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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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28 hot topic(s) found with the query "Dengue"

COVID spurs boom in genome sequencing for infectious diseases
S Mallapaty, Nature, December 15, 2022 (Posted: Dec 15, 2022 8AM)

From Dengue to Ebola, laboratories in Asia and Africa are using sequencing technology and skills acquired during the pandemic to quickly track endemic diseases. Before the pandemic, genomic sequencing was mainly reserved for research in many regions, but now it is being used for public health. As testing for SARS-CoV-2 declines in many regions, countries are starting to pivot to sequencing endemic pathogens. This increased interest in sequencing is generating more data for research, and opportunities to collaborate on new treatments and vaccines, say researchers. But there is a shortage of people who can interpret sequencing data such as bioinformaticians and epidemiologists,

An 8-gene machine learning model improves clinical prediction of severe dengue progression
YE Liu et al, Genome Medicine, March 28, 2022 (Posted: Mar 30, 2022 7AM)

The 8-gene XGBoost model, trained on heterogeneous public datasets, accurately predicted progression to SD in a large, independent, prospective cohort, including during the early febrile stage when SD prediction remains clinically difficult. The model has potential to be translated to a point-of-care prognostic assay to reduce dengue morbidity and mortality without overwhelming limited healthcare resources.

First genetically modified mosquitoes released in the United States
E Watz, Nature News, May 4, 2021 (Posted: May 05, 2021 7AM)

After a decade of fighting for regulatory approval and public acceptance, a biotechnology firm has released genetically engineered mosquitoes into the open air in the United States for the first time. The experiment, launched this week in the Florida Keys tests a method for suppressing populations of wild Aedes aegypti mosquitoes, which can carry diseases such as Zika, dengue, chikungunya and yellow fever.

Genetically engineered mosquitoes resist spreading any form of dengue
K Servick, Science, January 16, 2020 (Posted: Jan 18, 2020 9AM)

By endowing a line of mosquitoes with an antibody against the virus, researchers have for the first time made insects that—at least in lab tests—appear unable to spread any form of the disease. In theory, these mosquitoes could be released into the wild to suppress the circulation of the virus.

Modified mosquitoes reduce cases of dengue fever- Insects infected with a disease-inhibiting bacterium were released in communities in Asia and South America
E Callaway, Nature, November 27, 2019 (Posted: Nov 29, 2019 9AM)

The findings, presented on 21 November at the annual meeting of the American Society of Tropical Medicine and Hygiene in National Harbor, Maryland, come from experimental releases of mosquitoes that carry Wolbachia bacteria, which block the replication of mosquito-borne pathogens such as the dengue, chikungunya and Zika viruses.

Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population.
Evans Benjamin R et al. Scientific reports 2019 Sep (1) 13047 (Posted: Sep 15, 2019 8AM)

To control the mosquito-borne diseases yellow fever, dengue, chikungunya, and Zika fevers, a strain of transgenically modified Aedes aegypti mosquitoes containing a dominant lethal gene has been developed. Approximately 450 thousand males of this strain were released each week for 27 months in Jacobina, Bahia, Brazil.

Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis.
Cahill Megan E et al. BMC infectious diseases 2018 Jun (1) 282 (Posted: Aug 10, 2018 9AM)

Genomic approaches for understanding dengue: insights from the virus, vector, and host
S Sim et al, Genome Biology, March 2016 (Posted: Mar 02, 2016 9AM)

Using AMD to track changes in dengue and chikungunya viruses
Brand (Posted: Oct 28, 2015 4PM)

Can genetically modified mosquitoes curb Dengue fever?
PBS Newshour, May 16, 2015 (Posted: May 19, 2015 10AM)

Complete genome sequencing and phylogenetic analysis of dengue type 1 virus isolated from Jeddah, Saudi Arabia.
Azhar Esam I et al. Virol. J. 2015 (1) 1 (Posted: May 15, 2015 10AM)

