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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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119 hot topic(s) found with the query "Malaria "

Genomics reveals heterogeneous Plasmodium falciparum transmission and selection signals in Zambia.
Abebe A Fola et al. Commun Med (Lond) 2024 4 (1) 67 (Posted: Apr 10, 2024 8AM)

From the abstract: "We conducted genomic surveillance of Plasmodium falciparum parasites from the 2018 Malaria Indicator Survey in Zambia, a nationally representative household survey of children under five years of age. We whole-genome sequenced and analyzed 241?P. falciparum genomes from regions with varying levels of malaria transmission across Zambia and estimated genetic metrics that are informative about transmission intensity, genetic relatedness between parasites, and selection. We provide genomic evidence of widespread within-host polygenomic infections, regardless of epidemiological characteristics, underscoring the extensive and ongoing endemic malaria transmission in Zambia. Our analysis reveals country-level clustering of parasites from Zambia and neighboring regions, with distinct separation in West Africa. "

Using genomics to track malaria in the US
T Locke, MedicalXpress, December 20, 2023 (Posted: Dec 22, 2023 10AM)

From the website: "Both the parasite genome and the mosquito genome are very important because each of those represents a unique fingerprint. You can characterize the disease that's caused by that particular parasite and also track the parasites and the mosquitoes. Malaria parasites, for example, in parts of Ethiopia or India are different from each other, but those malaria parasites in India are similar to each other. If you don't know the origin of a malaria parasite, you can track it back to where it might have come from by comparing it with lots of different genomes of malaria parasites throughout the endemic world. "

Rapid profiling of Plasmodium parasites from genome sequences to assist malaria control.
Jody E Phelan et al. Genome Med 2023 11 (1) 96 (Posted: Nov 11, 2023 3PM)

From the abstract: "Malaria continues to be a major threat to global public health. Whole genome sequencing (WGS) of the underlying Plasmodium parasites has provided insights into the genomic epidemiology of malaria. Genome sequencing is rapidly gaining traction as a diagnostic and surveillance tool for clinical settings, where the profiling of co-infections, identification of imported malaria parasites, and detection of drug resistance are crucial for infection control and disease elimination. To support this informatically, we have developed the Malaria-Profiler tool, which rapidly (within minutes) predicts Plasmodium species, geographical source, and resistance to antimalarial drugs directly from WGS data. "

Spreading awareness of sickle cell trait and its possible complications A better understanding of the trait is crucial for both patients and providers
M Shaniqua, Sickle Cell New, August 2023 (Posted: Aug 11, 2023 11AM)

Scientists have found that sickle cell trait originated as an evolutionary response to malaria, one of the deadliest illnesses in tropical regions. The trait offers natural protection against the infectious disease. According to the U.S. Centers for Disease Control and Prevention (CDC), “Sickle cell trait is not a disease, but having it means that a person has inherited the sickle cell gene from one of his or her parents.” If a child inherits two sickle cell genes, one from each parent, then they will have sickle cell disease.

Why we need more Black blood donors to treat sickle cell anemia
SB Peter, CNN, June 27, 2023 (Posted: Jun 30, 2023 10AM)

Sickle cell disease is a global health issue, with around 66% of the 120 million people affected worldwide living in Africa, according to the World Health Organization. It affects about 100,000 people in the US and about 14,000 people in the UK. It’s more common in areas of the world, such as Sub-Saharan Africa, where malaria is prevalent, and researchers believe that the genetic mutation that causes sickle cell disease has a protective effect against malaria. Most sickle cell patients in the US and UK have African ancestry.

The science events to watch for in 2023 Moon landings, mRNA vaccines and climate finance are among the developments set to shape research in the coming year.
M Naddaf et al, Nature, December 19, 2022 (Posted: Dec 19, 2022 8AM)

Following the successful deployment of mRNA vaccines during the COVID-19 pandemic, a host of them are in development. BioNTech in Mainz, Germany, is expected to initiate first-in-human trials for mRNA vaccines against malaria, tuberculosis and genital herpes in the coming weeks. BioNTech is also collaborating with Pfizer, based in New York City, to trial an mRNA-based vaccine candidate to reduce the rate of shingles. Moderna in Cambridge, Massachusetts, also has mRNA vaccine candidates for the viruses that cause genital herpes and shingles.

