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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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145 hot topic(s) found with the query "Tuberculosis"

Targeted next-generation sequencing (NGS) to diagnose drug-resistant tuberculosis: a systematic review and meta-analysis
(Posted: May 26, 2024 11AM)

From the abstract: "Targeted NGS is highly sensitive and specific for detecting drug resistance across panels of tuberculosis drugs and can be performed directly on clinical samples. There is a paucity of data on performance for some currently recommended drugs. The barriers preventing the use of targeted NGS to diagnose drug-resistant tuberculosis in high-burden countries need to be addressed. "

Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: a systematic review and individual isolate meta-analysis
C Nimmo et al, Lancet Microbe, January 9, 2024 (Posted: Jan 10, 2024 8AM)

From the abstract: "Clinical bedaquiline resistance predominantly involves mutations in mmpR5 (Rv0678). However, mmpR5 resistance-associated variants (RAVs) have a variable relationship with phenotypic Mycobacterium tuberculosis resistance. We did a systematic review to assess the maximal sensitivity of sequencing bedaquiline resistance-associated genes and evaluate the association between RAVs and phenotypic resistance, using traditional and machine-based learning techniques. "

An AI-Enhanced Electronic Health Record Could Boost Primary Care Productivity.
Jeffrey E Harris et al. JAMA 2023 8 (Posted: Aug 08, 2023 8PM)

More than a few commentators have seriously inquired whether artificial intelligence (AI) could ultimately replace many clinicians. The far likelier prospect, however, is that the newly emerging technology will enhance clinical productivity. To be sure, AI-based pattern recognition software can already scan retinal photos for complications of diabetes, detect tuberculosis on chest x-rays, and evaluate screening mammograms. And some AI applications have been found to be comparable if not superior to human clinical judgment.

A new class of antibiotics delivers promising trial results against tuberculosis.
Carvalho Thiago et al. Nature medicine 2022 11 (Posted: Dec 28, 2022 11AM)

Nature Medicine explores the latest translational and clinical research news, with a clinical trial of a tRNA synthetase inhibitor for tuberculosis. The molecule functions as an inhibitor of the Mycobacterium tuberculosis enzyme leucyl-tRNA synthetase, blocking protein synthesis. Patients with drug-susceptible pulmonary tuberculosis treated with the investigational drug for 14 days showed a significant, dose-dependent reduction in colony-forming units in their sputum, the trial’s primary endpoint.

The science events to watch for in 2023 Moon landings, mRNA vaccines and climate finance are among the developments set to shape research in the coming year.
M Naddaf et al, Nature, December 19, 2022 (Posted: Dec 19, 2022 8AM)

Following the successful deployment of mRNA vaccines during the COVID-19 pandemic, a host of them are in development. BioNTech in Mainz, Germany, is expected to initiate first-in-human trials for mRNA vaccines against malaria, tuberculosis and genital herpes in the coming weeks. BioNTech is also collaborating with Pfizer, based in New York City, to trial an mRNA-based vaccine candidate to reduce the rate of shingles. Moderna in Cambridge, Massachusetts, also has mRNA vaccine candidates for the viruses that cause genital herpes and shingles.

Making cough count in tuberculosis care
AJ Zimmer et al, Comm Medicine, July 6, 2022 (Posted: Jul 07, 2022 7AM)

Acoustic epidemiology is an emerging field that uses technology to detect cough sounds and analyze cough patterns to improve health outcomes among people with respiratory conditions linked to cough. This field is increasingly exploring the potential of artificial intelligence (AI) for more advanced applications, such as analyzing cough sounds as a biomarker for disease screening. While much of the data are preliminary, objective cough assessment could potentially transform disease control programs, including TB, and support individual patient management.

Using Pharmacogenetics to Enhance Tuberculosis (TB) Treatment
M Moore et al, CDC Blog Post, February 22, 2022 Brand (Posted: Feb 23, 2022 7AM)

A new CDC project provides an unprecedented opportunity to develop a tailored approach, by leveraging existing information collected in the international phase 3 clinical trial, to identify specific dosage recommendations of TB drugs for populations, which can improve TB treatment across all patient groups. Researchers will utilize precision public health techniques to assess treatment outcomes for TB treatment regimens, which may lead to improvements in the prevention and treatment of TB disease.

