Effective August 1, 2024, this database was discontinued. All content will remain searchable and be preserved online for historical purposes only until 2029.
Spotlight
Crossing the Equity Chasm: Addressing a Second Valley of Death in Biomedical Innovation
From the article: "Recent transformative advances in health and medicine have successfully traversed the valley of death, including progress in genomics, precision medicine, innovative medicines and vaccines, gene therapy, and artificial intelligence. However, it is critical to call attention to a second, important valley of death: the failure to deliver scientific advances to populations most in need. The second valley of death is fueled by socioeconomic, environmental, political, and systemic factors; health system failures; and persistent challenges in closing the last mile in health care, resulting in significant disparities in morbidity and mortality worldwide. "
Precision public health in the era of genomics and big data
From the abstract: "Precision public health (PPH) considers the interplay between genetics, lifestyle and the environment to improve disease prevention, diagnosis and treatment on a population level—thereby delivering the right interventions to the right populations at the right time. In this Review, we explore the concept of PPH as the next generation of public health. We discuss the historical context of using individual-level data in public health interventions and examine recent advancements in how data from human and pathogen genomics and social, behavioral and environmental research, as well as artificial intelligence, have transformed public health. "
From the abstract: "Targeted NGS is highly sensitive and specific for detecting drug resistance across panels of tuberculosis drugs and can be performed directly on clinical samples. There is a paucity of data on performance for some currently recommended drugs. The barriers preventing the use of targeted NGS to diagnose drug-resistant tuberculosis in high-burden countries need to be addressed. "
Evolution of Gene Therapy for Inborn Errors of Immunity
From the article: "Inborn errors of immunity comprise more than 500 monogenic defects that predispose affected individuals to life-threatening infections, autoimmunity, and lymphoproliferation. The diagnosis and treatment of inborn errors of immunity have significantly evolved in the past few decades. Currently, a hematopoietic stem cell transplant (HSCT) is the definitive treatment of many IEIs. However, an HSCT carries risks, such as graft-vs-host disease and decreased survival rates in the absence of an HLA-matched donor. Gene therapy (GT) offers a promising alternative by targeting and correcting specific genetic mutations. "
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Single-cell analysis of lung epithelial cells reveals age and cell population-specific responses to SARS-CoV-2 infection in ciliated cells.
Osborn Raven M, et al. Clinical and experimental immunology 2025 0 0.
Targeted Enrichment Sequencing Utilizing a Respiratory Pathogen Panel for Genomic Wastewater-Based Viral Epidemiology in Uruguay.
Cancela Florencia, et al. Food and environmental virology 2025 0 0. (1) 14
Trends in Mental Health Outcomes of College Students Amid the Pandemic (Roadmap mHealth App): Longitudinal Observational Study.
Jayaraj Gautham, et al. Journal of medical Internet research 2025 0 0. e67627
Tuberculosis healthcare service disruptions during the COVID-19 pandemic in Brazil, India and South Africa: A model-based analysis of country-level data.
de Villiers Abigail K, et al. PLOS global public health 2025 0 0. (1) e0003309
A Global Collaborative Comparison of SARS-CoV-2 Antigenicity Across 15 Laboratories.
Brangel Polina, et al. Viruses 2025 0 0. (12)
A multi-city COVID-19 categorical forecasting model utilizing wastewater-based epidemiology.
Rankin Naomi, et al. The Science of the total environment 2025 0 0. 178172
A review of RNA nanoparticles for drug/gene/protein delivery in advanced therapies: Current state and future prospects.
Vosoughi Pegah, et al. International journal of biological macromolecules 2025 0 0. 139532
Affinity Tag-Free Purification of SARS-CoV-2 N Protein and Its Crystal Structure in Complex with ssDNA.
Maiti Atanu, et al. Biomolecules 2025 0 0. (12)
Aged Garlic Extract (AGE) and Its Constituent S-Allyl-Cysteine (SAC) Inhibit the Expression of Pro-Inflammatory Genes Induced in Bronchial Epithelial IB3-1 Cells by Exposure to the SARS-CoV-2 Spike Protein and the BNT162b2 Vaccine.
