Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP3A4 and CYP1A2 and antipsychotics
L Beunk et al, EJHG, March 31, 2023 (Posted: Mar-31-2023 7AM)
Digital cognitive behavioral therapy for insomnia on depression and anxiety: a systematic review and meta-analysis
S Lee et al, NPJ Digital Medicine, March 25, 2023 (Posted: Mar-25-2023 8AM)
Pharmacogenetics in the Treatment of Huntington’s Disease: Review and Future Perspectives
XG Gonzalez et al, J Pers Med, February 22, 2023 (Posted: Feb-22-2023 6AM)
Systematic review of economic evaluations for internet- and mobile-based interventions for mental health problems
F Kahlke et al, NPJ Digital Medicine, November 2022 (Posted: Nov-28-2022 11AM)
Parental Depression and Anxiety Associated with Newborn Bloodspot Screening for Rare and Variable-Onset Disorders
NB Boychuk et al, IJNS, November 10, 2022 (Posted: Nov-11-2022 6AM)
Clinical utility of pharmacogenetics in a psychiatric and primary care population
KN Bohlen et al, The PGX Journal, October 27, 2022 (Posted: Oct-27-2022 9AM)
Meta-analysis of pharmacogenetic clinical decision support systems for the treatment of major depressive disorder
V Skryabin et al, The PGX journal, October 22, 2022 (Posted: Oct-24-2022 10AM)
Fitbit step counts clarify the association between activity and chronic disease risk
Nature Medicine, October 11, 2022 (Posted: Oct-12-2022 8AM)
Genome-by-Trauma Exposure Interactions in Adults With Depression in the UK Biobank.
Chuong Melisa et al. JAMA psychiatry 2022 9 (Posted: Sep-30-2022 7AM)
A systematic review of digital and face-to-face cognitive behavioral therapy for depression
NPJ Digital Medicine, September 15, 2022 (Posted: Sep-15-2022 7AM)
Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning: Dementia Praecox Revisited.
Koutsouleris Nikolaos et al. JAMA psychiatry 2022 8 (Posted: Aug-05-2022 8AM)
Association of Everyday Discrimination With Depressive Symptoms and Suicidal Ideation During the COVID-19 Pandemic in the All of Us Research Program
YH Lee et al, JAMA Psychiatry, July 27, 2022 (Posted: Jul-27-2022 2PM)
Incorporating family history of disease improves polygenic risk scores in diverse populations
MLA Hujeol et al, Cell Genomics, July 13, 2022 (Posted: Jul-14-2022 7AM)
Association of Molecular Senescence Markers in Late-Life Depression With Clinical Characteristics and Treatment Outcome.
Diniz Breno S et al. JAMA network open 2022 6 (6) e2219678 (Posted: Jul-01-2022 8AM)
Mendelian randomization analysis for attention deficit/hyperactivity disorder: studying a broad range of exposures and outcomes.
Soler Artigas María et al. International journal of epidemiology 2022 6 (Posted: Jun-18-2022 10AM)
Effects of social support on depression risk during the COVID-19 pandemic: What support types and for whom?
KW Choi et al, MEDRXIV, May 16, 2022 (Posted: Jun-15-2022 9AM)
Machine learning of language use on Twitter reveals weak and non-specific predictions
SW Kelley et al, NPJ Digital Medicine, March 25, 2022 (Posted: Mar-26-2022 3PM)
Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression
J Wen et al, JAMA Psychiatry, March 9, 2022 (Posted: Mar-09-2022 11AM)
Impact of CYP2C19 metaboliser status on SSRI response: a retrospective study of 9500 participants of the Australian Genetics of Depression Study
AI Campos et al, The PGX journal, January 29, 2022 (Posted: Jan-31-2022 9AM)
Digital health tools for the passive monitoring of depression: a systematic review of methods
V de Angel et al, NPJ Digital Medicine, January 10, 2022 (Posted: Jan-11-2022 8AM)
Association between maternal depression during pregnancy and newborn DNA methylation
E Drzymalla et al, Trans Psychiatry, November 9, 2021 (Posted: Nov-10-2021 9AM)
Evidence Used to Update the List of Underlying Medical Conditions Associated with Higher Risk for Severe COVID-19
CDC Science Brief, October 14, 2021 (Posted: Oct-16-2021 8AM)
Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis.
Nikolova Viktoriya L et al. JAMA psychiatry 2021 9 (Posted: Sep-18-2021 11AM)
What is pharmacogenomics?
