Effective August 1, 2024, this database was discontinued. All content will remain searchable and be preserved online for historical purposes only until 2029.
Spotlight
A roadmap for affordable genetic medicines
From the abstract: "Nineteen genetic therapies have been approved by the U.S. Food and Drug Administration (FDA) to date, a number that now includes the first CRISPR genome editing therapy for sickle cell disease, CASGEVY (exagamglogene autotemcel). This extraordinary milestone is widely celebrated because of the promise for future genome editing treatments of previously intractable genetic disorders and cancers. At the same time, such genetic therapies are the most expensive drugs on the market, with list prices exceeding $4 million per patient. "
Efanesoctocog Alfa Prophylaxis for Children with Severe Hemophilia A
From the abstract: "In children with severe hemophilia A, once-weekly prophylaxis with efanesoctocog alfa provided high sustained factor VIII activity in the normal to near-normal range (>40 IU per deciliter) for 3 days and more than 10 IU per deciliter for almost 7 days after administration, leading to effective bleeding prevention. Efanesoctocog alfa was associated with mainly nonserious adverse events. "
From the abstract: "Familial hypercholesterolemia (FH), while highly prevalent, is a significantly underdiagnosed monogenic disorder. Improved detection could reduce the large number of cardiovascular events attributable to poor case finding. We aimed to assess whether machine learning algorithms outperform clinical diagnostic criteria (signs, history, and biomarkers) and the recommended screening criteria in the United Kingdom in identifying individuals with FH-causing variants, presenting a scalable screening criteria for general populations. "
Exceptional Genetics, Generalizable Therapeutics, and Coronary Artery Disease
From the article: "The increasingly widespread availability of genomic sequencing has enabled the identification of persons and families with uniquely favorable traits, including a very low incidence of clinical events. Such exceptional persons across diverse communities are playing an important role in the genesis of medicines for common cardiovascular diseases. "
Latest News and Publications
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COVID-19 in Individuals with Severe Alpha 1-Antitrypsin Deficiency.
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Gentile I, et al. Annals of medicine 2024 0 0. (1) 2439541
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Kal M, et al. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2024 0 0. (5)
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Home-Based Testing as an Approach to Estimate Influenza Vaccine Effectiveness in South Africa, 2021-2022-A Pilot Study.
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Real-world experience of tixagevimab/cilgavimab prophylaxis in Japanese patients with immunodeficiency.
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Bridging the gap: strategies for recognizing and managing post-COVID conditions.
Khan Muhammad H, et al. Frontiers in medicine 2024 0 0. 1395420
Human Genetic Evidence to Inform Clinical Development of IL-6 Signaling Inhibition for Abdominal Aortic Aneurysm.
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Deciphering the lung microbiota in COVID-19 patients: insights from culture analysis, FilmArray pneumonia panel, ventilation impact, and mortality trends.
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Single cell multiomics reveal divergent effects of DNMT3A and TET2 mutant clonal hematopoiesis in inflammatory response.
Mohammed Ismail Wazim, et al. Blood advances 2024 0 0.
Symptoms can predict COVID-19 pneumonia in patients infected with SARS-CoV-2 Omicron variants.
Liao Qian-Qian, et al. Scientific reports 2024 0 0. (1) 30037
ACE2, From the Kidney to SARS-CoV-2: Donald Seldin Award Lecture 2023.
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An Update on Kawasaki Disease.
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Analysis of coinfections in patients with hematologic malignancies and COVID-19 by next-generation sequencing of bronchoalveolar lavage fluid.
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LARYNGEAL MUCORMYCOSIS IN AN UNCONTROLLED DIABETIC PATIENT: A CASE REPORT.
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Research progress of spike protein mutation of SARS-CoV-2 mutant strain and antibody development.
Huan Xinkang, et al. Frontiers in immunology 2024 0 0. 1407149
Differences in patient characteristics, treatments, and mortality of COVID-19 between 2022 and 2020-2021.