Precision Public Health in Action: New CDC Pilot Projects Integrating Human Genomics into Public Health Surveillance and Applied Research
M Clyne et al, CDC Blog Post, February 14, 2022 Brand (Posted: Feb 15, 2022 7AM)

Six CDC projects were selected for funding in 2022 and 2023. They cover a wide range of topics, including: Assessing the impact of genetics in the control of two infectious diseases (Tuberculosis and Ebola), enhancing the reporting of gene/genome sequencing in newborn screening programs, examining the role of medications and genetics in the National Birth Defects Prevention Study (NBDPS), establishing population-based, ethnicity-specific allele frequencies for pharmacogenomic traits of public health importance using the National Health and Nutrition Examination Survey (NHANES), and enhancing the evaluation of genetic risk prediction models for inhibitor development among people with hemophilia in different populations.

Using Genomic Epidemiology to Advance Public Health Action
CDC Preventive Medicine Grand Rounds, February 22, 2022 Brand (Posted: Jan 25, 2022 8AM)

Rapid advances in genomic technologies, such as genomic sequencing, are transforming how we respond to public health threats. Scientists use genomic sequencing to identify and prevent a wide variety of pathogens, including those that cause foodborne illness, tuberculosis, and COVID-19. Combining genomics and epidemiology—coined “genomic epidemiology”—provides a powerful tool for surveillance, outbreak detection, as well as response, and indicates a future where the human genome can direct public health action.

COVID-19: endemic doesn’t mean harmless
A Katzourakis, Nature, January 24, 2022 (Posted: Jan 24, 2022 2PM)

To an epidemiologist, an endemic infection is one in which overall rates are static — not rising, not falling. More precisely, it means that the proportion of people who can get sick balances out the ‘basic reproduction number’ of the virus, the number of individuals that an infected individual would infect, assuming a population in which everyone could get sick. Yes, common colds are endemic. So are Lassa fever, malaria and polio. So was smallpox, until vaccines stamped it out. In other words, a disease can be endemic and both widespread and deadly. Malaria killed more than 600,000 people in 2020. Ten million fell ill with tuberculosis that same year and 1.5 million died. Endemic certainly does not mean that evolution has somehow tamed a pathogen so that life simply returns to ‘normal’.

Importance of next-generation diagnostics in control of tuberculosis in LMICs
Z Hassan et al, Lancet Inf Dis, December 13, 2021 (Posted: Dec 15, 2021 8AM)

Given the growing importance of genomics in TB diagnostics, it is essential that LMICs establish reference-level laboratory infrastructure for next-generation sequencing to validate genomics and transcriptomic biomarker tests for local use. This would facilitate improved diagnostics and also inform regional variations which may occur in both MTB strains and host populations.

Covid-19: Why Africa’s pandemic is different
M Sentilingham et al, BMJ, October 19, 2021 (Posted: Oct 20, 2021 4AM)

“Inequity” is a word firmly attached to Africa, and not just in the pandemic. Inequity in resources, funding, and infrastructure means that diseases—malaria, tuberculosis, HIV, and intestinal worms, among others—persist in Africa long after other regions overcame them. It comes as no surprise, then, that when covid-19 struck the scenario was similar, with treatments and vaccines rolled out largely in high income settings. While many parts of the world are now reopening enabled by coronavirus vaccines, Africa is facing a continued, possibly exponential, rise in deaths as new waves of infection with new variants of covid-19 strike an unvaccinated population.

