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Hot Topics of the Day|PHGKB
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06/15/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Association of Immune Checkpoint Inhibitor Therapy With Survival in Patients With Cancers With MUC16 Variants
Y Yu, et al, JAMA Network Open, June 12, 2020

We found a significant association of MUC16 variation with elevated tumor variant burden and prolonged PFS and OS during ICI treatment in pancancer and specifically in NSCLC, suggesting that MUC16 might be an important component of the immunogenetic landscape and should be integrated into multiomics for precise selection of patients to receive ICI.

Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy- A Nonrandomized Controlled Trial
JR Mendell et al, JAMA Neurology, June 15, 2020

In this nonrandomized controlled trial of 4 young patients with Duchenne muscular dystrophy, rAAVrh74.MHCK7.micro-dystrophin gene transfer was well tolerated, with minimal adverse events, and was associated with robust micro-dystrophin expression, reduced serum creatine kinase levels, and functional improvement.

Analysis of Infected Host Gene Expression Reveals Repurposed Drug Candidates and Time-Dependent Host Response Dynamics for COVID-19
J Xing et al, BIORXIV, June 13, 2020

Sentinel surveillance of SARS-CoV-2 in wastewater anticipates the occurrence of COVID-19 cases
GC Miro et al, MEDRXIV, June 13, 2020

Improving effectiveness of different deep learning-based models for detecting COVID-19 from computed tomography (CT) images
E Acar et al, MEDRXIV, June 14, 2020

Genome sequencing of the first SARS-CoV-2 reported from patients with COVID-19 in Ecuador.
S Marquez et al, MEDRXIV, June 14, 2020

Critical Questions when Interpreting Coronavirus PCR Diagnostics
J Durner et al, MEDRXIV, June 14, 2020

Assessment of spread of SARS-CoV-2 by RT-PCR and concomitant serology in children in a region heavily affected by COVID-19 pandemic
R Cohen et al, MEDRXIV, June 14, 2020

Total predicted MHC-I epitope load is inversely associated with mortality from SARS-CoV-2
E Wilson et al, MEDRXIV, June 14, 2020

A Machine Learning Solution Framework for Combatting COVID-19 in Smart Cities from Multiple Dimensions
I Abaker et al, MEDRXIV, June 14, 2020

How Data Became One of the Most Powerful tools to fight an epidemic
S Johnson, New York Magazine, June 2020

As public-health experts have known since the 19th century, information can be the best medicine. What new data streams could help quell future outbreaks?


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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