Advanced Molecular Detection Clips Content (Published on 04/22/2021)
NEWS
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Texas A&M researchers spot new coronavirus variant
Rivas K. Fox News, Apr 20, 2021. -
U.S. to spend $1.7 billion to detect, monitor coronavirus variants
Pager T, Achenbach J. Washington Post, Apr 16, 2021. -
AMP Cautions Against Using Cycle Threshold Values for PCR SARS-CoV-2 Tests in Clinical Practice
GenomeWeb, Apr 21, 2021. -
ACMG Presentation Highlights Broad Institute's Massive Expansion of COVID-19 Testing Program
GenomeWeb, Apr 19, 2021. -
CDC-NIH Initiative Provides Roadmap for Broad Use of Rapid COVID-19 Antigen Testing
Bonislawski A. 360dx, Apr 16, 2021. -
Team Tracks Genetic Factors Linked to Severe COVID-19, Other Viral Infections in Children
GEnomeWeb, Apr 16, 2021. -
The Blood-Clot Problem Is Multiplying--So are theories to explain it.
Khamsi R. Atlantic, Apr 16, 2021. -
UK Researchers Publish Data on qPCR-Based Early-Stage Lyme Disease Test
Petrone J. GenomeWeb, Apr 20, 2021.
CONCEPTS / COMMENTS
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How accurately can we assess zoonotic risk?
Wille Michelle et al. PLoS biology 2021 4 (4) e3001135 -
Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes.
Ong Sean Wei Xiang et al. The Lancet. Infectious diseases 2021 4 -
Why stop at just SARS-CoV-2? Vaccines in development aim to protect against many coronaviruses at once.
Cohen J. Science, Apr 16, 2021.
METHODS / TOOLS
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A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch.
Sánchez-Busó Leonor et al. Genome medicine 2021 4 (1) 61
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Rapid Open-Source SNP-Based Clustering Offers an Alternative to Core Genome MLST for Outbreak Tracing in a Hospital Setting
Szarvas J, et al. Front Microbio. 2021 Apr 1;12:636608.
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Data mining of coronavirus: SARS-CoV-2, SARS-CoV and MERS-CoV.
Huh Jung Eun et al. BMC research notes 2021 4 (1) 150 -
Sequence deeper without sequencing more: Bayesian resolution of ambiguously mapped reads.
Shah Rohan N et al. PLoS computational biology 2021 4 (4) e1008926 -
Fostering global data sharing: highlighting the recommendations of the Research Data Alliance COVID-19 working group
Austin CC, et al. Wellcome Open Research, Apr 8, 2021.
EVOLUTION / ECOLOGY / POPULATIONS
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Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2
Zhang J, et al. bioRxiv, Apr 16, 2021. -
Genomic Evolution and Variation of SARS-CoV-2 in the Early Phase of COVID-19 Pandemic in Guangdong Province, China.
Li Bai-Sheng et al. Current medical science 2021 4 (2) 228-235 -
Emergence of the novel SARS-CoV-2 lineage P.4.1 and massive spread of P.2 in South Brazil
Sant'Anna FH, et al. medRxiv, Apr 20, 2021. -
High prevalence of SARS-CoV-2 B.1.1.7 (UK variant) and the novel B.1.5.2.5 lineage in Oyo State, Nigeria.
Ozer Egon A et al. medRxiv : the preprint server for health sciences 2021 4 -
Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States.
Washington Nicole L et al. Cell 2021 4 -
Co-Circulation of 3 Dengue Virus Serotypes led to a Severe dengue outbreak in Xishuangbanna, a border area of China, Myanmar and Laos, 2019.
Zhang Juan et al. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2021 4 -
Short report: Introduction of chikungunya virus ECSA genotype into the Brazilian Midwest and its dispersion through the Americas.
de Oliveira Elaine Cristina et al. PLoS neglected tropical diseases 2021 4 (4) e0009290 -
Evaluation of bat adenoviruses suggests co-evolution and host roosting behaviour as drivers for diversity.
