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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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142 hot topic(s) found with the query "Heart diseases"

What to Know About PREVENT, the AHA's New Cardiovascular Disease Risk Calculator.
Howard Larkin et al. JAMA 2023 12 (Posted: Jan 02, 2024 10AM)

From the article: "After 10 years, the American Heart Association (AHA) has updated its cardiovascular disease risk calculator for all adults aged 30 to 79 years without known cardiovascular disease. The Predicting Risk of Cardiovascular Disease Events (PREVENT) calculator is based on newer data from a larger, more diverse sample than the existing tool, the commonly used Pooled Cohort Equations (PCEs), released in 2013 for non-Black Hispanic and White adults aged 40 to 79 years. The PREVENT equations also take into account other health conditions, such as kidney and metabolic diseases, for determining the 10- and 30-year chances of both atherosclerotic cardiovascular disease and heart failure. "

A deep learning-based electrocardiogram risk score for long term cardiovascular death and disease
JW Hughes et al, NPJ Digital Medicine, September 12, 2023 (Posted: Sep 13, 2023 0PM)

From the abstract: "The electrocardiogram (ECG) is the most frequently performed cardiovascular diagnostic test, but it is unclear how much information resting ECGs contain about long term cardiovascular risk. Here we report that a deep convolutional neural network can accurately predict the long-term risk of cardiovascular mortality and disease based on a resting ECG alone."

The role of aldehyde dehydrogenase 2 in cardiovascular disease.
Jian Zhang et al. Nature reviews. Cardiology 2023 2 (Posted: Feb 26, 2023 8AM)

Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating ALDH2 rs671 polymorphism, present in up to 8% of the global population and in up to 50% of the East Asian population, is associated with increased risk of cardiovascular conditions such as coronary artery disease, alcohol-induced cardiac dysfunction, pulmonary arterial hypertension, heart failure and drug-induced cardiotoxicity.

Implementing Cardiogenomics in Clinical Practice
Northwestern University and the Jackson Labs, 2023 (Posted: Feb 08, 2023 9AM)

15 to 30-minute modules that let you practice assessing patients’ risk for a genetic cardiac condition. Upcoming modules will address genetic test results interpretation and management of patients with hereditary cardiovascular disease.

Finding causal genes underlying risk for coronary artery disease
PL Auer, Nature Genetics, December 6, 2022 (Posted: Dec 06, 2022 0PM)

Previous genome-wide association studies of coronary artery disease (CAD) have discovered multiple susceptibility loci but have largely failed to uncover causal genes. A new study identifies hundreds of likely causal genes underlying the genetic risk for CAD.

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
KG Aragam et al, Nature Genetics, December 6, 2022 (Posted: Dec 06, 2022 0PM)

The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci. Cross-ancestry meta-analysis with a Japanese GWAS yielded 38 additional new loci.

Genetic Basis of Childhood Cardiomyopathy
RD Bagnall et al, Circ Genomics Prec Medicine, October 12, 2022 (Posted: Oct 12, 2022 8AM)

We recruited children from a pediatric cardiology service or genetic heart diseases clinic. We performed Sanger, gene panel, exome or genome sequencing and classified variants for pathogenicity using American College of Molecular Genetics and Genomics guidelines. The highest genetic testing diagnostic yields were in restrictive cardiomyopathy (n=16, 80%) and hypertrophic cardiomyopathy (n=65, 66%), and lowest in dilated cardiomyopathy (n=26, 29%) and left ventricular noncompaction (n=3, 25%). Pathogenic variants were primarily found in genes encoding sarcomere proteins, with TNNT2 and TNNI3 variants associated with more severe clinical outcomes.

Burden of Rare Genetic Variants in Spontaneous Coronary Artery Dissection With High-risk Features
Y Wang et al, JAMA Cardiology, September 15, 2022 (Posted: Sep 16, 2022 8AM)

In a whole-exome sequencing genetic study, 17% of individuals with high-risk SCAD had rare variants in vascular connective tissue disease genes, representing a significant enrichment compared with the Genome Aggregation Database (gnomAD), especially in COL3A1 and Loeys-Dietz syndrome genes. Rare variants in genes recently discovered by genome-wide association study, ADAMTSL4 and LRP1, identified in 6% of the cohort, were also enriched.

