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| ITPA Polymorphisms and the Incidence of Toxicities in Children with Acute Lymphoblastic Leukemia. Mediterranean journal of hematology and infectious diseases 2023 3 15 (1): e2023024. Svasdisant Patpetra, Glomglao Waraporn, Siraprapapat Preeyanun, Inthararujikul Wiyakan, Tachavanich Kalaya, Boonthimat Chetsada, Ardsiri Sakkarin, Chansing Kochpinchon, Sriprach Suwimon, Tongsai Sasima, Sinlapamongkolkul Phakatip, Sanpakit Kleebsabai, Buaboonnam Jassa |
| Association of ITPA gene polymorphisms with adverse effects of AZA/6-MP administration: a systematic review and meta-analysis. The pharmacogenomics journal 2022 1 22 (1): 39-54. Barba Evaggelia, Kontou Panagiota I, Michalopoulos Ioannis, Bagos Pantelis G, Braliou Georgia |
| Effect of ITPA Polymorphism on Adverse Drug Reactions of 6-Mercaptopurine in Pediatric Patients with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis. Pharmaceuticals (Basel, Switzerland) 2022 4 15 (4): . Lee Yeonhong, Jang Eun Jeong, Yoon Ha-Young, Yee Jeong, Gwak Hye-S |
| NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine. Drug metabolism and pharmacokinetics 2022 1 43 100436. Khaeso Kanyarat, Komvilaisak Patcharee, Chainansamit Su-On, Nakkam Nontaya, Suwannaying Kunanya, Kuwatjanakul Pitchayanan, Hikino Keiko, Dornsena Areerat, Kanjanawart Sirimas, Laoaroon Napat, Vannaprasaht Suda, Taketani Takeshi, Tassaneeyakul Wichitt |
| ABCC4, ITPA, NUDT15, TPMT and their interaction as genetic predictors of 6-mercaptopurine intolerance in chinese patients with acute lymphoblastic leukemia. Pediatric hematology and oncology 2021 10 39 (3): 254-266. Fan Paroni O L, Leung Kam-Tong, Chan Kathy Y Y, Leung Alex W K, Lam Grace K S, Chow Terry T W, Cheng Frankie W T, Yuen Liz Y P, Moriyama Takaya, Yang Jun J, Li Chi-Ko |
| Association of Multiple Gene Polymorphisms Including Homozygous NUDT15 R139C With Thiopurine Intolerance During the Treatment of Acute Lymphoblastic Leukemia. Journal of pediatric hematology/oncology 2021 2 43 (8): e1173-e1176. Kudo Ko, Sato Tomohiko, Takahashi Yuka, Yuzawa Kentaro, Kobayashi Akie, Kamio Takuya, Sasaki Shinya, Shimada Jun, Otani Katsuki, Tusjimoto Shinichi, Kato Motohiro, Toki Tsutomu, Terui Kiminori, Ito Etsu |
| Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China. Frontiers in pediatrics 2021 10 9 719803. Mao Xiaoyan, Yin Runxiu, Sun Gaoyuan, Zhou Yan, Yang Chunhui, Fang Chunlian, Wu Yuhong, Cui Tingting, Liu Li, Gan Jiaxin, Tian X |
| ITPA:c.94C>A and NUDT15:c.415C>T Polymorphisms and Their Relation to Mercaptopurine-Related Myelotoxicity in Childhood Leukemia in Thailand. The application of clinical genetics 2021 14 341-351. Boonyawat Boonchai, Monsereenusorn Chalinee, Photia Apichat, Lertvivatpong Nawachai, Kaewchaivijit Varissara, Jindatanmanusan Punyanuch, Rujkijyanont Pi |
| NUDT15 c.415C>T Polymorphism Predicts 6-MP Induced Early Myelotoxicity in Patients with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy. Pharmacogenomics and personalized medicine 2021 10 14 1303-1313. Pai Aswin Anand, Mohan Ajith, Benjamin Esther Sathya Bama, Illangeswaran Raveen Stephen Stallon, Xavier Raj Infencia, Janet Nancy Beryl, Arunachalam Arun Kumar, Kavitha M L, Kulkarni Uday, Devasia Anup J, Fouzia N A, Abraham Aby, Srivastava Alok, George Biju, Mathews Vikram, Korula Anu, Balasubramanian Poonkuzha |
