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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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5 hot topic(s) found with the query "Mpox"

Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal.
Vítor Borges et al. Nat Med 2023 9 (Posted: Sep 12, 2023 7AM)

From the abstract: "Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that several international sublineages probably emerged or spread early."

Description of the first global outbreak of mpox: an analysis of global surveillance data
HLS Schafer et al, Lancet Global Health, July 2023 (Posted: Jun 26, 2023 8AM)

In this analysis of global surveillance data we analysed data for all confirmed mpox cases reported by WHO Member States through the global surveillance system from Jan 1, 2022, to Jan 29, 2023. Data from 82?807 cases were included in the analysis. Cases were primarily due to clade IIb MPXV (mainly lineage B.1, followed by lineage A.2). The outbreak was driven by transmission among males (73?560 [96·4%] of 76?293 cases) who self-identify as men who have sex with men (25?938 [86·9%] of 29?854 cases). The most common reported route of transmission was sexual contact (14?941 [68·7%] of 21?749).

A deep-learning algorithm to classify skin lesions from mpox virus infection.
Alexander H Thieme et al. Nature medicine 2023 3 (Posted: Mar 03, 2023 9AM)

We assembled a dataset of 139,198 skin lesion images, split into training/validation and testing cohorts, comprising non-MPXV images (n?=?138,522) from eight dermatological repositories and MPXV images (n?=?676) from the scientific literature, news articles, social media and a prospective cohort of the Stanford University Medical Center (n?=?63 images from 12 patients, all male). In the validation and testing cohorts, the sensitivity of the MPXV-CNN was 0.83 and 0.91, the specificity was 0.965 and 0.898 and the area under the curve was 0.967 and 0.966, respectively.

Use of Wastewater for Mpox Outbreak Surveillance in California.
Wolfe Marlene K et al. The New England journal of medicine 2023 1 (Posted: Jan 19, 2023 6AM)

As part of the response to the spread of MPXV infection, we adapted and deployed polymerase-chain-reaction assays targeting MPXV genomic DNA5 as part of our ongoing wastewater surveillance program. Testing was implemented within a month after the first identified case of MPXV infection in the United States, and the results were used in real time for the public health response in California.

Detection of Monkeypox Virus DNA in Airport Wastewater, Rome, Italy.
La Rosa Giuseppina et al. Emerging infectious diseases 2022 12 (1) (Posted: Dec 10, 2022 7AM)

Wastewater surveillance for SARS-CoV-2 was adapted for MPX virus detection from the wastewater treatment plant of an international airport with >3M passengers monthly (Rome, Italy, May–Aug 2022). Real-time and nested PCR assays were modified to detect mpox DNA in 24hr composite wastewater samples collected 2x/week. Among 20 samples, 3 had detectable MPXV. Average quantification cycle (Cq) ranged from 38.37–40.18, indicating relatively low DNA concentrations. Consensus sequences found 100% similarity with MPXV strains available in GenBank.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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