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Last Posted: Jan 04, 2024
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Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss.
Rick Essers et al. Nat Med 2023 11

From the abstract: "Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The prevalence of these abnormalities and the allocation of (ab)normal cells in embryonic and placental lineages during intrauterine development remain elusive. In this study, we analyzed 1,745 spontaneous pregnancy losses and found that roughly half (50.4%) of the products of conception (POCs) were karyotypically abnormal, with maternal and paternal age independently contributing to the increased genomic aberration rate. "

Early Pregnancy Loss
K Walter, JAMA, April 2023

Early pregnancy loss is caused most commonly by fetal chromosomal abnormalities, which account for more than two-thirds of all early pregnancy loss between 6 and 10 weeks of gestation. Risk factors for early pregnancy loss include older age at onset of pregnancy, prior pregnancy loss, some medical conditions (such as diabetes, hyperthyroidism, and lupus), and exposures during pregnancy that may harm a developing fetus (such as alcohol; some viral or bacterial infections; environmental exposure to lead, mercury, or radiation; and certain medications).

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