Gasparello Jessica, et al. Molecules (Basel, Switzerland) 2025 0 0. (24)
An Easy-to-Use Tool to Predict SARS-CoV-2 Risk of Infection in Closed Settings: Validation with the Use of an Individual-Based Monte Carlo Simulation.
Santoro Benedetta, et al. Microorganisms 2025 0 0. (12)
An Epigenetic Locus Associated with Loss of Smell in COVID-19.
Aslan Elif Sibel, et al. Diagnostics (Basel, Switzerland) 2025 0 0. (24)
An Evaluation of the Cellular and Humoral Response of a Multi-Epitope Vaccine Candidate Against COVID-19 with Different Alum Adjuvants.
Vega Rojas Lineth Juliana, et al. Pathogens (Basel, Switzerland) 2025 0 0. (12)
Antibody Avidity Maturation Following Booster Vaccination with an Intranasal Adenovirus Salnavac Vaccine.
Astakhova Ekaterina A, et al. Vaccines 2025 0 0. (12)
Antigenic Imprinting Dominates Humoral Responses to New Variants of SARS-CoV-2 in a Hamster Model of COVID-19.
Degryse Joran, et al. Microorganisms 2025 0 0. (12)
Artificial intelligence applied to bed regulation in Rio Grande do Norte: Data analysis and application of machine learning on the "RegulaRN Leitos Gerais" platform.
Barreto Tiago de Oliveira, et al. PloS one 2025 0 0. (12) e0315379
Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters.
Neary Megan, et al. Viruses 2025 0 0. (12)
Assessment of Placental Antioxidant Defense Markers in Vaccinated and Unvaccinated COVID-19 Third-Trimester Pregnancies.
Rolfo Alessandro, et al. Life (Basel, Switzerland) 2025 0 0. (12)
Association of Single-Nucleotide Variants in ACE2 with the Persistence of Positive qPCR Test for SARS-CoV-2 in Healthcare Professionals During the First Wave of the COVID-19 Pandemic.
Jiménez-Gil Karina, et al. Microorganisms 2025 0 0. (12)
Associations Between Clinical Manifestations of SARS-CoV-2 Infection and HLA Alleles in a Caucasian Population: A Molecular HLA Typing Study.
Tymoniuk Boguslaw, et al. Journal of clinical medicine 2025 0 0. (24)
AutoML-Driven Insights into Patient Outcomes and Emergency Care During Romania's First Wave of COVID-19.
Simon Sonja C S, et al. Bioengineering (Basel, Switzerland) 2025 0 0. (12)
BharatSim: An agent-based modelling framework for India.
Cherian Philip, et al. PLoS computational biology 2025 0 0. (12) e1012682
Bioinformatic Tools for Studying the Cellular Immune Response to SARS-CoV-2, Vaccine Efficacy, and Future Pandemics at the Global Population Level.
López Daniel, et al. International journal of molecular sciences 2025 0 0. (24)
Bioinformatics analysis of myelin-microbe interactions suggests multiple types of molecular mimicry in the pathogenesis of multiple sclerosis.
Bigdeli Ali, et al. PloS one 2025 0 0. (12) e0308817
Cardiac Damage in Patients Infected with Different SARS-CoV-2 Variants of Concern.
Burkert Francesco Robert, et al. Microorganisms 2025 0 0. (12)
Characterization and Fluctuations of an Ivermectin Binding Site at the Lipid Raft Interface of the N-Terminal Domain (NTD) of the Spike Protein of SARS-CoV-2 Variants.
Lefebvre Marine, et al. Viruses 2025 0 0. (12)
Characterization of Site-Specific N- and O-Glycopeptides from Recombinant Spike and ACE2 Glycoproteins Using LC-MS/MS Analysis.