Aso Shotaro, et al. Japanese journal of infectious diseases 2024 0 0.
In Silico analysis unveils rs2109069 of DPP9 as a potential catalyst for COVID-19 severity and risk of inflammatory symptoms.
Lee Chi-Ying, et al. Experimental and molecular pathology 2024 0 0. 104946
Overexpression of PIN1 in patients with severe COVID-19.
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Severity and prognosis of COVID-19 complicated by autoimmune pulmonary alveolar proteinosis.
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Lightweight convolutional neural network for chest X-ray images classification.
Yen Chih-Ta, et al. Scientific reports 2024 0 0. (1) 29759
Nationwide Survey of Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019 in Japan.
Matsubara Daisuke, et al. Journal of clinical immunology 2024 0 0. (1) 51
Real-world assessment of reinfection with SARS-CoV-2: Implications for vaccines.
Tseng Kuang-Hung, et al. Journal of infection and public health 2024 0 0. (1) 102599
Identification and validation of respiratory subphenotypes in patients with COVID-19 acute respiratory distress syndrome undergoing prone position.
da Cruz Mônica R, et al. Annals of intensive care 2024 0 0. (1) 178
Influence of Clinical, Angiographic, and Developmental Characteristics and COVID-19 Severity and Vaccination Status on Young Patients with Acute Myocardial Infarction.
Vityala Yethindra, et al. Journal of mid-life health 2024 0 0. (3) 173-181
Assessing the factors affecting the accessibility of primary dental care for people with haemophilia.
Sipos Kitti, et al. Haemophilia : the official journal of the World Federation of Hemophilia 2024 0 0.
Autoantibodies targeting interferons and GM-CSF are associated with adverse outcome risk, comorbidities, and pathogen in community-acquired pneumonia.
Von Stemann Jakob Hjorth, et al. Frontiers in immunology 2024 0 0. 1459616
Gut microbiome dysbiosis and immune activation correlate with somatic and neuropsychiatric symptoms in COVID-19 patients.
Scalzo Paula L, et al. medRxiv : the preprint server for health sciences 2024 0 0.
Impact of COVID-19 Omicron variant on lung transplantation patients with 1-year follow-up: A single tertiary medical center experience.
Chang Ko-Wei, et al. Journal of the Formosan Medical Association = Taiwan yi zhi 2024 0 0.
Severity of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Diminished during Successive Waves of the COVID-19 Pandemic: Data from a Nationwide German Survey.
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Clinical, biochemical, and genetic study of TACE/TNF-α/ACE signaling pathway in pediatric COVID-19 infection.
Ahmed Ahmed El-Abd, et al. Clinical and experimental pediatrics 2024 0 0.
Coronavirus Disease 2019-Associated Thrombotic Microangiopathy: A Single-Center Experience.
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Cost-Utility Analysis of Supervised Inspiratory Muscle Training Added to Post-COVID Rehabilitation Program in the Public Health System of Brazil.
Modesto Guilherme Pacheco, et al. International journal of environmental research and public health 2024 0 0. (11)
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants-Single-Center Study.
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Enhancing Lung Ultrasound Diagnostics: A Clinical Study on an Artificial Intelligence Tool for the Detection and Quantification of A-Lines and B-Lines.
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Identification of Biomarkers and Molecular Pathways Implicated in Smoking and COVID-19 Associated Lung Cancer Using Bioinformatics and Machine Learning Approaches.
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Novel Core Gene Signature Associated with Inflammation-to-Metaplasia Transition in Influenza A Virus-Infected Lungs.
Savin Innokenty A, et al. International journal of molecular sciences 2024 0 0. (22)
SARS-CoV-2 N protein induces alveolar epithelial apoptosis via NLRP3 pathway in ARDS.
Huang Xiaopei, et al. International immunopharmacology 2024 0 0. 113503
Sex Differences in Long-Term Cardiovascular Outcomes and Mortality After COVID-19 Hospitalization During Alpha, Delta and Omicron Waves.
