Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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The role of aldehyde dehydrogenase 2 in cardiovascular disease.
Jian Zhang et al. Nature reviews. Cardiology 2023 2 (Posted: Feb-26-2023 8AM)
Implementing Cardiogenomics in Clinical Practice
Northwestern University and the Jackson Labs, 2023 (Posted: Feb-08-2023 9AM)
Finding causal genes underlying risk for coronary artery disease
PL Auer, Nature Genetics, December 6, 2022 (Posted: Dec-06-2022 0PM)
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
KG Aragam et al, Nature Genetics, December 6, 2022 (Posted: Dec-06-2022 0PM)
Genetic Basis of Childhood Cardiomyopathy
RD Bagnall et al, Circ Genomics Prec Medicine, October 12, 2022 (Posted: Oct-12-2022 8AM)
Burden of Rare Genetic Variants in Spontaneous Coronary Artery Dissection With High-risk Features
Y Wang et al, JAMA Cardiology, September 15, 2022 (Posted: Sep-16-2022 8AM)
New Cardiovascular Risk Assessment Techniques for Primary Prevention: JACC Review Topic of the Week.
Verma Kunal P et al. Journal of the American College of Cardiology 2022 7 (4) 373-387 (Posted: Jul-25-2022 7AM)
Everyone deserves a diagnosis
The Family Heart Foundation, July 18, 2022 (Posted: Jul-20-2022 0PM)
CDC, June 29, 2022 (Posted: Jun-28-2022 4PM)
March 24 is Lipoprotein(a) Awareness Day
Family Heart Foundation, March 2022 (Posted: Mar-24-2022 0PM)
Cardiovascular Genetics: The Role of Genetics in Predicting Risk.
Chowns Jessica et al. The Medical clinics of North America 2022 106(2) 313-324 (Posted: Mar-05-2022 7AM)
Decision-making and experiences of preimplantation genetic diagnosis in inherited heart diseases: a qualitative study
L Yeates et al, EJHG, September 21, 2021 (Posted: Sep-21-2021 7AM)
Mapping gene and gene pathways associated with coronary artery disease: a CARDIoGRAM exome and multi-ancestry UK biobank analysis
P Hariharan et al, Scientific Reports, August 12, 2021 (Posted: Aug-12-2021 7AM)
Genetic testing in ambulatory cardiology clinics reveals high rate of findings with clinical management implications.
Murdock David R et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021 8 (Posted: Aug-09-2021 11AM)
Lipoprotein(a) and Cardiovascular Diseases.
Miksenas Hannah et al. JAMA 2021 7 (Posted: Jul-11-2021 2PM)
Genetic variants associated with inherited cardiovascular disorders among 13,131 asymptomatic older adults of European descent
P Lacaze et al, NPJ Genomic Medicine, June 16, 2021 (Posted: Jun-17-2021 9AM)
Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development.
Holmes Michael V et al. Nature reviews. Cardiology 2021 3 (Posted: Mar-16-2021 8AM)
Association of the V122I Transthyretin Amyloidosis Genetic Variant With Cardiac Structure and Function in Middle-aged Black Adults - Coronary Artery Risk Development in Young Adults (CARDIA) Study
A Sinha et al, JAMA Cardiology, December 23, 2020 (Posted: Dec-24-2020 7AM)
Disease-specific variant pathogenicity prediction significantly improves variant interpretation in inherited cardiac conditions.
Zhang Xiaolei et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 Oct (Posted: Oct-14-2020 8AM)
Identification of Undetected Monogenic Cardiovascular Disorders
JW AbdulRahim et al, JACC, August 7, 2020 (Posted: Aug-11-2020 7AM)
The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor
R Sidlow et al, JAMA Cardiology, May 2020 (Posted: Jun-02-2020 6AM)
Antisense oligonucleotides for atherosclerotic disease
A Bajaj et al Nature Medicine, April 6, 2020 (Posted: Apr-07-2020 10AM)
Does Heart Disease Run in Families? Here's Everything You Need to Know
TG Hope, Better Homes and Garden, January 2020 (Posted: Jan-28-2020 7AM)
It Is Now Time to Focus on Risk Before Age 40.
Gidding Samuel S et al. Journal of the American College of Cardiology 2019 Jul (3) 342-345 (Posted: Jul-20-2019 4PM)
Making The Case For Cascade Screening Amongst Families With Inherited Heart Diseases.
