Effective August 1, 2024, this database was discontinued. All content will remain searchable and be preserved online for historical purposes only until 2029.
Sickle Cell Disease
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Last Posted: Jul 18, 2024
- A roadmap for affordable genetic medicines
- Exagamglogene Autotemcel for Severe Sickle Cell Disease
- Impact of Race, Socioeconomic Status, and Geography on Healthcare Outcomes for Children With Sickle Cell Disease in the United States: A Scoping Review
- Birth Prevalence of Sickle Cell Disease and County-Level Social Vulnerability - Sickle Cell Data Collection Program, 11 States, 2016-2020.
Mariam Kayle et al. MMWR Morb Mortal Wkly Rep 2024 3 (12) 248-254 - Sickle Cell Disease Approvals Include First CRISPR Gene Editing Therapy
E Harris, JAMA, January 3, 2024 - Genomic medicine year in review: 2023.
Teri A Manolio et al. Am J Hum Genet 2023 12 (12) 1992-1995 - How CRISPR gene editing could help treat Alzheimer’s
T Thompson, Nature, December 11, 2023 - CRISPR 2.0: a new wave of gene editors heads for clinical trials Landmark approval of the first CRISPR therapy paves the way for treatments based on more efficient and more precise genome editors.
H Ledford, Nature, December 7, 2023 - In historic decision, FDA approves a CRISPR-based medicine for treatment of sickle cell disease
A Feurstein, StatNews, December 8, 2023 - UK first to approve CRISPR treatment for diseases: what you need to know
C Wong. Nature. November 16, 2023 - Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.
Justin K Kirkham et al. JAMA Netw Open 2023 10 (10) e2337484 - Pregnant and Living with Sickle Cell Disease: A Push for Better Outcomes
NIH, September 2023 - A Proclamation on National Sickle Cell Awareness Month, 2023
The White House, September 2023. - CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease.
Akshay Sharma et al. N Engl J Med 2023 8 (9) 820-832 - Genetic counseling in sickle cell disease: Insights from the Indian tribal population.
Pooja Aggarwal et al. J Community Genet 2023 8 - Spreading awareness of sickle cell trait and its possible complications A better understanding of the trait is crucial for both patients and providers
M Shaniqua, Sickle Cell New, August 2023 - Base-edited gene therapies ‘may be superior’ for sickle cell disease
Healio, July 2023 - The Importance of Patient-Doctor Relationships With Sickle Cell Disease
L Poret, WebMD, July 2023 - Sickle cell cures are coming. African children can’t be left behind
JK Iyer, Statnews, July 2023 - Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000-2021: a systematic analysis from the Global Burden of Disease Study 2021.
et al. Lancet Haematol 2023 6 - Social determinants of health: the next frontier for improving care and outcomes in sickle cell disease
JS Porter et al, Lancet Heamtology, July 2023 - Gene therapy in sickle cell disease: Attitudes and informational needs of patients and caregivers.
Akshay Sharma et al. Pediatric blood & cancer 2023 e30319 - Knowledge to date on secondary malignancy following hematopoietic cell transplantation for sickle cell disease.
Fitzhugh Courtney D et al. Hematology. American Society of Hematology. Education Program 2022 2022(1) 266-271 - Clonal hematopoiesis in sickle cell disease.
Liggett L Alexander et al. The Journal of clinical investigation 2022 - Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease.
Kanter Julie et al. The New England journal of medicine 2021 - Newborn screening for sickle cell disease in sub-Saharan Africa: Is the glass half-full yet?
Smart Luke R et al. Pediatric blood & cancer 2021 e29137 - Implementing newborn screening for sickle cell disease in Korle Bu Teaching Hospital, Accra: Results and lessons learned.
Segbefia Catherine I et al. Pediatric blood & cancer 2021 e29068 - Sickle Cell Treatment Not Linked to Cancer, Researchers Say
G Kolata, NY Times, March 10, 2021 - Gene therapy trials for sickle cell disease halted after two patients develop cancer
J Kaiser, Science, February 16, 2021 - Primary caregiver decision-making in hematopoietic cell transplantation and gene therapy for sickle cell disease.
Sinha Cynthia B et al. Pediatric blood & cancer 2020 Oct e28749 - Administrative data identify sickle cell disease: A critical review of approaches in U.S. health services research.