New Cardiovascular Risk Assessment Techniques for Primary Prevention: JACC Review Topic of the Week.
Verma Kunal P et al. Journal of the American College of Cardiology 2022 7 (4) 373-387 (Posted: Jul 25, 2022 7AM)

Risk factor-based models fail to accurately estimate risk in select populations, in particular younger individuals. A sizable number of people are also classified as being at intermediate risk, for whom the optimal preventive strategy could be more precise. Several personalized risk prediction tools, including coronary artery calcium scoring, polygenic risk scores, and metabolic risk scores may be able to improve risk assessment, pending supportive outcome data from clinical trials.

Everyone deserves a diagnosis
The Family Heart Foundation, July 18, 2022 (Posted: Jul 20, 2022 0PM)

“Runs in the family” is not a diagnosis- Over the past 10 years, we have heard from thousands of people who have heart disease or had a stroke caused by an inherited cholesterol disorder. Unfortunately, they did not learn of their genetic condition until it was too late. The damage was done. They were told that heart disease or high cholesterol “runs in the family” but were never given the name of the genetic cause that leads to so much heartache across generations. We believe families deserve a diagnosis so they can get the care they deserve. That is why we have launched this campaign. We hope you will join us to help reach people who have never heard of FH or elevated Lipoprotein(a).

Lipoprotein (a)
CDC, June 29, 2022 Brand (Posted: Jun 28, 2022 4PM)

High levels of lipoprotein (a) increase your likelihood of having a heart attack, a stroke, and aortic stenosis, especially if you have familial hypercholesterolemia or signs of coronary heart disease. High Lp(a) levels, defined as greater than 50 mg/dL (125 nmol/L),3 are common. Median Lp(a) levels vary by race and sex.4 High Lp(a) is seen in people of all races and ethnicities but appears to be more common in Black people.4 Many people with high Lp(a) have no symptoms. However, your doctor may suspect that you have high Lp(a) if you have one or more risk factors such as family history, familial hypercholesterolemia, peripheral artery disease and others.

March 24 is Lipoprotein(a) Awareness Day
Family Heart Foundation, March 2022 (Posted: Mar 24, 2022 0PM)

The Family Heart Foundation established Lipoprotein(a) Awareness Day to raise awareness worldwide of elevated Lipoprotein(a), also known as Lp(a). On March 24, we will use the power of our voices so that everyone understands why they should #KnowLpa. Through national and local media, as well as social media engagement, we will draw attention to this important inherited disorder and encourage everyone to join the movement.

Cardiovascular Genetics: The Role of Genetics in Predicting Risk.
Chowns Jessica et al. The Medical clinics of North America 2022 106(2) 313-324 (Posted: Mar 05, 2022 7AM)

Many cardiovascular disorders have underlying genetic causes. Clinical genetic testing for cardiovascular disease has become widely available and can be useful for diagnosis, management, and cascade screening in selected conditions and circumstances. This article gives an overview of the current state of genetic testing in inherited cardiovascular conditions, who can benefit from it, and the associated challenges.

Decision-making and experiences of preimplantation genetic diagnosis in inherited heart diseases: a qualitative study
L Yeates et al, EJHG, September 21, 2021 (Posted: Sep 21, 2021 7AM)

Mapping gene and gene pathways associated with coronary artery disease: a CARDIoGRAM exome and multi-ancestry UK biobank analysis
P Hariharan et al, Scientific Reports, August 12, 2021 (Posted: Aug 12, 2021 7AM)

We performed gene and pathway-based association (GBA) tests on publicly available Coronary ARtery DIsease Genome wide Replication and Meta-analysis consortium Exome (n?=?120,575) and multi ancestry pan UK Biobank study (n?=?442,574) summary data using versatile gene-based association study (VEGAS2) and Multi-marker analysis of genomic annotation (MAGMA) to identify novel genes and pathways associated with CAD.

Genetic testing in ambulatory cardiology clinics reveals high rate of findings with clinical management implications.
Murdock David R et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021 8 (Posted: Aug 09, 2021 11AM)

We developed the "HeartCare" panel of genes associated with CVD, evaluating high-penetrance Mendelian conditions, coronary artery disease (CAD) polygenic risk, LPA gene polymorphisms, and specific pharmacogenetic (PGx) variants. We enrolled 709 individuals from cardiology clinics. Results were returned to the ordering physician and uploaded to the electronic medical record. Notably, 32% of patients had a genetic finding with clinical management implications, even after excluding PGx results, including 9% who were molecularly diagnosed with a Mendelian condition.