Monoclonal antibodies for malaria prevention.
Aleshnick Maya et al. Molecular therapy : the journal of the American Society of Gene Therapy 2022 4 (5) 1810-1821 (Posted: Aug 04, 2022 8AM)

Despite several approaches to prevent established infection, no single approach offers complete protection, so a multilayered approach is needed. One potential layer, the monoclonal antibody. opens in new tab, is the focus of a new trial. The authors describe protection conferred by a long-acting, next-generation monoclonal antibody against controlled human malaria infection in healthy persons.

Identification of novel genetic variants in the malaria vaccine candidate PfRh5: structure-guided insights into potential function
K Mangou et al, MEDRXIV, March 20, 2022 (Posted: Mar 20, 2022 1PM)

The recent stall in the global reduction of malaria deaths has made the development of a highly effective vaccine essential. A major challenge to developing an efficacious vaccine is the extensive diversity of Plasmodium falciparum antigens. While genetic diversity plays a major role in immune evasion and is a barrier to the development of both natural and vaccine-induced protective immunity, it has been under-prioritized in the evaluation of malaria vaccine candidates.

COVID-19: endemic doesn’t mean harmless
A Katzourakis, Nature, January 24, 2022 (Posted: Jan 24, 2022 2PM)

To an epidemiologist, an endemic infection is one in which overall rates are static — not rising, not falling. More precisely, it means that the proportion of people who can get sick balances out the ‘basic reproduction number’ of the virus, the number of individuals that an infected individual would infect, assuming a population in which everyone could get sick. Yes, common colds are endemic. So are Lassa fever, malaria and polio. So was smallpox, until vaccines stamped it out. In other words, a disease can be endemic and both widespread and deadly. Malaria killed more than 600,000 people in 2020. Ten million fell ill with tuberculosis that same year and 1.5 million died. Endemic certainly does not mean that evolution has somehow tamed a pathogen so that life simply returns to ‘normal’.

Vaccine Development Is Charting a New Path in Malaria Control
BM Kuehn, JAMA, January 19, 2022 (Posted: Jan 19, 2022 2PM)

Malaria protection due to sickle haemoglobin depends on parasite genotype
G Band et al, Nature, December 9, 2021 (Posted: Dec 13, 2021 8AM)

Host genetic factors can confer resistance against malaria1, raising the question of whether this has led to evolutionary adaptation of parasite populations. In this study we searched for association between candidate host and parasite genetic variants in 3,346 Gambian and Kenyan children ascertained with severe malaria due to Plasmodium falciparum. We identified a strong association between sickle haemoglobin (HbS) in the host and three regions of the parasite genome, that is not explained by population structure or other covariates, and that is replicated in additional samples. The HbS-associated alleles include nonsynonymous variants in the acyl-CoA synthetase family member2–4 PfACS8.

Contributions of Genomics to the Fight Against Malaria
C Scott et al, CDC Blog, November 22, 2021 Brand (Posted: Nov 23, 2021 9AM)

Traditional genotyping methods based on Sanger sequencing, used by PARMA during 2015-2019, allowed scientists to capture only the tip of the iceberg, analyzing only a limited subset of the available TES samples and limited to a few sequences per sample. The more robust and sensitive next-generation sequencing (NGS) method, which was used to publish the first malaria parasite genome for Plasmodium falciparum in 2002, with dramatically decreased sequencing costs, since 2014 has become the sequencing method of choice for routine surveillance

Covid-19: Why Africa’s pandemic is different
M Sentilingham et al, BMJ, October 19, 2021 (Posted: Oct 20, 2021 4AM)

“Inequity” is a word firmly attached to Africa, and not just in the pandemic. Inequity in resources, funding, and infrastructure means that diseases—malaria, tuberculosis, HIV, and intestinal worms, among others—persist in Africa long after other regions overcame them. It comes as no surprise, then, that when covid-19 struck the scenario was similar, with treatments and vaccines rolled out largely in high income settings. While many parts of the world are now reopening enabled by coronavirus vaccines, Africa is facing a continued, possibly exponential, rise in deaths as new waves of infection with new variants of covid-19 strike an unvaccinated population.

