Published on 11/12/2015
Human Genomics across the Lifespan
Cancer
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Clinical And Budget Impact Of Using A Molecular Test To Detect Kras Mutations In Metastatic Colorectal Cancer Patients In Denmark.
Cheng I et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A349 -
A Cost-Effectiveness Analysis Of A Genomic Test Compared To Standard Of Care In Breast Cancer Patients In France.
Dorey J et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A457 -
Cost-Effectiveness Analysis of Testing for Brca1 and Brca2 Mutations In Women Diagnosed With Ovarian Cancer and Their Female First- And Second Degree Relatives Using A Discrete Event Simulation: A Uk Health Service Perspective.
Eccleston A et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A361 -
Economic Analysis Of Epicup, An Epigenetic Test To Predict The Tissue Of Origin In Cancer Of Unknown Primary Site, The Usa Payors Perspective.
Gracia A et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A356 -
Economic Analysis Of Epicup, An Epigenetic Test To Predict The Tissue Of Origin In Cancer Of Unknown Primary Site, From The Spanish Nhs Perspective.
Gracia A et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A356-7 -
Comparison Of Kras Tested And Not-Tested Metastatic Colorectal Cancer (Mcrc) Patient Cohorts In Europe.
Narayanan S et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A365 -
Economical and Organizational Impact of Adopting Different in Situ Hybridization Technologies to Assess HER2 Gene Amplification in Breast Cancer.
Paolini D et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A361-2 -
From prospective biobanking to precision medicine: BIO-RAIDs - an EU study protocol in cervical cancer.
Ngo Charlotte et al. BMC cancer 2015 15842 -
Clinical follow-up and breast and ovarian cancer screening of true BRCA1/2 noncarriers: a qualitative investigation.
Pelletier Sylvie et al. Genetics in medicine : official journal of the American College of Medical Genetics 2015 Nov -
Towards personalized screening: Cumulative risk of breast cancer screening outcomes in women with and without a first-degree relative with a history of breast cancer.
Ripping T M et al. International journal of cancer. Journal international du cancer 2015 Nov -
High Satisfaction and Low Distress in Breast Cancer Patients One Year after BRCA-Mutation Testing without Prior Face-to-Face Genetic Counseling.
Sie Aisha S et al. Journal of genetic counseling 2015 Nov -
Clinical Practice Guideline for the prevention and early detection of breast and ovarian cancer in women from HBOC (hereditary breast and ovarian cancer) families.
Singer C F et al. Wiener klinische Wochenschrift 2015 Nov -
Clinical And Economic Impact Of The Implementation Of Hpv 16/18 Genotyping Test For Cervical Cancer Screening In Mexican Healthcare System.
Picó J et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A344-5 -
Budget Impact Analysis Of High-Risk Hpv Dna (Hrhpv) Test With 16/18 Genotyping As A Primary Screening Method For Cervical Cancer In Greece.
Skroumpelos A et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A349 -
Next-Generation Testing for Cancer Risk: Perceptions, Experiences, and Needs Among Early Adopters in Community Healthcare Settings.
Blazer Kathleen R et al. Genetic testing and molecular biomarkers 2015 Nov -
Next-Generation Sequencing in Oncology in the Era of Precision Medicine.
Blumenthal Gideon M et al. JAMA oncology 2015 Nov 1-2
Chronic Disease
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Communicating the promise for ocular gene therapies: challenges and recommendations.
Benjaminy Shelly et al. American journal of ophthalmology 2015 Sep 160(3) 408-415.e2 -
Review of Commercially Available Epilepsy Genetic Panels.
Chambers Chelsea et al. Journal of genetic counseling 2015 Nov
Ethics/Policy/Law
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FDA Sends DNA4Life Untitled Letter Regarding Pharmacogenetic Report Product,
Genome Web, November 9, 2015 [by free subscription only] -
Direct-to-consumer genomics on the scales of autonomy.
Vayena Effy et al. Journal of medical ethics 2015 Apr 41(4) 310-4
Practice
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Precision Medicine in the Age of Big Data: The Present and Future Role of Large Scale Unbiased Sequencing in Drug Discovery and Development.
Vicini Paolo et al. Clinical pharmacology and therapeutics 2015 Nov -
The promise and peril of genomic screening in the general population.
Adams Michael C et al. Genetics in medicine : official journal of the American College of Medical Genetics 2015 Nov -
Predictive or not predictive: understanding the mixed messages from the patient's DNA sequence.
Janssens A Cecile J W, et al. Journal of clinical nursing 2015 12 0. (23-24) 3730-5 -
Genomics is changing personal healthcare and medicine: the dawn of iPH (individualized preventive healthcare).
Mehrian-Shai Ruty et al. Human genomics 2015 9(1) 29 -
Establshing The Cost-Effectiveness of Genomic-Based Diagnostic Tests: Are Current Methods Sufficient and Appropriate?
Spackman E et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A727 -
A Next-Generation Framework: Deciding On The Role Of Costs In The Clinical Use Of Targeted Gene Panels, Exome And Genome Sequencing.
van Nimwegen K et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A352 -
Information and Communication Technologies, Genes, and Peer-Production of Knowledge to Empower Citizens' Health.
Biggeri Annibale et al. Science and engineering ethics 2015 Nov -
Crowdsourced direct-to-consumer genomic analysis of a family quartet.
