Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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A new class of antibiotics delivers promising trial results against tuberculosis.
Carvalho Thiago et al. Nature medicine 2022 11 (Posted: Dec-28-2022 11AM)
The science events to watch for in 2023 Moon landings, mRNA vaccines and climate finance are among the developments set to shape research in the coming year.
M Naddaf et al, Nature, December 19, 2022 (Posted: Dec-19-2022 8AM)
Making cough count in tuberculosis care
AJ Zimmer et al, Comm Medicine, July 6, 2022 (Posted: Jul-07-2022 7AM)
Using Pharmacogenetics to Enhance Tuberculosis (TB) Treatment
M Moore et al, CDC Blog Post, February 22, 2022 (Posted: Feb-23-2022 7AM)
Precision Public Health in Action: New CDC Pilot Projects Integrating Human Genomics into Public Health Surveillance and Applied Research
M Clyne et al, CDC Blog Post, February 14, 2022 (Posted: Feb-15-2022 7AM)
Using Genomic Epidemiology to Advance Public Health Action
CDC Preventive Medicine Grand Rounds, February 22, 2022 (Posted: Jan-25-2022 8AM)
COVID-19: endemic doesn’t mean harmless
A Katzourakis, Nature, January 24, 2022 (Posted: Jan-24-2022 2PM)
Importance of next-generation diagnostics in control of tuberculosis in LMICs
Z Hassan et al, Lancet Inf Dis, December 13, 2021 (Posted: Dec-15-2021 8AM)
Covid-19: Why Africa’s pandemic is different
M Sentilingham et al, BMJ, October 19, 2021 (Posted: Oct-20-2021 4AM)
Evidence Used to Update the List of Underlying Medical Conditions Associated with Higher Risk for Severe COVID-19
CDC Science Brief, October 14, 2021 (Posted: Oct-16-2021 8AM)
Derivation and external validation of a risk score for predicting HIV-associated tuberculosis to support case finding and preventive therapy scale-up: A cohort study
AF Aud et al, PLOS Medicine, September 7, 2021 (Posted: Sep-08-2021 9AM)
Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States
CDC Update, August 31, 2021 (Posted: Sep-01-2021 7AM)
CDC, July 2021 (Posted: Aug-10-2021 10AM)
An implementation science approach to evaluating pathogen whole genome sequencing in public health
AS Ferdinand et al, Genome Medicine, July 29, 2021 (Posted: Jul-30-2021 7AM)
Genomic evidence for prisons as amplifiers of community tuberculosis epidemics
KS Walter et al, MEDRXIV, June 24, 2021 (Posted: Jun-24-2021 7AM)
These Algorithms Could Bring an End to the World’s Deadliest Killer- In rural India and other places where tuberculosis is rampant, A.I. that scans lung X-rays might eliminate the scourge.
A Mandavilli, NY Times, November 20, 2020 (Posted: Nov-21-2020 11AM)
A clinical score for identifying active tuberculosis while awaiting microbiological results: Development and validation of a multivariable prediction model in sub-Saharan Africa
Y Baik et al, PLOS Medicine, November 11, 2020 (Posted: Nov-12-2020 8AM)
Discovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings
RK Gupta et al, Nature Medicine, October 19, 2020 (Posted: Oct-19-2020 0PM)
How artificial kidneys and miniaturized dialysis could save millions of lives
C Huff, Nature News, March 11, 2020 (Posted: Mar-14-2020 6AM)
Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex.
Merker Matthias et al. Genome medicine 2020 Mar (1) 27 (Posted: Mar-08-2020 10AM)
Powerful antibiotics discovered using AI- Machine learning spots molecules that work even against ‘untreatable’ strains of bacteria.
J Marchant, Nature, February 20, 2020 (Posted: Feb-21-2020 9AM)
Beyond the Data Podcast, CDC Public Health Grand Rounds
CDC, January 2020 (Posted: Jan-28-2020 7AM)
The Emerging Role of Pathogen Genomics in Public Health
CDC Public Health Grand Rounds, January 21, 2020 (Posted: Jan-08-2020 10AM)
Progress in Pathogen Genomics as a Prototype for Precision Public Health
MJ Khoury, CDC Blog Post, January 2, 2020 (Posted: Jan-04-2020 2PM)
High-resolution mapping of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain.
