
Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
The Multi-Omic Approach to Newborn Screening: Opportunities and Challenges
(Posted: Jun 26, 2024 7AM)
Challenges and best practices in omics benchmarking.
Thomas G Brooks et al. Nat Rev Genet 2024 1
(Posted: Jan 15, 2024 10AM)
A framework for evaluating long-term impact of newborn screening
S Kalkman et al, EJHG, October 3, 2023
(Posted: Oct 03, 2023 9AM)
Power of Public Investment in Curated Big Health Data.
Paula Anne Newman-Casey et al. JAMA Ophthalmol 2023 9
(Posted: Sep 08, 2023 9AM)
From Mendel to multi-omics: shifting paradigms
TB Mersha, EJHG, July 20, 2023
(Posted: Jul 20, 2023 7AM)
The artificial sweetener erythritol and cardiovascular event risk.
Marco Witkowski et al. Nature medicine 2023 2
(Posted: Mar 01, 2023 11AM)
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.
Raaj S Mehta et al. Nature medicine 2023 2
(Posted: Feb 24, 2023 7AM)
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.
Chen Yiheng et al. Nature genetics 2023 1 (1) 44-53
(Posted: Jan 15, 2023 3PM)
Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes.
Tomofuji Yoshihiko et al. Communications medicine 2023 1 (1) 5
(Posted: Jan 11, 2023 6AM)
Dietary metabolic signatures and cardiometabolic risk.
Shah Ravi V et al. European heart journal 2022 11
(Posted: Dec 17, 2022 9AM)
Rare and common genetic determinants of metabolic individuality and their effects on human health
P Surendran et al, Nature Medicine, November 10, 2022
(Posted: Nov 11, 2022 7AM)
Discovering a trans-omics biomarker signature that predisposes high risk diabetic patients to diabetic kidney disease
I W Wu et al, NPJ Digital Medicine, November 2, 2022
(Posted: Nov 03, 2022 8AM)
Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome.
Chen Lianmin et al. Nature medicine 2022 10
(Posted: Oct 11, 2022 2PM)
Metabolomic profiles predict individual multidisease outcomes
T Buergel et al, Nature Medicine, September 22, 2022
(Posted: Sep 23, 2022 7AM)
Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.
Yin Xianyong et al. American journal of human genetics 2022 9
(Posted: Sep 08, 2022 10AM)
Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction
NA Fraunhoffer et al, NPJ Precision Oncology, August 17, 2022
(Posted: Aug 18, 2022 1PM)
The growing need for controlled data access models in clinical proteomics and metabolomics
TM Keane et al, Nature Communications, October 2021
(Posted: Oct 04, 2021 9AM)
The blood metabolome of incident kidney cancer: A case–control study nested within the MetKid consortium
F Guida et al, PLOS Medicine, September 21, 2021
(Posted: Sep 21, 2021 9AM)
Comparison of Untargeted Metabolomic Profiling vs Traditional Metabolic Screening to Identify Inborn Errors of Metabolism
N Liu et al, JAMA Network Open, July 12, 2021
(Posted: Jul 13, 2021 8AM)
Untargeted saliva metabolomics reveals COVID-19 severity: Saliva Metabolomics for SARS-COV-2 Prognosis
M Bailey et al, MEDRXIV, July 7, 2021
(Posted: Jul 08, 2021 8AM)
COMETS Analytics: An online tool for analyzing and meta-analyzing metabolomics data in large research consortia
M Temprosa et al, AM J Epidemiology, April 2021
(Posted: May 02, 2021 0PM)
Development and Validation of a Serum Metabolomic Signature for Endometrial Cancer Screening in Postmenopausal Women
J Troisi et al, JAMA Network Open, September 28, 2020
(Posted: Sep 29, 2020 8AM)
Integrated analysis of metabolomic profiling and exome data supplements sequence variant interpretation, classification, and diagnosis
JT ALaimo et al, Eur J Human Genetics, May 22, 2020
(Posted: May 22, 2020 0PM)
Metabolites and you- People leave molecular wakes that may give away their secrets
The Economist, February 2020
(Posted: Feb 15, 2020 9AM)
Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging.
