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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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118 hot topic(s) found with the query "Precision health"

Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality
E Stamatakis et al, Nature Medicine, December 8, 2022 (Posted: Dec-09-2022 6AM)

Here, we examined the association of VILPA with all-cause, cardiovascular disease (CVD) and cancer mortality in 25,241 nonexercisers (mean age 61.8?years, 14,178 women/11,063 men) in the UK Biobank. Over an average follow-up of 6.9?years, during which 852 deaths occurred, VILPA was inversely associated with all three of these outcomes in a near-linear fashion. Compared with participants who engaged in no VILPA, participants who engaged in VILPA at the sample median VILPA frequency of 3?length-standardized bouts per day (lasting 1 or 2?min each) showed a 38%–40% reduction in all-cause and cancer mortality risk and a 48%–49% reduction in CVD mortality risk.

Prospective evaluation of smartwatch-enabled detection of left ventricular dysfunction
ZI Attoa et al, Nature Medicine, November 14, 2022 (Posted: Nov-15-2022 7AM)

Although artificial intelligence (AI) algorithms have been shown to be capable of identifying cardiac dysfunction, defined as ejection fraction (EF) = 40%, from 12-lead electrocardiograms (ECGs), identification of cardiac dysfunction using the single-lead ECG of a smartwatch has yet to be tested. We digitally enrolled 2,454 unique patients from 46 US states and 11 countries, who sent 125,610 ECGs to the data platform between August 2021 and February 2022; 421 participants had at least one watch-classified sinus rhythm ECG within 30?d of an echocardiogram, of whom 16 (3.8%) had an EF?=?40%. The AI algorithm detected patients with low EF with an area under the curve of 0.885.

Evaluation of physical health status beyond daily step count using a wearable activity sensor
Z Xu et al, NPJ Digital Medicine, November 9, 2022 (Posted: Nov-09-2022 7AM)

Multimodal machine learning in precision health: A scoping review
A Kline et al, NPJ Digital Medicine, November 7, 2022 (Posted: Nov-08-2022 7AM)

Machine learning is frequently being leveraged to tackle problems in the health sector including utilization for clinical decision-support. Its use has historically been focused on single modal data. Attempts to improve prediction and mimic the multimodal nature of clinical expert decision-making has been met in the biomedical field of machine learning by fusing disparate data. This review was conducted to summarize the current studies in this field and identify topics ripe for future research.

Unsettled Liability Issues for "Prediagnostic" Wearables and Health-Related Products.
Simon David A et al. JAMA 2022 9 (Posted: Sep-24-2022 7AM)

Prediagnostic products and other health-related applications are bringing exciting technologies directly to consumers and mesh well with the goal of meeting patients “where they live,” sometimes literally. But these products also present a context that is rife with legal uncertainty

Building Capacity for Implementation Science in Precision Health and Society: Development of a Course for Professional and Graduate Students in Pharmacy
MC Roberts, J Personalized Medicine, September 14, 2022 (Posted: Sep-14-2022 3AM)

Training in the field of implementation science is critical for future pharmacists and pharmaceutical scientists to successfully implement precision health interventions in pharmacy practice. We developed an elective course for second- and third-year students at the UNC Eshelman School of Pharmacy to develop foundational knowledge in implementation science with a focus on precision health implementation. The eight-week course used a flipped classroom format featuring lecture videos, suggested readings, quizzes, guest lectures from experts, case studies, and a group project.

Wearable accelerometer-derived physical activity and incident disease.
Khurshid Shaan et al. NPJ digital medicine 2022 9 (1) 131 (Posted: Sep-04-2022 8AM)

A wearable ultrasound patch.
O'Leary Karen et al. Nature medicine 2022 8 (Posted: Aug-13-2022 6PM)

Wearable technologies are advancing rapidly and can provide a multitude of skin-based physical and chemical readouts. However, harnessing wearable technologies for internal imaging applications such as ultrasound – which provides crucial information on organ function and disease – has been challenging. Now scientists have engineered a stick-on wearable ultrasound device for continuous monitoring.

Bioadhesive ultrasound for long-term continuous imaging of diverse organs.
Wang Chonghe et al. Science (New York, N.Y.) 2022 7 (6605) 517-523 (Posted: Aug-01-2022 11AM)

Ultrasound is widely used for the noninvasive imaging of tissues and organs, but this method requires close contact between the transducer and the target area. This can make it difficult to acquire images over a long period of time, especially if the patient needs to be mobile. A new study describes a wearable ultrasound imaging device. A rigid piezoelectric probe array is bonded to the skin with an acoustically transparent hydrogel elastomer. In vivo testing showed that the device could be comfortably worn for 48 hours, and hooking the array up to a commercially available ultrasound platform allowed for continuous ultrasound images of the carotid artery, lung, and abdomen.