Lipoprotein(a) and Cardiovascular Diseases.
Miksenas Hannah et al. JAMA 2021 7 (Posted: Jul 11, 2021 2PM)

Recent studies have clarified the role of lipoprotein(a) [Lp(a)], relative to other lipoproteins, in atherogenesis. This JAMA Insights article discusses several clinical aspects of Lp(a), including the association with cardiovascular disease risk, considerations regarding measurement, guideline recommendations, and emerging therapies.

Genetic variants associated with inherited cardiovascular disorders among 13,131 asymptomatic older adults of European descent
P Lacaze et al, NPJ Genomic Medicine, June 16, 2021 (Posted: Jun 17, 2021 9AM)

We performed targeted sequencing of 25 genes used routinely in clinical genetic testing for inherited cardiovascular disorders in a population of 13,131 asymptomatic older individuals (mean age 75 years) enrolled in the ASPREE trial. In total, 119 participants had pathogenic/deleterious variants in one of 25 genes analyzed (carrier rate of 1 in 110 or 0.9%)

Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development.
Holmes Michael V et al. Nature reviews. Cardiology 2021 3 (Posted: Mar 16, 2021 8AM)

Association of the V122I Transthyretin Amyloidosis Genetic Variant With Cardiac Structure and Function in Middle-aged Black Adults - Coronary Artery Risk Development in Young Adults (CARDIA) Study
A Sinha et al, JAMA Cardiology, December 23, 2020 (Posted: Dec 24, 2020 7AM)

In this population-based cohort study of 875 Black adults, there was a significant association of the TTR V122I variant with worse left ventricular structure and cardiac mechanics at a mean age of 54 years. Earlier screening with echocardiography may inform use of novel therapies and intensification of risk factor modification to prevent heart failure.

Disease-specific variant pathogenicity prediction significantly improves variant interpretation in inherited cardiac conditions.
Zhang Xiaolei et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 Oct (Posted: Oct 14, 2020 8AM)

We developed a disease-specific variant classifier, CardioBoost, that estimates the probability of pathogenicity for rare missense variants in inherited cardiomyopathies and arrhythmias. We assessed CardioBoost's ability to discriminate known pathogenic from benign variants, prioritize disease-associated variants, and stratify patient outcomes.

Identification of Undetected Monogenic Cardiovascular Disorders
JW AbdulRahim et al, JACC, August 7, 2020 (Posted: Aug 11, 2020 7AM)

Exomes from 8,574 individuals referred for cardiac catheterization were analyzed. Overall, 149 individuals (1.7% of cohort) had monogenic cardiovascular diseases, but only 35% were diagnosed. These patients represents a “missed opportunity,” which could be addressed by greater use of genetic testing of patients seen by cardiologists.

The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor
R Sidlow et al, JAMA Cardiology, May 2020 (Posted: Jun 02, 2020 6AM)

Antisense oligonucleotides for atherosclerotic disease
A Bajaj et al Nature Medicine, April 6, 2020 (Posted: Apr 07, 2020 10AM)

Novel RNA-targeting antisense therapy is shown to reduce lipoprotein(a) levels in 286 patients with existing atherosclerotic disease by upwards of 80% in a phase 2 clinical trial.

Does Heart Disease Run in Families? Here's Everything You Need to Know
TG Hope, Better Homes and Garden, January 2020 (Posted: Jan 28, 2020 7AM)

Knowing the who, what, when, and whys of your relatives’ heart disease histories helps you best protect your own. The heart health of your first-degree relatives—parents, siblings, children—impacts your own risk the most, especially if they developed heart disease prematurely.