Grosse Scott D et al. Pediatric blood & cancer 2020 Sep e28703 - Extremely high birth prevalence of sickle cell disease in rural Tanzania.
Eastburg Luke et al. Pediatric blood & cancer 2020 Aug e28620 - Folic acid supplementation in children with sickle cell disease: study protocol for a double-blind randomized cross-over trial.
Williams Brock A et al. Trials 2020 Jun 21(1) 593 - Sickle cell disease in Germany: Early insights from a national registry.
Odame Isaac et al. Pediatric blood & cancer 2020 67(4) e28168 - Integrated psychology support and comprehensive cognitive evaluation improves access to special education services for children with sickle cell disease.
Ghafuri Djamila Labib et al. Pediatric blood & cancer 2019 66(8) e27755 - Sickle cell disease in Germany: Results from a national registry.
Kunz Joachim B et al. Pediatric blood & cancer 2019 Dec e28130 - Variation in hospital admission of sickle cell patients from the emergency department using the Pediatric Health Information System.
Jacob Seethal A et al. Pediatric blood & cancer 2019 Nov e28067 - CRISPR Approach To Fighting Cancer Called 'Promising' In 1st Safety Test
R Stein, NPR, November 6, 2019 - Vision of the Future of Medical Science
Francis Collins, Time, October 25, 2019 - Gene-Based Cures for SCD and HIV
NIH, October 23, 2019 - Scientists Create New, More Powerful Technique To Edit Genes
R Stein, NPR, October 21, 2019 - People at High Risk For Flu Complications
CDC, 2019 - Universal screening for social determinants of health in pediatric sickle cell disease: A quality-improvement initiative.
Power-Hays Alexandra et al. Pediatric blood & cancer 2019 Oct e28006 - Correlates of successful transition in young adults with sickle cell disease.
Darbari Isha et al. Pediatric blood & cancer 2019 Aug e27939 - Men and Stroke
CDC, 2019 - CRISPR enters its first human clinical trials- The gene editor targets cancer, blood disorders and blindness
T Hesman, Science News, August 14, 2019 - Sickle Cell Patient Reveals Why She Is Volunteering For Landmark Gene-Editing Study
R Stein, NPR, July 29, 2019 - Newborn screening in Nigeria: Associating the screening of congenital hypothyroidism and sickle cell disease can be a winning choice?
Yarhere Iroro Enameguolo et al. Acta bio-medica : Atenei Parmensis 2019 May 90(2) 316-320 - Sickle Cell Clinical Research and Intervention Program (SCCRIP): A lifespan cohort study for sickle cell disease progression from the pediatric stage into adulthood.
Hankins Jane S et al. Pediatric blood & cancer 2018 65(9) e27228 - Sickle cell screening in Uganda: High burden, human immunodeficiency virus comorbidity, and genetic modifiers.
Kiyaga Charles et al. Pediatric blood & cancer 2019 May e27807 - Mobile health intervention for youth with sickle cell disease: Impact on adherence, disease knowledge, and quality of life.
Anderson Lindsay M et al. Pediatric blood & cancer 2018 65(8) e27081 - Results of a multicenter universal newborn screening program for sickle cell disease in Italy: A call to action.
Colombatti Raffaella et al. Pediatric blood & cancer 2019 Feb e27657 - Cancer specific survival in patients with sickle cell disease.
Brunson Ann et al. British journal of haematology 2018 Nov - NIH launches initiative to accelerate genetic therapies to cure sickle cell disease
NIH, September 13, 2018 - Cancer Scientists Have Ignored African DNA in the Search for Cures
J Wapner, Newsweek, July 2018 - Are Payers Ready To Address The Financial Challenges Associated With Gene Therapy?
Health Affairs Blog, June 28, 2018 - New approach to accurate interpretation of sickle cell disease newborn screening by applying multiple of median cutoffs and ratios.
Allaf Bichr et al. Pediatric blood & cancer 2018 May e27230 - Gene therapy helps patients avoid blood transfusion, study says
CNN, Apr 19, 2018 - Minor operations: Genetic testing for children and adolescents presents complex ethical issues
L Beil, Genome Magazine, Apr 2018 - Views of parents of children with sickle cell disease on pre-implantation genetic diagnosis.
Darbari Isha et al. Pediatric blood & cancer 2018 Apr e27102
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Cancer PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the translation of genomic and other precision health discoveries into improved health care and prevention related to cancer...more
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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
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