A Multipurpose, High-Throughput Single-Nucleotide Polymorphism Chip for the Dengue and Yellow Fever Mosquito, Aedes aegypti.
Evans Benjamin R et al. G3 (Bethesda) 2015 (5) 711-8 (Posted: May 15, 2015 10AM)

Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia.
Sasmono R Tedjo et al. Infect. Genet. Evol. 2015 Jun 165-77 (Posted: May 15, 2015 10AM)

Clinical Outcome and Genetic Differences within a Monophyletic Dengue Virus Type 2 Population.
Hapuarachchi Hapuarachchige Chanditha et al. PLoS ONE 2015 (3) e0121696 (Posted: May 15, 2015 10AM)

Genome Engineering with CRISPR-Cas9 in the Mosquito Aedes aegypti.
Kistler Kathryn E et al. Cell Rep 2015 Apr 7. (1) 51-60 (Posted: May 15, 2015 10AM)

Molecular Epidemiology of Dengue Viruses Co-circulating in Upper Myanmar in 2006.
Thant Kyaw Zin et al. Trop Med Health 2015 Mar (1) 21-7 (Posted: May 15, 2015 10AM)

A combined genetic-proteomic approach identifies residues within Dengue virus NS4B critical for interaction with NS3 and viral replication.
Chatel-Chaix Laurent et al. J. Virol. 2015 Apr 29. (Posted: May 15, 2015 10AM)

Targeting host factors to treat West Nile and dengue viral infections.
Krishnan Manoj N et al. Viruses 2014 Feb (2) 683-708 (Posted: May 15, 2015 10AM)

Review: progress in the diagnosis of dengue virus infections and importance of point of care test: a review.
Fatima Aneela et al. Pak J Pharm Sci 2015 Jan (1) 271-80 (Posted: May 15, 2015 10AM)

Dengue pathogenesis: a disease driven by the host response.
Martina Byron E E et al. Sci Prog 2014 (Pt 3) 197-214 (Posted: May 15, 2015 10AM)

Reviewing Dengue: Still a Neglected Tropical Disease?
Horstick Olaf et al. PLoS Negl Trop Dis 2015 Apr (4) e0003632 (Posted: May 15, 2015 10AM)

A Critical Assessment of Vector Control for Dengue Prevention.
Achee Nicole L et al. PLoS Negl Trop Dis 2015 May (5) e0003655 (Posted: May 15, 2015 10AM)

The Burden of Dengue and Chikungunya Worldwide: Implications for the Southern United States and California.
Fredericks Anthony C et al. Ann Glob Health 2014 Nov-Dec (6) 466-475 (Posted: May 15, 2015 10AM)

Dengue and Chikungunya in Our Backyard: Preventing Aedes Mosquito-Borne Disease
CDC Public Health Grand Rounds, May 2015 Brand (Posted: Feb 25, 2015 0PM)

CDC Information: Dengue virus is a leading cause of illness and death in the tropics and subtropics.
Brand (Posted: Feb 25, 2015 0PM)

Dengue Fever
Brand (Posted: Jan 11, 2014 11AM)

Dengue fever is an infectious disease carried by mosquitoes and caused by any of four related dengue viruses. This disease used to be called "break-bone" fever because it sometimes causes severe joint and muscle pain that feels like bones are breaking. Health experts have known about dengue fever for more than 200 years.

Zika Virus
Brand (Posted: Jan 11, 2014 11AM)

Discovered in the Zika forest, Uganda, in 1947, Zika virus is a member of the flavivirus family. Other flaviviruses include those that cause dengue, yellow fever, and West Nile fever. Like its relatives, Zika virus is primarily transmitted to humans through the bite of infected Aedes aegypti mosquitoes. Zika virus can be transmitted from an infected pregnant woman to her baby during pregnancy and can result in serious birth defects, including microcephaly. Less commonly, the virus can be spread through intercourse or blood transfusion.

Dengue fever
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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