Ingles Jodie et al. Heart rhythm 2019 Jul (Posted: Jul-17-2019 8AM)
Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification.
Perrot Nicolas et al. JAMA cardiology 2019 May (Posted: May-31-2019 10AM)
Progress Toward Improved Cardiovascular Health in the United States.
Pahigiannis Katherine et al. Circulation 2019 Apr (16) 1957-1973 (Posted: May-31-2019 9AM)
Rare Gene Mutations May Prevent Heart Disease
Boston University, May 10, 2019 (Posted: May-14-2019 2PM)
Perceptions of genetic variant reclassification in patients with inherited cardiac disease
EJ Wong et al, EJHGH, March 21, 2019 (Posted: Mar-24-2019 9AM)
Acute Management of Ventricular Arrhythmia in Patients With Suspected Inherited Heart Rhythm Disorders
Z Laskman et al, JACC Electrophysiology, March 2019 (Posted: Mar-21-2019 3PM)
Myocardial Infarction in Young Women.
Vaccarino Viola et al. Circulation 2019 Feb (8) 1057-1059 (Posted: Feb-22-2019 9AM)
Lifelong genetically lowered sclerostin and risk of cardiovascular disease.
J Bovjin et al, BIORxIV, February 1, 2019 (Posted: Feb-02-2019 0PM)
What genetics could mean for your heart disease risk and what you can do about it
K Musunuru etal, Philadelphia Inquirer, February 1, 2019 (Posted: Feb-01-2019 11AM)
Genetic factor may identify patients at risk for spontaneous coronary artery dissection
DL Bhatt, Healio, January 2019 (Posted: Jan-20-2019 8AM)
Is Heart Disease Genetic?
L Meyers, Genome Medical, December 2018 (Posted: Dec-30-2018 9AM)
Simple blood and saliva tests that cost just £40 could help prevent heart attacks, scientists say
B Spencer, Daily Mail, October 8, 2018 (Posted: Oct-09-2018 11AM)
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention
M Inouye et al, JACC< October 2018 (Posted: Oct-09-2018 9AM)
5 reasons you could develop heart disease before 50
American Heart Association, September 14, 2018 (Posted: Sep-17-2018 7AM)
HLBS-PopOmics: an online knowledge base to accelerate dissemination and implementation of research advances in population genomics to reduce the burden of heart, lung, blood, and sleep disorders
Mensah GA, et al, Genetics in Medicine, September 10, 2018 (Posted: Sep-10-2018 10AM)
Preventing 1 Million Heart Attacks and Strokes- Middle-aged adults are being hard hit
CDC Vital Signs, September 6, 2018 (Posted: Sep-07-2018 8AM)
Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments: A Scientific Statement From the American Heart Association.
Volgman Annabelle Santos et al. Circulation 2018 May (Posted: May-29-2018 3PM)
Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association
K Musunuru et al, Circulation: Genomics and Precision Medicine, May 2018 (Posted: May-29-2018 0PM)
Fitness Helps Prevent Heart Disease, Even for Those with Genetic Risk Factors
N Westman, Genome Magazine, Apr 2018 (Posted: May-03-2018 9AM)
When heart disease runs in the family, exercise tied to lower risk
L Rapaport, Reuters, Apr 10, 2018 (Posted: Apr-11-2018 9AM)
Keeping Fit Helps Fight Heart Disease, Even Among Those at Genetic Risk
Frontline Genomics, Apr 10, 2018 (Posted: Apr-11-2018 9AM)
Associations of Fitness, Physical Activity, Strength, and Genetic Risk With Cardiovascular Disease: Longitudinal Analyses in the UK Biobank Study
E Tikanen et al, Circulation, Apr 10, 2018 (Posted: Apr-11-2018 9AM)
Managing dyslipidaemia for the primary prevention of cardiovascular disease
A Ryan et al, BMJ Practice Pointer, Mar 2018 (Posted: Apr-03-2018 8AM)
Cardiovascular disease: The rise of the genetic risk score.