Evidence Used to Update the List of Underlying Medical Conditions Associated with Higher Risk for Severe COVID-19
CDC Science Brief, October 14, 2021 Brand (Posted: Oct 16, 2021 8AM)

Chronic lung disease (including bronchiectasis, bronchopulmonary dysplasia, interstitial lung disease, pulmonary hypertension, pulmonary embolism, tuberculosis) and chronic liver disease (including cirrhosis, non-alcoholic fatty liver disease, alcoholic liver disease, and autoimmune hepatitis) were added September 2021 based on evidence published between December 1, 2019 and August 31, 2021 using the updated review methods outlined below. Mental health disorders (such as mood disorders including depression, and schizophrenia spectrum disorders) were added September 2021 based on evidence published between December 1, 2019 and August 31, 2021. No conditions were removed from the previous underlying medical conditions list.

Derivation and external validation of a risk score for predicting HIV-associated tuberculosis to support case finding and preventive therapy scale-up: A cohort study
AF Aud et al, PLOS Medicine, September 7, 2021 (Posted: Sep 08, 2021 9AM)

Tuberculosis remains the most common cause of death among people living with HIV (PLHIV) and is often undiagnosed at time of death. Rapid scale-up of tuberculosis preventive therapy to 13 million PLHIV in low- and middle-income countries has been proposed for 2021; however, active TB is commonly asymptomatic and therefore missed by current WHO-recommended 4-symptom TB screening rules. Therefore, more sensitive TB screening tools are needed to better facilitate early TB diagnosis and safer scale-up of TPT to PLHIV by avoiding TPT prescription to clients with asymptomatic active TB, who need TB treatment. We derived a TB risk score for PLHIV from XPRES trial data and validated the score on 3 external datasets.

Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States
CDC Update, August 31, 2021 Brand (Posted: Sep 01, 2021 7AM)

Recent changes include: New Advisory Committee on Immunization Practices (ACIP) recommendation for use of the U.S. Food and Drug Administration (FDA)-approved Pfizer-BioNTech (COMIRNATY) COVID-19 Vaccine in persons aged =16 years- Updated information in Key points to reflect currently available evidence-Updated information on COVID-19 vaccines in the Background section- Updated information in the section on Considerations for use of an additional dose of COVID-19 vaccine following a primary vaccine series- Updated laboratory testing information on timing of immune-based tests for tuberculosis infection in relation to COVID-19 vaccine administration

TB Genotyping
CDC, July 2021 Brand (Posted: Aug 10, 2021 10AM)

TB genotyping is a laboratory-based approach used to analyze the genetic material (e.g., DNA) of Mycobacterium tuberculosis, the bacterium that causes TB disease. The total genetic content is referred to as the genome. Specific sections of the M. tuberculosis genome form distinct genetic patterns that help distinguish different strains of M. tuberculosis

An implementation science approach to evaluating pathogen whole genome sequencing in public health
AS Ferdinand et al, Genome Medicine, July 29, 2021 (Posted: Jul 30, 2021 7AM)

We developed the Pathogen Genomics in Public HeAlth Surveillance Evaluation (PG-PHASE) Framework to guide examination of the use of WGS in public health surveillance and disease control. We illustrate the use of this framework with three pathogens as case studies: Listeria monocytogenes, Mycobacterium tuberculosis and SARS-CoV-2.

Genomic evidence for prisons as amplifiers of community tuberculosis epidemics
KS Walter et al, MEDRXIV, June 24, 2021 (Posted: Jun 24, 2021 7AM)

By integrating timed phylogenies and detailed location data, we reconstructed probabilistic transmission histories. M. tuberculosis sequences from incarcerated and non-incarcerated people were closely phylogenetically related. We found that 57% of recent community-wide tuberculosis cases were attributable to transmission from individuals with an incarceration history, 2.6% of the population. Further, we find genomic evidence that the prison system disseminates M. tuberculosis genotypes through frequent transfers across the state.

These Algorithms Could Bring an End to the World’s Deadliest Killer- In rural India and other places where tuberculosis is rampant, A.I. that scans lung X-rays might eliminate the scourge.
A Mandavilli, NY Times, November 20, 2020 (Posted: Nov 21, 2020 11AM)

In some of the most remote and impoverished corners of the world, where respiratory illnesses abound and trained medical professionals fear to tread, diagnosis is increasingly powered by artificial intelligence and the internet. In less than a minute, a new app on a phone or a computer can scan an X-ray for signs of tuberculosis, Covid-19 and 27 other conditions.

