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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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42 hot topic(s) found with the query "E. coli"

A one-year genomic investigation of Escherichia coli epidemiology and nosocomial spread at a large US healthcare network
EG Mills et al, Genome Medicine, December 30, 2022 (Posted: Dec 31, 2022 7AM)

Whole-genome sequencing (WGS), phylogenetic analysis, and antibiotic susceptibility testing were performed for a complete set of 2075 E. coli clinical isolates collected from 1776 patients at a large tertiary healthcare network in the USA between October 2019 and September 2020. The study provides a rare and contemporary survey on the epidemiology and spread of E. coli in a large US healthcare network. While surveillance and infection control efforts often focus on ESBL and MDR lineages, our findings reveal that non-MDR isolates represent a large burden of infections, including those of predicted nosocomial origins.

Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination.
de Koff Emma M et al. Nature communications 2022 11 (1) 6638 (Posted: Nov 16, 2022 8AM)

We assess the association between mode of delivery, gut microbiota development in the first year of life, and mucosal antigen-specific antibody responses against pneumococcal vaccination in 101 infants at age 12 months and against meningococcal vaccination in 66 infants at age 18 months. Birth by vaginal delivery is associated with higher antibody responses against both vaccines. Relative abundances of vaginal birth-associated Bifidobacterium and Escherichia coli in the first weeks of life are positively associated with anti-pneumococcal antibody responses, and relative abundance of E. coli in the same period is also positively associated with anti-meningococcal antibody responses.

Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning
C Weiss et al, Nature Medicine, January 10, 2022 (Posted: Jan 11, 2022 8AM)

This dataset combines more than 300,000 mass spectra with more than 750,000 antimicrobial resistance phenotypes from four medical institutions. Validation on a panel of clinically important pathogens, including Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae, resulting in areas under the receiver operating characteristic curve of 0.80, 0.74 and 0.74, respectively, demonstrated the potential of using machine learning to substantially accelerate antimicrobial resistance determination and change of clinical management.

Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant.
DeFilipp Zachariah et al. The New England journal of medicine 2019 Nov (21) 2043-2050 (Posted: Nov 21, 2019 7AM)

We describe two patients in whom extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor by means of genomic sequencing.

Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant
Z DeFilip et al, NEJM, October 30, 2019 (Posted: Oct 31, 2019 0PM)

A Population-Based Surveillance Study of Shared Genotypes of Escherichia coli Isolates from Retail Meat and Suspected Cases of Urinary Tract Infections.
Yamaji Reina et al. mSphere 2018 08 (4) (Posted: Sep 01, 2018 6PM)

Shiga Toxin-Producing E. coli & Food Safety
Outbreak Alert Brand (Posted: Apr 17, 2018 6PM)

Shiga Toxin-Producing E. coli Infections Associated with Flour.
Crowe Samuel J et al. The New England journal of medicine 2017 Nov (21) 2036-2043 (Posted: Nov 25, 2017 11AM)

Shiga Toxin–Producing E. coli Infections Associated with Flour
S Crowe et al, NEJM, Nov 22, 2017 (Posted: Nov 22, 2017 10PM)

Longitudinal genomic surveillance of multidrug-resistant Escherichia coli carriage in a long-term care facility in the United Kingdom
HJ Broderick et al, Genome Medicine, July 25, 2017 (Posted: Aug 02, 2017 0PM)

The Genetics of Enteropathogenic Escherichia coli Virulence.
Pearson Jaclyn S et al. Annual review of genetics 2016 Nov 493-513 (Posted: Jun 12, 2017 9AM)

Investigation of Escherichia coli Harboring the mcr-1 Resistance Gene — Connecticut, 2016
MMWR, September 9, 2016 (Posted: Sep 09, 2016 5PM)

Whole Genome Sequencing for Genomics-Guided Investigations of Escherichia coli O157:H7 Outbreaks.
Rusconi Brigida et al. Frontiers in microbiology 2016 985 (Posted: Sep 05, 2016 7PM)

Discovery of first mcr-1 gene in E. coli bacteria found in a human in United States
MCR-1 causes resistance to colistin, a last-resort drug for treating resistant infections Brand (Posted: Jun 01, 2016 7PM)

Multistate Outbreaks of Shiga toxin-producing Escherichia coli O26 Infections Linked to Chipotle Mexican Grill Restaurants
Brand (Posted: Jan 27, 2016 0PM)

Multistate Outbreak of Shiga toxin-producing Escherichia coli O157:H7
Brand (Posted: Dec 04, 2015 0PM)

Prevalence of Mycobacterium avium subsp. paratuberculosis and Escherichia coli in blood samples from patients with inflammatory bowel disease.
Nazareth Nair et al. Medical microbiology and immunology 2015 Dec (6) 681-92 (Posted: Nov 05, 2015 4PM)

Rapid and Easy In Silico Serotyping of Escherichia coli Isolates by Use of Whole-Genome Sequencing Data.
Joensen Katrine G et al. J. Clin. Microbiol. 2015 Aug (8) 2410-26 (Posted: Aug 20, 2015 2PM)

Bacterial Factors Associated with Lethal Outcome of Enteropathogenic Escherichia coli Infection: Genomic Case-Control Studies.
Donnenberg Michael S et al. PLoS Negl Trop Dis 2015 May 9(5) e0003791 (Posted: Jul 01, 2015 2PM)

Impact of virulence genes on sepsis severity and survival in Escherichia coli bacteremia.
Mora-Rillo Marta et al. Virulence 2015 (1) 93-100 (Posted: May 14, 2015 7AM)

