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Hot Topics of the Day|PHGKB
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Sep 21, 2019

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date
Last Posted: Sep-21-2019 13:08:00

Rethinking the ethical principles of genomic medicine services
SB Johnson et al, Eur J Hum Genetics, September 18, 2019

This paper examines ethical principles that should guide regulatory processes regarding consent and data sharing in this context. We argue that genomic data in a health system carries substantial societal benefits, and that the collective nature of genomics means that patients who benefit from sequencing have an ethical obligation to share health information

Deep learning algorithm predicts diabetic retinopathy progression in individual patients
F Arcadu et al, NPJ Digital Medicine, September 20, 2019

The global burden of diabetic retinopathy (DR) continues to worsen and DR remains a leading cause of vision loss worldwide. Here, we describe an algorithm to predict DR progression by means of deep learning (DL), using as input color fundus photographs (CFPs) acquired at a single visit from a patient with DR.

Role of vitamin D in disease through the lens of Mendelian randomization—Evidence from Mendelian randomization challenges the benefits of vitamin D supplementation for disease prevention
D Manousaki et al, IJE, September 2019

Two studies add to the increasing repertoire of Mendelian randomization papers exploring the causal role of vitamin D on a variety of health outcomes. Indeed, among 62 Mendelian randomization papers for vitamin D published over the past 8?years, evidence supporting a causal role of vitamin D was provided only for a limited number of outcomes.

ALS gene may be a hitchhiker’s guide to the neuron
NIH, September 19, 2019 Brand

ALS is a paralyzing and highly fatal neurodegenerative disorder for which there are no effective treatments. Scientists peered inside neurons and watched the workings of annexin A11, a gene linked to a rare form of ALS. They found that neurons may normally use the gene to ship internal housekeeping instructions via a newly discovered “hitchhiking” system.

Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.