Ntumvi Nkom F et al. Microbial genomics 2021 4 (4) -
Microsatellite based molecular epidemiology of Leishmania infantum from re-emerging foci of visceral leishmaniasis in Armenia and pilot risk assessment by ecological niche modeling.
Kuhls Katrin et al. PLoS neglected tropical diseases 2021 4 (4) e0009288 -
Evidence for natural hybridization and novel
Jeffries Claire L et al. Royal Society open science 2021 4 (4) 202032
PATHOGENICITY / ANTIMICROBIAL RESISTANCE
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Genomic epidemiology of group B streptococci spanning 10 years in an Irish Maternity Hospital, 2008-2017
Meehan M, et al. J Infect. 2021 Apr 13;S0163-4453(21)00166-3. -
Increase in penicillin-resistant invasive meningococcal serogroup W ST-11 complex isolates in England
Willerton L, et al. Vaccine. 2021 Apr 13;S0264-410X(21)00270-X. -
Predicting the animal hosts of coronaviruses from compositional biases of spike protein and whole genome sequences through machine learning.
Brierley Liam et al. PLoS pathogens 2021 4 (4) e1009149 -
Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
Deng X, et al. Cell, Apr 20, 2021. -
High drug resistance levels could compromise the control of HIV infection in paediatric and adolescent population in Kinshasa, the Democratic Republic of Congo.
Rubio-Garrido Marina et al. PloS one 2021 4 (4) e0248835 -
Association of Plasmodium falciparum kelch13 R561H genotypes with delayed parasite clearance in Rwanda: an open-label, single-arm, multicentre, therapeutic efficacy study.
Uwimana Aline et al. The Lancet. Infectious diseases 2021 4
DETECTION / DIAGNOSIS
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Development and validation of real-time PCR assays for the detection of Ehrlichia species and E. chaffeensis in clinical specimens.
Chung Ida H et al. Journal of microbiological methods 2021 4 106225
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Targeting Multicopy Prophage Genes for the Increased Detection of Borrelia burgdorferi Sensu Lato (s.l.), the Causative Agents of Lyme Disease, in Blood
Shan Jinyu et al. Frontiers in microbiology 2021 4 651217 -
Mechanical transmission of SARS-CoV-2 by house flies.
Balaraman Velmurugan et al. Parasites & vectors 2021 4 (1) 214 -
Rapid screening for SARS-CoV-2 variants of concern in clinical and environmental samples using nested RT-PCR assays targeting key mutations of the spike protein.
La Rosa G et al. Water research 2021 4 117104
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Sensitive tracking of circulating viral RNA through all stages of SARS-CoV-2 infection.
Huang Zhen et al. The Journal of clinical investigation 2021 2 (7) -
Respiratory Viral Shedding in Healthcare Workers Reinfected with SARS-CoV-2, Brazil, 2020
Amorim MR, et al. Emerg Infect Dis, Apr 19, 2021. -
Field Deployment of a Mobile Biosafety Laboratory Reveals the Co-Circulation of Dengue Viruses Serotype 1 and Serotype 2 in Louga City, Senegal, 2017.
Dieng Idrissa et al. Journal of tropical medicine 2021 4 8817987
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Application of whole-genome sequencing for norovirus outbreak tracking and surveillance efforts in Orange County, CA
Silva AJ, et al. Food Microbiol. 2021 Sep;98:103796
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Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil
Adelino TE, et al. Nat Commun. 2021 Apr 16;12(1):2296.
EPIDEMIOLOGY / OUTBREAKS / TRANSMISSION
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Carbapenem resistant bacteria in Intensive Care Unit during COVID-19 pandemic: multicenter before-after cross sectional study
Pascale R, et al. Infect Control Hosp Epidemiol. 2021 Apr 16;1-25. -
Retrospective Use of Whole-Genome Sequencing Expands the Multicountry Outbreak Cluster of Listeria monocytogenes ST1247
Maesaar M, et al. Int J Genomics. 2021 Apr 1;2021:6636138. -
Infection and transmission of SARS-CoV-2 in London care homes reporting no cases or outbreaks of COVID-19: Prospective observational cohort study, England 2020.
