Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
Genomes in clinical care
O Riess et al, NPJ Genomic Medicine, March 14, 2024
(Posted: Mar 18, 2024 9AM)
Challenges and best practices in omics benchmarking.
Thomas G Brooks et al. Nat Rev Genet 2024 1
(Posted: Jan 15, 2024 10AM)
What Will 2024 Mean for NGS and Genomics?
J Lemieux, GenNew, January 12, 2024
(Posted: Jan 14, 2024 10AM)
Computational immunogenomic approaches to predict response to cancer immunotherapies.
Venkateswar Addala et al. Nat Rev Clin Oncol 2023 11
(Posted: Nov 03, 2023 8AM)
Multi-Omics for Health and Disease (Multi-Omics)
NIH, September 2023
(Posted: Sep 16, 2023 2PM)
From Mendel to multi-omics: shifting paradigms
TB Mersha, EJHG, July 20, 2023
(Posted: Jul 20, 2023 7AM)
Integrated multi-omics for rapid rare disease diagnosis on a national scale.
Sebastian Lunke et al. Nat Med 2023 6
(Posted: Jun 09, 2023 8AM)
Precision Medicine in Oral Health and Diseases: A Systematic Review
G Malcangi et al, J Per Med, April 25, 2023
(Posted: Apr 25, 2023 7AM)
Predicting response to enzalutamide and abiraterone in metastatic prostate cancer using whole-omics machine learning.
Anouk C de Jong et al. Nature communications 2023 4 (1) 1968
(Posted: Apr 10, 2023 7AM)
Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention.
Kengo Watanabe et al. Nature medicine 2023 3
(Posted: Mar 22, 2023 7AM)
Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective.
Mireia Valles-Colomer et al. Nature medicine 2023 3
(Posted: Mar 18, 2023 7PM)
Secrets of microbiota drug metabolism.
Andrew J Macpherson et al. Nature medicine 2023 2
(Posted: Feb 24, 2023 7AM)
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.
Raaj S Mehta et al. Nature medicine 2023 2
(Posted: Feb 24, 2023 7AM)
Advancing CAR T cell therapy through the use of multidimensional omics data.
Jingwen Yang et al. Nature reviews. Clinical oncology 2023 1
(Posted: Feb 02, 2023 6AM)
Development and Trends in Artificial Intelligence in Critical Care Medicine: A Bibliometric Analysis of Related Research over the Period of 2010–2021
X Cui et al, J Per Med, December 27, 2022
(Posted: Dec 28, 2022 11AM)
Multi-objective optimization identifies a specific and interpretable COVID-19 host response signature.
Cappuccio Antonio et al. Cell systems 2022 12 (12) 989-1001.e8
(Posted: Dec 26, 2022 0PM)
The Use of Cell-free DNA in Clinical Practice: Work in Progress
M Clyne et al, CDC Blog Post, December 14, 2022
(Posted: Dec 14, 2022 5PM)
Multi-omics signatures of the human early life exposome
L Maitre et al, Nature Comm, November 21, 2022
(Posted: Nov 21, 2022 8AM)
Medicine and health of 21st Century: Not just a high biotech-driven solution.
Assidi Mourad et al. NPJ genomic medicine 2022 11 (1) 67
(Posted: Nov 16, 2022 8AM)
Discovering a trans-omics biomarker signature that predisposes high risk diabetic patients to diabetic kidney disease
I W Wu et al, NPJ Digital Medicine, November 2, 2022
(Posted: Nov 03, 2022 8AM)
Nanopore-based technologies beyond DNA sequencing
YL Ying et al, Nature Biotechnology, September 26, 2022
(Posted: Sep 27, 2022 7AM)
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease
N Mishra et al, Genome Medicine, September 24, 2022
(Posted: Sep 26, 2022 6AM)
Genetic discrimination still casts a large shadow in 2022
Y Joly et al, EJHG, September 26, 2022
(Posted: Sep 26, 2022 6AM)
Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.
Yin Xianyong et al. American journal of human genetics 2022 9
(Posted: Sep 08, 2022 10AM)
Big data in basic and translational cancer research.
Jiang Peng et al. Nature reviews. Cancer 2022 9
(Posted: Sep 07, 2022 8AM)
Social and scientific motivations to move beyond groups in allele frequencies: The TOPMed experience.