Precision Health Innovations in the Pandemic Era
D Rasooly et al, CDC Blog Post, July 8, 2022 Brand (Posted: Jul-08-2022 0PM)

Two recent articles, one in Nature Medicine and another in Nature Biotechnology, highlight areas of health innovation that have been accelerated by the COVID-19 pandemic. This blog post focuses on two precision health applications of technology—(1) genomics and (2) wearable devices and smartphone apps—that are likely to have a lasting impact beyond the pandemic. Increased interest in these applications is reflected in the scientific literature captured by the COVID-19 GPH database

Shaping the future of cardiovascular medicine in the new era of wearable devices.
Gehr Sinje et al. Nature reviews. Cardiology 2022 6 (Posted: Jun-11-2022 9AM)

Wearable devices are widely used and have a high level of societal acceptance, opening unimagined and unexploited possibilities in cardiovascular medicine. In this Clinical Outlook, we highlight the disruptive potential of wearables for cardiovascular disease prevention, diagnosis and management, and suggest strategies for quickly and safely translating these lifestyle products into medical devices.

COVID-19 GPH: tracking the contribution of genomics and precision health to the COVID-19 pandemic response
W Yu et al, BMC Infectious Diseases, April 25, 2022 (Posted: Apr-25-2022 8AM)

To quantify and track the ongoing contributions of genomics and precision health to the COVID-19 response, the Office of Genomics and Precision Public Health at the Centers for Disease Control and Prevention created the COVID-19 Genomics and Precision Health database (COVID-19 GPH), an open access knowledge management system and publications database that is continuously updated through machine learning and manual curation. This unique knowledge management database makes it easier to explore, describe, and track how the pandemic response is accelerating the applications of genomics and precision health technologies.

Tracking the Scientific Literature on the Impact of Pharmacogenomics on Clinical Practice and Public Health
S Abrishamcar et al, CDC blog Post, April 4 2022 Brand (Posted: Apr-04-2022 2PM)

Our office has created a comprehensive resource to help researchers, providers, and policy makers track progress and impact of genomics and precision health on population health. The resource features a continuously updated and curated database of scientific literature and other information. One component of this resource is a specific PGx database that focuses on progress in PGx in clinical practice and population health. A quick examination of our PGx database shows significant growth in translation and implementation science in the last decade. The number of published studies in these areas increased from 12 in 2012 to 333 in 2021.

Advancing Implementation Science in Precision Public Health: Ensuring Health Equity and Balancing Evolution and Sustainment
Precision Public Health Network webinar, April 27, 2022 Brand (Posted: Mar-22-2022 7AM)

The rapid development of advances in biomedical research creates levers to improve precision health and health care. However, without complementary attention to a robust agenda on implementation science, we risk replicating the “bench” to “bookshelf” pathway for scientific discoveries. Dr David Chambers will discuss challenges and opportunities, assumptions and ongoing activities toward advancing implementation science in the context of dynamic systems, an evolving evidence base and a desire to sustain effective and equitable health interventions over time.

Real life experience with the wearable cardioverter-defibrillator in an international multicenter Registry.
El-Battrawy Ibrahim et al. Scientific reports 2022 2 (1) 3203 (Posted: Feb-27-2022 10AM)

Patients at high risk for sudden cardiac death (SCD) may benefit from wearable cardioverter defibrillators (WCD) by avoiding immediate implantable cardioverter defibrillator (ICD) implantation. Different factors play an important role including patient selection, compliance and optimal drug treatment. We aimed to present real world data from 4 centers from Germany and Switzerland. Between 04/2012 and 03/2019, 708 patients were included in this registry. Patients were followed up over a mean time of 28?±?35.5 months. Outcome data including gender differences and different etiologies of cardiomyopathy were analyzed. Out of 708 patients (81.8% males, mean age 61.0?±?14.6), 44.6% of patients had non-ischemic cardiomyopathy, 39.8% ischemic cardiomyopathy, 7.9% myocarditis, 5.4% prior need for ICD explantation and 2.1% channelopathy.

Improving Diversity of the Genomics Workforce
NASEM RoundTable on Genomics and Precision Health, February 18, 2022 (Posted: Feb-18-2022 0PM)

The workshop, Improving Diversity of the Genomics Workforce, examined the current state of diversity of the genetics and genomics workforce; the structural and social factors associated with the lack of workforce diversity; the impact of diversity in the workforce on access to genetic services and patient outcomes; and possible actions that could lead to a more diverse, equitable, and inclusive genomics workforce. This Proceedings of a Workshop-in Brief highlights the presentations and discussions that occurred during the workshop.

The Use of Machine Learning in Health Care: No Shortcuts on the Long Road to Evidence-based Precision Health
D Rasooly et al, CDC Blog Post, December 7, 2021 Brand (Posted: Dec-07-2021 1PM)

Two recent systematic reviews reveal the high risk of bias present in randomized controlled trials (RCTs) and observational studies based on machine learning and artificial intelligence. Given that methodological challenges and risk of biases in ML-based models can occur across different development stages, such as data curation, model selection and implementation, and validation, there is a need for broad discussion of possible solutions.

Digital twins for predictive oncology will be a paradigm shift for precision cancer care
TH Boussard et al, Nature Medicine, November 2, 2021 (Posted: Nov-27-2021 9AM)

Cancer patient digital twins (CPDTs) use emerging computing and biotechnologies to build in silico individual representations that dynamically reflect molecular, physiological and lifestyle status across different treatments and time. We propose a CPDT framework with a continuous life cycle for shared decision-making.

