Last data update: Sep 16, 2024. (Total: 47680 publications since 2009)
Records 1-2 (of 2 Records) |
Query Trace: Coulibaly-Traore D [original query] |
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Epidemiology of rubella infection and genotyping of rubella virus in Cote d'Ivoire, 2012-2016.
Kadjo HA , Waku-Kouomou D , Adagba M , Abernathy ES , Abdoulaye O , Adjogoua DE , Coulibaly-Traore F , Aboubacar S , Daniel E , Icenogle J , Dosso M . J Med Virol 2018 90 (11) 1687-1694 BACKGROUND: Rubella is a contagious disease cause by the rubella virus (RuV) that can lead to serious birth defects when women are infected in early pregnancy. This work aimed to describe the epidemiology and genetic diversity of rubella viruses in Cote d'Ivoire (CIV). MATERIAL AND METHODS: Blood or oral fluid samples collected from suspected measles cases were first tested for the presence of measles specific IgM antibodies by ELISA. All measles IgM negative or indeterminate samples were tested for rubella IgM antibody using ELISA. Rubella- IgM positive samples were tested by real-time reverse transcription PCR (RT-PCR) for the presence of rubella virus RNA. Real-time RT-PCR positive RNA samples were used as template to amplify the 739-nt region used for rubella genotyping. PCR positive samples were sequenced and phylogenetic analysis performed. RESULTS: Between 2012 and 2016, 4121 serums and 126 oral fluids were collected through the measles surveillance system. Of these, 3823 and 108 respectively were measles IgM negative or indeterminate. Subsequent testing for rubella found that 690/3823 (18%) serum samples and 25/108 (23%) oral fluid samples were rubella IgM positive. The 739-nt segment of the E1 glycoprotein gene was amplified and sequenced for 2 serums and 7 oral fluids samples. Phylogenetic analysis showed that the rubella viruses from CIV belonged to genotypes 1G (8 samples) and 2B (1 sample). CONCLUSION: Rubella virus genotype 2B was found in CIV for the first time. These data contribute to baseline information on rubella virus strains found in CIV prior to the introduction of rubella vaccine This article is protected by copyright. All rights reserved. |
Saving lives for a lifetime: supporting orphans and vulnerable children impacted by HIV/AIDS
Nyberg BJ , Yates DD , Lovich R , Coulibaly-Traore D , Sherr L , Thurman TR , Sampson A , Howard B . J Acquir Immune Defic Syndr 2012 60 S127-S135 President's Emergency Plan for AIDS Relief (PEPFAR's) response to the millions of children impacted by HIV/AIDS was to designate 10% of its budget to securing their futures, making it the leading supporter of programs reaching orphan and vulnerable children (OVC) programs globally. This article describes the evolution of PEPFAR's OVC response based on programmatic lessons learned and an evergrowing understanding of the impacts of HIV/AIDS. In launching this international emergency effort and transitioning it toward sustainable local systems, PEPFAR helped establish both the technical content and the central importance of care and support for OVC as a necessary complement to biomedical efforts to end the HIV/AIDS epidemic. Critical services are reaching millions of HIV-affected children and families through vast networks of community-based responders and strengthened national systems of care. But rapid program scale-up has at times resulted in inconsistent responses, failure to match resources to properly assessed needs, and a dearth of rigorous program evaluations. Key investments should continue to be directed toward more sustainable and effective responses. These include greater attention to children's most significant developmental stages, a focus on building the resilience of families and communities, a proper balance of government and civil society investments, and more rigorous evaluation and research to ensure evidence-based programming. Even as HIV prevalence declines and medical treatment improves and expands, the impacts of HIV/AIDS on children, families, communities, economies, and societies will continue to accumulate for generations. Protecting the full potential of children-and thus of societies-requires sustained and strategic global investments aligned with experience and science. |
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