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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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23 hot topic(s) found with the query "Von willebrand disease "

Population-based prevalence and mutational landscape of von Willebrand disease using large-scale genetic databases
O Seidizadeh et al, NPJ Genomic Medicine, October 16, 2023 (Posted: Oct 17, 2023 10AM)

From the abstract: "The global prevalence of dominant VWD in 1000 individuals was established to be 74 for type 1, 3 for 2A, 3 for 2B and 6 for 2M. The global prevalences for recessive VWD forms (type 2N and type 3) were 0.31 and 0.7 in 1000 individuals, respectively. This comprehensive analysis provided a global mutational landscape of VWF by means of 927 already reported variants in the HGMD and LOVD datasets and 287 novel pathogenic variants identified in the gnomAD. Our results reveal that there is a considerably higher than expected prevalence of putative disease alleles and variants associated with VWD and suggest that a large number of VWD patients are undiagnosed. "


Higher Rates of Bleeding and Use of Treatment Products Found Among Young Boys Compared to Girls with von Willebrand Disease
CDC, May 17, 2021 Brand (Posted: May 18, 2021 8AM)

Researchers analyzed information from 2,712 children with VWD. The children were 2–12 years old and enrolled in the Universal Data Collection (UDC) system during 1998 to 2011. On average, among all VWD types, boys were younger at their first bleed and at diagnosis of VWD than girls. There were no differences in life quality or well-being status in boys versus girls. Some minority children with VWD (Hispanic or Asian/Pacific Islander/American Indian/American Native) were at higher risk of bleeding, compared to children who are non-Hispanic white.


Bleeding Disorders in Women: Free Materials
CDC, 2019 (Posted: Aug 12, 2019 8AM)

“Better You Know” Materials to increase awareness of the signs and symptoms of bleeding disorders among women. CDC also provides fact sheets and other information about von Willebrand Disease, a genetic blood disorder in which the blood does not clot properly.


Current approaches to diagnostic testing in von Willebrand Disease.
Rao Emily Southard et al. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2018 Jul (Posted: Aug 08, 2018 9AM)


Advances in the diagnosis and treatment of Von Willebrand disease.
Sharma Ruchika et al. Blood 2017 11 (22) 2386-2391 (Posted: Feb 13, 2018 1PM)


Advances in the diagnosis and treatment of Von Willebrand disease.
Sharma Ruchika et al. Hematology. American Society of Hematology. Education Program 2017 Dec (1) 379-384 (Posted: Feb 13, 2018 1PM)


Signs and symptoms of a bleeding disorder
Brand (Posted: Feb 13, 2018 1PM)


Molecular diagnosis of von Willebrand disease.
Baronciani L et al. Haemophilia : the official journal of the World Federation of Hemophilia 2017 Feb (Posted: Mar 13, 2017 6PM)


Bleeding disorders in women
Brand (Posted: Dec 14, 2016 7AM)


Budget Impact Analysis of Blood Clotting Factor Concentrates In The Treatment of Von Willebrand Disease.
Yagudina R et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov (7) A663 (Posted: Dec 01, 2015 1PM)


Von Willebrand disease in the emergency department.
Livesey K et al. Haemophilia : the official journal of the World Federation of Hemophilia 2015 Nov (Posted: Dec 01, 2015 1PM)


Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13.
Tersteeg Claudia et al. Seminars in thrombosis and hemostasis 2015 Nov (Posted: Dec 01, 2015 1PM)


Use of a Pediatric Bleeding Questionnaire in the Screening of Von Willebrand Disease in Young Females at Menarche in the Primary Care Setting.
Duran Joana et al. Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners 2015 Nov (Posted: Dec 01, 2015 1PM)


Women and Bleeding Disorders: Living with von Willebrand Disease
Brand (Posted: Sep 23, 2015 1PM)


Data and Statistics on von Willebrand Disease
Brand (Posted: Sep 23, 2015 1PM)


Information on von Willebrand disease
Brand (Posted: Sep 23, 2015 1PM)


Diagnostic approach to von Willebrand disease.
Ng Christopher et al. Blood 2015 Mar 26. (13) 2029-37 (Posted: Aug 28, 2015 0PM)


Treatment of Hemophilia A and B and von Willebrand disease: A Systematic Review
et al. Stockholm:Swedish Council on Health Technology Assessment (SBU) 2011 May (Posted: Aug 28, 2015 0PM)


Hemophilia And Von Willebrand Disease In Children: Emergency Department Evaluation And Management.
Schwartz Kevin R et al. Emerg Med Pract 2015 Sep (9) 1-24 (Posted: Aug 28, 2015 0PM)


Diagnosis of von Willebrand Disease: Challenges and Opportunities
Special CDC seminar Sep 24, 2015 2:00 PM - 3:00 PM EDT (Posted: Aug 28, 2015 0PM)


Current controversies in the diagnosis and management of von Willebrand disease.
Neff Anne T et al. Ther Adv Hematol 2015 Aug (4) 209-16 (Posted: Aug 28, 2015 0PM)


Von Willebrand Disease
From NHLBI health topic site Brand (Posted: Jan 01, 2014 0AM)

What Is Von Willebrand disease (VWD) is a bleeding disorder. It affects your blood's ability to clot. If your blood doesn't clot, you can have heavy, hard-to-stop bleeding after an injury. The bleeding can damage your internal organs. Rarely, the bleeding may even cause death. In VWD, you either have low levels of a certain protein in your blood or the protein doesn't work well. The protein is called von Willebrand factor, and it helps your blood clot. Normally, when one of your blood vessels is injured, you start to bleed. Small blood cell fragments called platelets (PLATE-lets) clump together to plug the hole in the blood vessel and stop the bleeding. Von Willebrand factor acts like glue to help the platelets stick together and form a blood clot. Von Willebrand factor also carries clotting factor VIII (8), another important protein that helps your blood clot. Factor VIII is the protein that's missing or doesn't work well in people who have hemophilia, another bleeding disorder. VWD is more common and usually milder than hemophilia. In fact, VWD is the most common inherited bleeding disorder. It occurs in about 1 out of every 100 to 1,000 people. VWD affects both males and females, while hemophilia mainly affects males. Types of von Willebrand Disease The three major types of VWD are called type 1, type 2, and type 3. Type 1 People who have type 1 VWD have low levels of von Willebrand factor and may have low levels of factor VIII. Type 1 is the mildest and most common form of VWD. About 3 out of 4 people who have VWD have type 1. Type 2 In type 2 VWD, the von Willebrand factor doesn't work well. Type 2 is divided into subtypes: 2A, 2B, 2M, and 2N. Different gene mutations (changes) cause each type, and each is treated differently. Thus, it's important to know the exact type of VWD that you have. Type 3 People who have type 3 VWD usually have no von Willebrand factor and low levels of factor VIII. Type 3 is the most serious form of VWD, but it's very rare. Overview Most people who have VWD have type 1, a mild form. This type usually doesn't cause life-threatening bleeding. You may need treatment only if you have surgery, tooth extraction, or trauma. Treatment includes medicines and medical therapies. Some people who have severe forms of VWD need emergency treatment to stop bleeding before it becomes life threatening. Early diagnosis is important. With the proper treatment plan, even people who have type 3 VWD can live normal, active lives.


Pseudo-Von Willebrand disease
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)



Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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