Song Ju Hwan, et al. International journal of molecular sciences 2025 0 0. (24)
Comparative Evolutionary Epidemiology of SARS-CoV-2 Delta and Omicron Variants in Kuwait.
Alkhamis Moh A, et al. Viruses 2025 0 0. (12)
Comparing Different Data Partitioning Strategies for Segmenting Areas Affected by COVID-19 in CT Scans.
Oliveira Anne de Souza, et al. Diagnostics (Basel, Switzerland) 2025 0 0. (24)
COVID-19 Vaccinations, Infections, and Outcomes Among 784 People Living with HIV.
Mahlab-Guri Keren, et al. Viruses 2025 0 0. (12)
CRISPR/Cas12a with Universal crRNA for Indiscriminate Virus Detection.
Shang Zhenlin, et al. Molecules (Basel, Switzerland) 2025 0 0. (24)
Detrimental Effects of Anti-Nucleocapsid Antibodies in SARS-CoV-2 Infection, Reinfection, and the Post-Acute Sequelae of COVID-19.
Nakayama Emi E, et al. Pathogens (Basel, Switzerland) 2025 0 0. (12)
Development and Evaluation of a Newcastle Disease Virus-like Particle Vaccine Expressing SARS-CoV-2 Spike Protein with Protease-Resistant and Stability-Enhanced Modifications.
Chen Yu, et al. Viruses 2025 0 0. (12)
Development, Pre-Clinical Safety, and Immune Profile of RENOVAC-A Dimer RBD-Based Anti-Coronavirus Subunit Vaccine.
Muminov Muzaffar, et al. Vaccines 2025 0 0. (12)
Diagnostic Models for Differentiating COVID-19-Related Acute Ischemic Stroke Using Machine Learning Methods.
Gul Ates Eylem, et al. Diagnostics (Basel, Switzerland) 2025 0 0. (24)
Differential TLR-ERK1/2 Activity Promotes Viral ssRNA and dsRNA Mimic-Induced Dysregulated Immunity in Macrophages.
Shrestha Rakshya, et al. Pathogens (Basel, Switzerland) 2025 0 0. (12)
Disruption of seasonal influenza circulation and evolution during the 2009 H1N1 and COVID-19 pandemics in Southeastern Asia.
Chen Zhiyuan, et al. Nature communications 2025 0 0. (1) 475
Durability of Adaptive Immunity in Immunocompetent and Immunocompromised Patients Across Different Respiratory Viruses: RSV, Influenza, and SARS-CoV-2.
Livieratos Achilleas, et al. Vaccines 2025 0 0. (12)
Early Mortality Prediction in Intensive Care Unit Patients Based on Serum Metabolomic Fingerprint.
Araújo Rúben, et al. International journal of molecular sciences 2025 0 0. (24)
Effective Inhibitor Removal from Wastewater Samples Increases Sensitivity of RT-dPCR and Sequencing Analyses and Enhances the Stability of Wastewater-Based Surveillance.
Linzner Nico, et al. Microorganisms 2025 0 0. (12)
Effectiveness of mRNA COVID-19 vaccines and hybrid immunity in preventing SARS-CoV-2 infection and symptomatic COVID-19 among adults in the United States.
Feldstein Leora R, et al. The Journal of infectious diseases 2025 0 0.
Emerging SARS-CoV-2 Variants in Uganda in the Era of COVID-19 Vaccination.
Bbosa Nicholas, et al. Viruses 2025 0 0. (12)
Empirical Comparison and Analysis of Artificial Intelligence-Based Methods for Identifying Phosphorylation Sites of SARS-CoV-2 Infection.
Lai Hongyan, et al. International journal of molecular sciences 2025 0 0. (24)
Enhanced D614G and Omicron Variants Antibody Persistence in Infants at 2 Months of Age Following Maternal mRNA Booster Vaccination During Pregnancy or Postpartum.
Munoz Flor M, et al. The Pediatric infectious disease journal 2025 0 0. (11) 1065-1073
Environmental Dissemination of SARS-CoV-2: An Analysis Employing Crassphage and Next-Generation Sequencing Protocols.
