challenging but important transition.

Rights, interests and expectations: Indigenous perspectives on unrestricted access to genomic data
M Hudson et al, Nat Rev Genetics, April 7, 2020

Although Indigenous experiences with genetic research have been shaped by negative interactions, there is increasing recognition that equitable benefits can only be realized through greater participation of Indigenous communities. Issues of trust, accountability and equity underpin Indigenous critiques of genetic research and the sharing of genomic data.

Recent advances in understanding inherited deficiencies in immunity to infections
GM Constantine et al, F1000, April 7, 2020

Inherited immunodeficiencies that manifest with susceptibility to bacterial, viral, and/or fungal infections have provided fundamental insights into the indispensable contribution of key immune pathways in host defense against various pathogens. In this mini-review, we summarize the findings from recent publications on inherited immunodeficiencies.


Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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