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Oct 25, 2020

Last Posted: Oct-25-2020 10:38:52

Guide to Global Digital Tools for COVID-19 Response
CDC, October 23, 2020 Brand

The guide compares the District Health Information Software (DHIS2), the Surveillance, Outbreak Response Management and Analysis System (SORMAS), Go.Data, Open Data Kit (ODK), Epi Info, CommCare, KoboToolbox, Excel, and paper. Each has been deployed in various countries for contact tracing, investigations, and/or, in the case of DHIS2 and SORMAS, national surveillance

Identification of required host factors for SARS-CoV-2 infection in human cells
Z Daniloski et al, Cell, October 24, 2020

We performed a genome-scale CRISPR loss-of-function screen to identify host factors required for SARS-CoV-2 viral infection of human alveolar epithelial cells. Top-ranked genes cluster into distinct pathways, including the vacuolar ATPase proton pump, Retromer, and Commander complexes. Given the key role of the ACE2 receptor in the early stages of viral entry, we show that loss of RAB7A reduces viral entry by sequestering the ACE2 receptor inside cells.

Spatial Inequities in COVID-19 Testing, Positivity, Incidence and Mortality in 3 US Cities: a Longitudinal Ecological Study
U Bilal et al, MEDRXIV, October 23, 2020

SARS-CoV-2 induces inflammasome-dependent pyroptosis and downmodulation of HLA-DR in human monocytes
AC Ferreira et al, MEDRXIV, October 23, 2020

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19
BL Le et al, BIORXIV, October 22, 2020

PharmaNet: Pharmaceutical discovery with deep recurrent neural networks.
PR Puentes et al, BIORXIV, October 22, 2020

Exposome changes in primary school children following the wide population non-pharmacological interventions implemented due to COVID-19 in Cyprus: a national survey
C Constantino et al, MEDRXIV, October 23, 2020

Impact of body composition on COVID-19 susceptibility and severity: a two-sample multivariable Mendelian randomization study
D Freuer et al, MEDRXIV, October 24,2020

Using Mendelian randomization, we investigated the causal impact of body composition on the susceptibility and severity of COVID-19. Genetically predicted BMI was strongly associated with both, susceptibility (OR=1.31 per 1 SD increase) and hospitalization (OR=1.62 per 1 SD increase) even after adjustment for genetically predicted visceral obesity traits. These associations were neither mediated substantially by T2D nor by CVD.

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.