Hou Ying-Chen Claire et al. Proceedings of the National Academy of Sciences of the United States of America 2020 Jan
(Posted: Jan 29, 2020 8AM)
Real-time health monitoring through urine metabolomics
IJ Miller et al, NPJ Digital Medicine, November 11, 2019
(Posted: Nov 12, 2019 8AM)
Quantitative methods for metabolomic analyses evaluated in the Children’s Health Exposure Analysis Resource (CHEAR)
CHEAR team, J Exp Sci and Env Epi, September 2019
(Posted: Oct 01, 2019 8AM)
Enteric dysbiosis is associated with sepsis in patients
Z Liu et al, FASEB journal, August 28, 2019
(Posted: Aug 30, 2019 7AM)
Leveraging -omics for asthma endotyping
SR Tyler et al, JACI, July 2019
(Posted: Jul 02, 2019 0PM)
The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies
B Yu, Am J Epidemiology, February 2019
(Posted: Feb 25, 2019 9AM)
Metabolome-Wide Mendelian Randomization Analysis of Emotional and Behavioral Responses to Traumatic Stress
CM Carvalho et al, February 10, 2019
(Posted: Feb 11, 2019 10AM)
Genomics, microbiomics, proteomics, and metabolomics in bronchopulmonary dysplasia.
Lal Charitharth Vivek et al. Seminars in perinatology 2018 Nov (7) 425-431
(Posted: Jan 23, 2019 10AM)
Metabolomic Biomarkers in Gynecology: a Treasure Path or a False Path?
Igor Govorov et al. Current medicinal chemistry 2019 Jan
(Posted: Jan 13, 2019 11AM)
Exposure to tobacco smoke and low birth weight: from epidemiology to metabolomics.
Dessì Angelica et al. Expert review of proteomics 2018 Jul
(Posted: Jul 30, 2018 8AM)
Integration of genomics and metabolomics for prioritization of rare disease variants: a 2018 literature review.
Graham Emma et al. Journal of inherited metabolic disease 2018 May
(Posted: May 09, 2018 8AM)
Profound perturbation of the human metabolome by obesity
ET Cerulli et al, BioRXIV, Apr 2018
(Posted: Apr 10, 2018 8AM)
Metabolomics in Sepsis and Its Impact on Public Health.
Evangelatos Nikolaos et al. Public health genomics 2018 Jan
(Posted: Feb 05, 2018 1PM)
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.
Varma Vijay R et al. PLoS medicine 2018 Jan (1) e1002482
(Posted: Jan 31, 2018 2PM)
Beyond genomics: understanding exposotypes through metabolomics.
Rattray Nicholas J W et al. Human genomics 2018 Jan 12(1) 4
(Posted: Jan 31, 2018 9AM)
The role of metabolomics in tuberculosis treatment research.
Luies Laneke et al. Biomarkers in medicine 2017 Oct
(Posted: Oct 22, 2017 9AM)
Use of Metabolomics in Improving Assessment of Dietary Intake.
Guasch-Ferré Marta et al. Clinical chemistry 2017 Oct
(Posted: Oct 22, 2017 9AM)
Objective Metabolomics Research
M Ala-Korpela, Clinical Chemistry, Oct 2017
(Posted: Oct 22, 2017 9AM)
Metabolomics as a Driver in Advancing Precision Medicine in Sepsis.
Eckerle Michelle et al. Pharmacotherapy 2017 Sep (9) 1023-1032
(Posted: Oct 05, 2017 3PM)
Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma.
Siskos Alexandros P et al. Analytical chemistry 2017 01 (1) 656-665
(Posted: Aug 23, 2017 5PM)
New frontiers in metabolomics: from measurement to insight.
Riekeberg Eli et al. F1000Research 2017 1148
(Posted: Aug 16, 2017 9AM)
Working Up a Good Sweat - The Challenges of Standardising Sweat Collection for Metabolomics Analysis.
Hussain Joy N et al. The Clinical biochemist. Reviews 2017 Feb (1) 13-34
(Posted: Aug 16, 2017 9AM)
Metabolomics Interest Group Events and Webinars
NIH Metabolomics Interest Group
(Posted: Aug 16, 2017 9AM)
Key elements of metabolomics in the study of biomarkers of diabetes.