A clinical score for identifying active tuberculosis while awaiting microbiological results: Development and validation of a multivariable prediction model in sub-Saharan Africa
Y Baik et al, PLOS Medicine, November 11, 2020 (Posted: Nov 12, 2020 8AM)

Discovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings
RK Gupta et al, Nature Medicine, October 19, 2020 (Posted: Oct 19, 2020 0PM)

We developed a personalized risk predictor for incident TB that combines a quantitative measure of T cell sensitization and clinical covariates. Internal–external cross-validation of the model demonstrated a random effects meta-analysis C-statistic of 0.88 (95% CI, 0.82–0.93) for incident TB. In decision curve analysis, the model demonstrated clinical utility for targeting preventative treatment, compared to treating all, or no, people with LTBI.

How artificial kidneys and miniaturized dialysis could save millions of lives
C Huff, Nature News, March 11, 2020 (Posted: Mar 14, 2020 6AM)

After decades of slow progress, researchers are exploring better treatments for kidney failure — which kills more people than HIV or tuberculosis.

Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex.
Merker Matthias et al. Genome medicine 2020 Mar (1) 27 (Posted: Mar 08, 2020 10AM)

Powerful antibiotics discovered using AI- Machine learning spots molecules that work even against ‘untreatable’ strains of bacteria.
J Marchant, Nature, February 20, 2020 (Posted: Feb 21, 2020 9AM)

A pioneering machine-learning approach has identified powerful new types of antibiotic from a pool of more than 100 million molecules — including one that works against a wide range of bacteria, including tuberculosis and strains considered untreatable.

Beyond the Data Podcast, CDC Public Health Grand Rounds
CDC, January 2020 Brand (Posted: Jan 28, 2020 7AM)

New technologies are helping detect and fight infectious diseases such as bacterial foodborne illness, tuberculosis, influenza, malaria and Legionnaires' disease. Doctors John Iskander and Greg Armstrong discuss rapid advances in Advanced Molecular Detection and how these technologies are being applied in public health now and in the future.

The Emerging Role of Pathogen Genomics in Public Health
CDC Public Health Grand Rounds, January 21, 2020 Brand (Posted: Jan 08, 2020 10AM)

The Advanced Molecular Detection technologies are now in use across the range of infectious diseases of public health importance, such as bacterial foodborne illness, tuberculosis, influenza, malaria and Legionnaires’ Disease. This session of Public Health Grand Rounds will address how these technologies are being applied in public health, and their future uses.

Progress in Pathogen Genomics as a Prototype for Precision Public Health
MJ Khoury, CDC Blog Post, January 2, 2020 Brand (Posted: Jan 04, 2020 2PM)

Rapid advances in pathogen genomics have ushered in a new era of “precision public health.” Next-generation sequencing is already enabling more effective investigations of outbreaks of foodborne illnesses, better-targeted tuberculosis control, and more timely and granular influenza surveillance.

High-resolution mapping of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain.
Xu Yuanwei et al. PLoS medicine 2019 Oct (10) e1002961 (Posted: Nov 07, 2019 8AM)

Overall, we show that a transition to individual-based genomic epidemiology will likely close some of the knowledge gaps in TB transmission and may redirect efforts towards cost-effective contact investigations for improved TB control.

Evaluation of the accuracy of 99DOTS, a novel cellphone-based strategy for monitoring adherence to tuberculosis medications
BE Thomas et al, MedRXIV, November 5, 2019 (Posted: Nov 06, 2019 8AM)

99DOTS is a cellphone-based strategy for monitoring tuberculosis medication adherence. In a cohort of 650 Indian tuberculosis patients, we compared 99DOTS' adherence record against results of urine isoniazid tests collected during unannounced home visits. 99DOTS had suboptimal accuracy for measuring adherence, partly due to poor patient engagement.

Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.
Phelan Jody E et al. Genome medicine 2019 Jun (1) 41 (Posted: Jun 27, 2019 9AM)

Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues.
Meehan Conor J et al. Nature reviews. Microbiology 2019 Jun (Posted: Jun 19, 2019 8AM)

Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures
H Warsinske et al, PLOS Medicine, April 23, 2019 (Posted: Apr 23, 2019 2PM)

World TB Day 2019
CDC, 2019 Brand (Posted: Mar 19, 2019 0PM)

Precision medicine in resistant Tuberculosis: Treat the correct patient, at the correct time, with the correct drug.
Mahomed Sharana et al. The Journal of infection 2019 Mar (Posted: Mar 19, 2019 0PM)

The Future of TB Resistance Diagnosis: The Essentials on Whole Genome Sequencing and Rapid Testing Methods.
Moreno-Molina Miguel et al. Archivos de bronconeumologia 2019 Feb (Posted: Feb 24, 2019 2PM)

Advances in the molecular diagnosis of tuberculosis: From probes to genomes.
Machado Diana et al. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2018 Nov (Posted: Feb 13, 2019 9AM)

Mycobacterium tuberculosis Next-Generation Whole Genome Sequencing: Opportunities and Challenges.
Iketleng Thato et al. Tuberculosis research and treatment 2018 1298542 (Posted: Feb 13, 2019 9AM)

Tuberculosis Genetic Epidemiology: A Latin American Perspective.
Woodman Marc et al. Genes 2019 Jan (1) (Posted: Feb 13, 2019 9AM)

World TB Day 2019
CDC, 2019 Brand (Posted: Feb 13, 2019 9AM)

A high five for TB screening
C Langelier et al, Sci Trans Med, December 5, 2018 (Posted: Dec 06, 2018 7PM)

Impact of Genomics on Clarifying the Evolutionary Relationships amongst Mycobacteria: Identification of Molecular Signatures Specific for the Tuberculosis-Complex of Bacteria with Potential Applications for Novel Diagnostics and Therapeutics.
Gupta Radhey S et al. High-throughput 2018 Oct (4) (Posted: Dec 06, 2018 9AM)

Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies.
Cao Yan et al. Archives of medical science : AMS 2018 Oct (6) 1212-1232 (Posted: Dec 06, 2018 9AM)

CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis.
Richardson Marty et al. Systematic reviews 2018 Nov (1) 204 (Posted: Dec 06, 2018 9AM)

DNA markers for tuberculosis diagnosis.
Chin Kai Ling et al. Tuberculosis (Edinburgh, Scotland) 2018 Dec 139-152 (Posted: Dec 06, 2018 9AM)

Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
HC Warsinke et al, JAMA Network Open, October 26, 2018 (Posted: Oct 29, 2018 9AM)

Genomics England-supported study reveals new opportunities for personalised TB treatment
Genomics England, September 27,2018 (Posted: Sep 27, 2018 7AM)

NIH releases strategic plan to address tuberculosis research
NIH, September 26, 2018 Brand (Posted: Sep 27, 2018 7AM)

Addressing the Tuberculosis Epidemic- 21st Century Research for an Ancient Disease
A Fauci, JAMA, September 26, 2018 (Posted: Sep 27, 2018 7AM)

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing
Cryptic consortium, NEJM, September 27, 2019 (Posted: Sep 27, 2018 7AM)

The Coming of Age of Drug-Susceptibility Testing for Tuberculosis.
Cox Helen et al. The New England journal of medicine 2018 Sep (Posted: Sep 27, 2018 7AM)

Progression of recent Mycobacterium tuberculosis exposure to active tuberculosis is a highly heritable complex trait driven by 3q23 in Peruvians
Y Luo et al, BioRXIV, August 2018 (Posted: Aug 28, 2018 0PM)

Association of Rapid Molecular Testing With Duration of Respiratory Isolation for Patients With Possible Tuberculosis in a US Hospital
LH Chaisson et al, JAMA Internal Medicine, AUgust 27, 2018 (Posted: Aug 27, 2018 2PM)

