"Phylogenetic-epidemiological analysis enabled the reconstruction of superspreading events and charts a map of tourism-related viral spread originating from Austria in spring 2020.... Time-resolved virus sequencing unveiled viral mutation dynamics within individuals with COVID-19, and epidemiologically validated infector-infectee pairs enabled us to determine an average transmission bottleneck size of 103 SARS-CoV-2 particles. In conclusion, this study illustrates the power of combining epidemiological analysis with deep viral genome sequencing to unravel the spread of SARS-CoV-2, and to gain fundamental insights into mutational dynamics and transmission properties."

The COVID-19 genetic risk variant rs657152-A at the ABO locus is strongly associated with increased levels of the CD209 antigen. This dendritic cell-surface protein has been found to facilitate infection by SARS-CoV-2 and other viruses.

Recently, two families in which COVID-19 segregates like an X-linked recessive monogenic disorder have been reported leading to identification of variants in TLR7. We sought to determine whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients. In 1178 SARS-CoV-2-infected subjects (<60y, 79 severe cases versus 77 control cases). Missense mutations in TLR7 disorder may contribute to disease susceptibility in up to 4% of severe COVID-19.

Among 515 individuals with Covid-19 we found that CH was associated with severe Covid-19 outcomes (OR=1.9, 95%=1.2-2.9, p=0.01). We further explored the relationship between CH and risk of other infections in 14,211 solid tumor patients at MSK. CH was significantly associated with risk of Clostridium Difficile and Streptococcus/Enterococcus infections. These findings suggest a relationship between CH and risk of severe infections that warrants further investigation.

A recent article presents an apt case study on the role of virus genomics in epidemiology and clinical practice. The D614G substitution is one example of how SARS-CoV-2 is evolving. Continuing to use whole genome sequencing as an epidemiological tool will facilitate the rapid detection and monitoring of new SARS-CoV-2 variants when they emerge.

"Phylogenetic-epidemiological analysis enabled the reconstruction of superspreading events and charts a map of tourism-related viral spread originating from Austria in spring 2020.... Time-resolved virus sequencing unveiled viral mutation dynamics within individuals with COVID-19, and epidemiologically validated infector-infectee pairs enabled us to determine an average transmission bottleneck size of 103 SARS-CoV-2 particles. In conclusion, this study illustrates the power of combining epidemiological analysis with deep viral genome sequencing to unravel the spread of SARS-CoV-2, and to gain fundamental insights into mutational dynamics and transmission properties."

The COVID-19 genetic risk variant rs657152-A at the ABO locus is strongly associated with increased levels of the CD209 antigen. This dendritic cell-surface protein has been found to facilitate infection by SARS-CoV-2 and other viruses.

Recently, two families in which COVID-19 segregates like an X-linked recessive monogenic disorder have been reported leading to identification of variants in TLR7. We sought to determine whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients. In 1178 SARS-CoV-2-infected subjects (<60y, 79 severe cases versus 77 control cases). Missense mutations in TLR7 disorder may contribute to disease susceptibility in up to 4% of severe COVID-19.

Among 515 individuals with Covid-19 we found that CH was associated with severe Covid-19 outcomes (OR=1.9, 95%=1.2-2.9, p=0.01). We further explored the relationship between CH and risk of other infections in 14,211 solid tumor patients at MSK. CH was significantly associated with risk of Clostridium Difficile and Streptococcus/Enterococcus infections. These findings suggest a relationship between CH and risk of severe infections that warrants further investigation.

A recent article presents an apt case study on the role of virus genomics in epidemiology and clinical practice. The D614G substitution is one example of how SARS-CoV-2 is evolving. Continuing to use whole genome sequencing as an epidemiological tool will facilitate the rapid detection and monitoring of new SARS-CoV-2 variants when they emerge.

"Phylogenetic-epidemiological analysis enabled the reconstruction of superspreading events and charts a map of tourism-related viral spread originating from Austria in spring 2020.... Time-resolved virus sequencing unveiled viral mutation dynamics within individuals with COVID-19, and epidemiologically validated infector-infectee pairs enabled us to determine an average transmission bottleneck size of 103 SARS-CoV-2 particles. In conclusion, this study illustrates the power of combining epidemiological analysis with deep viral genome sequencing to unravel the spread of SARS-CoV-2, and to gain fundamental insights into mutational dynamics and transmission properties."

The COVID-19 genetic risk variant rs657152-A at the ABO locus is strongly associated with increased levels of the CD209 antigen. This dendritic cell-surface protein has been found to facilitate infection by SARS-CoV-2 and other viruses.

Recently, two families in which COVID-19 segregates like an X-linked recessive monogenic disorder have been reported leading to identification of variants in TLR7. We sought to determine whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients. In 1178 SARS-CoV-2-infected subjects (<60y, 79 severe cases versus 77 control cases). Missense mutations in TLR7 disorder may contribute to disease susceptibility in up to 4% of severe COVID-19.

Among 515 individuals with Covid-19 we found that CH was associated with severe Covid-19 outcomes (OR=1.9, 95%=1.2-2.9, p=0.01). We further explored the relationship between CH and risk of other infections in 14,211 solid tumor patients at MSK. CH was significantly associated with risk of Clostridium Difficile and Streptococcus/Enterococcus infections. These findings suggest a relationship between CH and risk of severe infections that warrants further investigation.

A recent article presents an apt case study on the role of virus genomics in epidemiology and clinical practice. The D614G substitution is one example of how SARS-CoV-2 is evolving. Continuing to use whole genome sequencing as an epidemiological tool will facilitate the rapid detection and monitoring of new SARS-CoV-2 variants when they emerge.