CB de Villiers, PHG Foundation, August 2021 (Posted: Aug-26-2021 7AM)
Health Equity for People with Disabilities
CDC, July 2021 (Posted: Jul-08-2021 8AM)
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
N Mullins et al, Nature Genetics, May 17, 2021 (Posted: May-18-2021 8AM)
Symptom-level modelling unravels the shared genetic architecture of anxiety and depression
JG Thorp et al, Nature Human Behavior, April 15, 2021 (Posted: Apr-19-2021 10AM)
Pharmacogenomics guided versus standard antidepressant treatment in a community pharmacy setting: A randomized controlled trial.
Papastergiou John et al. Clinical and translational science 2021 (Posted: Mar-05-2021 9AM)
A machine learning approach predicts future risk to suicidal ideation from social media data.
Roy Arunima et al. NPJ digital medicine 2020 May 3(1) 78 (Posted: Feb-23-2021 9AM)
Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status.
Agerbo Esben et al. JAMA psychiatry 2021 Jan (Posted: Jan-14-2021 9AM)
Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders
A Multivariable Mendelian Randomization Analysis
DB Rosoff et al, JAMA Psychiatry, November 11, 2020 (Posted: Nov-11-2020 11AM)
Associations between the 1438A/G, 102T/C, and rs7997012G/A polymorphisms of HTR2A and the safety and efficacy of antidepressants in depression: a meta-analysis
YS Wan et al, The Pharmacogenomics Journal, October 23, 2020 (Posted: Oct-24-2020 10AM)
Alexa, do I have COVID-19?
E AnNthes, Nature News, September 30, 2020 (Posted: Oct-02-2020 9AM)
The association of alcohol polygenic risk scores with mental health outcomes: A multi-generational analysis in the Avon Longitudinal Study of Parents and Children
KE Easey et al, MEDRXIV, July 7, 2020 (Posted: Jul-08-2020 6AM)
Monitoring Depression Trend on Twitter during the COVID-19 Pandemic
Y Zhang et al, ARXIV, July 1, 2020 (Posted: Jul-02-2020 9AM)
Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals
WA Akingbuwa et al, JAMA Psychiatry, July 1, 2020 (Posted: Jul-02-2020 8AM)
Grant Report on SCH: Personalized Depression Treatment Supported by Mobile Sensor Analytics.
Kamath Jayesh et al. Journal of psychiatry and brain science 2020 5 (Posted: Jun-16-2020 3PM)
A pragmatic randomized waitlist-controlled effectiveness and cost-effectiveness trial of digital interventions for depression and anxiety
D Richards et al, NPJ Digital Medicine, June 15, 2020 (Posted: Jun-16-2020 9AM)
Our phones can now detect health problems from Parkinson’s to depression. Is that a good thing?
L Parshley, VOX, February 2020 (Posted: Feb-21-2020 9AM)
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
F Till et al, Molecular Psychiatry, November 11, 2019 (Posted: Nov-12-2019 8AM)
Does preventive oophorectomy increase the risk of depression in BRCA mutation carriers?
Kotsopoulos Joanne et al. Menopause (New York, N.Y.) 2019 Oct (Posted: Oct-30-2019 8AM)
A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping
C Fabri et al, MedRXIV, September 20, 2019 (Posted: Sep-20-2019 9AM)
Powering discovery in blood disorders and depression
A Cranage, Sanger Institute, September 2019 (Posted: Sep-16-2019 8AM)
A two-stage approach to identifying and validating modifiable factors for the prevention of depression
KW Choi et al, BioRXIV preprints, September 8, 2019 (Posted: Sep-10-2019 9AM)
Can Machine Learning help us in dealing with treatment resistant depression? A review.
Pigoni Alessandro et al. Journal of affective disorders 2019 Aug 25921-26 (Posted: Aug-27-2019 7PM)
Using Electronic Health Records and Machine Learning to Predict Postpartum Depression.
Wang Shuojia et al. Studies in health technology and informatics 2019 Aug 264888-892 (Posted: Aug-27-2019 6PM)
Robin Williams' Son Zak Says He Struggled with Depression: 'I Found Myself Self-Medicating'
H Murphy, People, August 20, 2019 (Posted: Aug-21-2019 8AM)
UnitedHealthcare To Cover Genetic Testing for Precision Medicine in Depression, Anxiety
Clinical Omics, August 2, 2019 (Posted: Aug-05-2019 8AM)
Blood samples reveal valuable data and life-changing surprises for donors
PD McCluskey, Boston Globe, July 5, 2019 (Posted: Jul-09-2019 10AM)
Causal associations between potentially modifiable risk factors and the Alzheimer's phenome: A Mendelian randomization study
SJ Andrews et al, BioRXIV preprints, July 2 , 2019 (Posted: Jul-03-2019 8AM)
Genetic and Environmental Risk Factors Associated With Trajectories of Depression Symptoms From Adolescence to Young Adulthood
ASF Kwong et al, JAMA Network Open, June 28, 2019 (Posted: Jun-28-2019 11AM)
How Artificial Intelligence Can Save Your Life
D Brooks, NY Times, June 24, 2019 (Posted: Jun-25-2019 9AM)
A Waste of 1,000 Research Papers
Decades of early research on the genetics of depression were built on non-existent foundations. How did that happen?