It Is Now Time to Focus on Risk Before Age 40.
Gidding Samuel S et al. Journal of the American College of Cardiology 2019 Jul (3) 342-345 (Posted: Jul 20, 2019 4PM)

Making The Case For Cascade Screening Amongst Families With Inherited Heart Diseases.
Ingles Jodie et al. Heart rhythm 2019 Jul (Posted: Jul 17, 2019 8AM)

Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification.
Perrot Nicolas et al. JAMA cardiology 2019 May (Posted: May 31, 2019 10AM)

Progress Toward Improved Cardiovascular Health in the United States.
Pahigiannis Katherine et al. Circulation 2019 Apr (16) 1957-1973 (Posted: May 31, 2019 9AM)

Rare Gene Mutations May Prevent Heart Disease
Boston University, May 10, 2019 (Posted: May 14, 2019 2PM)

Perceptions of genetic variant reclassification in patients with inherited cardiac disease
EJ Wong et al, EJHGH, March 21, 2019 (Posted: Mar 24, 2019 9AM)

Acute Management of Ventricular Arrhythmia in Patients With Suspected Inherited Heart Rhythm Disorders
Z Laskman et al, JACC Electrophysiology, March 2019 (Posted: Mar 21, 2019 3PM)

Myocardial Infarction in Young Women.
Vaccarino Viola et al. Circulation 2019 Feb (8) 1057-1059 (Posted: Feb 22, 2019 9AM)

Lifelong genetically lowered sclerostin and risk of cardiovascular disease.
J Bovjin et al, BIORxIV, February 1, 2019 (Posted: Feb 02, 2019 0PM)

What genetics could mean for your heart disease risk — and what you can do about it
K Musunuru etal, Philadelphia Inquirer, February 1, 2019 (Posted: Feb 01, 2019 11AM)

Genetic factor may identify patients at risk for spontaneous coronary artery dissection
DL Bhatt, Healio, January 2019 (Posted: Jan 20, 2019 8AM)

Is Heart Disease Genetic?
L Meyers, Genome Medical, December 2018 (Posted: Dec 30, 2018 9AM)

Simple blood and saliva tests that cost just £40 could help prevent heart attacks, scientists say
B Spencer, Daily Mail, October 8, 2018 (Posted: Oct 09, 2018 11AM)

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention
M Inouye et al, JACC< October 2018 (Posted: Oct 09, 2018 9AM)

5 reasons you could develop heart disease before 50
American Heart Association, September 14, 2018 (Posted: Sep 17, 2018 7AM)

HLBS-PopOmics: an online knowledge base to accelerate dissemination and implementation of research advances in population genomics to reduce the burden of heart, lung, blood, and sleep disorders
Mensah GA, et al, Genetics in Medicine, September 10, 2018 (Posted: Sep 10, 2018 10AM)

Preventing 1 Million Heart Attacks and Strokes- Middle-aged adults are being hard hit
CDC Vital Signs, September 6, 2018 Brand (Posted: Sep 07, 2018 8AM)

Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments: A Scientific Statement From the American Heart Association.
Volgman Annabelle Santos et al. Circulation 2018 May (Posted: May 29, 2018 3PM)

Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association
K Musunuru et al, Circulation: Genomics and Precision Medicine, May 2018 (Posted: May 29, 2018 0PM)

Fitness Helps Prevent Heart Disease, Even for Those with Genetic Risk Factors
N Westman, Genome Magazine, Apr 2018 (Posted: May 03, 2018 9AM)

When heart disease runs in the family, exercise tied to lower risk
L Rapaport, Reuters, Apr 10, 2018 (Posted: Apr 11, 2018 9AM)

Keeping Fit Helps Fight Heart Disease, Even Among Those at Genetic Risk
Frontline Genomics, Apr 10, 2018 (Posted: Apr 11, 2018 9AM)

Associations of Fitness, Physical Activity, Strength, and Genetic Risk With Cardiovascular Disease: Longitudinal Analyses in the UK Biobank Study
E Tikanen et al, Circulation, Apr 10, 2018 (Posted: Apr 11, 2018 9AM)

Managing dyslipidaemia for the primary prevention of cardiovascular disease
A Ryan et al, BMJ Practice Pointer, Mar 2018 (Posted: Apr 03, 2018 8AM)

Cardiovascular disease: The rise of the genetic risk score.
Knowles Joshua W et al. PLoS medicine 2018 Mar (3) e1002546 (Posted: Mar 31, 2018 5PM)

Primary prevention of cardiovascular disease: The past, present, and future of blood pressure- and cholesterol-lowering treatments
MJG Leening et al, PLOS Medicine, Mar 20, 2018 (Posted: Mar 20, 2018 4PM)