Knowles Joshua W et al. PLoS medicine 2018 Mar (3) e1002546 (Posted: Mar-31-2018 5PM)
Primary prevention of cardiovascular disease: The past, present, and future of blood pressure- and cholesterol-lowering treatments
MJG Leening et al, PLOS Medicine, Mar 20, 2018 (Posted: Mar-20-2018 4PM)
What Genetic Testing Might Uncover About Your (And Your Family Members) Heart Health
A Morales, Genome Magazine, Feb 28, 2018 (Posted: Feb-28-2018 3PM)
Beyond the Data - Million Hearts® 2022: A Compelling Call to Action
CDC You Tube Video, Feb 2018 (Posted: Feb-27-2018 3PM)
Bad genes dont mean you are doomed to heart disease and early death
M Cimons, Washington Post, Feb 24, 2018 (Posted: Feb-27-2018 9AM)
Science Saturday: Is your family at risk for genetic cardiovascular disease?
S Sparks, Mayo Clinic, Feb 2018 (Posted: Feb-26-2018 8AM)
Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review.
Fiatal Szilvia et al. Frontiers in public health 2017 5358 (Posted: Feb-21-2018 10AM)
Genetic determinants of heart failure: facts and numbers.
Czepluch Frauke S et al. ESC heart failure 2018 Feb (Posted: Feb-21-2018 10AM)
Screening for rare genetic variants associated with atherosclerosis: opportunity for personalized medicine.
Peterlin Ana et al. Current vascular pharmacology 2018 Feb (Posted: Feb-14-2018 11AM)
Taking personalized medicine to heart.
et al. Nature medicine 2018 Feb (2) 113 (Posted: Feb-14-2018 10AM)
Best Practices for Cardiovascular Disease Prevention Programs
(Posted: Feb-09-2018 9AM)
February is American Heart Month
(Posted: Feb-06-2018 0PM)
CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation
N Whiffin et al, Genetics in Medicine, Jan 25, 2018 (Posted: Jan-25-2018 0PM)
An automated and interactive web tool that supports disease specific interpretation of genetic variants in genes associated with Inherited Cardiac Conditions. (Posted: Jan-25-2018 0PM)
Genetics in the prevention and management of coronary artery disease.
Roberts Robert et al. Current opinion in cardiology 2018 Jan (Posted: Jan-21-2018 6PM)
New Test For Early Heart Disease Risk Based on Multiple Genetic Differences,
by Kenny Walter, R and D Magazine, January 8, 2018 (Posted: Jan-10-2018 9AM)
Polygenic Contribution in Individuals With Early-Onset Coronary Artery Disease
Sébastien Thériault et al, Circ Cardio Genetics, Jan 2018 (Posted: Jan-08-2018 11AM)
Genetics of CVD in 2017: Expanding the spectrum of CVD genetics.
Schunkert Heribert et al. Nature reviews. Cardiology 2017 Dec (Posted: Dec-31-2017 8AM)
How close are we to implementing a genetic risk score for coronary heart disease?
Beaney Katherine et al. Expert review of molecular diagnostics 2017 Oct (10) 905-915 (Posted: Dec-31-2017 8AM)
The Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease
Pim van der Harst, et al, Circ Res, Dec 2017 (Posted: Dec-09-2017 11AM)
Contemporary genetic testing in inherited cardiac disease: tools, ethical issues, and clinical applications.
Girolami Francesca et al. Journal of cardiovascular medicine (Hagerstown, Md.) 2017 Nov (Posted: Nov-29-2017 10AM)
Tracing the genetic etiology of cardiovascular disease using a hierarchy of common genetic variants derived from patient subgroups stratified by differential levels in severity
SN Fatakia, BioRXIV, Nov 24, 2017 (Posted: Nov-25-2017 11AM)
Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults.
Millwood Iona Y et al. JAMA cardiology 2017 Nov (Posted: Nov-20-2017 2PM)
Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease
AV Khera et al, BioRXIV, Nov 15, 2017 (Posted: Nov-15-2017 2PM)
Towards Cardio-Precision medicine.
Sayed Nazish et al. European heart journal 2017 Apr 38(14) 1014-1016 (Posted: Nov-15-2017 9AM)
A 45-SNP genetic risk score is increased in early-onset coronary artery disease but independent of familial disease clustering.
Christiansen Morten K et al. Atherosclerosis 2017 Feb 257172-178 (Posted: Nov-14-2017 8AM)
Exome chip meta-analysis identifies novel loci and East Asianspecific coding variants that contribute to lipid levels and coronary artery disease
X Lu et al, Nat Genetics, Oct 30, 2017 (Posted: Oct-30-2017 11AM)
Exome-wide association study of plasma lipids in >300,000 individuals
DJ Liu et al, Nat Genetics, Oct 30, 2017 (Posted: Oct-30-2017 11AM)
Genetic Risk Stratification and Prevention of CAD: An Idea Whose Time Is Now.
