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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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60 hot topic(s) found with the query "Gene-environment interaction"

Gene–environment interactions in human health
(Posted: May 29, 2024 9AM)

From the abstract: "Gene–environment interactions (G×E), the interplay of genetic variation with environmental factors, have a pivotal impact on human complex traits and diseases. Statistically, G×E can be assessed by determining the deviation from expectation of predictive models based solely on the phenotypic effects of genetics or environmental exposures. Despite the unprecedented, widespread and diverse use of G×E analytical frameworks, heterogeneity in their application and reporting hinders their applicability in public health. "

An approach to identify gene-environment interactions and reveal new biological insight in complex traits
(Posted: Apr 25, 2024 9AM)

From the abstract: " Here, we present a powerful new approach to screen for interactions across the genome, an approach that shares substantial similarity to the Mendelian randomization framework. We identify and confirm 5 loci (6 independent signals) interacted with either cigarette smoking or alcohol consumption for serum lipids, and empirically demonstrate that interaction and mediation are the major contributors to genetic effect size heterogeneity across populations. "

Many roads to a gene-environment interaction.
Kenneth E Westerman et al. Am J Hum Genet 2024 4 (4) 626-635 (Posted: Apr 10, 2024 8AM)

From the abstract: "Despite the importance of gene-environment interactions (GxEs) in improving and operationalizing genetic discovery, interpretation of any GxEs that are discovered can be surprisingly difficult. There are many potential biological and statistical explanations for a statistically significant finding and, likewise, it is not always clear what can be claimed based on a null result. Here, we provide a detailed explanation of five “phenomena,” or data-generating mechanisms, that can lead to nonzero interaction estimates, as well as a discussion of specific instances in which they might be relevant. "

It’s time to admit that genes are not the blueprint for life The view of biology often presented to the public is oversimplified and out of date.
D Noble, Nature book Review, February 5, 2024 (Posted: Feb 05, 2024 11AM)

From the article: " When the human genome was sequenced in 2001, many thought that it would prove to be an ‘instruction manual’ for life. But the genome turned out to be no blueprint. In fact, most genes don’t have a pre-set function that can be determined from their DNA sequence. Instead, genes’ activity — whether they are expressed or not, for instance, or the length of protein that they encode — depends on myriad external factors, from the diet to the environment in which the organism develops."

A gene-by-sex interaction contributes to liver disease susceptibility in women
Nature Medicine, October 2, 2023 (Posted: Oct 02, 2023 11AM)

From the abstract: "Clinical and population-based cohorts revealed an interaction between the inherited PNPLA3 p.I148M variant and female sex in determining liver disease. Transcriptomic and functional studies showed that the mechanism encompasses ERa-dependent upregulation of PNPLA3 in hepatocytes, highlighting a target for precision medicine therapeutics in cisgender women. "

Improved two-step testing of genome-wide gene–environment interactions
ES Kawagushi et al, Genetic Epidemiology, December 26, 2022 (Posted: Dec 26, 2022 11AM)

We introduce a new significance-based allocation into bins for Step-2 testing that overcomes the displacement issue and propose a computationally efficient approach to account for multiple testing within bins. Simulation results demonstrate that these simple improvements can provide substantially greater power than current methods under several scenarios. An application to a multistudy collaboration for understanding colorectal cancer reveals a G?×?Sex interaction located near the SMAD7 gene.

Genes influence complex traits through environments that vary between geographic regions
Nature Genetics, September 6, 2022 (Posted: Sep 07, 2022 7AM)

Migration can increase regional differences in both DNA variants and environmental factors that are associated with socio-economic status. Without controlling for geography, associations between genes and complex traits will therefore include effects of environmental differences between high-income and low-income regions.

Integrative analysis of genomic and exposomic influences on youth mental health.
Choi Karmel W et al. Journal of child psychology and psychiatry, and allied disciplines 2022 8 (Posted: Aug 11, 2022 7AM)

Understanding complex influences on mental health problems in young people is needed to inform early prevention strategies. Both genetic and environmental factors are known to influence youth mental health, but a more comprehensive picture of their interplay, including wide-ranging environmental exposures – that is, the exposome – is needed. We perform an integrative analysis of genomic and exposomic data in relation to internalizing and externalizing symptoms in a cohort of 4,314 unrelated youth from the Adolescent Brain and Cognitive Development (ABCD) Study.

Environmental human genomics
J Janus, PHG Foundation, March 2022 (Posted: Apr 01, 2022 8AM)

Every one of us is exposed to multiple environmental factors throughout our lifetime. Environmental human genomics seeks to understand how these external factors interact with the human genome (known as gene-environment interactions, or GxE) to determine responses to environmental exposures. Its study can be divided into two broad categories: the effect of environmental exposures on the human genome as a whole i.e. which genes interact with environmental factors to cause disease, and how this occurs; Identifying genetic variants associated with different types of response. i.e. even if exposed to the same level of a particular environmental factor, not everyone will respond the same way.