E Yong, The Atlantic, May 17, 2019 (Posted: May-17-2019 11AM)
Anxiety and depression in children: Get the facts
CDC, 2019 (Posted: May-14-2019 7AM)
Association of Rare Copy Number Variants With Risk of Depression
KM Kendal et al. JAMA Psychiatry, April 17, 2019 (Posted: Apr-17-2019 1PM)
Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort.
Khandaker Golam M et al. Molecular psychiatry 2019 Mar (Posted: Mar-21-2019 8AM)
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples.
Border Richard et al. The American journal of psychiatry 2019 Mar appiajp201818070881 (Posted: Mar-14-2019 8AM)
Insomnia tied to depression, cardiovascular disease
M Prize, Science, February 25, 2019 (Posted: Feb-25-2019 1PM)
Exercise May Help to Fend Off Depression
G Reynolds, NY Times, February 13, 2019 (Posted: Feb-20-2019 9AM)
Genetics of Depression Linked with Hundreds of Genes and Different Behavioral Traits
Gen News, February 6, 2019 (Posted: Feb-06-2019 10AM)
Investigating the Association Between Body Fat and Depression via Mendelian Randomization
M Speed et al, BioRXIV, February 3, 2019 (Posted: Feb-05-2019 2PM)
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
DM Howard et al, Nature Neurology, February 4, 2019 (Posted: Feb-04-2019 0PM)
Links between gut microbes and depression strengthened- The once-wild idea that intestinal bacteria influence mental health has transformed into a major research pursuit
Nature editorial, February 4, 2019 (Posted: Feb-04-2019 11AM)
Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-Sample Mendelian Randomization Study.
Choi Karmel W et al. JAMA psychiatry 2019 Jan (Posted: Jan-25-2019 10AM)
A Mendelian Randomization Approach for Assessing the Relationship Between Physical Activity and Depression.
Chekroud Adam Mourad et al. JAMA psychiatry 2019 Jan (Posted: Jan-25-2019 10AM)
An economic model of the cost-utility of pre-emptive genetic testing to support pharmacotherapy in patients with major depression in primary care.
Sluiter Reinier L et al. The pharmacogenomics journal 2019 Jan (Posted: Jan-23-2019 1PM)
Genetic associations with suicide attempt severity and genetic overlap with major depression.
Levey Daniel F et al. Translational psychiatry 2019 Jan (1) 22 (Posted: Jan-19-2019 7AM)
Huge trove of British biodata is unlocking secrets of depression, sexual orientation, and more
J Kaiser et al, Science, January 3, 2019 (Posted: Jan-04-2019 9AM)
Does obtaining CYP2D6 and CYP2C19 pharmacogenetic testing predict antidepressant response or adverse drug reactions?
Solomon Haley V et al. Psychiatry research 2018 Dec 271604-613 (Posted: Dec-19-2018 10AM)
Pharmacogenetic tests and depressive symptom remission: a meta-analysis of randomized controlled trials.
Bousman Chad A et al. Pharmacogenomics 2019 Jan 20(1) 37-47 (Posted: Dec-12-2018 10AM)
Pharmacogenomics and Biomarkers of Depression.
Jha Manish K et al. Handbook of experimental pharmacology 2018 Oct (Posted: Oct-24-2018 9AM)
Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals
DM Howard et al, BioRXIV, October 9, 2018 (Posted: Oct-11-2018 7AM)
In the race to use genetic tests to predict whether antidepressants will work, science might be getting left behind
R Robbins, StatNews, September 28, 2018 (Posted: Sep-29-2018 0PM)
Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores
N Mullins et al, BioRXIV Preprints, September 2018 (Posted: Sep-16-2018 2PM)
Does education protect against depression? Evidence from the Young Finns Study using Mendelian randomization.
Viinikainen Jutta et al. Preventive medicine 2018 Aug (Posted: Aug-28-2018 9AM)
DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies.