Nelson Sarah C et al. American journal of human genetics 2022 9 (9) 1582-1590
(Posted: Sep 04, 2022 8AM)
Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction
NA Fraunhoffer et al, NPJ Precision Oncology, August 17, 2022
(Posted: Aug 18, 2022 1PM)
Precision Medicine in Diabetes, Current Research and Future Perspectives
R Franceschi, J Per Medicine, July 28, 2022
(Posted: Jul 28, 2022 6AM)
Multi-omics provide evidence for an anti-inflammatory immune signature and metabolic alterations in patients with Long COVID Syndrome; an exploratory study
JJ Kovarik et al, MEDRXIV, July 12, 2022
(Posted: Jul 13, 2022 7AM)
Measuring biological age using omics data.
Rutledge Jarod et al. Nature reviews. Genetics 2022 6
(Posted: Jun 20, 2022 10AM)
An integrated multiomic approach as an excellent tool for the diagnosis of metabolic diseases: our first 3720 patients
LS Almeida et al, EJHG, May 25, 2022
(Posted: May 25, 2022 7AM)
An ethical plan for including forcibly displaced persons in omics and digital technology research
F Taki et al, Nature Medicine,May 5, 2022
(Posted: May 09, 2022 7AM)
Multi-omics identify LRRC15 as a COVID-19 severity predictor and persistent pro-thrombotic signals in convalescence
JS Gisby et al, MEDRXIV, May 1, 2022
(Posted: May 02, 2022 9AM)
Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19
SM Recktenwald et al, MEDRXIV, April 4, 2022
(Posted: Apr 05, 2022 7AM)
Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19
SM. Recktenwald et al, MEDRXIV, March 31, 2022
(Posted: Apr 01, 2022 7AM)
Genetic modifiers of Huntington disease differentially influence motor and cognitive domains
JM Lee et al, AJHG, March 23, 2022
(Posted: Mar 24, 2022 9AM)
Multi-omics in COVID-19: Seeing the unseen but overlooked in the clinic
T Lu et al, Cell Reports Medicine, March 15, 2022
(Posted: Mar 18, 2022 0PM)
Before the heart attack
EE Blaak et al, Nature Medicine, February 17, 2022
(Posted: Feb 19, 2022 7AM)
Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
K Sacco et al, Nature Medicine, February 17, 2022
(Posted: Feb 17, 2022 8AM)
Multi-omic machine learning predictor of breast cancer therapy response
SJ Sammut et al, Nature, December 7, 2021
(Posted: Dec 08, 2021 8AM)
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data
AA Connor et al, Nat Rev Cancer, November 17, 2021
(Posted: Nov 17, 2021 10AM)
Deep learning in cancer diagnosis, prognosis and treatment selection.
Tran Khoa A et al. Genome medicine 2021 9 (1) 152
(Posted: Sep 29, 2021 6AM)
Multi-omics approach identifies novel age-, time- and treatment-related immunopathological signatures in MIS-C and pediatric COVID-19
K Sacco et al, MEDRXIV, September 27, 2021
(Posted: Sep 28, 2021 6AM)
The genetics of obesity: from discovery to biology
RJF Loos et al, Nat Rev Genetics, September 23, 2021
(Posted: Sep 24, 2021 6AM)
Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases
B Zurek et al, EJHG, June 1, 2021
(Posted: Jun 01, 2021 10AM)
Solving unsolved rare neurological diseases—a Solve-RD viewpoint
R Schule et al, EJHG, May 10, 2021
(Posted: May 11, 2021 8AM)
Single-cell multi-omics analysis of the immune response in COVID-19
E Stephenson et al, Nature Medicine, April 20, 2021
(Posted: Apr 21, 2021 7AM)
Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health
M Shuai et al, Ebiomedicine, March 2021,
(Posted: Mar 21, 2021 7AM)
The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres
E Stephenson et al, MEDRXIV, January 15, 2021
(Posted: Jan 16, 2021 3PM)
A novel multi-omics-based identification of symptoms, comorbid conditions, and possible long-term complications in COVID-19
D Barh et al, MEDRXIV, December 9, 2020
(Posted: Dec 09, 2020 10AM)
Functional genomics
PHG Foundation, November 2020
(Posted: Nov 27, 2020 9AM)
One in Eight Cancer Patients Harbors Inherited Mutation that Increases Risk of Disease Development
Clinical Omics, November 3, 2020
(Posted: Nov 04, 2020 8AM)
Translating the microbiome in health and disease
Genome Medicine special issue, October 2020
(Posted: Oct 23, 2020 7AM)
Genetic markers and phosphoprotein forms of beta-catenin pβ-Cat552 and pβ-Cat675 are prognostic biomarkers of cervical cancer
SM Scholl et al, EBiomedicine, October 21, 2020
(Posted: Oct 22, 2020 9AM)
Exploring the coronavirus pandemic with the WashU Virus Genome Browser
Nature Genetics, September 9, 2020
(Posted: Sep 11, 2020 8AM)
Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics
AS Nam et al, Nat Rev Genetics, August 17, 2020
(Posted: Aug 17, 2020 8AM)
The Trans-omics Landscape of COVID-19
P Wu et al, MEDRXIV, July 22, 2020
(Posted: Jul 23, 2020 9AM)
The use of machine learning in rare diseases: a scoping review
J Schaefer et al, Orphanet J Rare Dis, June 9, 2020
(Posted: Jun 11, 2020 8AM)
Multi-omic strategies for transcriptome-wide prediction and association studies
BIORXIV, April 18, 2020
(Posted: Apr 18, 2020 8AM)
Machine Learning, COVID-19 (2019-nCoV), and multi-OMICS.
