Goal: identify articles describing the evaluation of genomic applications and interventions, including their 1) clinical utility, 2) subsequent evidence-based recommendations, guidelines and policies, 3) use in practice, and 4) effect on the health and disease burden within the population.

Include:

• Research that promotes the integration of genomics into real-world practice settings and improved population health outcomes (T2-T4 phases of translational research).
• Observational or experimental studies that evaluate genomic interventions, reporting on clinical validity, clinical utility and/or their comparative effectiveness.
• Systematic reviews that report on genomics evidence-based interventions.
• Pre-implementation studies identifying barriers and facilitators to applications and interventions.
• Implementation and dissemination studies that identify effective strategies and/or measure outcomes including acceptability, adoption, appropriateness, cost, feasibility, fidelity, etc.
• Publications of guidelines and evidence reports on genomics applications.
• Expert opinion articles, editorials and nonsystematic reviews determined, by consensus, as significant for moving translational research forward.

Exclude:

• Studies of the characterization and development of candidate genomic health applications (T0-T1 phases of translational research).
• Epidemiologic studies of gene-disease association (Human Genome Epidemiology-separate database in PHGKB).
• Non-human genomics application studies.
• Case studies.

Goal: identify articles describing the evaluation of non-genomics precision health applications and interventions, including their 1) clinical utility, 2) subsequent evidence-based recommendations, guidelines and policies, 3) use in practice, and 4) effect on the health and disease burden within the population.

Include:

• Research that promotes the integration of precision health into real-world practice settings and improved population health outcomes (T2-T4 phases of translational research).
• Observational or experimental studies that evaluate precision health interventions, reporting on clinical validity, clinical utility and/or their comparative effectiveness.
• Systematic reviews that report on precision health evidence-based interventions.
• Pre-implementation studies identifying barriers and facilitators to applications and interventions.
• Implementation and dissemination studies that identify effective strategies and/or measure outcomes including acceptability, adoption, appropriateness, cost, feasibility, fidelity, etc.
• Publications of guidelines and evidence reports on precision health applications.
• Expert opinion articles, editorials and nonsystematic reviews determined, by consensus, as significant for moving translational research forward.

Exclude:

• Basic science studies .
• Non-human precision health studies.
• Case studies.