What Genetic Testing Might Uncover About Your (And Your Family Members’) Heart Health
A Morales, Genome Magazine, Feb 28, 2018 (Posted: Feb 28, 2018 3PM)

Beyond the Data - Million Hearts® 2022: A Compelling Call to Action
CDC You Tube Video, Feb 2018 Brand (Posted: Feb 27, 2018 3PM)

Bad genes don’t mean you are doomed to heart disease and early death
M Cimons, Washington Post, Feb 24, 2018 (Posted: Feb 27, 2018 9AM)

Science Saturday: Is your family at risk for genetic cardiovascular disease?
S Sparks, Mayo Clinic, Feb 2018 (Posted: Feb 26, 2018 8AM)

Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review.
Fiatal Szilvia et al. Frontiers in public health 2017 5358 (Posted: Feb 21, 2018 10AM)

Genetic determinants of heart failure: facts and numbers.
Czepluch Frauke S et al. ESC heart failure 2018 Feb (Posted: Feb 21, 2018 10AM)

Screening for rare genetic variants associated with atherosclerosis: opportunity for personalized medicine.
Peterlin Ana et al. Current vascular pharmacology 2018 Feb (Posted: Feb 14, 2018 11AM)

Taking personalized medicine to heart.
et al. Nature medicine 2018 Feb (2) 113 (Posted: Feb 14, 2018 10AM)

Best Practices for Cardiovascular Disease Prevention Programs
Brand (Posted: Feb 09, 2018 9AM)

February is American Heart Month
Brand (Posted: Feb 06, 2018 0PM)

CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation
N Whiffin et al, Genetics in Medicine, Jan 25, 2018 (Posted: Jan 25, 2018 0PM)

CardioClassifier
An automated and interactive web tool that supports disease specific interpretation of genetic variants in genes associated with Inherited Cardiac Conditions. (Posted: Jan 25, 2018 0PM)

Genetics in the prevention and management of coronary artery disease.
Roberts Robert et al. Current opinion in cardiology 2018 Jan (Posted: Jan 21, 2018 6PM)

New Test For Early Heart Disease Risk Based on Multiple Genetic Differences,
by Kenny Walter, R and D Magazine, January 8, 2018 (Posted: Jan 10, 2018 9AM)

Polygenic Contribution in Individuals With Early-Onset Coronary Artery Disease
Sébastien Thériault et al, Circ Cardio Genetics, Jan 2018 (Posted: Jan 08, 2018 11AM)

Genetics of CVD in 2017: Expanding the spectrum of CVD genetics.
Schunkert Heribert et al. Nature reviews. Cardiology 2017 Dec (Posted: Dec 31, 2017 8AM)

How close are we to implementing a genetic risk score for coronary heart disease?
Beaney Katherine et al. Expert review of molecular diagnostics 2017 Oct (10) 905-915 (Posted: Dec 31, 2017 8AM)

The Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease
Pim van der Harst, et al, Circ Res, Dec 2017 (Posted: Dec 09, 2017 11AM)

Contemporary genetic testing in inherited cardiac disease: tools, ethical issues, and clinical applications.
Girolami Francesca et al. Journal of cardiovascular medicine (Hagerstown, Md.) 2017 Nov (Posted: Nov 29, 2017 10AM)

Tracing the genetic etiology of cardiovascular disease using a hierarchy of common genetic variants derived from patient subgroups stratified by differential levels in severity
SN Fatakia, BioRXIV, Nov 24, 2017 (Posted: Nov 25, 2017 11AM)

Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults.
Millwood Iona Y et al. JAMA cardiology 2017 Nov (Posted: Nov 20, 2017 2PM)

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease
AV Khera et al, BioRXIV, Nov 15, 2017 (Posted: Nov 15, 2017 2PM)

Towards Cardio-Precision medicine.
Sayed Nazish et al. European heart journal 2017 Apr 38(14) 1014-1016 (Posted: Nov 15, 2017 9AM)

A 45-SNP genetic risk score is increased in early-onset coronary artery disease but independent of familial disease clustering.
Christiansen Morten K et al. Atherosclerosis 2017 Feb 257172-178 (Posted: Nov 14, 2017 8AM)

Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease
X Lu et al, Nat Genetics, Oct 30, 2017 (Posted: Oct 30, 2017 11AM)