Transdisciplinary Conference for Future Leaders in Precision Public Health
Speakers Slide Presentations, November 2021 (Posted: Nov-12-2021 7AM)

This virtual event held in October 2021 connected future research leaders around the world interested in the role of genetics and precision health in the promotion of public health. The speakers provided opportunities for early career investigators to discuss new developments in precision public health with leading experts in the field. Attendees heard from expert epidemiologists, behavioral scientists, statisticians, and global public health leaders about topics such as health equity in genetic epidemiology, genetic risk communication in cancer care, and biostatistics and modeling.

Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset
E Grzesiak et al, JAMA Network Open, September 29, 2021 (Posted: Sep-30-2021 7AM)

In a cohort study of 31 participants inoculated with H1N1 and 18 participants with rhinovirus, infection detection and severity prediction models trained using data on wearable devices were able to distinguish between infection and noninfection with 92% accuracy for H1N1 and 88% accuracy for rhinovirus and were able to distinguish between mild and moderate infection 24 hours prior to symptom onset with 90% accuracy for H1N1 and 89% accuracy for rhinovirus.

Improving Diversity of the Genomics Workforce: A Workshop
NASEM Roundtable on Genomics and Precision Health workshop, October 5, 2021 (Posted: Sep-20-2021 3PM)

This virtual public workshop that will examine the current state of diversity (e.g., racial, ethnic) of the genetics and genomics workforce, structural issues that have contributed to diversity challenges, and potential steps forward. Workshop discussions may address topics such as the impact of racism on the culture of the fields of genetics and genomics; how the genetics/genomics workforce is or is not uniquely affected by structural racism; and the relationship between the lack of diversity in the workforce and patient access to genetic services.

A systematic literature review of disclosure practices and reported outcomes for medically actionable genomic secondary findings.
Sapp Julie C et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021 8 (Posted: Aug-27-2021 7AM)

Secondary findings (SFs) are present in 1–4% of individuals undergoing genome/exome sequencing. A review of how SFs are disclosed and what outcomes result from their receipt is urgent and timely.Variation in how SF disclosure and outcomes were described limited our ability to compare findings. We conclude the literature provided limited insight into how the American College of Medical Genetics and Genomics (ACMG) guidelines have been translated into precision health outcomes for SF recipients. Robust studies of SF recipients are needed and should be prioritized for future research.

Personalized lab test models to quantify disease potentials in healthy individuals
NM Cohen et al, Nature Medicine, August 23, 2021 (Posted: Aug-25-2021 8AM)

Using EHRs, we generated a filtered dataset, including ~0.5 billion lab measurements from 2.8?M individuals. Based on these data we developed tools for multivariate longitudinal analysis and showed that they can predict patients’ within-normal lab trajectories at surprisingly high accuracy. Personalized lab models can then be applied to patients with still-normal lab readouts to evaluate risks for future lab test abnormalities, deterioration toward multiple types of chronic diseases and overall mortality.

Tracking the Scientific Literature on SARS-CoV-2 Variants Using the COVID-19 Genomics and Precision Health Knowledge Base
M Feero et al, CDC blog post, July 27, 2021 Brand (Posted: Jul-27-2021 1PM)

From December 2020 to January 2021, the number of preprints and journal publications on variants doubled from 106 to 213). By March 2021, more than 300 new publications on variants were appearing each month. Preprints accounted for 37% of the total publications in both 2020 and 2021. Most publications on variants focused on mechanism (e.g., effects of mutations on binding to host receptors) or on potential clinical applications (e.g., diagnosis, treatment, or vaccines). Only a small fraction addressed public health topics, such as surveillance or forecasting, prevention, or health equity.

Mobile health strategies for blood pressure self-management in urban populations with digital barriers: systematic review and meta-analyses
EC Khoong et al, NPJ Digital Medicine, July 22, 2021 (Posted: Jul-23-2021 7AM)

Mobile health (mHealth) technologies improve hypertension outcomes, but it is unknown if this benefit applies to all populations. This review aimed to describe the impact of mHealth interventions on blood pressure outcomes in populations with disparities in digital health use.

Resources in Genomics and Precision Health to Enhance Public Health Impact of New Technologies
CDC slide set, 2021 Brand (Posted: Jul-19-2021 2PM)

The presentation reviews the CDC Public Health Genomics and Precision Health Knowledge Base (PHGKB), a suite of searchable databases that includes publications and other resources. It includes: 1) COVID Genomics and Precision Health, a database that includes publications and other resources about the impact of genomics and precision health technologies on the investigation and control of COVID-19; 2) My Family Health Portrait, a family health history collection tool that allows users to save and share their family health history information; and 3) Specialized PHGKB databases such as reproductive and child health, family health history, and health equity.

‘It’s hard to know what’s trustworthy’: A new research effort aims to vet digital health data from wearables
K Palmer, Stat News, June 22, 2021 (Posted: Jun-23-2021 8AM)

Continuous health monitoring: An opportunity for precision health.
Gambhir Sanjiv S et al. Science translational medicine 2021 6 (597) (Posted: Jun-12-2021 7AM)

Continuous health monitoring and integrated diagnostic devices, worn on the body and used in the home, will help to identify and prevent early manifestations of disease. However, challenges lie ahead in validating new health monitoring technologies and in optimizing data analytics to extract actionable conclusions from continuously obtained health data.