Xu Yuanwei et al. PLoS medicine 2019 Oct (10) e1002961 (Posted: Nov-07-2019 8AM)
Evaluation of the accuracy of 99DOTS, a novel cellphone-based strategy for monitoring adherence to tuberculosis medications
BE Thomas et al, MedRXIV, November 5, 2019 (Posted: Nov-06-2019 8AM)
Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.
Phelan Jody E et al. Genome medicine 2019 Jun (1) 41 (Posted: Jun-27-2019 9AM)
Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues.
Meehan Conor J et al. Nature reviews. Microbiology 2019 Jun (Posted: Jun-19-2019 8AM)
Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures
H Warsinske et al, PLOS Medicine, April 23, 2019 (Posted: Apr-23-2019 2PM)
World TB Day 2019
CDC, 2019 (Posted: Mar-19-2019 0PM)
Precision medicine in resistant Tuberculosis: Treat the correct patient, at the correct time, with the correct drug.
Mahomed Sharana et al. The Journal of infection 2019 Mar (Posted: Mar-19-2019 0PM)
The Future of TB Resistance Diagnosis: The Essentials on Whole Genome Sequencing and Rapid Testing Methods.
Moreno-Molina Miguel et al. Archivos de bronconeumologia 2019 Feb (Posted: Feb-24-2019 2PM)
Advances in the molecular diagnosis of tuberculosis: From probes to genomes.
Machado Diana et al. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2018 Nov (Posted: Feb-13-2019 9AM)
Mycobacterium tuberculosis Next-Generation Whole Genome Sequencing: Opportunities and Challenges.
Iketleng Thato et al. Tuberculosis research and treatment 2018 1298542 (Posted: Feb-13-2019 9AM)
Tuberculosis Genetic Epidemiology: A Latin American Perspective.
Woodman Marc et al. Genes 2019 Jan (1) (Posted: Feb-13-2019 9AM)
World TB Day 2019
CDC, 2019 (Posted: Feb-13-2019 9AM)
A high five for TB screening
C Langelier et al, Sci Trans Med, December 5, 2018 (Posted: Dec-06-2018 7PM)
Impact of Genomics on Clarifying the Evolutionary Relationships amongst Mycobacteria: Identification of Molecular Signatures Specific for the Tuberculosis-Complex of Bacteria with Potential Applications for Novel Diagnostics and Therapeutics.
Gupta Radhey S et al. High-throughput 2018 Oct (4) (Posted: Dec-06-2018 9AM)
Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies.
Cao Yan et al. Archives of medical science : AMS 2018 Oct (6) 1212-1232 (Posted: Dec-06-2018 9AM)
CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis.
Richardson Marty et al. Systematic reviews 2018 Nov (1) 204 (Posted: Dec-06-2018 9AM)
DNA markers for tuberculosis diagnosis.
Chin Kai Ling et al. Tuberculosis (Edinburgh, Scotland) 2018 Dec 139-152 (Posted: Dec-06-2018 9AM)
Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
HC Warsinke et al, JAMA Network Open, October 26, 2018 (Posted: Oct-29-2018 9AM)
Genomics England-supported study reveals new opportunities for personalised TB treatment
Genomics England, September 27,2018 (Posted: Sep-27-2018 7AM)
NIH releases strategic plan to address tuberculosis research
NIH, September 26, 2018 (Posted: Sep-27-2018 7AM)
Addressing the Tuberculosis Epidemic- 21st Century Research for an Ancient Disease
A Fauci, JAMA, September 26, 2018 (Posted: Sep-27-2018 7AM)
Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing
Cryptic consortium, NEJM, September 27, 2019 (Posted: Sep-27-2018 7AM)
The Coming of Age of Drug-Susceptibility Testing for Tuberculosis.
Cox Helen et al. The New England journal of medicine 2018 Sep (Posted: Sep-27-2018 7AM)
Progression of recent Mycobacterium tuberculosis exposure to active tuberculosis is a highly heritable complex trait driven by 3q23 in Peruvians
Y Luo et al, BioRXIV, August 2018 (Posted: Aug-28-2018 0PM)
Association of Rapid Molecular Testing With Duration of Respiratory Isolation for Patients With Possible Tuberculosis in a US Hospital
LH Chaisson et al, JAMA Internal Medicine, AUgust 27, 2018 (Posted: Aug-27-2018 2PM)
Molecular Assay Testing to Rule Out TuberculosisBe That Early Adopter
M Salfinger, JAMA Internal Medicine, August 27, 2018 (Posted: Aug-27-2018 2PM)
Advances in the development of molecular genetic tools for Mycobacterium tuberculosis.