EcoliNet: a database of cofunctional gene network for Escherichia coli.
Kim Hanhae et al. Database (Oxford) 2015 (Posted: Apr 24, 2015 10AM)

Genomic analysis and clinical importance of Escherichia coli isolate from patients with sepsis.
Chakraborty Arindam et al. Indian J Pathol Microbiol 2015 Jan-Mar (1) 22-6 (Posted: Apr 24, 2015 10AM)

Insight into Shiga toxin genes encoded by Escherichia coli O157 from whole genome sequencing.
Ashton Philip M et al. PeerJ 2015 e739 (Posted: Apr 24, 2015 10AM)

Interactions between genotype and environment drive the metabolic phenotype within Escherichia coli isolates.
Sabarly Victor et al. Environ. Microbiol. 2015 Mar 25. (Posted: Apr 24, 2015 10AM)

Complete Genome Sequences of Escherichia coli Strains 1303 and ECC-1470 Isolated from Bovine Mastitis.
Leimbach Andreas et al. Genome Announc 2015 (2) (Posted: Apr 24, 2015 10AM)

Comparison of whole genome sequences from human and non-human Escherichia coli O26 strains.
Norman Keri N et al. Front Cell Infect Microbiol 2015 21 (Posted: Apr 24, 2015 10AM)

Clinical epidemiology and molecular analysis of extended-spectrum ß-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types ST131 and ST648.
Sherchan Jatan Bahadur et al. Antimicrob. Agents Chemother. 2015 Mar 30. (Posted: Apr 24, 2015 10AM)

Comparative Genomic Analysis of Two Novel Sporadic Shiga Toxin-Producing Escherichia coli O104:H4 Strains Isolated 2011 in Germany.
Tietze Erhard et al. PLoS ONE 2015 (4) e0122074 (Posted: Apr 24, 2015 10AM)

Draft Genome Sequence of Enterotoxigenic Escherichia coli Strain E24377A, Obtained from a Tribal Drinking Water Source in India.
Tamhankar Ashok J et al. Genome Announc 2015 (2) (Posted: Apr 24, 2015 10AM)

Public health investigation of two outbreaks of Shiga toxin-producing Escherichia coli O157 associated with consumption of watercress.
Jenkins Claire et al. Appl. Environ. Microbiol. 2015 Apr 3. (Posted: Apr 24, 2015 10AM)

Draft Genome Sequence of NDM-5-Producing Escherichia coli Sequence Type 648 and Genetic Context of blaNDM-5 in Australia.
Wailan Alexander M et al. Genome Announc 2015 (2) (Posted: Apr 24, 2015 10AM)

Genome Sequences of Two Bovine Mastitis-Causing Escherichia coli Strains.
Kempf Florent et al. Genome Announc 2015 (2) (Posted: Apr 24, 2015 10AM)

Complete Genome Sequence of a Carbapenem-Resistant Extraintestinal Pathogenic Escherichia coli Strain Belonging to the Sequence Type 131 H30R Subclade.
Johnson Timothy J et al. Genome Announc 2015 (2) (Posted: Apr 24, 2015 10AM)

GeneSippr: A Rapid Whole-Genome Approach for the Identification and Characterization of Foodborne Pathogens such as Priority Shiga Toxigenic Escherichia coli.
Lambert Dominic et al. PLoS ONE 2015 (4) e0122928 (Posted: Apr 24, 2015 10AM)

Genome sequencing and comparative genomics provides insights on the evolutionary dynamics and pathogenic potential of different H-serotypes of Shiga toxin-producing Escherichia coli O104.
Yan Xianghe et al. BMC Microbiol. 2015 (1) 83 (Posted: Apr 24, 2015 10AM)

Analysis of whole genome sequencing for the Escherichia coli O157:H7 typing phages.
Cowley Lauren A et al. BMC Genomics 2015 Apr 8. (1) 271 (Posted: Apr 24, 2015 10AM)

Comparative genomic analysis of a multiple antimicrobial resistant enterotoxigenic E. coli O157 lineage from Australian pigs.
Wyrsch Ethan et al. BMC Genomics 2015 165 (Posted: Apr 24, 2015 10AM)

Insights from 20 years of bacterial genome sequencing.
Land Miriam et al. Funct. Integr. Genomics 2015 Mar (2) 141-61 (Posted: Apr 24, 2015 10AM)

The utility and public health implications of PCR and whole genome sequencing for the detection and investigation of an outbreak of Shiga toxin-producing Escherichia coli serogroup O26:H11.
Dallman T J et al. Epidemiol. Infect. 2014 Oct 15. 1-9 (Posted: Apr 24, 2015 10AM)

Whole Genome Sequencing for National Surveillance of Shiga Toxin Producing Escherichia coli O157.
Dallman Timothy J et al. Clin. Infect. Dis. 2015 Apr 17. (Posted: Apr 24, 2015 10AM)

CDC Information: E.coli (Escherichia coli)
Although most strains of E. coli are harmless, others can make you sick. Some kinds of E. coli can cause diarrhea, while others cause urinary tract infections, respiratory illness and pneumonia, and other illnesses Brand (Posted: Feb 25, 2015 0PM)

E. coli
Brand (Posted: Jan 11, 2014 11AM)

Escherichia coli (E. coli) bacteria live in the intestines of people and animals, and are key to a healthy intestinal tract. Most E. coli strains are harmless, but some can cause diarrhea through contact with contaminated food or water while other strains can cause urinary tract infections, respiratory illness and pneumonia.

Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.