Ribeiro André Vinicius Costa, et al. Food and environmental virology 2025 0 0. (1) 13
Epistatic hotspots organize antibody fitness landscape and boost evolvability.
Schulz Steven, et al. Proceedings of the National Academy of Sciences of the United States of America 2025 0 0. (2) e2413884122
Equivocating and Deliberating on the Probability of COVID-19 Infection Serving as a Risk Factor for Lung Cancer and Common Molecular Pathways Serving as a Link.
Amara Abdelbasset, et al. Pathogens (Basel, Switzerland) 2025 0 0. (12)
Evaluation of anti-SARS-CoV-2 RBD antibody response after booster dose of SpikoGen® in individuals with two previous doses of Sinopharm and its association with HLA-DR and -DQ alleles.
Hajijafary Amir Hossein, et al. Human immunology 2025 0 0. (1) 111227
Examination of the requirements for powered air-purifying respirator (PAPR) utilization as an alternative to lockdown.
Fujii Yusaku, et al. Scientific reports 2025 0 0. (1) 1217
From Emergence to Evolution: Dynamics of the SARS-CoV-2 Omicron Variant in Florida.
Ali Sobur, et al. Pathogens (Basel, Switzerland) 2025 0 0. (12)
From Tradition to Innovation: Diverse Molecular Techniques in the Fight Against Infectious Diseases.
Alsharksi Ahmed Nouri, et al. Diagnostics (Basel, Switzerland) 2025 0 0. (24)
Genomic Diversity and Evolution of Identified SARS-CoV-2 Variants in Iraq.
Al-Mankhee Ahmed A, et al. Pathogens (Basel, Switzerland) 2025 0 0. (12)
Genomic Evolution of the SARS-CoV-2 Omicron Variant in Córdoba, Argentina (2021-2022): Analysis of Uncommon and Prevalent Spike Mutations.
Olivero Nadia B, et al. Viruses 2025 0 0. (12)
IL-18 and IL-18BP: A Unique Dyad in Health and Disease.
Novick Daniela, et al. International journal of molecular sciences 2025 0 0. (24)
Immune Response to SARS-CoV-2 XBB.1.5 and JN.1 Variants Following XBB.1.5 Booster Vaccination in Liver Transplant Recipients.
von der Schulenburg Philippa, et al. Viruses 2025 0 0. (12)
Impact of Repeated Variant Exposures on Cellular and Humoral Immunogenicity Induced by SARS-CoV-2 Vaccines.
Fernández-Ciriza Leire, et al. Vaccines 2025 0 0. (12)
Impact of Vaccination Status on COVID-19 Severity and Pulmonary Involvement.
Laitin Sorina Maria Denisa, et al. Medicina (Kaunas, Lithuania) 2025 0 0. (12)
Inferring effects of mutations on SARS-CoV-2 transmission from genomic surveillance data.
Lee Brian, et al. Nature communications 2025 0 0. (1) 441
Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome.
Mand Nadine, et al. BMJ paediatrics open 2025 0 0. (1)
Integrating Interpretability in Machine Learning and Deep Neural Networks: A Novel Approach to Feature Importance and Outlier Detection in COVID-19 Symptomatology and Vaccine Efficacy.
Jacob Khoury Shadi, et al. Viruses 2025 0 0. (12)
Interaction of HERVs with PAMPs in Dysregulation of Immune Response Cascade Upon SARS-CoV-2 Infections.
Turcic Marijana, et al. International journal of molecular sciences 2025 0 0. (24)
Interactomic Analyses and a Reverse Engineering Study Identify Specific Functional Activities of One-to-One Interactions of the S1 Subunit of the SARS-CoV-2 Spike Protein with the Human Proteome.
Colonna Giovanni, et al. Biomolecules 2025 0 0. (12)
Lessons Learned from COVID-19 Pandemic in Combating Antimicrobial Resistance-Experience of Hong Kong, China.
