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Last Posted: Sep 29, 2022
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Health digital twins as tools for precision medicine: Considerations for computation, implementation, and regulation
KP Venkatesh et al, NPJ Digital Medicine, Sepetmber 22, 2022

Health digital twins are defined as virtual representations (“digital twin”) of patients (“physical twin”) that are generated from multimodal patient data, population data, and real-time updates on patient and environmental variables. With appropriate use, HDTs can model random perturbations on the digital twin to gain insight into the expected behavior of the physical twin—offering groundbreaking applications in precision medicine, clinical trials, and public health.

Implementing precision medicine in a regionally organized healthcare system in Sweden
T Fioretos et al, Nature Medicine, September 19, 2022

Although some governments have created national strategies for precision medicine and utilized centralized infrastructures, the process has proven more challenging for countries like Sweden with a regionally organized healthcare system. In Sweden, the key to a successful implementation of precision medicine has instead been a bottom-up approach in which academia and healthcare joined forces to build a nationally distributed infrastructure.

Building Capacity for Implementation Science in Precision Health and Society: Development of a Course for Professional and Graduate Students in Pharmacy
MC Roberts, J Personalized Medicine, September 14, 2022

Training in the field of implementation science is critical for future pharmacists and pharmaceutical scientists to successfully implement precision health interventions in pharmacy practice. We developed an elective course for second- and third-year students at the UNC Eshelman School of Pharmacy to develop foundational knowledge in implementation science with a focus on precision health implementation. The eight-week course used a flipped classroom format featuring lecture videos, suggested readings, quizzes, guest lectures from experts, case studies, and a group project.

Integrating rapid exome sequencing into NICU clinical care after a pilot research study
AM D'Gama et al, NPJ Genomic Medicine, September 5, 2022

Compared to other genetic tests, rapid ES had similar or higher diagnostic yield and similar or decreased time to result. Overall, rapid ES was utilized in the NICU after the pilot research study, often as the first-tier sequencing test, and could identify the majority of disease-causing variants, shorten the diagnostic odyssey, and impact clinical care. Based on our experience, we have identified strategies to optimize the clinical implementation of rapid ES in the NICU.

Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.