Gene-lifestyle interactions in the genomics of human complex traits
V Laville et al, EJHG, March 22, 2022 (Posted: Mar 23, 2022 8AM)

The role and biological significance of gene-environment interactions in human traits and diseases remain poorly understood. To address these questions, the CHARGE Gene-Lifestyle Interactions Working Group conducted series of genome-wide interaction studies (GWIS) involving up to 610,475 individuals across four ancestries for three lipids and four blood pressure traits, while accounting for interaction effects with drinking and smoking exposures.

Social Determinants of Health Factors for Gene–Environment COVID-19 Research: Challenges and Opportunities
J Phuong et al, Advanced Genetics, March 9, 2022 (Posted: Mar 09, 2022 4PM)

The characteristics of a person's health status are often guided by how they live, grow, learn, their genetics, as well as their access to health care. Yet, all too often, studies examining the relationship between social determinants of health (behavioral, sociocultural, and physical environmental factors), the role of demographics, and health outcomes poorly represent these relationships, leading to misinterpretations, limited study reproducibility, and datasets with limited representativeness and secondary research use capacity. This is a profound hurdle in what questions can or cannot be rigorously studied about COVID-19. Here, a conceptual framework is proposed, adapted from the population health framework, socioecological model, and causal modeling in gene–environment interaction studies to integrate the core constructs from each domain with practical considerations needed for multidisciplinary science.

The Science of Gene-Environment Interaction at the Centers for Disease Control and Prevention and Agency for Toxic Substances and Disease Registry
S Foster et al, CDC Blog Post, October 18, 2021 Brand (Posted: Oct 19, 2021 6AM)

Now, more than ever, we are aware that our environment has implications for our health. We are also learning more about the effects of inherited traits, such as blood type, on disease susceptibility and progression. Understanding the interactions between our environment and our genes and how they affect health outcomes offers a multitude of potential opportunities in public health.

Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individuals
CA Melbourne et al, MEDRXIV, June 7, 2021 (Posted: Jun 07, 2021 9AM)

We conducted a genome-wide gene-air pollution interaction analysis of spirometry measures with three measures of air pollution at home address: particulate matter (PM2.5 & PM10) and nitrogen dioxide (NO2), in approximately 300,000 unrelated European individuals from UK Biobank. We identified seven genome-wide interaction signals. We observed up to 440ml lower lung function for certain genotypes associated with mean levels of outdoor air pollution at baseline, which is approximately equivalent to nine years of normal loss of lung function.

Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study
G Jin et al, Lancet Oncology, September 29, 2020 (Posted: Sep 30, 2020 9AM)

Chinese individuals at an increased risk of incident gastric cancer could be identified by use of our newly developed polygenic risk score. Compared with individuals at a high genetic risk who adopt an unhealthy lifestyle, those who adopt a healthy lifestyle could substantially reduce their risk of incident gastric cancer.

Tumour predisposition and cancer syndromes as models to study gene–environment interactions
M Carbone et al, Nature Rev Cancer, May 2020 (Posted: Jun 05, 2020 6AM)

Tumour predisposition syndromes in which cancers arise at an accelerated rate and in different organs — the equivalent of a sensitized background — provide a unique opportunity to examine how gene–environment interactions influence cancer risk when the initiating genetic defect responsible for malignancy is known.

Whole‐Genome Approach Discovers Novel Genetic and Nongenetic Variance Components Modulated by Lifestyle for Cardiovascular Health
X Zhou et al, JAHA, April 2020 (Posted: Apr 23, 2020 8AM)

We used a novel whole-genome approach to estimate the genetic and nongenetic effects on—and hence their predispositions to—cardiovascular risk and determined whether they vary with respect to lifestyle factors such as physical activity, smoking, alcohol consumption, and dietary intake.

Parkinsons disease determinants, prediction and gene-environment interactions in the UK Biobank
BM Jacobs, BIORXIV, February 15, 2020 (Posted: Feb 16, 2020 9AM)

The study used UK Biobank data to reproduce several well-known associations with PD, to demonstrate the validity and predictive power of a polygenic risk score, and to demonstrate a novel gene-environment interaction, whereby the effect of diabetes on PD risk appears to depend on prior genetic risk for PD.

New Insights Into the APOE ε4-Soccer Heading Interaction: Handle With Care.
Banks Sarah J et al. JAMA neurology 2020 Jan (Posted: Jan 28, 2020 7AM)

Headers have become a concern in soccer, as we become more aware that repetitive mild and even subconcussive head injuries are associated with measures of brain health, which could imply an increased risk of neurodegeneration. Carrying the apolipoprotein E e4 allele is known to be a major risk factor in Alzheimer disease, but also in other brain conditions.