How An Altered Strand Of DNA Can Cause Malaria-Spreading Mosquitoes To Self-Destruct
R Stein, NPR, July 28, 2021 (Posted: Jul 28, 2021 10AM)

The male mosquitoes were engineered with a sequence of DNA known as a "gene drive" that can rapidly transmit a deleterious mutation that essentially wipes out populations of the insects. The goal is to create a powerful new tool to fight malaria, which remains one of the world's most terrible scourges.

Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field
A Hammond et al, Nature Communication, July 28, 2021 (Posted: Jul 28, 2021 10AM)

CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles gambiae effectively suppressed the reproductive capability of mosquito populations reared in small laboratory cages. To bridge the gap between laboratory and the field, this gene-drive technology must be challenged with vector ecology. Here we report the suppressive activity of the gene-drive in age-structured An. gambiae populations in indoor cages that permit feeding and reproductive behaviors.

Glucose-6-phosphate dehydrogenase activity in individuals with and without malaria: Analysis of clinical trial, cross-sectional and case-control data from Bangladesh.
Ley Benedikt et al. PLoS medicine 2021 4 (4) e1003576 (Posted: Apr 28, 2021 11AM)

Patients with acute malaria had significantly higher G6PD activity than individuals without malaria, and this could not be accounted for by a protective effect of G6PD deficiency. G6PD-deficient patients with malaria may have higher than expected G6PD enzyme activity and an attenuated risk of primaquine-induced hemolysis compared to the risk when not infected.

The changing epidemiology of Plasmodium vivax: Insights from conventional and novel surveillance tools.
Auburn Sarah et al. PLoS medicine 2021 4 (4) e1003560 (Posted: Apr 28, 2021 11AM)

Genetic tools to study the spatial and temporal patterns of P. vivax transmission in different endemicities and ultrasensitive PCR (uPCR)-based techniques are expanding our knowledge of the magnitude and biology of low-density P. vivax infections. Serology offers alternative ways of detecting recent P. vivax infections and monitoring of the impact of public health interventions at very low endemicity.

Advances and opportunities in malaria population genomics
DE Neafsey et al, Nature Rev Genetics, April 8, 2021 (Posted: Apr 09, 2021 7AM)

Population genomic data are increasingly being used to guide our understanding of malaria epidemiology, for example by assessing connectivity between populations and the efficacy of parasite and vector interventions. The potential value of these applications to malaria control strategies, together with the increasing diversity of genomic data types and contexts in which data are being generated, raise both opportunities and challenges in the field.

How COVID unlocked the power of RNA vaccines The technology could revolutionize efforts to immunize against HIV, malaria, influenza and more.
E Dolgin, Nature News, January 12, 2021 (Posted: Jan 12, 2021 1PM)

Molecular malaria surveillance using a novel protocol for extraction and analysis of nucleic acids retained on used rapid diagnostic tests
EA Guirou et al, Scientific Reports, July 23, 2020 (Posted: Jul 24, 2020 9AM)

WHO launches global megatrial of the four most promising coronavirus treatments
Science Magazine, March 22, 2020 (Posted: Mar 23, 2020 8AM)

A drug combo already used against HIV. A malaria treatment first tested during World War II. A new antiviral whose promise against Ebola fizzled last year. Could any of these drugs be used to save COVID-19 patients from serious harm or death? WHO announced a large global trial, called SOLIDARITY, to find out if any can treat infections with the new coronavirus.

Assessment of Expert-Level Automated Detection of Plasmodium falciparum in Digitized Thin Blood Smear Images
PC Kuo et al, JAMA Network Open, March 2, 2020 (Posted: Mar 03, 2020 8AM)

In this diagnostic study that used a 1-stage deep learning framework and benchmark data sets, the malaria detection algorithm achieved expert-level performance in detecting Plasmodium falciparum in thin blood smear images.

Beyond the Data Podcast, CDC Public Health Grand Rounds
CDC, January 2020 Brand (Posted: Jan 28, 2020 7AM)

New technologies are helping detect and fight infectious diseases such as bacterial foodborne illness, tuberculosis, influenza, malaria and Legionnaires' disease. Doctors John Iskander and Greg Armstrong discuss rapid advances in Advanced Molecular Detection and how these technologies are being applied in public health now and in the future.