Ma Edmond Siu-Keung, et al. Microorganisms 2025 0 0. (12)
lncRNA CARINH regulates expression and function of innate immune transcription factor IRF1 in macrophages.
Cyr Yannick, et al. Life science alliance 2025 0 0. (3)
Longitudinal monitoring of sewershed resistomes in socioeconomically diverse urban neighborhoods.
Lee Jangwoo, et al. Communications medicine 2025 0 0. (1) 7
Longitudinal Study of SARS-CoV-2 Vaccinations and Infections in Patients with Gastrointestinal Cancer: Stabilizing Immune Responses and Neutralizing Emerging Variants with Variant-Adapted Antigen Exposures.
Gonzalez-Carmona Maria A, et al. International journal of molecular sciences 2025 0 0. (24)
Low Prevalence of SARS-CoV-2 in Farmed and Free-Ranging White-Tailed Deer in Florida.
Grace Savannah G, et al. Viruses 2025 0 0. (12)
Lung-Selective Delivery of mRNA-Encoding Anti-MERS-CoV Nanobody Exhibits Neutralizing Activity Both In Vitro and In Vivo.
Zhang Yuhang, et al. Vaccines 2025 0 0. (12)
Macromolecular interaction mechanism of the bacteriocin EntDD14 with the receptor binding domain (RBD) for the inhibition of SARS-CoV-2 and the JN.1 variant: Biomedical study based on elastic networks, stochastic Markov models, and macromolecular volumetric analysis.
Molina Luis Moncayo, et al. Biophysical chemistry 2025 0 0. 107388
Mast Cells and Basophils in Major Viral Diseases: What Are the Correlations with SARS-CoV-2, Influenza A Viruses, HIV, and Dengue?
Gammeri Luca, et al. Cells 2025 0 0. (24)
miR-24-3p Is Antiviral Against SARS-CoV-2 by Downregulating Critical Host Entry Factors.
Evers Parrish, et al. Viruses 2025 0 0. (12)
Molecular Insights into Structural Dynamics and Binding Interactions of Selected Inhibitors Targeting SARS-CoV-2 Main Protease.
Wang Yuanyuan, et al. International journal of molecular sciences 2025 0 0. (24)
Multi-Modal Machine Learning Approach for COVID-19 Detection Using Biomarkers and X-Ray Imaging.
Tur Kagan, et al. Diagnostics (Basel, Switzerland) 2025 0 0. (24)
Multidrug-Resistant Klebsiella pneumoniae Strains in a Hospital: Phylogenetic Analysis to Investigate Local Epidemiology.
Ristori Maria Vittoria, et al. Microorganisms 2025 0 0. (12)
Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice.
Halfmann Peter J, et al. Nature communications 2025 0 0. (1) 462
Multivariate Techniques for Monitoring Susceptible, Exposed, Infected, Recovered, Death, and Vaccination Model Parameters for the COVID-19 Pandemic for Qatar.
Abdel-Salam Abdel-Salam G, et al. International journal of environmental research and public health 2025 0 0. (12)
National Multicenter Study on the Prevalence of Carbapenemase-Producing Enterobacteriaceae in the Post-COVID-19 Era in Argentina: The RECAPT-AR Study.
Echegorry Mariano, et al. Antibiotics (Basel, Switzerland) 2025 0 0. (12)
Perceptions and Attitudes of Registered Nurses and Nursing Students Toward Advanced Technology and Artificial Intelligence: A Review of Literature.
Abdelaziz Omar, et al. Computers, informatics, nursing : CIN 2025 0 0.
Persistence of Long COVID Symptoms Two Years After SARS-CoV-2 Infection: A Prospective Longitudinal Cohort Study.
Joseph Gili, et al. Viruses 2025 0 0. (12)
Post-Pandemic Perspectives: Willingness, Risk Perception and Factors Influencing COVID-19 Booster Vaccine Uptake Among Thai Healthcare Workers and Vulnerable Populations.
Kitro Amornphat, et al. Vaccines 2025 0 0. (12)
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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.