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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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7 hot topic(s) found with the query "Infant mortality"

Newborn sequencing is only part of the solution for better child health.
Luca Brunelli et al. Lancet Reg Health Am 2023 9 100581 (Posted: Sep 05, 2023 9AM)

From the abstract: "Our analysis of more than 130 million births in the United States between 1959 and 1995 shows that traditional NBS led to improvements in infant mortality and health equity only when it was implemented in association with measures to improve healthcare access for children. We suggest that the new genomic NBS will lead to better child health only when the same degree of attention devoted to genomic technologies will be directed to the promotion of public health measures that facilitate access to high-quality healthcare for all children."


Implications of Genomic Newborn Screening for Infant Mortality
MH Wojick et al, IJNS, March 2023 (Posted: Mar 09, 2023 1PM)

Current diagnostic genetic workflows are designed to initiate genetic testing after an infant develops disease symptoms, at which time therapies may not be clinically useful. There is increasing interest and an international effort to incorporate genome-wide sequencing into newborn screening approaches, though ethical considerations and other implementation concerns remain unresolved. Here, we comment on the implications of this approach for infant mortality reduction.


Reclassification of the Etiology of Infant Mortality With Whole-Genome Sequencing.
Mallory J Owen et al. JAMA network open 2023 2 (2) e2254069 (Posted: Feb 11, 2023 8AM)

What proportion of infant mortality is explained by genetic diseases? In this cohort study of 112 infant deaths, single-locus genetic diseases were the most common antecedent of infant mortality (41%). Treatments positively associated with outcomes were available for 30% of these genetic diseases. The study results suggest that because treatable genetic diseases are associated with considerable infant mortality, strategies for neonatal diagnosis may be associated with decreased infant mortality.


When They Warn of Rare Disorders, These Prenatal Tests Are Usually Wrong
S Kliff et al, NY Times, January 2, 2022 (Posted: Jan 02, 2022 4PM)

Noninvasive prenatal testing, or NIPT — performs much worse when it looks for less common conditions. Most are caused by small missing pieces of chromosomes called microdeletions. Others stem from missing or extra copies of entire chromosomes. They can have a wide range of symptoms, including intellectual disability, heart defects, a shortened life span or a high infant mortality rate.


Measurement of genetic diseases as a cause of mortality in infants receiving whole genome sequencing
SF Kingsmore et al, NPJ Genomic Medicine, November 2, 2020 (Posted: Nov 03, 2020 7AM)

We sought to measure the contribution of genetic diseases to mortality among infants by secondary analysis of babies enrolled in two clinical studies and a systematic literature review. Our results suggest that rapid genomic sequencing has substantial potential to decrease infant mortality among infants in ICUs.


Infant mortality: the contribution of genetic disorders.
Wojcik Monica H et al. Journal of perinatology : official journal of the California Perinatal Association 2019 Aug (Posted: Aug 12, 2019 8AM)

To determine the proportion of infant deaths occurring in the setting of a confirmed genetic disorder. Five hundred and seventy three deceased infants were identified. 117 were confirmed to have a molecular or cytogenetic diagnosis in a clinical diagnostic laboratory and an additional 7 were diagnosed by research testing for a total of 124/573 (22%)infants.


September is Infant Mortality Awareness Month
Brand (Posted: Sep 07, 2016 2PM)



Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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