The Gene Drive Dilemma: We Can Alter Entire Species, but Should We?
J Kahn, NY Times, January 8, 2020 (Posted: Jan 09, 2020 8AM)

A new genetic engineering technology could help eliminate malaria and stave off extinctions — if humanity decides to unleash it.

The Emerging Role of Pathogen Genomics in Public Health
CDC Public Health Grand Rounds, January 21, 2020 Brand (Posted: Jan 08, 2020 10AM)

The Advanced Molecular Detection technologies are now in use across the range of infectious diseases of public health importance, such as bacterial foodborne illness, tuberculosis, influenza, malaria and Legionnaires’ Disease. This session of Public Health Grand Rounds will address how these technologies are being applied in public health, and their future uses.

Malaria-carrying mosquitoes get a leg up on insecticides
Nature News, December 25, 2019 (Posted: Dec 26, 2019 7PM)

A chemosensory protein enriched in the legs of malaria-carrying mosquitoes gives them resistance to insecticides used to treat bed nets. This discovery points to the challenges of tackling malaria.

High-resolution micro-epidemiology of parasite spatial and temporal dynamics in a high malaria transmission setting in Kenya
CS Nelson et al, Nature Communications, December 9, 2019 (Posted: Dec 10, 2019 8AM)

Novel interventions that leverage the heterogeneity of parasite transmission are needed to achieve malaria elimination. To better understand spatial and temporal dynamics of transmission, we applied amplicon next-generation sequencing of two polymorphic gene regions to a cohort identified in a high-transmission setting in western Kenya.

Malaria parasites fine-tune mutations to resist drugs
L Tilley et al,Nature, November 27, 2019 (Posted: Nov 29, 2019 9AM)

A novel metabarcoded DNA sequencing tool for the detection of Plasmodium species in malaria positive patients
A Wahab et al, BIORXIV, November 201 (Posted: Nov 18, 2019 9AM)

The study describes a next-generation sequencing method using metabarcoded DNA has potential applications in the diagnosis, surveillance, treatment, and control of Plasmodium infections, as well as to study the parasite biology.

Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections
AN Cowell et al, Genome Medicine, October 22, 2019 (Posted: Oct 23, 2019 8AM)

Here, we review recent studies that have used omics-based methods to identify novel targets for interventions against protozoan parasites, focusing on malaria, and we highlight the advantages and limitations of the approaches used. These approaches have also been extended to other protozoan pathogens.

See A Controversial Swarm Of Genetically Modified Mosquitoes In A Lab In Italy
NPR, October 20. 2019 (Posted: Oct 22, 2019 9AM)

An international team of scientists is conducting a controversial experiment in Italy. The experiment is designed to test genetically modified mosquitoes that researchers hope could provide a powerful new weapon to fight malaria, which remains one of the world's greatest scourges.

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and Oceania
Malaria Genomic Epidemiology Network, BioRXIV, October 14, 2019 (Posted: Oct 15, 2019 8AM)

A genome-wide association study of host resistance to severe Plasmodium falciparum malaria in over 17,000 individuals from 11 malaria-endemic countries shows a newly implicated variant on chromosome 6 associated with risk of cerebral malaria, and the discovery of an erythroid-specific transcription start site.

Deep Learning for Smartphone-based Malaria Parasite Detection in Thick Blood Smears.
Yang Feng et al. IEEE journal of biomedical and health informatics 2019 Sep (Posted: Sep 25, 2019 9AM)

This work investigates the possibility of automated malaria parasite detection in thick blood smears with smartphones.We are developing the first deep learning method that can detect malaria parasites in thick blood smear images and can run on smartphones.

You (don’t) give me fever
PM Brunner, Sci Trans Med, September 18, 2018 (Posted: Sep 20, 2019 10AM)

A baseline transcriptional signature in peripheral blood is associated with protection from febrile malaria in children.The authors found that immune children harbored several markers of activated immune state, consisting of monocyte and platelet activation, interferon signaling, T helper cell activation, and B cell enrichment, with better reactivity of specific IgG.

