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Hot Topics of the Day|PHGKB
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02/18/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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When will the coronavirus outbreak peak? Officials want to know but predictions vary wildly, from now to after hundreds of millions of people are infected
D Cyranoski, Nature, February 18, 2020

Although peak predictions can be illuminating, some researchers warn that accuracy is difficult to achieve, especially when the data used in models are incomplete.

Indicators of retention in remote digital health studies: a cross-study evaluation of 100,000 participants
A Pratap et al, NPJ Digital Health, February 17, 2020

We report the findings regarding recruitment and retention from eight remote digital health studies conducted between 2014–2019 that provided individual-level study-app usage data from more than 100,000 participants completing nearly 3.5 million remote health evaluations.

An immune-cell signature of bacterial sepsis
M Reyes et al, Nature Medicine, February 17, 2020

A Clinician's Guide to Artificial Intelligence: How to Critically Appraise Machine Learning Studies
L Faes et al, TVST, February 2020

This article aims to empower clinicians and researchers to critically appraise studies of clinical applications of machine learning, through: (1) introducing basic machine learning concepts and nomenclature; (2) outlining key applicable principles of evidence-based medicine; and (3) highlighting potential pitfalls in the design and reporting of these studies.

Randomized Clinical Trials of Artificial Intelligence
DC Angus, JAMA, February 17, 2020

As patient data are increasingly captured digitally, the opportunities to deploy artificial intelligence (AI), especially machine learning, are increasing rapidly. Machine learning is automated learning by computers using tools such as artificial neural networks to search data iteratively for optimal solutions.

Notes from the Field: Carbapenem-resistant Klebsiella pneumoniae with mcr-1 Gene Identified in a Hospitalized Patient — Wyoming, January 2019
H Rhoades et al, MMWR, February 14, 2020

First identified in the United States in Pennsylvania in 2016 and since then reported in 20 more states, this is the first mcr-1 isolate reported in Wyoming or surrounding states. The patient’s frequent intermittent antibiotic use could have increased the risk for contracting antibiotic-resistant bacteria, but the route of acquisition is unknown


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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