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Urticarial vasculitis.
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Behavioral Changes During COVID-19 Omicron Variant Infection on Children with Autism Spectrum Disorder in China.
Ye Fang, et al. Psychology research and behavior management 2024 0 0. 3979-3991
Clinical Characteristics and Outcomes of Hospitalized COVID-19 Patients with Different Variants of SARS-CoV-2 in a Tertiary Care Hospital, Thailand.
Hengkrawit Kitchawan, et al. Tropical medicine and infectious disease 2024 0 0. (11)
Clinical effects of dexamethasone among patients with sickle cell disease hospitalized with COVID-19: Outcomes from a single academic health system.
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Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization.
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Persistent COVID-19 improved with immunoglobulin replacement therapy in Good's syndrome.
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Analysis of immunological and biochemical parameters after booster dose vaccination using protein-based and inactivated virus vaccine for safety.
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CLINICAL MANIFESTATION AND EPIDEMIOLOGICAL PECULIARITIES OF LEPTOSPIROSIS AT THE MODERN STAGE IN GEORGIA.
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Miyashita Naoyuki, et al. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2024 0 0.
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Multiplatform Metabolomics: Enhancing the Severity Risk Prognosis of SARS-CoV-2 Infection.
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Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study.
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Inborn Error of WAS Presenting with SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children.
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A Novel Heterozygous NFKB2 Variant in a Multiplex Family with Common Variable Immune Deficiency and Autoantibodies Against Type I IFNs.
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A Mouse Model of Ovalbumin-Induced Airway Allergy Exhibits Altered Localization of SARS-CoV-2-Susceptible Cells in the Lungs, Which Reflects Omicron BA.5 Infection Dynamics, Viral Mutations, and Immunopathology.
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A self-driven ESN-DSS approach for effective COVID-19 time series prediction and modelling.
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An Interesting Case of Hypogammaglobulinemia Caused by the Combined Effect of Rituximab Infusion and Common Variable Immunodeficiency (CVID).
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Causal association between COVID-19 vaccination and thrombosis-related biomarkers/thrombosis/ischemic stroke: Mendelian randomization study.
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Identifying Topics Around Nicotine Gum: A Machine Learning Approach with Twitter Data.
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Radiomic Features Based Automatic Classification of CT Lung Findings for COVID-19 Patients.
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Remote monitoring and teleconsultations can reduce greenhouse gas emissions while maintaining quality of care in cystic fibrosis.
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Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA.1 infection of K18-hACE2 mice.
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Critical Crossroads: The Vital Role of Timely Diagnosis in Severe Amyopathic Dermatomyositis.
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Deciphering Bordetella pertussis epidemiology through culture-independent multiplex amplicon and metagenomic sequencing.
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SARS-CoV-2 seroprevalence screening study of a children's hospital health care workers.
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Emergence of carbapenemase-producing Enterobacterales (CPE) in patients with severe COVID-19 infection and successful control in intensive care.
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Length of Stay, Readmission Rates, and Mortality Are Similar Between Hospitalized Individuals With Sickle Cell Disease With and Without COVID-19.
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Prediction of COVID-19 in-hospital mortality in older patients using artificial intelligence: a multicenter study.
Fedecostante Massimiliano, et al. Frontiers in aging 2024 0 0. 1473632
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Divine life force: the fragile power of blood.
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A Pair of Hearts: Two Cases of Mitral Valve Gonococcal Endocarditis.
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Early pulmonary fibrosis-like changes between delta and pre-delta periods in patients with severe COVID-19 pneumonia on mechanical ventilation.
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Chen Yuxian, et al. Frontiers in oncology 2024 0 0. 1445245
An electronic patient-reported outcome symptom monitor: the Chinese experience with rapid development of a ready-to-go symptom monitor.
Zhang Jingyu, et al. BMC public health 2024 0 0. (1) 2989
Developing a machine learning model with enhanced performance for predicting COVID-19 from patients presenting to the emergency room with acute respiratory symptoms.