| The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia. Children (Basel, Switzerland) 2021 4 8 (3): . Lee Jae Min, Shim Ye Jee, Kim Do-Hoon, Jung Nani, Ha Jung-So |
| TPMT*3C as a Predictor of 6-Mercaptopurine-Induced Myelotoxicity in Thai Children with Acute Lymphoblastic Leukemia. Journal of personalized medicine 2021 8 11 (8): . Jantararoungtong Thawinee, Wiwattanakul Supaporn, Tiyasirichokchai Rawiporn, Prommas Santirhat, Sukprasong Rattanaporn, Koomdee Napatrupron, Jinda Pimonpan, Rachanakul Jiratha, Nuntharadthanaphong Nutthan, Pakakasama Samart, Anurathapan Usanarat, Hongeng Suradej, Sukasem Chonlaph |
| Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants. Pediatric research 2020 Mar . Wang Der-Shiun, Yu Chih-Hsiang, Lin Chien-Yu, Chang Ya-Hsuan, Lin Kai-Hsin, Lin Dong-Tsamn, Jou Shiann-Tarng, Lu Meng-Yao, Chang Hsiu-Hao, Lin Shu-Wha, Chen Hsuan-Yu, Yang Yung- |
| Dosage of 6-Mercaptopurine in Relation to Genetic TPMT and ITPA Variants: Toward Individualized Pediatric Acute Lymphoblastic Leukemia Maintenance Treatment. Journal of pediatric hematology/oncology 2020 1 42 (2): e94-e97. Kouwenberg Theodorus W, van den Bosch Bianca J C, Bierau Jörgen, Te Loo Dunja Maroeska W M, Coenen Marieke J H, Hagleitner Melanie |
| Prevalence of TPMT, ITPA and NUDT 15 genetic polymorphisms and their relation to 6MP toxicity in north Indian children with acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology 2019 Feb 83 (2): 341-348. Khera Sanjeev, Trehan Amita, Bhatia Prateek, Singh Minu, Bansal Deepak, Varma Neel |
| ITPA, TPMT, and NUDT15 Genetic Polymorphisms Predict 6-Mercaptopurine Toxicity in Middle Eastern Children With Acute Lymphoblastic Leukemia. Frontiers in pharmacology 2019 9 10 916. Moradveisi Borhan, Muwakkit Samar, Zamani Fatemeh, Ghaderi Ebrahim, Mohammadi Ebrahim, Zgheib Nathalie |
| The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia. The Journal of pediatrics 2019 10 216 150-157.e1. Wahlund Martina, Nilsson Anna, Kahlin Anna Zimdahl, Broliden Kristina, Myrberg Ida Hed, Appell Malin Lindqvist, Berggren An |
| Variants in TPMT, ITPA, ABCC4 and ABCB1 Genes As Predictors of 6-mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia. Journal of medical biochemistry 2019 1 37 (3): 320-327. Milosevic Goran, Kotur Nikola, Krstovski Nada, Lazic Jelena, Zukic Branka, Stankovic Biljana, Janic Dragana, Katsila Theodora, Patrinos George P, Pavlovic Sonja, Dokmanovic Lidi |
| Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants? BMC cancer 2018 May 18 (1): 516. Zhou Hong, Li Lei, Yang Peng, Yang Lin, Zheng Jin E, Zhou Ying, Han Yo |
| SLCO1B1 Polymorphisms are Associated With Drug Intolerance in Childhood Leukemia Maintenance Therapy. Journal of pediatric hematology/oncology 2018 Apr . Eldem ?rem, Yavuz Duygu, Cumao?ullari Özge, ?leri Talia, Ünal ?nce Elif, Ertem Mehmet, Do?anay Erdo?an Beyza, Bindak Recep, Özda? Hilal, ?atiro?lu-Tufan N Lale, Uysal L Zümr |
| Role of TPMT and ITPA variants in mercaptopurine disposition. Cancer chemotherapy and pharmacology 2018 Feb . Gerbek Tina, Ebbesen Maria, Nersting Jacob, Frandsen Thomas L, Appell Malin Lindqvist, Schmiegelow Kje |