Tárnok Attila et al. Cytometry. Part A : the journal of the International Society for Analytical Cytology 2020 97(3) 215-216
(Posted: Mar 25, 2020 9AM)
Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections
AN Cowell et al, Genome Medicine, October 22, 2019
(Posted: Oct 23, 2019 8AM)
NIH’s All of Us Partners with HudsonAlpha on Long-Read Sequencing Project
Clinical Omics, October 18, 2019
(Posted: Oct 21, 2019 10AM)
Heart Failure in the Era of Precision Medicine: A Scientific Statement From the American Heart Association.
Cresci Sharon et al. Circulation. Genomic and precision medicine 2019 Sep HCG0000000000000058
(Posted: Sep 13, 2019 10AM)
The Evolving Field Of Genetic Epidemiology: From Familial Aggregation To Genomic Sequencing.
Duggal Priya et al. American journal of epidemiology 2019 Sep
(Posted: Sep 12, 2019 7AM)
Machine Learning Classifiers for Endometriosis Using Transcriptomics and Methylomics Data
S Akter et al, Front Genetics, September 2019
(Posted: Sep 06, 2019 7AM)
Leveraging Omics Profiling to Advance the Treatment of Pediatric Obesity.
Koch Sarah et al. JAMA pediatrics 2019 Aug
(Posted: Aug 27, 2019 7AM)
UnitedHealthcare To Cover Genetic Testing for Precision Medicine in Depression, Anxiety
Clinical Omics, August 2, 2019
(Posted: Aug 05, 2019 8AM)
Leveraging -omics for asthma endotyping
SR Tyler et al, JACI, July 2019
(Posted: Jul 02, 2019 0PM)
Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism
J Scheiman et al, Nature Medicine, June 24, 2019
(Posted: Jun 24, 2019 1PM)
"Omics" Education in Dietetic Curricula: A Comparison between Two Institutions in the USA and Mexico.
VanBuren Christine et al. Lifestyle genomics 2019 May 1-11
(Posted: May 15, 2019 8AM)
What did we learn from multiple omics studies in asthma?
Ivanova Olga et al. Allergy 2019 Apr
(Posted: May 06, 2019 2PM)
Gene Therapy Leaders Push for Germline Editing Moratorium
Clinical Omics, April 24, 2019
(Posted: Apr 29, 2019 11AM)
Systematic benchmarking of omics computational tools.
Mangul Serghei et al. Nature communications 2019 Mar (1) 1393
(Posted: Apr 01, 2019 9AM)
Challenges in the Integration of Omics and Non-Omics Data.
López de Maturana Evangelina et al. Genes 2019 Mar 10(3)
(Posted: Mar 27, 2019 8AM)
Dynamic molecular changes during the first week of human life follow a robust developmental trajectory
AH Lee et al, Nature Communications, March 2019
(Posted: Mar 20, 2019 8AM)
Rise of Deep Learning for Genomic, Proteomic, and Metabolomic Data Integration in Precision Medicine.
Grapov Dmitry et al. Omics : a journal of integrative biology 2018 Aug
(Posted: Aug 22, 2018 11AM)
Exposure to tobacco smoke and low birth weight: from epidemiology to metabolomics.
Dessì Angelica et al. Expert review of proteomics 2018 Jul
(Posted: Jul 30, 2018 8AM)
Integrating -Omics Approaches into Human Population-Based Studies of Prenatal and Early-Life Exposures.