Roberts Robert et al. Clinical chemistry 2017 Sep (Posted: Sep-28-2017 7PM)
CardioClassifier: demonstrating the power of disease- and gene-specific computational decision support for clinical genome interpretation
http://www.biorxiv.org/content/early/2017/08/23/180109 (Posted: Aug-29-2017 9AM)
Genetic Studies Help Clarify the Complexities of Lipid Biology and Treatment
AD Sniderman et al, JAMA August 27, 2017 (Posted: Aug-28-2017 1PM)
Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk
BA Ference, et al. JAMA, August 28, 2017 (Posted: Aug-28-2017 1PM)
Charting Our Future Together- Turning Discovery Science Into Cardiovascular Health
GH Gibbons, Circulation. 2017;136:615-617 (Posted: Aug-16-2017 1PM)
Role of Genetic Testing in Inherited Cardiovascular Disease: A Review.
Cirino Allison L et al. JAMA cardiology 2017 Aug (Posted: Aug-16-2017 8AM)
Incorporating Genetic Testing Into Cardiovascular Practice.
McNally Elizabeth M et al. JAMA cardiology 2017 Aug (Posted: Aug-16-2017 8AM)
Kathiresan and Topol on Genomics of Heart Disease
Focusing on Heart Attacks Among the Young, Medscape, August 2, 2017 (Posted: Aug-03-2017 8AM)
Is ANGPTL3 a Target to Reduce Cardiovascular Risk?
NEJM video, July 18, 2017, (Posted: Jul-19-2017 7PM)
Assessment of the clinical utility of adding common single nucleotide polymorphism genetic scores to classical risk factor algorithms in coronary heart disease risk prediction in UK men.
Beaney Katherine E et al. Clinical chemistry and laboratory medicine 2017 Jun (Posted: Jun-07-2017 9AM)
Common Variants for Cardiovascular Disease- Clinical Utility Confirmed
SE Humphries, Circulation, editorial, May 30, 2017 (Posted: May-30-2017 8PM)
Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting.
Natarajan Pradeep et al. Circulation 2017 Feb (Posted: May-30-2017 8PM)
Genetics of coronary artery disease: discovery, biology and clinical
AV Khera et al, Nature Rev Genetics, 2017 (Posted: May-23-2017 8AM)
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
J MM Howson et al, Nature Genetics (Posted: May-22-2017 2PM)
Delivering Clinical Grade Sequencing and Genetic Test Interpretation for Cardiovascular Medicine.
Harper Andrew R et al. Circulation. Cardiovascular genetics 2017 Apr 10(2) (Posted: Apr-19-2017 9AM)
Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults.
Seidelmann Sara B et al. Circulation. Cardiovascular genetics 2017 Feb 10(1) (Posted: Apr-19-2017 8AM)
PCSK9 Inhibition to Reduce Cardiovascular Events.
Dullaart Robin P F et al. The New England journal of medicine 2017 Mar (Posted: Apr-02-2017 6PM)
Genome-based cholesterol drug boosts heart health
Treatment reduces the risk of heart attack and stroke, but might not live up to outsized expectations.
H Ledford, Nature News, March 18 2017 (Posted: Mar-20-2017 4PM)
Novel Drug Delivers Long Term Cholesterol Reduction
L Husten, Cardio Brief, March 18, 2017 (Posted: Mar-19-2017 7AM)
PCSK9 Inhibition to Reduce Cardiovascular Events
Robin P.F. Dullaart, NEJM, March 17, 2017 (Posted: Mar-17-2017 1PM)
Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine
AV Khera, et al. Circulation, March 2017 (Posted: Mar-16-2017 8AM)
Genetic Risk Could Guide Heart Disease Prevention
D Macnamara, Medscape, March 10, 2017 (Posted: Mar-13-2017 11AM)
Genetics of coronary artery disease: discovery, biology and clinical translation
AV Khera et al. Nat Rev Genetics, March 2017 (Posted: Mar-13-2017 9AM)
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease
AV Khera et al, JAMA, March 7, 2017 (Posted: Mar-08-2017 4PM)
Keys to Your Genetic Heart Health
AC Sturm, NSGC Blog Post, March 2017 (Posted: Mar-06-2017 3PM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2023
- Page last updated:Mar 21, 2023
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