Multidrug-Resistant Malaria Expands its Reach
B Kuehn, JAMA, September 17, 2019 (Posted: Sep 18, 2019 9AM)

Genomic epidemiology shows spread of multidrug resistant strain of malaria in Asia. Simultaneously, first line treatment of malaria is effective half of the time with variable efficacy in different sites in Asia.

Sequencing for malaria diversity
DJ Burgess, Nat Rev Genetics, September 16, 2019 (Posted: Sep 17, 2019 7AM)

The advancing capabilities and reduced costs of sequencing technologies are enabling a deeper appreciation of the genotypic and phenotypic variability of infectious disease pathogens. Two new studies survey diversity in malarial Plasmodium species, assessing genetic diversity across Africa, as well as transcriptomic diversity through the pathogen life cycle.

Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects.
Damena Delesa et al. BMC medical genomics 2019 Aug (1) 120 (Posted: Aug 17, 2019 9AM)

Precision identification of high-risk phenotypes and progression pathways in severe malaria without requiring longitudinal data
Johnston IG, et. al. npj Digital Medicine 2, Article number: 63 (2019) (Posted: Jul 12, 2019 8AM)

The study applies tools from machine learning and model-based inference to harness large-scale data and dissect the heterogeneity in patterns of clinical features associated with severe malaria in 2904 Gambian children admitted to hospital with malaria. The analysis reveals features predicting the severity of individual patient outcomes, and the dynamic pathways of progression.

First proven malaria vaccine rolled out in Africa — but doubts linger- The RTS,S vaccine is up to 40% effective at preventing malaria in young children.
A Maxmen, Nature News, April 25, 2019 (Posted: Apr 26, 2019 10AM)

A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy.
Weedall Gareth D et al. Science translational medicine 2019 Mar (484) (Posted: Mar 22, 2019 10AM)

Scientists Release Controversial Genetically Modified Mosquitoes In High-Security Lab
R Stein, NPR, February 20, 2019 (Posted: Feb 20, 2019 9AM)

Combating malaria by modifying mosquitoes could save thousands of lives. It’s also risky.
HT Greely, Washington Post, February 7, 2019 (Posted: Feb 07, 2019 11AM)

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and Oceania
G Band et al, BIORXIV, February 4, 2019 (Posted: Feb 05, 2019 2PM)

Here's the Plan to End Malaria With Crispr-Edited Mosquitoes
M Molteni, WIRED, September 24, 2018 (Posted: Sep 25, 2018 9AM)

Scientists use gene drive to eradicate lab mosquitoes for the first time
I Swetlitz, Stat News, September 24, 2018 (Posted: Sep 25, 2018 9AM)

Giving Malaria a Deadline- With a new genetic tool, scientists move a step closer to eradicating mosquitoes and the deadly diseases they carry.
N Wade, September 24, 2018 (Posted: Sep 25, 2018 9AM)

Genetic approach towards a vaccine against malaria.
Garrido-Cardenas Jose Antonio et al. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2018 Jun (Posted: Aug 03, 2018 0PM)

Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.
Lee Hyun Jae et al. Microbiology and molecular biology reviews : MMBR 2018 Jun (2) (Posted: May 04, 2018 0PM)

Scientists Reveals Genes for the Most Deadly Human Malaria Parasite
Frontline Genomics, May 4, 2018 (Posted: May 04, 2018 11AM)

How One Child’s Sickle Cell Mutation Helped Protect the World From Malaria
C Zimmer, NY Times, Mar 8, 2018 (Posted: Mar 08, 2018 5PM)

Whole metagenome sequencing reveals links between mosquito microbiota and insecticide resistance in malaria vectors.
Dada Nsa et al. Scientific reports 2018 Feb (1) 2084 (Posted: Feb 06, 2018 3PM)

Multidrug resistant malaria spread under the radar for years in Cambodia- Study suggests that ongoing genomic surveillance is vital to inform malaria control strategies
Sanger Institute, Feb 1, 2018 (Posted: Feb 02, 2018 11AM)

Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania.
Ravenhall Matt et al. PLoS genetics 2018 Jan (1) e1007172 (Posted: Jan 31, 2018 1PM)

Lethal malaria parasite’s weaknesses revealed - Genomic insights could inform discovery of more durable drugs.
Nature, Jan 16, 2018 (Posted: Jan 18, 2018 9AM)