Everson Todd M et al. Current environmental health reports 2018 Jul
(Posted: Jul 30, 2018 8AM)
Next-generation sequencing and prenatal 'omics: advanced diagnostics and new insights into human development.
Vora Neeta L et al. Genetics in medicine : official journal of the American College of Medical Genetics 2018 Jul
(Posted: Jul 23, 2018 11AM)
Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission.
Tasaki Shinya et al. Nature communications 2018 Jul (1) 2755
(Posted: Jul 19, 2018 9AM)
Precision Medicine in Targeted Therapies for Severe Asthma: Is There Any Place for "Omics" Technology?
Galeone Carla et al. BioMed research international 2018 20184617565
(Posted: Jul 18, 2018 9AM)
Precision Medicine Goes Global: How to Get It Right? Four Ways to Mobilize Scientific Knowledge.
Özdemir Vural et al. Omics : a journal of integrative biology 2018 Jul
(Posted: Jul 18, 2018 9AM)
Translational -omics: Future potential and current challenges in precision medicine.
Wafi Arsalan et al. Methods (San Diego, Calif.) 2018 May
(Posted: May 29, 2018 2PM)
Genomics and Epigenomics of Congenital Heart Defects: Expert Review and Lessons Learned in Africa.
Thomford Nicholas Ekow et al. Omics : a journal of integrative biology 2018 May 22(5) 301-321
(Posted: May 17, 2018 1PM)
Omics of Blood Pressure and Hypertension
DK Arnett et al, Circulation Res, May 2018
(Posted: May 12, 2018 10AM)
Building Global Genomics Initiatives and Enabling Data Sharing: Insights from Multiple Case Studies.
Fusi Federica et al. Omics : a journal of integrative biology 2018 Mar
(Posted: Apr 04, 2018 11AM)
Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research.
Lim Weng Khong et al. PLoS biology 2018 Feb (2) e2004285
(Posted: Mar 03, 2018 9AM)
Food allergy and omics.
Dhondalay Gopal Krishna et al. The Journal of allergy and clinical immunology 2018 Jan (1) 20-29
(Posted: Feb 27, 2018 9AM)
The use of omics profiling to improve outcomes of bone regeneration and osseointegration. How far are we from personalized medicine in dentistry?
Calciolari E et al. Journal of proteomics 2018 Feb
(Posted: Feb 27, 2018 9AM)
Academic medical centers as innovation ecosystems to address population -omics challenges in precision medicine.
Silva Patrick J et al. Journal of translational medicine 2018 Feb (1) 28
(Posted: Feb 27, 2018 9AM)
Integrative omics for health and disease.
Karczewski Konrad J et al. Nature reviews. Genetics 2018 Feb
(Posted: Feb 27, 2018 9AM)
Personal Genome Project Canada Makes Case for WGS in Healthcare
Clinical Omics, Feb 5, 2018
(Posted: Feb 06, 2018 10AM)
From pharmacogenomics to pharmaco-omics individualized care for every patient
S Rosen, Mayo Clinic, Individualized Medicine Blog, 2017
(Posted: Feb 02, 2018 11AM)
Precision Health: Use of Omics to Optimize Self-Management of Chronic Pain in Aging.
Dorsey Susan G et al. Research in gerontological nursing 2018 Jan (1) 7-13
(Posted: Feb 02, 2018 10AM)
Integrative Personal Omics Profiles during Periods of Weight Gain and Loss.
Piening Brian D et al. Cell systems 2018 Jan
(Posted: Jan 26, 2018 9AM)
Application of "Omics" and Systems Biology to Sarcoidosis Research.
Crouser Elliott D et al. Annals of the American Thoracic Society 2017 Dec (Supplement_6) S445-S451
(Posted: Jan 03, 2018 11AM)
LinkedOmics: analyzing multi-omics data within and across 32 cancer types.
Vasaikar Suhas V et al. Nucleic acids research 2017 Nov
(Posted: Nov 25, 2017 11AM)
Improving -Omics-Based Research and Precision Health in Minority Populations: Recommendations for Nurse Scientists.
Taylor Jacquelyn Y et al. Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing 2017 Nov
(Posted: Nov 21, 2017 9AM)
Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities.
Owolabi Mayowa et al. Journal of the neurological sciences 2017 Nov 18-28
(Posted: Nov 15, 2017 9AM)
Using omics approaches to understand pulmonary diseases.
Kan Mengyuan et al. Respiratory research 2017 Aug (1) 149
(Posted: Oct 25, 2017 3PM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
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