Molecular Assay Testing to Rule Out Tuberculosis—Be That Early Adopter
M Salfinger, JAMA Internal Medicine, August 27, 2018 (Posted: Aug 27, 2018 2PM)

Advances in the development of molecular genetic tools for Mycobacterium tuberculosis.
Chhotaray Chiranjibi et al. Journal of genetics and genomics = Yi chuan xue bao 2018 Jun (Posted: Aug 07, 2018 8AM)

Treating Latent TB infection
CDC Information, August 2018 Brand (Posted: Aug 07, 2018 8AM)

New blood test found to predict onset of TB up to two years in advance
Medical Xpress, Apr 6,2018 (Posted: Apr 06, 2018 7AM)

Genotyping of Mycobacterium tuberculosis using whole genome sequencing.
Amlerova Jana et al. Folia microbiologica 2018 Mar (Posted: Mar 29, 2018 1PM)

Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease.
Goletti Delia et al. Respirology (Carlton, Vic.) 2018 Feb (Posted: Mar 13, 2018 11AM)

Patients at high risk of tuberculosis recurrence.
Mirsaeidi Mehdi et al. International journal of mycobacteriology (1) 1-6 (Posted: Mar 13, 2018 11AM)

New ways to fight HIV and tuberculosis emerge at AIDS conference
J Cohen, Science Magazine, Mar 5, 2018 (Posted: Mar 06, 2018 11AM)

Deep Learning Predicts Tuberculosis Drug Resistance Status from Whole-Genome Sequencing Data
ML Chen et al, BioRxIV, March 2018 (Posted: Mar 05, 2018 8AM)

Wanted: Leaders for a TB-Free United States. We can make history. End TB.
Brand (Posted: Feb 19, 2018 1PM)

Research matters: How a brother with Down syndrome inspired a PhD in tuberculosis and an ardor for science communication
M Wright, PLOS Pathogens, Feb 8, 2018 (Posted: Feb 08, 2018 6PM)

Tuberculosis (TB) Disease: Symptoms and Risk Factors
Brand (Posted: Jan 31, 2018 2PM)

Fast, Cheap Testing for Tuberculosis? Soon It May Be Possible
DG McNeil, New York Times, January 1,2017 (Posted: Jan 02, 2018 8AM)

Genomic Epidemiology of Tuberculosis.
Comas Iñaki et al. Advances in experimental medicine and biology 2017 79-93 (Posted: Nov 16, 2017 1PM)

The role of metabolomics in tuberculosis treatment research.
Luies Laneke et al. Biomarkers in medicine 2017 Oct (Posted: Oct 22, 2017 9AM)

CDC Announces New Center to Strengthen U.S. Tuberculosis Surveillance and Infrastructure
Brand (Posted: Aug 11, 2017 8AM)

Predicting TB's Behavior Can new molecular tests beat standard lab cultures in predicting TB outcome?
Harvard Medical School, August 3, 2017 (Posted: Aug 07, 2017 1PM)

Human genetic factors in tuberculosis: an update.
van Tong Hoang et al. Tropical medicine & international health : TM & IH 2017 Jul (Posted: Aug 02, 2017 8AM)

Heterogeneity in tuberculosis.
Cadena Anthony M et al. Nature reviews. Immunology 2017 Jul (Posted: Aug 02, 2017 8AM)

Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa.
Magee Matthew J et al. PloS one 2017 12(7) e0180916 (Posted: Jul 19, 2017 8AM)

Whole genome sequencing for M/XDR tuberculosis surveillance and for resistance testing.
Walker T M et al. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2017 Mar (3) 161-166 (Posted: Mar 23, 2017 8AM)

Recommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations.
Choi Rihwa et al. Annals of laboratory medicine 2017 Mar (2) 97-107 (Posted: Mar 23, 2017 8AM)

Relational TB Sequencing Data Platform (ReSeq TB)
WHO Collaboration (Posted: Feb 13, 2017 7PM)

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
D Stucki et al, Nature Genetics, October 31, 2016 (Posted: Nov 01, 2016 9AM)