Wearable sensors enable personalized predictions of clinical laboratory measurements
J Dunn et al, Nature Medicine, May 24, 2021 (Posted: May-25-2021 7AM)

We examined whether vital signs as measured by consumer wearable devices (that is, continuously monitored heart rate, body temperature, electrodermal activity and movement) can predict clinical laboratory test results using machine learning models, including random forest and Lasso models. Our results demonstrate that vital sign data collected from wearables give a more consistent and precise depiction of resting heart rate than do measurements taken in the clinic

Mobile Health: making the leap to research and clinics
JP Ku et al, NPJ Digital Medicine, May 14, 2021 (Posted: May-15-2021 7AM)

Health applications for mobile and wearable devices continue to experience tremendous growth, but their impact on healthcare has yet to be fully realized. This commentary introduces three articles in a special issue that provides guidance on how to successfully address translational barriers to bringing mobile health technologies into clinical research and care. We also discuss how the cross-organizational sharing of data, software, and other digital resources can lower such barriers and accelerate progress across mobile health

Wearables as a tool for measuring therapeutic adherence in behavioral health
L Wedlund et al, NPJ Digital Medicine, May 10, 2021 (Posted: May-11-2021 8AM)

When the FDA approved digital aripiprazole (an antipsychotic medication containing an ingestible sensor to track consumption), the medical community gained a new tool for measuring compliance, theoretically paving the way for new initiatives to find and help nonadherent patients. However, digital aripiprazole comes with a hefty price tag of $1700 for a 30-day supply (85× the price of generic aripiprazole)4, and with no existing randomized control trials to show how digital aripiprazole changes medication adherence5, it may be difficult to justify the cost.

Precision Health Diagnostic and Surveillance Network uses S Gene Target Failure (SGTF) combined with sequencing technologies to identify emerging SARS-CoV-2 variants.
RG Preston et al, MEDRXIV, May 7, 2021 (Posted: May-08-2021 6AM)

Several genomic epidemiology tools have been developed to track the public and population health impact of SARS-CoV-2 community spread worldwide. A SARS-CoV-2 Variant of Concern (VOC) B.1.1.7, known as 501Y.V1, which shows increased transmissibility, has rapidly become the dominant VOC in the United States (US). Our objective was to develop an evidenced-based genomic surveillance algorithm that combines RT-PCR and sequencing technologies to identify VOCs.

Ensuring that biomedical AI benefits diverse populations
J Zhou et al, E Biomedicine, May 4, 2021 (Posted: May-04-2021 3PM)

Artificial Intelligence (AI) can potentially impact many aspects of human health, from basic research discovery to individual health assessment. It is critical that these advances in technology broadly benefit diverse populations from around the world. This can be challenging because AI algorithms are often developed on non-representative samples and evaluated based on narrow metrics. Here we outline key challenges to biomedical AI in outcome design, data collection and technology evaluation, and use examples from precision health to illustrate how bias and health disparity may arise.

Stool-based Colorectal Cancer Screening in the COVID-19 Era
WD Dotson et al, CDC Blog, April, 12, 2021 Brand (Posted: Apr-13-2021 7AM)

The broad aftermath of the pandemic will be with us for many years to come. Some of the resulting changes can be positive, including an increased awareness of digital, genomic and other precision health technologies which may provide alternatives to traditional screening methods.

Remote Patient Monitoring — Overdue or Overused?
K Mecklai et al, NEJM, April 10, 2021 (Posted: Apr-12-2021 8AM)

The Covid-19 pandemic has challenged clinicians to find innovative ways to provide essential services while minimizing risks for themselves and their patients. These approaches increasingly leverage remote patient monitoring (RPM), using technology to support treatment for chronic conditions. As the use of RPM services grows, clinicians, payers, and patients face important questions regarding the volume, value, and appropriate use of this care model.

CDC Resources in Genomics and Precision Health to Enhance Public Health Impact of New Technologies
CDC Webinar, March 25,2021 (Posted: Feb-27-2021 7AM)

Advances in genomics and precision health are ushering a new era of precision medicine and precision public health. The pace of scientific discoveries is accelerating and the applications in research, clinical, and public health practice are multiplying. For just about anyone – researchers, practitioners and the general public alike – staying abreast of the latest news and publications is a daunting task.

Development and Validation of Risk Scores for All-Cause Mortality for a Smartphone-Based "General Health Score" App: Prospective Cohort Study Using the UK Biobank.
Clift Ashley K et al. JMIR mHealth and uHealth 2021 Feb 9(2) e25655 (Posted: Feb-19-2021 10AM)

The objective of the study was to develop and validate a novel, easily interpretable, points-based health score ("C-Score") derived from metrics measurable using smartphone components and iterations thereof that utilize statistical modeling and machine learning (ML) approaches.A literature review was conducted to identify relevant predictor variables for inclusion in the first iteration of a points-based model. This was followed by a prospective cohort study in a UK Biobank population.

Precision Nutrition: Research Gaps and Opportunities Workshop
NIH Workshop, January 11-12, 2021 Brand (Posted: Jan-05-2021 8AM)

Precision nutrition science enables individualized dietary recommendations or therapies based on these factors. This workshop will bring together scientists with diverse expertise to explore how best to address these complex factors. It also will focus on diet-related chronic diseases and how artificial intelligence (AI) and deep-learning techniques may be used to generate individualized dietary recommendations and algorithms.

