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Last Posted: Nov 16, 2023
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Federated Analysis for Privacy-Preserving Data Sharing: A Technical and Legal Primer.
James Casaletto et al. Annu Rev Genomics Hum Genet 2023 5

Continued advances in precision medicine rely on the widespread sharing of data that relate human genetic variation to disease. However, data sharing is severely limited by legal, regulatory, and ethical restrictions that safeguard patient privacy. Federated analysis addresses this problem by transferring the code to the data—providing the technical and legal capability to analyze the data within their secure home environment rather than transferring the data to another institution for analysis.

Old and new challenges regarding comparable and viable data sharing in population-scale genomic research
A Raz et al, EJHG, March 31, 2023

Despite the rapid expansion of large-scale national genomic repositories and efforts to create diverse datasets, genomic diversity, which is crucial in comparative research, is not easily attainable. Many barriers to sharing genomic data have already been identified, including the interrelated challenges of comparability, confidentiality, and viability.

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Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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