Chhotaray Chiranjibi et al. Journal of genetics and genomics = Yi chuan xue bao 2018 Jun (Posted: Aug-07-2018 8AM)
Treating Latent TB infection
CDC Information, August 2018 (Posted: Aug-07-2018 8AM)
New blood test found to predict onset of TB up to two years in advance
Medical Xpress, Apr 6,2018 (Posted: Apr-06-2018 7AM)
Genotyping of Mycobacterium tuberculosis using whole genome sequencing.
Amlerova Jana et al. Folia microbiologica 2018 Mar (Posted: Mar-29-2018 1PM)
Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease.
Goletti Delia et al. Respirology (Carlton, Vic.) 2018 Feb (Posted: Mar-13-2018 11AM)
Patients at high risk of tuberculosis recurrence.
Mirsaeidi Mehdi et al. International journal of mycobacteriology (1) 1-6 (Posted: Mar-13-2018 11AM)
New ways to fight HIV and tuberculosis emerge at AIDS conference
J Cohen, Science Magazine, Mar 5, 2018 (Posted: Mar-06-2018 11AM)
Deep Learning Predicts Tuberculosis Drug Resistance Status from Whole-Genome Sequencing Data
ML Chen et al, BioRxIV, March 2018 (Posted: Mar-05-2018 8AM)
Wanted: Leaders for a TB-Free United States. We can make history. End TB.
(Posted: Feb-19-2018 1PM)
Research matters: How a brother with Down syndrome inspired a PhD in tuberculosis and an ardor for science communication
M Wright, PLOS Pathogens, Feb 8, 2018 (Posted: Feb-08-2018 6PM)
Tuberculosis (TB) Disease: Symptoms and Risk Factors
(Posted: Jan-31-2018 2PM)
Fast, Cheap Testing for Tuberculosis? Soon It May Be Possible
DG McNeil, New York Times, January 1,2017 (Posted: Jan-02-2018 8AM)
Genomic Epidemiology of Tuberculosis.
Comas Iñaki et al. Advances in experimental medicine and biology 2017 79-93 (Posted: Nov-16-2017 1PM)
The role of metabolomics in tuberculosis treatment research.
Luies Laneke et al. Biomarkers in medicine 2017 Oct (Posted: Oct-22-2017 9AM)
CDC Announces New Center to Strengthen U.S. Tuberculosis Surveillance and Infrastructure
(Posted: Aug-11-2017 8AM)
Predicting TB's Behavior
Can new molecular tests beat standard lab cultures in predicting TB outcome?
Harvard Medical School, August 3, 2017 (Posted: Aug-07-2017 1PM)
Human genetic factors in tuberculosis: an update.
van Tong Hoang et al. Tropical medicine & international health : TM & IH 2017 Jul (Posted: Aug-02-2017 8AM)
Heterogeneity in tuberculosis.
Cadena Anthony M et al. Nature reviews. Immunology 2017 Jul (Posted: Aug-02-2017 8AM)
Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa.
Magee Matthew J et al. PloS one 2017 12(7) e0180916 (Posted: Jul-19-2017 8AM)
Whole genome sequencing for M/XDR tuberculosis surveillance and for resistance testing.
Walker T M et al. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2017 Mar (3) 161-166 (Posted: Mar-23-2017 8AM)
Recommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations.