Systematic review of the clinical manifestations of glucose-6-phosphate dehydrogenase deficiency in the Greater Mekong Subregion: implications for malaria elimination and beyond.
Ong Ken Ing Cherng et al. BMJ global health 2017 (3) e000415 (Posted: Jan 05, 2018 7AM)

Five new malaria targets that could lead to an effective vaccine
Phys.org news, Oct 23, 2017 (Posted: Oct 24, 2017 10AM)

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito.
Hammond Andrew M et al. PLoS genetics 2017 Oct (10) e1007039 (Posted: Oct 10, 2017 10AM)

New genetic technique could help identify potential drug targets for malaria
Eureka Alert, June 15, 2017 (Posted: Jun 15, 2017 2PM)

Next-Generation Malaria Methods
Brand (Posted: May 02, 2017 5PM)

Dissecting malaria biology and epidemiology using population genetics and genomics.
Auburn Sarah et al. International journal for parasitology 2017 Feb (2-3) 77-85 (Posted: Apr 13, 2017 10AM)

Malaria Genomics in the Era of Eradication.
Neafsey Daniel E et al. Cold Spring Harbor perspectives in medicine 2017 Apr (Posted: Apr 13, 2017 10AM)

AMD Project: Detecting Changing Parasites
Using AMD methods to develop tools to detect changes in parasites that cause malaria (Posted: Apr 13, 2017 10AM)

Time for Genome Editing: Next-Generation Attenuated Malaria Parasites.
Singer Mirko et al. Trends in parasitology 2017 Mar (3) 202-213 (Posted: Mar 14, 2017 10AM)

Tools for attenuation of gene expression in malaria parasites.
Shaw Philip J et al. International journal for parasitology 2017 Jan (Posted: Mar 14, 2017 10AM)

In a remote West African village, a revolutionary genetic experiment is on its way — if residents agree to it
I Swetlitz, StatNews, March 2017 (Posted: Mar 14, 2017 10AM)

To Fight Malaria, Scientists Try Genetic Engineering To Wipe Out Mosquitoes
R Stein, NPR, December 2016 (Posted: Dec 22, 2016 8AM)

Two Genetic Markers that Predict Malaria Treatment Failure Found
NIAID, November 3, 2016 Brand (Posted: Nov 04, 2016 9AM)

Recent advances in malaria genomics and epigenomics.
Kirchner Sebastian et al. Genome medicine 2016 Sep (1) 92 (Posted: Oct 26, 2016 7PM)

Molecular basis of human cerebral malaria development.
Wah Saw Thu et al. Tropical medicine and health 2016 33 (Posted: Oct 26, 2016 7PM)

Immunomic approaches for antigen discovery of human parasites.
Kassegne Kokouvi et al. Expert review of proteomics 2016 Oct (Posted: Oct 26, 2016 7PM)

Advanced Molecular Detection of Malarone Resistance.
Talundzic Eldin et al. Antimicrobial agents and chemotherapy 2016 Jun (6) 3821-3 (Posted: Oct 26, 2016 7PM)

The Genetic Basis of Host Preference and Resting Behavior in the Major African Malaria Vector, Anopheles arabiensis.
Main Bradley J et al. PLoS genetics 2016 Sep (9) e1006303 (Posted: Sep 19, 2016 2PM)

Recent advances in malaria genomics and epigenomics
S Kirchner et al, Genome Medicine, September 7, 2016 (Posted: Sep 07, 2016 3PM)

Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species.
Ansari Hifzur Rahman et al. International journal for parasitology 2016 Jul (Posted: Jul 18, 2016 9PM)

The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum
EM Bunnick et al, Genome Biology, July 5, 2016 (Posted: Jul 06, 2016 9AM)

Genomic analysis of local variation and recent evolution in Plasmodium vivax
RD Pearson et al, Nature Genetics, June 27, 2016 (Posted: Jun 27, 2016 1PM)

Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax
DN Hupalo et al, Nature Genetics, June 27, 2016 (Posted: Jun 27, 2016 0PM)

World Malaria Day: April 25
Brand (Posted: Apr 25, 2016 1PM)

Researchers Design Malaria-Resistant Mosquitoes
T Hampton, JAMA, February 2, 2016 (Posted: Feb 03, 2016 8AM)

The influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential?
Lelliott Patrick M et al. Malaria journal 2015 289 (Posted: Feb 03, 2016 8AM)

Prospects and recommendations for risk mapping to improve strategies for effective malaria vector control interventions in Latin America.
Alimi Temitope O et al. Malaria journal 2015 (1) 519 (Posted: Feb 03, 2016 8AM)

New report signals country progress in the path to malaria elimination
WHO, December 9, 2015 (Posted: Dec 09, 2015 7AM)

Mosquitoes engineered to pass down genes that would wipe out their species
E Callaway, Nature News, December 7, 2015 (Posted: Dec 07, 2015 7PM)

Gene Drive Research Takes Aim at Malaria
Francis Collins, NIH Director, December 1, 2015 Brand (Posted: Dec 01, 2015 0PM)

Engineering Mosquitoes’ Genes to Resist Malaria
N Wade, New York Times, November 23, 2015 (Posted: Nov 30, 2015 8AM)

'Gene drive' mosquitoes engineered to fight malaria Mutant mozzies could rapidly spread through wild populations.
H Ledford, Nature News, November 23, 2015 (Posted: Nov 24, 2015 9AM)

Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi.
Assefa Samuel et al. Proceedings of the National Academy of Sciences of the United States of America 2015 Oct (42) 13027-32 (Posted: Nov 24, 2015 7AM)

Molecular tools for studying the major malaria vector Anopheles funestus: improving the utility of the genome using a comparative poly(A) and Ribo-Zero RNAseq analysis.
Weedall Gareth D et al. BMC genomics 2015 (1) 931 (Posted: Nov 24, 2015 7AM)

Mutant mosquitoes 'resist malaria'
M Roberts, BBC News, November 24, 2015 (Posted: Nov 24, 2015 7AM)

Applying chemical genetic tools to the study of phospho-signalling pathways in malaria parasites.
Mitcheson Deborah F et al. Biochimica et biophysica acta 2015 Oct (10 Pt B) 1650-6 (Posted: Nov 05, 2015 11AM)

Using AMD methods to develop tools for the detection and management of insecticide resistance in mosquitoes that transmit malaria
Brand (Posted: Nov 05, 2015 11AM)

The genes behind malaria resistance may reveal an intriguing evolutionary history
R Feltman, Washington Post, September 30, 2015 (Posted: Oct 05, 2015 9AM)

A novel locus of resistance to severe malaria in a region of ancient balancing selection
Malaria Genomic Epidemiology Consortium, Nature, September 30, 2015 (Posted: Oct 05, 2015 9AM)

Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of seventh biannual meeting (March 2015).
Malar. J. 2015 295 (Posted: Sep 23, 2015 2PM)

Parasitic Disease and Malaria Strategic Priorities: 2015—2020
Brand (Posted: Sep 23, 2015 2PM)

Evaluation of the diagnostic accuracy of CareStart G6PD deficiency Rapid Diagnostic Test (RDT) in a malaria endemic area in Ghana, Africa.
Adu-Gyasi Dennis et al. PLoS ONE 2015 (4) e0125796 (Posted: Sep 23, 2015 0PM)

G6PD gene variants and its association with malaria in a Sri Lankan population.
Dewasurendra Rajika L et al. Malar. J. 2015 93 (Posted: Sep 23, 2015 0PM)

G6PD deficiency in male individuals infected by Plasmodium vivax malaria in the Brazilian Amazon: a cost study.
Peixoto Henry M et al. Malar. J. 2015 126 (Posted: Sep 23, 2015 0PM)

G6PD Deficiency and Hemoglobinopathies: Molecular Epidemiological Characteristics and Healthy Effects on Malaria Endemic Bioko Island, Equatorial Guinea.
Lin Min et al. PLoS ONE 2015 (4) e0123991 (Posted: Sep 23, 2015 0PM)

Hemoglobin E and Glucose-6-Phosphate Dehydrogenase Deficiency and Plasmodium falciparum Malaria in the Chittagong Hill Districts of Bangladesh.
Shannon Kerry L et al. Am. J. Trop. Med. Hyg. 2015 Aug 5. (2) 281-6 (Posted: Sep 23, 2015 0PM)

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Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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