Jeffery-Smith Anna et al. The Lancet regional health. Europe 2021 4 100038 -
Severe Acute Respiratory Syndrome Coronavirus 2 P.2 Lineage Associated with Reinfection Case, Brazil, June-October 2020
Resende PC, et al. Emerg Infect Dis, Apr 21, 2021. -
Deciphering the introduction and transmission of SARS-CoV-2 in the Colombian Amazon Basin.
Ballesteros Nathalia et al. PLoS neglected tropical diseases 2021 4 (4) e0009327 -
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil.
Faria Nuno R et al. Science (New York, N.Y.) 2021 4 -
SARS-CoV-2 transmission in a Georgia school district - United States, December 2020-January 2021.
Gettings Jenna R et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 4
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Phylogenetic estimates of SARS-CoV-2 introductions into Washington State.
Tordoff Diana M et al. medRxiv : the preprint server for health sciences 2021 4 -
Viral sequencing reveals US healthcare personnel rarely become infected with SARS-CoV-2 through patient contact.
Braun Katarina M et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 4 -
Nosocomial outbreak of COVID-19 by possible airborne transmission leading to a superspreading event.
Cheng Vincent Chi-Chung et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 4 -
Increased Transmissibility of SARS-CoV-2 Lineage B.1.1.7 by Age and Viral Load: Evidence from Danish Households
Lyngse FP, et al. medRxiv, Apr 19, 2021. -
Genome-based local dynamics of canine rabies virus epidemiology, transmission, and evolution in Davao City, Philippines, 2018-2019.
Bacus Michael G et al. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2021 4 104868
ANTIMICROBIALS / VACCINES / INTERVENTIONS
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SARS-CoV-2 variants and convalescent plasma: reality, fallacies, and opportunities.
Casadevall Arturo et al. The Journal of clinical investigation 2021 2 (7) -
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality.
Morgenlander William R et al. The Journal of clinical investigation 2021 2 (7) -
Vaccine Breakthrough Infections with SARS-CoV-2 Variants
Hacisuleyman E, et al. New Engl J Med, Apr 21, 2021.
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Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2 mRNA vaccinated individuals
Kustin T, et al. medRxiv, Apr 16, 2021.
HOST-MICROBE INTERACTIONS
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Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients.
Li Cai-Xia et al. Mediators of inflammation 2021 4 6635925 -
Genetic screening for TLR7 variants in young and previously healthy men with severe COVID-19: a case series
Solanich X, et al. medRxiv, Mar 25, 2021. -
Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms.
Luo Hui et al. European journal of human genetics : EJHG 2021 4 -
Single-cell multi-omics analysis of the immune response in COVID-19.
Stephenson Emily et al. Nature medicine 2021 4 -
Transcriptional and Immunologic Correlates of Response to Pandemic Influenza Vaccine in Aviremic, HIV-Infected Children.
de Armas Lesley R et al. Frontiers in immunology 2021 4 639358 -
The human virome: assembly, composition and host interactions.
Liang Guanxiang et al. Nature reviews. Microbiology 2021 4 -
Microbiome-immune interactions in tuberculosis.
Mori Giorgia et al. PLoS pathogens 2021 4 (4) e1009377 -
Elevated rates of horizontal gene transfer in the industrialized human microbiome.
Groussin Mathieu et al. Cell 2021 4 (8) 2053-2067.e18 -
A population-based study on associations of stool microbiota with atopic diseases in school-age children.
Hu Chen et al. The Journal of allergy and clinical immunology 2021 4
indicates that at least one CDC-affiliated author; indicates that the article addresses aspects of implementation or evaluation in clinical or public health practice. Disclaimer: Articles listed in the Advanced Molecular Detection Clips are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the clips does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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- Page last updated:Sep 7, 2023
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