| [Multiplex Genotyping of Allelic Variants of Genes Involved in Metabolizing Antileukemic Drugs]. Molekuliarnaia biologiia 2018 4 52 (2): 238-245. Fesenko D O, Avdonina M A, Gukasyan L G, Surzhikov S A, Chudinov A V, Zasedatelev A S, Nasedkina T |
| A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs. Molecular diagnosis & therapy 2016 Oct 20 (5): 493-9. Skrzypczak-Zielinska Marzena, Borun Pawel, Bartkowiak-Kaczmarek Anna, Zakerska-Banaszak Oliwia, Walczak Michal, Dobrowolska Agnieszka, Kurzawski Mateusz, Waszak Malgorzata, Lipinski Daniel, Plawski Andrzej, Slomski Rysza |
| PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy. Scientific reports 2016 6 30244. Smid Alenka, Karas-Kuzelicki Natasa, Jazbec Janez, Mlinaric-Rascan Ire |
| Frequency of ITPA gene polymorphisms in Iranian patients with acute lymphoblastic leukemia and prediction of its myelosuppressive effects. Leukemia research 2015 Oct 39 (10): 1048-54. Azimi Fatemeh, Mortazavi Yousef, Alavi Samin, Khalili Mitra, Ramazani A |
| RETRACTED: Clinical significance of ITPA rs67002563 polymorphism in patients with acute lymphoblastic leukemia treated with 6-mercaptopurine. Pharmacological research 2015 Sep . Azimi Fatemeh, Esmaeilzadeh Abdolreza, Ramazani A |
| Influence of SLCO1B1 polymorphism on maintenance therapy for childhood leukemia. Pediatrics international : official journal of the Japan Pediatric Society 2015 Aug 57 (4): 572-7. Suzuki Ryoko, Fukushima Hiroko, Noguchi Emiko, Tsuchida Masahiro, Kiyokawa Nobutaka, Koike Kazutoshi, Ma Enbo, Takahashi Hideto, Kobayashi Chie, Nakajima-Yamaguchi Ryoko, Sakai Aiko, Saito Makoto, Iwabuchi Atsushi, Kato Keisuke, Nakao Tomohei, Yoshimi Ai, Sumazaki Ryo, Fukushima Takas |
| Genetic variants in 6-mercaptopurine pathway as potential factors of hematological toxicity in acute lymphoblastic leukemia patients. Pharmacogenomics 2015 Jul 16 (10): 1119-34. Hareedy Mohammad Salem, El Desoky Ehab S, Woillard Jean-Baptiste, Thabet Romany Helmy, Ali Amany Mohamad, Marquet Pierre, Picard Nicol |
| Comparative pharmacogenetic analysis of risk polymorphisms in Caucasian and Vietnamese children with acute lymphoblastic leukemia: prediction of therapeutic outcome? British journal of clinical pharmacology 2015 Mar 79 (3): 429-40. Hoang Phuong Thu Vu, Ambroise Jérôme, Dekairelle Anne-France, Durant Jean-François, Butoescu Valentina, Chi Vu Luan Dang, Huynh Nghia, Nguyen Tan Binh, Robert Annie, Vermylen Christiane, Gala Jean-L |
| Association of ITPA genotype with event-free survival and relapse rates in children with acute lymphoblastic leukemia undergoing maintenance therapy. PloS one 2014 9 (10): e109551. Smid Alenka, Karas-Kuzelicki Natasa, Milek Miha, Jazbec Janez, Mlinaric-Rascan Ire |
| Inosine triphosphate pyrophosphohydrolase (ITPA) polymorphic sequence variants in Chinese ALL children and possible association with mercaptopurine related toxicity. International journal of clinical and experimental pathology 2014 7 (7): 4552-6. Ma Xiaoli, Zheng Jie, Jin Mei, Li Weijing, Gao Chao, Zhang Dawei, Chen Yiqiao, Li Xingjun, Xie Jianj |
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- Page last updated:Mar 16, 2023
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