Public Health Genomics in Action: A State-based Approach to Genomics and Precision Health
CDC Webinar, January 28, 2021 Brand (Posted: Dec-22-2020 8AM)

To date, there are only a few state-based population-based efforts to leverage new science with capacity of medicine, public health and the private sector in improving health outcomes. This seminar will focus on two such initiatives, the Alabama Genomic Health Initiative (AGHI) and the North Carolina Precision Health Collaborative (NCPHC).

How blockchain and genetic engineering could make food safer for people with allergies
G Poppy, Nature Outlook, December 2020 (Posted: Dec-20-2020 11AM)

The two technologies might ultimately bring an end to ‘may contain’ food labels, which consumers find confusing. Technology and innovation play a major part in global health challenges, as demonstrated by current efforts to find a vaccine against COVID-19. In the case of food allergies, two technologies spring to mind.

2021: research and medical trends in a post-pandemic world
M May, Nature Medicine, December 7, 2020 (Posted: Dec-10-2020 11AM)

Goodbye 2020: Research and medical trends in a post-pandemic world include a new normal, open repositories, leaps ahead for immunology, more digital health and better preparedness.

Assessing Lifting Risk Factors Using Wearable Motion Sensors
MS Barim et al, NIOSH Blog, October 2020 Brand (Posted: Oct-26-2020 9AM)

A combination of work-related physical risk factors such as awkward postures or heavy lifting may lead to an increased risk of developing low back issues. Inertial measurement unit- (IMU) based wearable technologies are becoming popular as a tool to track whole body postures for ergonomic risk assessments.

Precision Medicine Leaders Summit
PMLS, North Carolina Precision Health Initiative, October 20-21, 2020 (Posted: Oct-06-2020 8AM)

Advances in genomics and precision health technologies are changing the practice of medicine and public health. The public health response to genomics and precision health technologies illustrates the current opportunities and challenges of new technologies in improving population health and preventing disease.

Enabling precision rehabilitation interventions using wearable sensors and machine learning to track motor recovery
CA Dester et al, NPJ Digital Medicine, September 21, 2020 (Posted: Sep-22-2020 10AM)

The approach proposed in this paper relies on machine learning-based algorithms to derive clinical score estimates from wearable sensor data collected during functional motor tasks. Sensor-based score estimates showed strong agreement with those generated by clinicians.

The Role of Digital Health Technologies in Drug Development: Proceedings of a Workshop
NASEM Roundtable on Genomics and Precision Health Workshop, 2020 (Posted: Aug-28-2020 10AM)

This workshop explored how virtual clinical trials facilitated by digital health technologies (DHTs) might change the landscape of drug development. Participants considered how DHTs could be applied to achieve the greatest impact—and perhaps even change the face of how clinical trials are conducted—in ways that are also ethical, equitable, safe, and effective.

Wearable-device-measured physical activity and future health risk
T Strain et al, Nature Medicine, August 17, 2020 (Posted: Aug-18-2020 7AM)

This UK Biobank study shows that higher volumes of activity energy expenditure are associated with lower mortality rates. This approach for converting device-measured activity signals to energy expenditure and relating this to health risk creates a framework for future personalized prevention from wearables.

Rare Diseases and COVID-19
CDC COVID-19 Genomics and Precision Health Portal, August 2020 Brand (Posted: Aug-08-2020 10AM)

This section of the portal lists all rare diseases, many of which are genetic diseases, that have been connected to COVID-19 in the literature. As of today, there are 84 diseases/conditions from the list of nearly 7,000 rare diseases extracted from the NIH website that are related to COVID-19 literature or news and reports.

Precision Health Analytics With Predictive Analytics and Implementation Research- JACC State-of-the-Art Review
TA Pearson et al, JACC, July 2020 (Posted: Jul-15-2020 0PM)

Predictive analytics expands the quality and quantity of data needed to inform patient care. Complex genome and exposome data will inform new cardiovascular decision tools. New decision tools require implementation research to define use, benefits, and sustainability. Precision health requires training for new teams of data scientists and clinicians.

From Precision Medicine to Precision Public Health: Beyond the Pandemic
MJ Khoury et al, CDC Blog Post, June 18, 2020 Brand (Posted: Jun-21-2020 3PM)

As the CDC Coronavirus Disease portal in genomics and precision health shows, an emerging display of scientific productivity is shifting the narrative from precision medicine to precision public health in response to the COVID-19 pandemic.

The Project Baseline Health Study: a step towards a broader mission to map human health
K Arges et al, NPJ Digital Medicine, June 5, 2020 (Posted: Jun-06-2020 6AM)

The PBHS will contribute to precision health and medicine by integrating state of the art testing, longitudinal monitoring and participant engagement, and by contributing to the development of an improved platform for data sharing and analysis

Using Digital Technologies in Precision Public Health: COVID-19 and Beyond
MJ Khoury et al, CDC Blog, April 2020 Brand (Posted: Apr-26-2020 8AM)

With the global spread of COVID-19, there is a proliferation of scientific information and publications that use novel approaches such as genomics and precision health tools (e.g., big data, wearables, and digital devices) in surveillance and epidemiologic investigations. Could these new technologies provide added value to traditional approaches?