Choi Rihwa et al. Annals of laboratory medicine 2017 Mar (2) 97-107 (Posted: Mar-23-2017 8AM)
Relational TB Sequencing Data Platform (ReSeq TB)
WHO Collaboration (Posted: Feb-13-2017 7PM)
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
D Stucki et al, Nature Genetics, October 31, 2016 (Posted: Nov-01-2016 9AM)
Genomic diversity in autopsy samples reveals within-host dissemination of HIV-associated Mycobacterium tuberculosis
TD Lieberman et al, Nature Medicine, October 31, 2016 (Posted: Nov-01-2016 9AM)
Using whole genome sequencing to transform tuberculosis outbreak detection and surveillance
(Posted: Oct-06-2016 10AM)
Whole Genome Sequence Analysis of a Large Isoniazid-Resistant Tuberculosis Outbreak in London: A Retrospective Observational Study
N Casali et al, PLOS Medicine, October 2016 (Posted: Oct-05-2016 8PM)
New York State Department of Health Wadsworth Center Using Whole-Genome Sequencing to Combat Spread and Improvement Treatment of Tuberculosis,
Department of Health, New York State, September 16, 2016 (Posted: Sep-21-2016 11AM)
Pathogen genomics used to determine the end of TB outbreak in landmark research
J Harris, PHG Foundation, June 15, 2016 (Posted: Jun-15-2016 8AM)
New Blood Test for TB Could Save Millions of Lives
Scientific American, May 2016 (Posted: May-17-2016 8PM)
The implications of whole-genome sequencing in the control of tuberculosis
RS Lee, Ther Adv Infect Dis. 2016 Apr; 3(2): 47?62. (Posted: Apr-07-2016 9PM)
Tackling tuberculosis: New models for an old disease
PLOS BLogs, March 24, 2016 (Posted: Mar-27-2016 10AM)
World TB Day 2016: Unite to End TB
(Posted: Mar-24-2016 4PM)
Simple test might predict who gets worlds deadliest infectious disease
Kai Kupferschmidt, Science news, March 23, 2016 (Posted: Mar-24-2016 2PM)
World TB Day March 24, 2016
MMWR. March 25, 2016 (Posted: Mar-24-2016 1PM)
A blood RNA signature for tuberculosis disease risk: a prospective cohort study
DE Zak et al, Lancet, March 23, 2016 (Posted: Mar-24-2016 10AM)
Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions
C. Linehardt et al, PLOS Medicine, March 2016 (Posted: Mar-14-2016 6AM)
A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals
RS Sobota, Am J Hum Genetics, March 4, 2016 (Posted: Mar-04-2016 9AM)
Tuberculosis: new approaches to an old disease
Genomics Education, UK, February 22, 2016 (Posted: Feb-23-2016 6AM)
HLA class II sequence variants influence tuberculosis risk in populations of European ancestry
G. Sveinbjornsson et al, Nature Genetics, February 1, 2016 (Posted: Feb-02-2016 8AM)
Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.
Saelens Joseph W et al. Tuberculosis (Edinburgh, Scotland) 2015 Dec (6) 810-6 (Posted: Jan-07-2016 2PM)
MycoCAP - Mycobacterium Comparative Analysis Platform.
Choo Siew Woh et al. Scientific reports 2015 18227 (Posted: Jan-07-2016 2PM)
Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis.
Bradley Phelim et al. Nature communications 2015 10063 (Posted: Jan-07-2016 2PM)
Precision methylome characterization of Mycobacterium tuberculosis complex (MTBC) using PacBio single-molecule real-time (SMRT) technology.
Zhu Lingxiang et al. Nucleic acids research 2015 Dec (Posted: Jan-07-2016 2PM)
Step up to Stop TB
PLOS Blogs, Médecins Sans Frontières, December 22, 2015 (Posted: Dec-23-2015 3PM)
National Action Plan to Combat Multidrug-Resistant Tuberculosis
White House, December 22, 2015 (Posted: Dec-22-2015 7PM)
Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis
P Bradley et al, Nature Communications, December 21, 2015 (Posted: Dec-21-2015 10AM)
Scientists use breakthrough DNA technology to diagnose cases of TB faster
University of Oxford, December 4, 2015 (Posted: Dec-07-2015 5PM)
Accelerating tuberculosis elimination in low-incidence settings: the role of genomics.
Guthrie Jennifer L et al. The European respiratory journal 2015 Dec (6) 1840-1 (Posted: Dec-04-2015 0PM)
Representativeness of Tuberculosis Genotyping Surveillance in the United States, 2009-2010.
Shak Emma B et al. Public health reports (Washington, D.C. : 1974) (6) 596-601 (Posted: Dec-04-2015 0PM)
Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study
LJ Pankhurst et al. Lancet Respiratory Diseases, December 4, 2015 (Posted: Dec-04-2015 0PM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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- Page last updated:Jun 04, 2023
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