Adamski Jerzy et al. Diabetologia 2016 Oct
(Posted: Oct 08, 2016 9AM)
Metabolomics in amyotrophic lateral sclerosis: how far can it take us?
Blasco H et al. European journal of neurology 2016 Jan
(Posted: Feb 24, 2016 1PM)
Metabolomics and Personalized Medicine.
Koen Nadia et al. Advances in protein chemistry and structural biology 2016 53-78
(Posted: Feb 24, 2016 1PM)
Radiation Metabolomics: Current Status and Future Directions.
Menon Smrithi S et al. Frontiers in oncology 2016 20
(Posted: Feb 24, 2016 1PM)
Metabolomics in diabetes, a review.
Pallares-Méndez Rigoberto et al. Annals of medicine 2016 Feb (1-2) 89-102
(Posted: Feb 24, 2016 1PM)
Metabolomics in diabetic complications.
Filla Laura A et al. Molecular bioSystems 2016 Feb
(Posted: Feb 24, 2016 1PM)
Integration of omics: more than the sum of its parts.
Buescher Joerg Martin et al. Cancer & metabolism 2016 4
(Posted: Feb 24, 2016 1PM)
Targeted metabolomics in the expanded newborn screening for inborn errors of metabolism.
Scolamiero Emanuela et al. Molecular bioSystems 2015 Jun (6) 1525-35
(Posted: Feb 24, 2016 1PM)
Data standards can boost metabolomics research, and if there is a will, there is a way.
Rocca-Serra Philippe et al. Metabolomics : Official journal of the Metabolomic Society (1) 14
(Posted: Dec 16, 2015 1PM)
Prediction of Gestational Diabetes through NMR Metabolomics of Maternal Blood.
Pinto Joana et al. Journal of proteome research 2015 Jun (6) 2696-706
(Posted: Nov 12, 2015 2PM)
Metabolomics of Neurodegenerative Diseases.
Botas Alejandro et al. International review of neurobiology 2015 53-80
(Posted: Oct 13, 2015 1PM)
Design and Analysis of Metabolomics Studies in Epidemiological Research:
A Primer on -Omic Technologies
A Tzoulaki et al, AM J Epidemiology 2015
(Posted: Aug 19, 2015 11AM)
Metabolomics in Population-Based Research
NCI Information
(Posted: Aug 19, 2015 8AM)
Innovation: Metabolomics: the apogee of the omics trilogy
GJ Patti, Nature April, 2012
(Posted: Aug 19, 2015 8AM)
Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects
Boca Raton (FL):CRC Press 2015
(Posted: Aug 18, 2015 0PM)
Sequencing and beyond: integrating molecular 'omics' for microbial community profiling.
Franzosa Eric A et al. Nat. Rev. Microbiol. 2015 Jun (6) 360-72
(Posted: Aug 17, 2015 7PM)
Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes.
Abu Bakar Mohamad Hafizi et al. Mol Biosyst 2015 Jul (7) 1742-74
(Posted: Aug 17, 2015 7PM)
Systems biology of host-microbe metabolomics.
Heinken Almut et al. Wiley Interdiscip Rev Syst Biol Med 2015 Jul-Aug (4) 195-219
(Posted: Aug 17, 2015 7PM)
Metabolomics in cardiovascular diseases.
Kordalewska Marta et al. J Pharm Biomed Anal 2015 Sep 10. 121-36
(Posted: Aug 17, 2015 7PM)
Metabolic Signatures of Human Breast Cancer.
Mishra Prachi et al. Mol Cell Oncol 2015 Jul-Sep (3)
(Posted: Aug 17, 2015 7PM)
Metabolomics and renal disease.
Rhee Eugene P et al. Curr. Opin. Nephrol. Hypertens. 2015 Jul (4) 371-9
(Posted: Aug 17, 2015 6PM)
A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes.
Park Seokjae et al. Mol. Cells 2015 Jul 31. (7) 587-96
(Posted: Aug 17, 2015 6PM)
Metabolomics for Biomarker Discovery: Moving to the Clinic.
Zhang Aihua et al. Biomed Res Int 2015 354671
(Posted: Aug 17, 2015 6PM)
Serum metabolomics in animal models and human disease.