Alghamdi Maha Mesfer, et al. IET systems biology 2024 0 0.
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Spottiswoode Natasha, et al. Nature communications 2024 0 0. (1) 9339
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A tri-light warning system for hospitalized COVID-19 patients: Credibility-based risk stratification for future pandemic preparedness.
Xu Chuanjun, et al. European journal of radiology open 2024 0 0. 100603
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Mao Siqi, et al. Journal of evaluation in clinical practice 2024 0 0.
Point-of-care breath sample analysis by semiconductor-based E-Nose technology discriminates non-infected subjects from SARS-CoV-2 pneumonia patients: a multi-analyst experiment.
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Differences in Susceptibility to SARS-CoV-2 Infection Among Transgenic hACE2-Hamster Founder Lines.
Gibson Scott A, et al. Viruses 2024 0 0. (10)
Pertussis Outbreak During 2023 in Gipuzkoa, North Spain.
Marimón José María, et al. Vaccines 2024 0 0. (10)
Predicting Clinical Outcomes in COVID-19 and Pneumonia Patients: A Machine Learning Approach.
Cai Kaida, et al. Viruses 2024 0 0. (10)
Predicting Survival Status in COVID-19 Patients: Machine Learning Models Development with Ventilator-Related and Biochemical Parameters from Early Stages: A Pilot Study.
Chou Shin-Ho, et al. Journal of clinical medicine 2024 0 0. (20)
Symptomatology and IgG Levels before and after SARS-CoV-2 Omicron Breakthrough Infections in Vaccinated Individuals.
Paula Nigella M, et al. Vaccines 2024 0 0. (10)
Understanding the Omicron Variant Impact in Healthcare Workers: Insights from the Prospective COVID-19 Post-Immunization Serological Cohort in Munich (KoCo-Impf) on Risk Factors for Breakthrough and Reinfections.
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Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process.
Zhang Cangang, et al. Immunity & ageing : I & A 2024 0 0. (1) 74
Cough2COVID-19 detection using an enhanced multi layer ensemble deep learning framework and CoughFeatureRanker.
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Enhanced COVID-19 Detection from X-ray Images with Convolutional Neural Network and Transfer Learning.
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Dos Santos Pérola Rodrigues, et al. Virology journal 2024 0 0. (1) 260
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Extracorporeal Membrane Oxygenation for COVID-19 During the Delta and Omicron Waves in North America.
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E.Co.Tech Breathalyzer: A Pilot Study of a Non-invasive COVID-19 Diagnostic Tool for Light and Non-smokers.
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Fused Audio Instance and Representation for Respiratory Disease Detection.
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Increased Activation Markers of Adaptive Immunity in Patients with Severe COVID-19.
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Randomized Controlled Trial to Assess the Feasibility of a Novel Clinical Decision Support System Based on the Automatic Generation of Alerts through Remote Patient Monitoring.
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SARS-CoV-2 Vaccine Improved Hemostasis of a Patient with Protein S Deficiency: A Case Report.
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Protocol for a pilot study: Feasibility of a web-based platform to improve nutrition, mindfulness, and physical function in people living with Post COVID-19 condition (BLEND).
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The severity assessment and nucleic acid turning-negative-time prediction in COVID-19 patients with COPD using a fused deep learning model.
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About HLBS-PopOmics
HLBS-PopOmics is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the translation of genomic and other precision health discoveries into improved health care and prevention related to Heart and Vascular Diseases(H), Lung Diseases(L), Blood Diseases(B), and Sleep Disorders(S)...more
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Mensah GA, Yu W, Barfield WL, Clyne M, Engelgau MM, Khoury MJ. HLBS-PopOmics: an online knowledge base to accelerate dissemination and implementation of research advances in population genomics to reduce the burden of heart, lung, blood, and sleep disorders. Genet Med. 2018 Sep 10. doi: 10.1038/s41436-018-0118-1
Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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