A New Resource for Genomics and Precision Health Information and Publications on the Investigation and Control of COVID-19 and other Coronaviruses
W Yu et al, BIORXIV, April 21, 2020 (Posted: Apr-22-2020 8AM)

We developed a new online database that contains the most updated published scientific literature, online news and reports, CDC and National Institutes of Health resources. The tool captures emerging discoveries and applications of genomics, molecular, and other precision health tools in the investigation and control of coronavirus diseases.

The Prospective Lynch Syndrome Database reports enable evidence-based personal precision health care.
Møller Pål et al. Hereditary cancer in clinical practice 2020 186 (Posted: Mar-25-2020 9AM)

The future of sleep health: a data-driven revolution in sleep science and medicine
NPJ Digital Medicine, March 23, 2020 (Posted: Mar-24-2020 6AM)

We introduce the state-of-the-art in sleep-monitoring technologies, and discuss the opportunities and challenges from data acquisition to the eventual application of insights in clinical and consumer settings. Further, we explore the strengths and limitations of current and emerging sensing methods with a particular focus on novel data-driven technologies.

Use of artificial intelligence in infectious diseases
S Aghrebi et al, AI in Precision Health, March 2020 (Posted: Mar-16-2020 8AM)

With the advent of mathematical tools, scientists are now able to better predict epidemics, understand the specificity of each pathogen, and identify potential targets for drug development.

Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units
HU Chung et al, Nature Medicine, March 11, 2020 (Posted: Mar-12-2020 10AM)

NHGRI establishes new intramural precision health research program
NIH, February 2020 Brand (Posted: Feb-17-2020 10AM)

The National Human Genome Research Institute has announced plans to establish a new precision health research program within its Division of Intramural Research. The goal of the program is to develop and evaluate next-generation healthcare that uses cutting-edge genomic and informatic tools to improve the diagnosis, treatment and prevention of disease.

Smartphones vs Wearable Devices for Remotely Monitoring Physical Activity After Hospital Discharge
MS Patel et al, JAMA Network Open, February 2020 (Posted: Feb-10-2020 9AM)

Nearly 80% of US adults own a smartphone,1 which accurately tracks physical activity. Wearable devices are growing in adoption and can track other biometrics.The objective of this study was to compare the duration of remotely monitoring physical activity from smartphones vs wearables in the 6 months after hospital discharge.

Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults.
Quer Giorgio et al. PloS one 2020 (2) e0227709 (Posted: Feb-06-2020 9AM)

Individuals have a daily resting heart rate (RHR) that is normal for them but can differ from another individual's normal by as much as 70 bpm. Within individuals, RHR was much more consistent over time, with a small but significant seasonal trend, and detectable discrete and infrequent episodes outside their norms

Introducing "Precision Health Promotion": The Convergence of Genomics, Health Education, and Lived Experience.
Terry Paul E et al. American journal of health promotion : AJHP 2020 Jan 890117120903129 (Posted: Feb-05-2020 9AM)

Some voice concerns that the growth of PM emphasize the medical model for health with undue focus on individual rather than societal solutions. We introduce precision health promotion as "the personalized design of lived experiences that foster improved health and well-being for individuals within the context of their families, organizations and communities."

Coronavirus Genomics and Precision Health Knowledge Base
PHGKB information and publications on coronavirus, genomics and precision health Brand (Posted: Jan-31-2020 9AM)

The latest information and publications on the role of genomics and precision health technologies in the investigation and control of coronavirus infection.

Deep phenotyping during pregnancy for predictive and preventive medicine
AG Paquette et al, Scit Trans Medicine, Januar 22, 2020 (Posted: Jan-24-2020 8AM)

Systems biology offers a holistic approach to deciphering physiology or disease by deriving and integrating biological information to delineate relevant networks and their dynamics. We discuss why pregnancy is particularly well suited for prototyping deep phenotyping, scientific wellness, and related systems biology approaches to predictive medicine.

An unsupervised learning approach to identify novel signatures of health and disease from multimodal data.
Shomorony Ilan et al. Genome medicine 2020 Jan (1) 7 (Posted: Jan-17-2020 8AM)

We collected 1385 data features from diverse modalities, including metabolome, microbiome, genetics, and advanced imaging, from 1253 individuals and from a longitudinal validation cohort of 1083 individuals. We utilized a combination of unsupervised machine learning methods to identify multimodal biomarker signatures of health and disease risk.

Innovation should support societal responsibility for health
R Milne et al, BMJ Blog, January 2020 (Posted: Jan-07-2020 8AM)

The popular emphasis on genomics and precision health technology being harnessed by individuals fails to consider how it can be used to improve social determinants of health.

Communication and Information Sharing about Genomics and Precision Health: Opportunities for Improvement
C Allen et al, CDC Blog, January 2, 2020 Brand (Posted: Jan-04-2020 2PM)

We describe our current approach to information sharing based on a recent review of our communication and engagement strategies. In order to improve our approaches to communication, we are asking you, our readers, for feedback—please share your thoughts here.