James Emma L et al. Curr Opin Clin Nutr Metab Care 2015 Sep (5) 478-83
(Posted: Aug 17, 2015 6PM)
Two elephants in the room: new hybrid nuclear magnetic resonance and mass spectrometry approaches for metabolomics.
Bingol Kerem et al. Curr Opin Clin Nutr Metab Care 2015 Sep (5) 471-7
(Posted: Aug 17, 2015 6PM)
Genetics of human metabolism: an update.
Kastenmüller Gabi et al. Hum. Mol. Genet. 2015 Jul 9.
(Posted: Aug 17, 2015 6PM)
Metabolomic profiling for the identification of novel diagnostic markers in prostate cancer.
Lucarelli Giuseppe et al. Expert Rev. Mol. Diagn. 2015 Jul 15. 1-14
(Posted: Aug 17, 2015 6PM)
High-Resolution Metabolomics: Review of the Field and Implications for Nursing Science and the Study of Preterm Birth.
Li Shuzhao et al. Biol Res Nurs 2015 Jul 16.
(Posted: Aug 17, 2015 6PM)
Metabolomics in the natural products field - a gateway to novel antibiotics.
Wu Changsheng et al. Drug Discov Today Technol 2015 Jun 11-7
(Posted: Aug 17, 2015 6PM)
The emergence of metabolomics as a key discipline in the drug discovery process.
Fillet Marianne et al. Drug Discov Today Technol 2015 Jun 19-24
(Posted: Aug 17, 2015 6PM)
Metabolomics in the pharmaceutical industry.
Reily Michael D et al. Drug Discov Today Technol 2015 Jun 25-31
(Posted: Aug 17, 2015 6PM)
Exploration of individuality in drug metabolism by high-throughput metabolomics: The fast line for personalized medicine.
Trifonova Oxana et al. Drug Discov. Today 2015 Jul 26.
(Posted: Aug 17, 2015 6PM)
Metabolic biomarkers for chronic kidney disease.
Breit Marc et al. Arch. Biochem. Biophys. 2015 Jul 31.
(Posted: Aug 17, 2015 6PM)
Metabolomic profiling of hormone-dependent cancers: a bird's eye view.
Lloyd Stacy M et al. Trends Endocrinol. Metab. 2015 Aug 1.
(Posted: Aug 17, 2015 6PM)
Metabolomics of cocaine: implications in toxicity.
Dinis-Oliveira Ricardo Jorge et al. Toxicol. Mech. Methods 2015 Aug 7. 1-7
(Posted: Aug 17, 2015 6PM)
Metabolomic biomarkers in diabetic kidney diseases-A systematic review.
Zhang Yumin et al. J. Diabetes Complicat. 2015 Jul 9.
(Posted: Aug 17, 2015 6PM)
Potential of metabolomics to reveal Burkholderia cepacia complex pathogenesis and antibiotic resistance.
Shommu Nusrat S et al. Front Microbiol 2015 668
(Posted: Aug 11, 2015 3PM)
Distinguishing between the metabolome and xenobiotic exposome in environmental field samples analysed by direct-infusion mass spectrometry based metabolomics and lipidomics.
Southam Andrew D et al. Metabolomics 2014 (6) 1050-1058
(Posted: May 20, 2015 2PM)
Metabolomics and diabetes: analytical and computational approaches.
Sas Kelli M et al. Diabetes 2015 Mar (3) 718-32
(Posted: Apr 10, 2015 2PM)
The Newest "Omics"-Metagenomics and Metabolomics-Enter the Battle against the Neglected Tropical Diseases.
Preidis Geoffrey A et al. PLoS Negl Trop Dis 2015 Feb (2) e0003382
(Posted: Mar 06, 2015 2PM)
Application of metabolomics in drug resistant breast cancer research.
Shajahan-Haq Ayesha N et al. Metabolites 2015 (1) 100-18
(Posted: Mar 04, 2015 8PM)
Comprehensive Metabolomics Identifies the Alarmin Uric Acid as a Critical Signal for the Induction of Peanut Allergy.
Kong Joshua et al. Allergy 2015 Feb 3.
(Posted: Feb 26, 2015 7PM)
Metabolomics in Population-Based Research
(Posted: Jan 11, 2014 11AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
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