Records 1-2 (of 2 Records) |
Query Trace: PDE4A[original query] |
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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Erola Pairo-Castineira et al. Nature 2023 5 (7962) 764-768 |
GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19. EP Castineira et al, MEDRXIV, March 7, 2022
In this new data release from the GenOMICC (Genetics Of Mortality in Critical Care) study we include new microarray genotyping data from additional critically-ill cases in the UK and Brazil, together with cohorts of severe Covid-19 from the ISARIC4C and SCOURGE studies, and meta-analysis with previously-reported data. We find an additional \numconvincingnew new genetic associations. Many are in potentially druggable targets, in inflammatory signalling (JAK1, PDE4A), monocyte-macrophage differentiation (CSF2), immunometabolism (SLC2A5, AK5), and host factors required for viral entry and replication (TMPRSS2, RAB2A).
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