A healthy childhood environment helps to combat inherited susceptibility to obesity
A Huels et al, BioRXIV, January 14, 2020 (Posted: Jan 16, 2020 8AM)

Cohort study with measurements of diet, lifestyle factors and anthropometry. Polygenic risk scores captured the inherited susceptibility of obesity were calculated using summary statistics from independent genome-wide association studies of BMI. We observed significant interactions with demographic and lifestyle factors for BMI as well as waist circumference.

No multiplicative GXE interactions for breast cancer risk: Have we reached a verdict or is the jury still out?
Terry Mary Beth et al. International journal of epidemiology 2019 Dec (Posted: Jan 06, 2020 8AM)

Thinking through ways to improve how we communicate the absence of multiplicative interactions while at the same time promoting a greater awareness of additive interactions, and absolute risk, remains a challenge.

Can one overcome “unhealthy genes”?
J Lazarte et al, NPJ Genomic Medicine (Posted: Oct 04, 2019 9AM)

Like a book, our genome is not isolated from innumerable relationships, including those with the environment and conscious lifestyle choices.1 Furthermore, an axis of complex interactions between individual genes underlies the phenotype at any point in time.

Case-Only Analysis of Gene-Environment Interactions Using Polygenic Risk Scores.
Meisner Allison et al. American journal of epidemiology 2019 Aug (Posted: Aug 24, 2019 4PM)

The authors propose a case-only method for the analysis of interactions with a PRS in case-control studies. Assuming the PRS and E are independent, they show how a linear regression of the PRS on E in a sample of cases can be used to efficiently estimate the interaction parameter.

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank
H Wang et al, Science Advances, AUgust 14, 2019 (Posted: Aug 15, 2019 8AM)

Zip Code vs. Genetic Code,
by Erin O?Donnell, Harvard Magazine, July-August 2019 (Posted: Jul 17, 2019 8AM)

It's common to think of disease and health �as this tension of ZIP code versus genetic code,� explains Chirag Patel, assistant professor of biomedical informatics at Harvard Medical School.But a study by Patel and his research team challenges this �either-or� thinking, using Big Data to tease apart the complex interplay of environment, genes, and other factors in disease. They analyzed an insurance database of almost 45 million people in the United States.

The study of interactions between genome and exposome in the development of systemic lupus erythematosus.
Leffers Henrik Christian Bidstrup et al. Autoimmunity reviews 2019 Apr (4) 382-392 (Posted: Apr 22, 2019 9AM)

A Unified Model for the Analysis of Gene-Environment Interaction.
Gauderman W James et al. American journal of epidemiology 2019 Apr (4) 760-767 (Posted: Apr 21, 2019 6PM)

Genetics and the geography of health, behaviour and attainment
Belsky DW, et al. Nature Human Behaviour(2019) Apr 8 (Posted: Apr 09, 2019 8AM)

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Bentley Amy R et al. Nature genetics 2019 Apr (4) 636-648 (Posted: Apr 01, 2019 10AM)

Gene-Environment Interaction in the Era of Precision Medicine.
Li Jingjing et al. Cell 2019 Mar (1) 38-44 (Posted: Mar 23, 2019 9AM)

Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines.
Kokubo Yoshihiro et al. Environmental health and preventive medicine 2019 Mar (1) 19 (Posted: Mar 14, 2019 9AM)

No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples.
Border Richard et al. The American journal of psychiatry 2019 Mar appiajp201818070881 (Posted: Mar 14, 2019 8AM)

Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine.
Maugeri Andrea et al. BioMed research international 2018 20187532507 (Posted: Sep 19, 2018 9AM)

Review of Statistical Methods for Gene-Environment Interaction Analysis
SS Han et al, Curr Epi Reports, Feb 2018 (Posted: Feb 18, 2018 8AM)

Improving adherence to healthy dietary patterns, genetic risk, and long term weight gain: gene-diet interaction analysis in two prospective cohort studies
T Wang et al, BMJ, Jan 10, 2018 (Posted: Jan 11, 2018 9AM)

Gene-Environment Research and Cancer Epidemiology
Risk of most cancer types are determined by a complex interplay of genetic and environmental factors, NCI 2017 (Posted: Dec 19, 2017 9AM)

Predictive accuracy of combined genetic and environmental risk scores.
Dudbridge Frank et al. Genetic epidemiology 2017 Nov (Posted: Dec 01, 2017 10AM)

Editorial: Emergence of Gene-Environment Interaction Analysis in Epidemiologic Research —Í
MJ Khoury, Am J Epi, Sep 2017 (Posted: Sep 20, 2017 6PM)