Story Jovanova Olivera et al. JAMA psychiatry 2018 Jul (Posted: Jul-17-2018 8AM)
New Genetic Links to Depression May Pave the Way for Novel Treatment Strategies
T Hampton, JAMA, July 3, 2018 (Posted: Jul-07-2018 5PM)
Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies.
Köhler Cristiano A et al. Journal of psychiatric research 2018 May 189-207 (Posted: Jun-12-2018 10AM)
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Wray Naomi R et al. Nature genetics 2018 Apr (Posted: May-01-2018 10AM)
Huge haul of depression genes shows its a complex condition
New Scientist, Apr 27, 2018 (Posted: Apr-28-2018 1PM)
The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: A systematic review.
Mistry Sumit et al. Journal of affective disorders 2018 Feb 148-155 (Posted: Apr-01-2018 0PM)
What do the genetic association data say about the high risk of suicide in people with depression? A novel network-based approach to find common molecular basis for depression and suicidal behavior and related therapeutic targets.
Bozorgmehr Ali et al. Journal of affective disorders 2018 Jan 463-468 (Posted: Jan-23-2018 0PM)
Genetic biomarkers for differential diagnosis of major depressive disorder and bipolar disorder: a systematic and critical review.
Menezes Itiana Castro et al. Behavioural brain research 2018 Jan (Posted: Jan-23-2018 0PM)
Battling depression with pharmacogenetics: Genetic screening could eliminate trial-and-error approach to medications
R Lewis, Genetic Literacy Project, Jan 23, 2018 (Posted: Jan-23-2018 0PM)
Translating GWAS Findings Into Therapies For Depression And Anxiety Disorders: Drug Repositioning Using Gene-Set Analyses Reveals Enrichment Of Psychiatric Drug Classes
BioRxiV, Sep 8,, 2017 (Posted: Sep-09-2017 0PM)
Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.
Andersen Allan M et al. JAMA psychiatry 2017 Aug (Posted: Aug-21-2017 11AM)
Genetics of Depression: Progress at Last.
Mullins Niamh et al. Current psychiatry reports 2017 Aug (8) 43 (Posted: Aug-11-2017 1PM)
Risk factors include family history of suicide (Posted: Aug-11-2017 1PM)
Genomewide association study identifies 30 loci associated with bipolar disorder
E Stahl et al, BioRxIV, AUgust 2017 (Posted: Aug-11-2017 1PM)
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
N Wray et al, BioRXiV, July 2017 (Posted: Jul-24-2017 11AM)
The Stratification Of Major Depressive Disorder Into Genetic Subgroups
DM Howard et al, BioXRIV, May 2017 (Posted: May-05-2017 6PM)
Translating GWAS Findings Into Therapies For Depression And Anxiety Disorders: Drug Repositioning Using Gene-Set Analyses And Testing For Enrichment Of Psychiatric Drug Classes
HC So, BioXRIV, May 2017 (Posted: May-03-2017 6PM)
Finding the Genes of Depression
F Addison, Front Line Genomics, April 2017, (Posted: Apr-06-2017 8AM)
Systematic review and meta-analysis of genetic studies of late-life depression.
Tsang Ruby S M et al. Neuroscience and biobehavioral reviews 2017 Apr 129-139 (Posted: Apr-05-2017 11AM)
Pharmacogenomic aspects of bipolar disorder: An update.
Budde M et al. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2017 Mar (Posted: Apr-05-2017 11AM)
Does Pharmacogenomic Testing Improve Clinical Outcomes for Major Depressive Disorder? A Systematic Review of Clinical Trials and Cost-Effectiveness Studies.
Rosenblat Joshua D et al. The Journal of clinical psychiatry 2017 Jan (Posted: Jan-11-2017 9AM)
Family history and perceived risk of diabetes, cardiovascular disease, cancer and depression.
Vornanen Marleena et al. Preventive medicine 2016 Jun (Posted: Jul-06-2016 10AM)
Can a Genetic Test Determine the Best Medications for My Son?
Dear Jeannie, NSGC blog post, June 2016 (Posted: Jun-15-2016 7AM)
Implementing Recommendations for Depression Screening of Adults
HS Mayberg, JAMA Neurology, January 26, 2016 (Posted: Jan-27-2016 1PM)
Depression: what you need to know
Many factors may play a role in depression, including genetics, brain biology and chemistry, and life events, NIMH Web Page (Posted: Jan-27-2016 9AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2023
- Page last updated:Mar 31, 2023
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