Ethical and Legal Considerations for the Inclusion of Underserved and Underrepresented Immigrant Populations in Precision Health and Genomic Research in the United States.
Wagner Jennifer K et al. Ethnicity & disease 2019 29(Suppl 3) 641-650 (Posted: Jan-02-2020 10AM)

Digital assessment of falls risk, frailty, and mobility impairment using wearable sensors
BR Greene, NPJ Digital Medicine, December 2019 (Posted: Dec-12-2019 9AM)

Mass-producing wearable sensors: No sweat
LH Han, Sci Trans Med, December 11, 2019 (Posted: Dec-12-2019 8AM)

Laser engraving can mass-produce cost-efficient, wearable sensors that monitor vital signs and sweat, detecting biomarkers linked to chronic diseases.

Epidemiologic Research in Dry Eye Disease and the Utility of Mobile Health Technology
MTM Wang et al, JAMA Ophthalmology, November 28 2019 (Posted: Nov-29-2019 9AM)

One of the particularly novel aspects of the current study was the use of a crowdsourced smartphone application for the purpose of epidemiologic data collection. The use of mobile health technology tools offers the ability to collect detailed information from a large population in a relatively cost-effective, time-efficient, and user-friendly manner.

Diagnosing With a Camera From a Distance—Proceed Cautiously and Responsibly
MP Turakhia, JAMA Cardiology, November 2019 (Posted: Nov-28-2019 9AM)

A new study asks whether video images of the human face can be used to assess pulsatile blood flow and assess for atrial fibrillation. Using a digital camera, the authors recorded 20 individuals with atrial fibrillation and 24 controls. This proof-of-concept study may have bold implications.

Wearable graphene sensors use ambient light to monitor health
Nature News, November 18, 2019 (Posted: Nov-19-2019 8AM)

Graphene coated with nanoparticles has been used to make wearable light sensors that measure the human pulse and blood oxygen levels from ambient light passing through tissue, offering a potential platform for health-care monitoring.

Integrated textile sensor patch for real-time and multiplex sweat analysis
W He et al, Science Advances, November 8, 2019 (Posted: Nov-11-2019 6AM)

Wearable sweat analysis devices for monitoring of multiple health-related biomarkers with high sensitivity are highly desired for noninvasive and real-time monitoring of human health. Here, we report a flexible sweat analysis patch based on a silk fabric–derived carbon textile for simultaneous detection of six health-related biomarkers.

Digital endpoints library can aid clinical trials for new medicines
J Goldsack et al, Stat News, November 6, 2019 (Posted: Nov-09-2019 8AM)

Digital endpoints can use sensors to capture existing measures in a new way, say using a smartphone microphone to measure cough instead of relying on a patient to record episodes of coughing in a diary. Continuous assessment of the quantity and intensity of activity, measured using a wearable sensor, can be a clinically important digital endpoint for heart failure.

Wearable technology and lifestyle management: the fight against obesity and diabetes
The Lancet Digital Health, Vol 1, Iss 6, Pe 243, October 1, 2019 (Posted: Oct-11-2019 0PM)

A Theoretical Framework for Clinical Implementation of Social Determinants of Health.
Hammond Gmerice et al. JAMA cardiology 2019 Oct (Posted: Oct-11-2019 8AM)

Social determinants of health are key drivers of poor outcomes and inequity. "But how to collect these data, who should collect it, how much data are needed, and how it should be used remain unclear." Read this informative framework. The paper discusses 4 use cases: Clinical assessment and risk prediction, performance evaluation, person-focused SDOH interventions, and population-based interventions and policies.

Introducing the CDC Office of Genomics and Precision Public Health: What’s in a Name?
M Khoury, CDC Blog, September 30, 2019 Brand (Posted: Oct-01-2019 8AM)

Starting this week, the CDC Office of Public Health Genomics will be renamed the CDC Office of Genomics and Precision Public Health. In many ways, this transition has been a few years in the making and reflects the continuous broadening of our scope from human genomics and public health to include other areas relevant to “precision” health technologies.

Exploring the Current Landscape of Consumer Genomics - A Workshop
NASEM workshop, October 29, 2019 (Posted: Sep-30-2019 9AM)

The Roundtable on Genomics and Precision Health will host a public workshop on October 29, 2019 to explore the current landscape of consumer genomics and implications for how genetic test information is used or may be used in research and clinical care. Discussions include topics such as health literacy and engagement, knowledge gaps and data privacy concerns.

Digital health: From clinical trials to diagnosis and surgery, artificial intelligence has the potential to transform medicine.
R Hodson, Nature Outlook, September 25, 2019 (Posted: Sep-27-2019 10AM)

In the past decade, the use of artificial intelligence (AI) has grown to the point where there are now few areas of our lives that it does not touch. The potential of digital transformation is particularly far-reaching in medicine.

Towards a tricorder for diagnosing paediatric conditions
J Chan et al, The Lancet, September 12, 2019 (Posted: Sep-13-2019 9AM)

This review explores how precision health technologies including smartphones, sensors, and artificial intelligence algorithms are changing the landscape of diagnosis of childhood conditions.

Enabling Web-scale data integration in biomedicine through Linked Open Data
MR Kamdar et al, NPJ Digital Medicine, September 10, 2019 (Posted: Sep-11-2019 9AM)

Toward clinical digital phenotyping: a timely opportunity to consider purpose, quality, and safety
K Huckvale, NPJ Digital Medicine, Septetmber 2019 (Posted: Sep-08-2019 6AM)

The authors identify four opportunities for research directed toward this goal: exploring intermediate outcomes and underlying disease mechanisms; focusing on purposes that are likely to be used in clinical practice; anticipating quality and safety barriers to adoption; and exploring the potential for digital personalized medicine.

