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Last Posted: Feb 29, 2024
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Prognostic Value of Preoperative Molecular Testing and Implications for Initial Surgical Management in Thyroid Nodules Harboring Suspected (Bethesda V) or Known (Bethesda VI) Papillary Thyroid Cancer.
Max A Schumm et al. JAMA Otolaryngol Head Neck Surg 2023 6

Is preoperative comprehensive molecular profiling associated with improved prognostication of Bethesda V and VI thyroid nodules with differentiated thyroid cancer, and how does it inform initial surgical treatment? In this cohort study of 105 consecutive patients with papillary thyroid cancer, those with high-risk molecular profiles at diagnosis were more likely to experience cancer persistence or recurrence and distance metastases and had worse 36-month recurrence-free survival than those with intermediate- and low-risk molecular profiles.

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