Effective August 1, 2024, this database was discontinued. All content will remain searchable and be preserved online for historical purposes only until 2029.
Spotlight
From the website: "The Training Institute for Dissemination and Implementation Research in Genomics and Precision Public Health (TIDIR-GPPH) Facilitated Course is being offered in 2024 and is open to all current ORISE fellows and mentors! The course is intended to provide participants with a thorough grounding in conducting dissemination and implementation (D&I) research with a specific focus on genomics and precision public health. TIDIR-GPPH will be a hybrid course including training through open access modules with assigned reading material and office hours and culminating with a 2-day in-person event (September 5-6, 2024)."
A new agenda for implementing population genomic screening
"Nearly a decade into the proliferation of population genomic screening programs, it is clear that such programs provide benefit in certain contexts. Determining whether these programs provide net positive outcomes across diverse populations, however, will require a significant shift in approach and scale. This shift can be modeled on a precision health research agenda that capitalizes on pragmatic and implementation science methods, learning health system principles, and stakeholder engagement. Acknowledging that research and clinical implementation must coexist will help us realize the promise of population genomic screening."
Implementation research: an approach to overcoming the know-do gap
From the article: " Many people who could benefit from evidence-based treatments do not receive them; a circumstance that is sometimes referred to as the know-do gap. We know the interventions that can be beneficial, but we do not know how to do those interventions in real-world settings. The gap can be particularly large if influenced adversely by social determinants of health. Implementation research seeks to produce evidence to reduce the know-do gap."
From the abstract: " Familial hypercholesterolemia (FH) is a heritable disorder affecting 1.3 million individuals in the USA. Eighty percent of people with FH are undiagnosed, particularly minoritized populations including Black or African American people, Asian or Asian American people, and women across racial groups. Family cascade screening is an evidence-based practice that can increase diagnosis and improve health outcomes but is rarely implemented in routine practice, representing an important care gap. In pilot work, we leveraged best practices from behavioral economics and implementation science—including mixed-methods contextual inquiry with clinicians, patients, and health system constituents—to co-design two patient-facing implementation strategies to address this care gap..."
Latest News and Publications
Hui Chi Yan, et al. PloS one 2024 0 0. (12) e0314914
Digital health implementation in Australia: A scientometric review of the research.
Krahe Michelle A, et al. Digital health 2024 0 0. 20552076241297729
The recent history and near future of digital health in the field of behavioral medicine: an update on progress from 2019 to 2024.
Arigo Danielle, et al. Journal of behavioral medicine 2024 0 0.
Factors influencing implementation of digital cardiac rehabilitation: A qualitative analysis of health workers perspectives.
Gibson Irene, et al. HRB open research 2024 0 0. 50
Telehealth for Rare Disease Care, Research, and Education Across the Globe: A Review of the Literature by the IRDiRC Telehealth Task Force.
Chen Faye H, et al. European journal of medical genetics 2024 0 0. 104977
Application of implementation science for improving the utilization of an international clinical practice guidance on familial hypercholesterolemia.
Laney K Jones et al. J Clin Lipidol 2024
Pharmacogenetic testing in primary care could bolster depression treatment: A value proposition.
Nina R Sperber et al. Clin Transl Sci 2024 17(6) e13837
Implementation of AZD7442 (Tixagevimab/Cilgavimab) COVID-19 Pre-exposure Prophylaxis (PrEP) in the Largest Health Maintenance Organization in Israel: Real-world Uptake and Sociodemographic and Clinical Characteristics Across Immunocompromised Patient Groups.
Hayek Samah, et al. Infectious diseases and therapy 2024 0 0.
Factors impacting the adoption of big data in healthcare: A systematic literature review.
Abeer Saleh Al Teneiji et al. Int J Med Inform 2024 187105460
Applying Machine Learning Techniques to Implementation Science.
Nathalie Huguet et al. Online J Public Health Inform 2024 16e50201
Family cascade screening for equitable identification of familial hypercholesterolemia: study protocol for a hybrid effectiveness-implementation type III randomized controlled trial.
Christina Johnson et al. Implement Sci 2024 19(1) 30
Genetically guided precision medicine clinical decision support tools: a systematic review.
Darren Johnson et al. J Am Med Inform Assoc 2024
Validation of a Multivariable Model to Predict Suicide Attempt in a Mental Health Intake Sample.
Santiago Papini et al. JAMA Psychiatry 2024
Codesign of Lynch Choices : Using implementation science to create a clinically deliverable patient decision support website to transform cancer genetics care pathways.
Kelly Kohut et al. Psychooncology 2024 33(3) e6330
The Science of Precision Prevention: Research Opportunities and Clinical Applications to Reduce Cardiovascular Health Disparities.
Thomas A Pearson et al. JACC Adv 2024 3(1)
Implementation of rapid genomic sequencing in safety-net neonatal intensive care units: protocol for the VIrtual GenOme CenteR (VIGOR) proof-of-concept study.
