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Hot Topics of the Day|PHGKB
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03/10/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Duchenne Muscular Dystrophy Education Series
American Academy of Pediatrics, 2020

The webinars in this 5-part education series focus on primary and specialty care for patients with Duchenne muscular dystrophy (DMD). Through this education series, pediatricians will be better informed about emerging therapies related to the care and management of patients with DMD. Further, they will be able to identify common issues affecting children with DMD. Finally, emphasis is placed on the valuable role of both primary care medical home and sub-specialty providers in coordinating effective treatment for patients with DMD.

LITCOVID: curated literature hub for tracking up-to-date scientific information about the 2019 novel Coronavirus
NCBI, 2020 Brand

A curated literature hub for tracking up-to-date scientific information about the 2019 novel Coronavirus. It is the most comprehensive resource on the subject, providing a central access to a growing number of peer-review articles. The articles are updated daily and are further categorized by different research topics and geographic locations for improved access

Coronavirus is hard on older people — and scientists aren't sure why
NBC News, March 10, 2020

Older adults appear to be more severely at risk from the new coronavirus, while young children seem to be largely spared — and understanding why could be crucial to treating people with the illness it causes, according to scientists.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
The Lancet, March 9, 2020

Interim Guidelines for Collecting, Handling, and Testing Clinical Specimens from Persons Under Investigation (PUIs) for Coronavirus Disease 2019 (COVID-19)
CDC, March 2020 Brand

Health care providers should contact their local/state health department immediately to notify them of patients with fever and lower respiratory illness who live in or have recently traveled to an affected area with sustained transmission or have been in close contact with a confirmed COVID-19 patient.

Risk Factors for Death From COVID-19 Identified in Wuhan Patients
R Lewis, Medscape, March 9, 2020

Patients who did not survive hospitalization for COVID-19 in Wuhan were more likely to be older, have comorbidities, and elevated D-dimer, according to the first study to examine risk factors associated with death among adults hospitalized with COVID-19.

Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster
R Woelfel et al, MedRXIV, March 8, 2020

The present study shows that COVID-19 can often present as a common cold-like illness. SARS-CoV-2 can actively replicate in the upper respiratory tract, and is shed for a prolonged time after symptoms end, including in stool.

Coronavirus Disease 2019 (COVID-19)
NIH, March 2020 Brand

A Second Interview With Dr. Nancy Wexler, 30 Years Later
D Grady, New York Times, March 10, 2020

It was a story worth waiting for, and I hope I’ve done it justice. She had thought for years that she had Huntington’s, but had the diagnosis confirmed only recently, through a physical exam by a neurologist. She never did take the genetic test that resulted from her own research.

Cost-effectiveness Evaluation of Targeted Surgical and Endoscopic Therapies for Early Colorectal Adenocarcinoma Based on Biomarker Profiles
SR Jang et al. JAMA Network Open, March 9, 2020

Assessment of Treatment Cost-effectiveness Using a Colorectal Cancer Mutation Profile
TJ Yeatman et al, JAMA Netwotk Open, March 9, 2020

The addition of genetic testing to clinicopathologic features (ie, the current standard of care) may provide a new means of determining the most cost-effective, highest-quality approach for this early stage of disease. A prospective comparison of genetic vs pathologic staging in predicting surgical pathologic staging will be necessary.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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