Genomic diversity in autopsy samples reveals within-host dissemination of HIV-associated Mycobacterium tuberculosis
TD Lieberman et al, Nature Medicine, October 31, 2016 (Posted: Nov 01, 2016 9AM)

Using whole genome sequencing to transform tuberculosis outbreak detection and surveillance
Brand (Posted: Oct 06, 2016 10AM)

Whole Genome Sequence Analysis of a Large Isoniazid-Resistant Tuberculosis Outbreak in London: A Retrospective Observational Study
N Casali et al, PLOS Medicine, October 2016 (Posted: Oct 05, 2016 8PM)

New York State Department of Health Wadsworth Center Using Whole-Genome Sequencing to Combat Spread and Improvement Treatment of Tuberculosis,
Department of Health, New York State, September 16, 2016 (Posted: Sep 21, 2016 11AM)

Pathogen genomics used to determine the end of TB outbreak in landmark research
J Harris, PHG Foundation, June 15, 2016 (Posted: Jun 15, 2016 8AM)

New Blood Test for TB Could Save Millions of Lives
Scientific American, May 2016 (Posted: May 17, 2016 8PM)

The implications of whole-genome sequencing in the control of tuberculosis
RS Lee, Ther Adv Infect Dis. 2016 Apr; 3(2): 47?62. Brand (Posted: Apr 07, 2016 9PM)

Tackling tuberculosis: New models for an old disease
PLOS BLogs, March 24, 2016 (Posted: Mar 27, 2016 10AM)

World TB Day 2016: Unite to End TB
Brand (Posted: Mar 24, 2016 4PM)

Simple test might predict who gets world’s deadliest infectious disease
Kai Kupferschmidt, Science news, March 23, 2016 (Posted: Mar 24, 2016 2PM)

World TB Day — March 24, 2016
MMWR. March 25, 2016 Brand (Posted: Mar 24, 2016 1PM)

A blood RNA signature for tuberculosis disease risk: a prospective cohort study
DE Zak et al, Lancet, March 23, 2016 (Posted: Mar 24, 2016 10AM)

Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions
C. Linehardt et al, PLOS Medicine, March 2016 (Posted: Mar 14, 2016 6AM)

A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals
RS Sobota, Am J Hum Genetics, March 4, 2016 (Posted: Mar 04, 2016 9AM)

Tuberculosis: new approaches to an old disease
Genomics Education, UK, February 22, 2016 (Posted: Feb 23, 2016 6AM)

HLA class II sequence variants influence tuberculosis risk in populations of European ancestry
G. Sveinbjornsson et al, Nature Genetics, February 1, 2016 (Posted: Feb 02, 2016 8AM)

Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.
Saelens Joseph W et al. Tuberculosis (Edinburgh, Scotland) 2015 Dec (6) 810-6 (Posted: Jan 07, 2016 2PM)

MycoCAP - Mycobacterium Comparative Analysis Platform.
Choo Siew Woh et al. Scientific reports 2015 18227 (Posted: Jan 07, 2016 2PM)

Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis.
Bradley Phelim et al. Nature communications 2015 10063 (Posted: Jan 07, 2016 2PM)

Precision methylome characterization of Mycobacterium tuberculosis complex (MTBC) using PacBio single-molecule real-time (SMRT) technology.
Zhu Lingxiang et al. Nucleic acids research 2015 Dec (Posted: Jan 07, 2016 2PM)

Step up to Stop TB
PLOS Blogs, Médecins Sans Frontières, December 22, 2015 (Posted: Dec 23, 2015 3PM)

National Action Plan to Combat Multidrug-Resistant Tuberculosis
White House, December 22, 2015 (Posted: Dec 22, 2015 7PM)

Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis
P Bradley et al, Nature Communications, December 21, 2015 (Posted: Dec 21, 2015 10AM)

Scientists use breakthrough DNA technology to diagnose cases of TB faster
University of Oxford, December 4, 2015 (Posted: Dec 07, 2015 5PM)

more


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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