Alissa M D'Gama et al. BMJ Open 2024 14(2) e080529
Publics' knowledge of, attitude to and motivation towards health-related genomics: a scoping review.
Angela Pearce et al. Eur J Hum Genet 2024
International Atherosclerosis Society Roadmap for Familial Hypercholesterolaemia.
Gerald F Watts et al. Glob Heart 2024 19(1) 12
Using implementation science to develop a familial hypercholesterolemia screening program in primary care: The CARE-FH study.
Laney K Jones et al. J Clin Lipidol 2024
Reanalysis of genomic data, how do we do it now and what if we automate it? A qualitative study.
Zoe Fehlberg et al. Eur J Hum Genet 2024
The Role of Pragmatic Implementation Science Methods in Achieving Equitable and Effective Use of Artificial Intelligence in Healthcare.
Anna M Maw et al. J Gen Intern Med 2024
Personalized medicine in a community health system: the NorthShore experience.
Sean P David et al. Front Genet 2023 141308738
The implementation and utility of clinical exome sequencing in a South African infant cohort.
L Campbell et al. Front Genet 2023 141277948
Educational needs of patients, families, and healthcare professionals to support the patient journey in haemophilia gene therapy in the UK.
Sara Boyce et al. Orphanet J Rare Dis 2023 18(1) 366
Exploring Barriers and Facilitators to Indirect Cascade Screening for Familial Hypercholesteraemia in a Paediatric/Parent Population.
Megan A Dickson et al. CJC Pediatr Congenit Heart Dis 2023 2(5) 211-218
Healthcare professionals' and consumers' knowledge, attitudes, perspectives, and education needs in oncology pharmacogenomics: A systematic review.
Chiao Xin Lim et al. Clin Transl Sci 2023
A Framework to Guide Implementation of AI in Health Care: Protocol for a Cocreation Research Project.
Per Nilsen et al. JMIR Res Protoc 2023 12e50216
Patient and health care professional acceptability of pharmacogenetic screening for DPYD and UGT1A1: a cross sectional survey.
Sarah Glewis et al. Clin Transl Sci 2023
Use of a multi-phased approach to identify and address facilitators and barriers to the implementation of a population-wide genomic screening program.
Caitlin G Allen et al. Implement Sci Commun 2023 4(1) 122
Applying the R = MC implementation science heuristic to assess the impact of readiness on reach and implementation of a population-wide genomic screening program.
Caitlin G Allen et al. J Genet Couns 2023
Patient Perspectives of Barriers and Facilitators for the Uptake of Pharmacogenomic Testing in Veterans Affairs' Pharmacogenomic Testing for the Veterans (PHASER) Program.
Karina Melendez et al. J Pers Med 2023 13(9)
A systematic review and knowledge mapping on ICT-based remote and automatic COVID-19 patient monitoring and care.
Chatterjee Ayan, et al. BMC health services research 2023 0 0. (1) 1047
CYP2D6-guided opioid therapy for adults with cancer pain: a randomized implementation clinical trial.
Scott A Mosley et al. Pharmacotherapy 2023
Providers' Use of Pharmacogenetic Testing to Inform Antidepressant Prescribing: Results of Qualitative Interviews.
Bonnie M Vest et al. Psychiatr Serv 2023 0
Scaling-up and future sustainability of a national reproductive genetic carrier screening program.
Zoe Fehlberg et al. NPJ Genom Med 2023 8(1) 18
Advancing Understanding of Inequities in Rare Disease Genomics.
Jillian G Serrano et al. Clin Ther 2023
Age-Based Genomic Screening during Childhood: Ethical and Practical Considerations in Public Health Genomics Implementation.
Laura V Milko et al. Int J Neonatal Screen 2023 9(3)
The Use of Machine Learning for Image Analysis Artificial Intelligence in Clinical Microbiology.
Bethany L Burns et al. J Clin Microbiol 2023 e0233621
Investigating genomic medicine practice and perceptions amongst Australian non-genetics physicians to inform education and implementation.
Amy Nisselle et al. NPJ Genom Med 2023 8(1) 13
International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia.
Gerald F Watts et al. Nat Rev Cardiol 2023
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About Implementation Science PHGKB
Implementation Science PHGKB is an online, continuously updated, searchable database of information and publications relevant to the role of implementation science to accelerate the translation of genomics and precision health applications into practice and programs. The ultimate success of these applications will depend on the incorporation of implementation science tools and methods in research. This research is relevant at the global, national, state, community and health systems level.
Content Summary
Quick Links
- Advancing Implementation Science in Precision Public Health: Ensuring Health Equity and Balancing Evolution and Sustainment
- Health Disparities in Implementation of Genomic Medicine: Challenges and Opportunities
- Center for Translation Research and Implementation Science
- Using Implementation Science Frameworks in Genomics and Precision Medicine: We Can Do Better!
- Implementation Science, NCI
Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
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