Mobile Devices and Health.
Sim Ida et al. The New England journal of medicine 2019 Sep (10) 956-968 (Posted: Sep-05-2019 8AM)

Mobile health is at the swirling confluence of remote sensing, consumer-facing personal technologies, and artificial intelligence. Data from smartphone apps and an ever-growing range of wearable and environmental sensors can be processed with the use of machine learning and other AI techniques to support health related decision making.

A protocol integrating remote patient monitoring patient reported outcomes and cardiovascular biomarkers
C Shufelt et al, NPJ Digital Medicine, September 3, 2019 (Posted: Sep-03-2019 10AM)

Using biosensor, biomarkers, and patient-reported outcomes in participants with stable ischemic heart disease, the PRE-MACE study is designed to measure cross-sectional correlations and establish the ability of remote monitoring to predict major adverse cardiovascular event.

Developing a digital intervention for cancer survivors: an evidence-, theory- and person-based approach
K Brabdbury et al, NPJ Digital Medicine, September 2, 2019 (Posted: Sep-02-2019 2PM)

Translating clinical trial results into personalized recommendations by considering multiple outcomes and subjective views
N Dagan et al, NPJ Digital Medicine, August 21, 2019 (Posted: Aug-22-2019 7AM)

This study proposes a process, focused on practical usability, for translating RCT data into personalized treatment recommendations that weighs benefits against harms and integrates subjective perceptions of relative severity. Intensive blood pressure treatment was selected as the test case to demonstrate the suggested process.

Why digital medicine depends on interoperability
M Lehne et al, NPJ Digital Medicine, August 20, 2019 (Posted: Aug-21-2019 8AM)

Interoperability is key to the success of digital medicine. This review that explores 4 crucial areas: artificial intelligence, medical communication, research and international cooperation.

Blockchains for Secure Digitized Medicine.
Shuaib Khaled et al. Journal of personalized medicine 2019 Jul (3) (Posted: Jul-29-2019 8AM)

Blockchain as an emerging technology has been gaining in popularity. With the offer of a decentralized, distributed environment without the need for a third trusted party (TTP), blockchains are being used in many fields. One possible field that could benefit from blockchains that researchers have been focusing on is digital healthcare.

Wellness culture's obsession with Fitbits, genetics and data isn't necessarily making us healthier
T Caulfied, NBC News, July 22, 2019 (Posted: Jul-23-2019 8AM)

Is more information ? about your exercise, the quality of your sleep, or the nature of your genetic predispositions ? going to make you healthier and happier? Not necessarily. A lot of the new data suggests our technology isn?t transforming us into a generation of street-dancing, step-maximizing, sleep-mastering triathletes.

Skin sensors are the future of health care
S Xu et al, Nature News, July 17, 2019 (Posted: Jul-18-2019 8AM)

The advantages of UK Biobank's open access strategy for health research
Conroy, M. et. al. JIM Journal of Internal Medicine, Jul 8, 2019 (Posted: Jul-15-2019 9AM)

The UK Biobank is an unparallel resource for public health research in genomics and precision health. It is also an exemplar for the development of open access approaches for other studies and Biobank.

A decade of digital medicine innovation
E Topol, Sci Trans Medicine, June 26, 2019 (Posted: Jun-27-2019 8AM)

The field of digital medicine has matured over the past decade, but its integration into routine practice will require evaluation of clinical utility including the use of randomized controlled clinical trials.

‘Scientific wellness’ searches for a business model
M Senior, Nature Biotechnology, June 12, 2019 (Posted: Jun-16-2019 8AM)

Patients’ views of wearable devices and AI in healthcare: findings from the ComPaRe e-cohort
VT Tran et al, NPJ Digital Medicine, June 14, 2019 (Posted: Jun-14-2019 1PM)

A systematic review of feasibility studies promoting the use of mobile technologies in clinical research
JP Bakker et al, NPJ Digital Medicine, June 7, 2019 (Posted: Jun-07-2019 1PM)

Digital Medicine: Digital Health, Plus Evidence, Plus Humility
D Shaywitz, Forbes, May 18, 2019 (Posted: May-21-2019 11AM)

Connected Health Technology for Cardiovascular Disease Prevention and Management.
Wongvibulsin Shannon et al. Current treatment options in cardiovascular medicine 2019 May (6) 29 (Posted: May-20-2019 8AM)

A Contrarian View of Digital Health
J Mandrola, Quillette, May 17, 2019 (Posted: May-20-2019 8AM)

A longitudinal big data approach for precision health
S Miryam et al, Nature Medicine, May 8, 2019 (Posted: May-08-2019 1PM)

Healthcare technology: Seven trends that may shape the future
Digital Health Age, March 26, 2019 (Posted: Mar-28-2019 8AM)

Why Does the Shift from "Personalized Medicine" to "Precision Health" and "Wellness Genomics" Matter?
Juengst Eric T et al. AMA journal of ethics 2018 Sep 20(9) E881-890 (Posted: Sep-26-2018 10AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.