A combination test for detection of gene-environment interaction in cohort studies.
Coombes Brandon et al. Genetic epidemiology 2017 Jul (5) 396-412 (Posted: Jul 08, 2017 7PM)

Gene-Environment Interactions-What Can These Tell Us about the Relationship between Asthma and Allergy?
Turner Steve et al. Frontiers in pediatrics 2017 118 (Posted: Jul 08, 2017 7PM)

Vulnerability or Sensitivity to the Environment? Methodological Issues, Trends, and Recommendations in Gene-Environment Interactions Research in Human Behavior.
Leighton Caroline et al. Frontiers in psychiatry 2017 106 (Posted: Jul 08, 2017 7PM)

Evaluating a Gene-Environment Interaction in Amyotrophic Lateral Sclerosis: Methylmercury Exposure and Mutated SOD1.
Bailey Jordan M et al. Current environmental health reports 2017 Jun (2) 200-207 (Posted: May 30, 2017 7AM)

Things genes can’t do
A Buchanan, Aeon Magazine, 2017 (Posted: May 12, 2017 8AM)

Gene and environment interaction: Is the differential susceptibility hypothesis relevant for obesity?
Dalle Molle Roberta et al. Neuroscience and biobehavioral reviews 2017 Feb 326-339 (Posted: May 12, 2017 8AM)

The role of gene-environment interplay in occupational and environmental diseases: current concepts and knowledge gaps.
Kwo Elizabeth et al. Current opinion in pulmonary medicine 2017 Mar (2) 173-176 (Posted: May 12, 2017 8AM)

Gene-Environment Interactions in Preventive Medicine: Current Status and Expectations for the Future.
Narimatsu Hiroto et al. International journal of molecular sciences 2017 Jan (2) (Posted: May 12, 2017 8AM)

A Review of the Genetics of Hypertension with a Focus on Gene-Environment Interactions.
Waken R J et al. Current hypertension reports 2017 Mar (3) 23 (Posted: May 12, 2017 8AM)

Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer
J Gong et al, PLOS Genetics, October 2016 (Posted: Oct 12, 2016 9AM)

The importance of gene-environment interactions in human obesity.
Reddon Hudson et al. Clinical science (London, England : 1979) 2016 Sep (18) 1571-97 (Posted: Oct 08, 2016 9AM)

Gene-environment interplay
J Berg, Science, October 7, 2016 (Posted: Oct 08, 2016 9AM)

Review of the Gene-Environment Interaction Literature in Cancer: What Do We Know?
Simonds Naoko I et al. Genetic epidemiology 2016 Jul (5) 356-65 (Posted: Jun 20, 2016 5PM)

Gene/environment interactions in the pathogenesis of autoimmunity: new insights on the role of Toll-like receptors.
Gianchecchi Elena et al. Autoimmunity reviews 2015 Nov (11) 971-83 (Posted: Feb 12, 2016 9AM)

Gene-environment interactions in psychopathology throughout early childhood: a systematic review.
Pinto Raquel Q et al. Psychiatric genetics 2015 Dec (6) 223-33 (Posted: Feb 12, 2016 9AM)

Gene × Environment Determinants of Stress- and Anxiety-Related Disorders.
Sharma Sumeet et al. Annual review of psychology 2016 Jan 239-61 (Posted: Feb 12, 2016 9AM)

Geography, Genetics and Leading Causes of Death
CDC Blog Post Brand (Posted: Feb 12, 2016 9AM)

Understanding Genetic and Environmental Causes of Human Disease
Shall we have pie or stew? CDC Blog Post Brand (Posted: Feb 12, 2016 9AM)

G = E: What GWAS Can Tell Us about the Environment
SH Gage et al, PLOS Genetics, February 11, 2016 (Posted: Feb 12, 2016 9AM)

Candidate gene-environment interaction research: reflections and recommendations.
Dick Danielle M et al. Perspectives on psychological science : a journal of the Association for Psychological Science 2015 Jan 10(1) 37-59 (Posted: Oct 22, 2015 10AM)

Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study.
Nalls Mike A et al. Lancet Neurol 2015 Aug 10. (Posted: Aug 19, 2015 0PM)

Gene-environment interaction involving recently identified colorectal cancer susceptibility Loci.
Kantor Elizabeth D et al. Cancer Epidemiol. Biomarkers Prev. 2014 Sep (9) 1824-33 (Posted: Mar 24, 2015 10AM)

Effect of occupational exposures on lung cancer susceptibility: a study of gene-environment interaction analysis.
Malhotra Jyoti et al. Cancer Epidemiol. Biomarkers Prev. 2015 Mar (3) 570-9 (Posted: Mar 15, 2015 1PM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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