Exome-wide association study of plasma lipids in >300,000 individuals
DJ Liu et al, Nat Genetics, Oct 30, 2017 (Posted: Oct 30, 2017 11AM)

Genetic Risk Stratification and Prevention of CAD: An Idea Whose Time Is Now.
Roberts Robert et al. Clinical chemistry 2017 Sep (Posted: Sep 28, 2017 7PM)

CardioClassifier: demonstrating the power of disease- and gene-specific computational decision support for clinical genome interpretation
http://www.biorxiv.org/content/early/2017/08/23/180109 (Posted: Aug 29, 2017 9AM)

Genetic Studies Help Clarify the Complexities of Lipid Biology and Treatment
AD Sniderman et al, JAMA August 27, 2017 (Posted: Aug 28, 2017 1PM)

Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk
BA Ference, et al. JAMA, August 28, 2017 (Posted: Aug 28, 2017 1PM)

Charting Our Future Together- Turning Discovery Science Into Cardiovascular Health
GH Gibbons, Circulation. 2017;136:615-617 (Posted: Aug 16, 2017 1PM)

Role of Genetic Testing in Inherited Cardiovascular Disease: A Review.
Cirino Allison L et al. JAMA cardiology 2017 Aug (Posted: Aug 16, 2017 8AM)

Incorporating Genetic Testing Into Cardiovascular Practice.
McNally Elizabeth M et al. JAMA cardiology 2017 Aug (Posted: Aug 16, 2017 8AM)

Kathiresan and Topol on Genomics of Heart Disease
Focusing on Heart Attacks Among the Young, Medscape, August 2, 2017 (Posted: Aug 03, 2017 8AM)

Is ANGPTL3 a Target to Reduce Cardiovascular Risk?
NEJM video, July 18, 2017, (Posted: Jul 19, 2017 7PM)

Assessment of the clinical utility of adding common single nucleotide polymorphism genetic scores to classical risk factor algorithms in coronary heart disease risk prediction in UK men.
Beaney Katherine E et al. Clinical chemistry and laboratory medicine 2017 Jun (Posted: Jun 07, 2017 9AM)

Common Variants for Cardiovascular Disease- Clinical Utility Confirmed
SE Humphries, Circulation, editorial, May 30, 2017 (Posted: May 30, 2017 8PM)

Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting.
Natarajan Pradeep et al. Circulation 2017 Feb (Posted: May 30, 2017 8PM)

Genetics of coronary artery disease: discovery, biology and clinical translation
AV Khera et al, Nature Rev Genetics, 2017 (Posted: May 23, 2017 8AM)

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
J MM Howson et al, Nature Genetics (Posted: May 22, 2017 2PM)

Delivering Clinical Grade Sequencing and Genetic Test Interpretation for Cardiovascular Medicine.
Harper Andrew R et al. Circulation. Cardiovascular genetics 2017 Apr 10(2) (Posted: Apr 19, 2017 9AM)

Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults.
Seidelmann Sara B et al. Circulation. Cardiovascular genetics 2017 Feb 10(1) (Posted: Apr 19, 2017 8AM)

PCSK9 Inhibition to Reduce Cardiovascular Events.
Dullaart Robin P F et al. The New England journal of medicine 2017 Mar (Posted: Apr 02, 2017 6PM)

Genome-based cholesterol drug boosts heart health Treatment reduces the risk of heart attack and stroke, but might not live up to outsized expectations.
H Ledford, Nature News, March 18 2017 (Posted: Mar 20, 2017 4PM)

Novel Drug Delivers Long Term Cholesterol Reduction
L Husten, Cardio Brief, March 18, 2017 (Posted: Mar 19, 2017 7AM)

PCSK9 Inhibition to Reduce Cardiovascular Events
Robin P.F. Dullaart, NEJM, March 17, 2017 (Posted: Mar 17, 2017 1PM)

Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine
AV Khera, et al. Circulation, March 2017 (Posted: Mar 16, 2017 8AM)

Genetic Risk Could Guide Heart Disease Prevention
D Macnamara, Medscape, March 10, 2017 (Posted: Mar 13, 2017 11AM)

Genetics of coronary artery disease: discovery, biology and clinical translation
AV Khera et al. Nat Rev Genetics, March 2017 (Posted: Mar 13, 2017 9AM)

more


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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