Corpas Manuel et al. BMC genomics 2015 16(1) 910
Heart, Lung, Blood and Sleep Diseases
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NSGC Cardiovascular Genetics Pocket Guide,
National Society of Genetic Counselors -
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 3: Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy and Other Cardiomyopathies, and Myocarditis: A Scientific Statement From the American Heart Association and American College of Cardiology.
Maron Barry J et al. Journal of the American College of Cardiology 2015 Oct -
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 4: Congenital Heart Disease: A Scientific Statement From the American Heart Association and American College of Cardiology.
Van Hare George F et al. Journal of the American College of Cardiology 2015 Oct -
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9: Arrhythmias and Conduction Defects: A Scientific Statement From the American Heart Association and American College of Cardiology.
Zipes Douglas P et al. Journal of the American College of Cardiology 2015 Oct -
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 10: The Cardiac Channelopathies: A Scientific Statement From the American Heart Association and American College of Cardiology.
Ackerman Michael J et al. Circulation 2015 Nov -
Clinical Characteristics, Lipid Treatment and Goal Attainment in a Familial Hypercholesterolemia Cohort in The Netherlands: a Cross Sectional Study.
Kuiper J G et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A379 -
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 14: Sickle Cell Trait: A Scientific Statement From the American Heart Association and American College of Cardiology.
Maron Barry J et al. Circulation 2015 Nov -
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 2: Preparticipation Screening for Cardiovascular Disease in Competitive Athletes: A Scientific Statement From the American Heart Association and American College of Cardiology.
Maron Barry J et al. Circulation 2015 Nov -
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble, Principles, and General Considerations: A Scientific Statement From the American Heart Association and American College of Cardiology.
Maron Barry J et al. Journal of the American College of Cardiology 2015 Oct -
The Magnitude of Increased Cardiovascular (Cv) Risk Associated with Familial Hypercholesterolemia (Fh) for use in Economic Analyses.
Wong B et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A340 -
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 7: Aortic Diseases, Including Marfan Syndrome: A Scientific Statement From the American Heart Association and American College of Cardiology.
Braverman Alan C et al. Journal of the American College of Cardiology 2015 Oct -
Factors influencing uptake of familial long QT syndrome genetic testing.
Burns Charlotte et al. American journal of medical genetics. Part A 2015 Nov
Newborn Screening
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Assessment of the Knowledge and Attitudes of Saudi Mothers towards Newborn Screening.
Al-Sulaiman Ayman et al. BioMed research international 2015 2015718674 -
Some states still won't disclose newborn testing data,
by Ellen Gabler, Milwaukee Wisconsin Journal Sentinel, November 7, 2015 -
Short-term follow-up systems for positive newborn screens in the Washington Metropolitan Area and the United States.
Viall Sarah et al. Molecular genetics and metabolism 2015 Nov
Pharmacogenomics
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DGIdb 2.0: mining clinically relevant drug-gene interactions.
Wagner Alex H et al. Nucleic acids research 2015 Nov -
The Economic Aspect Of Warfarin Pharmacogenetics Introduction Into Health System.
Janzic A et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A402 -
Economic Evaluation Of A Pharmacogenomic Test For Statin-Induced Myopathy In Cardiovascular High-Risk Patients Initiating A Statin.
Mitchell D et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A396
Reproductive Health
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Costs And Cost-Effectiveness Of Non-Invasive Prenatal Diagnosis (Nipt) For Detection Of Trisomy 21 In Sweden.
Davidson T et al. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2015 Nov 18(7) A352
Tools/Databases
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The Cancer Genome Atlas Clinical Explorer: a web and mobile interface for identifying clinical-genomic driver associations.
Lee HoJoon et al. Genome medicine 2015 7(1) 112
News/ Reviews/Comments
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Explainer: what has been holding gene therapy back?
the Conversation, November 11, 2015 -
FDA Warns Three Companies Over DTC Genetic Tests,
by Michael Mezher, RAPS, November 9, 2015 -
The Gene Hackers, by Michael Specter,
the New Yorker, November 16, 2015 Issue -
The dark side of the genome does it matter?
Genomics Education Programme, November 6, 2015 -
Cancer Drivers, Protein Complex Prediction, and Crawling and Gliding Cells: the PLOS Comp Biol October Issue,
PLoS Biologue, November 5, 2015 -
7 Things You Should Know About The Future Of Your Genetic Data,
by Alexander Howard, Huffington Post, November 6, 2015 -
Direct-to-consumer company tests FDA's resolve on gene testing,
by Julie Steenhuysen, Reuters, November 7, 2015 -
Leukaemia success heralds wave of gene-editing therapies,
by Sara Reardon, Nature News, November 5, 2015 -
The Hottest New Cancer Drugs Depend on Gut Microbes,
by Ed Yong, the Atlantic, November 5, 2015 -
Gene therapies offer dramatic promise but shocking costs
by Carolyn Y. Johnson and Brady Dennis, the Washington Post, November 11, 2015 -
Limiting Lynch Syndrome Screening in Endometrial Cancers May Be Harmful,
by Lourdes Briz, Cancer Therapy Advisor, November 10, 2015 -
CRISPR: A path through the thicket,
Nature News, November 10, 2015 -
AHA: Giving Genetic Risk Info Helps Rein in LDL,
Medpage Today, November 9, 2015 -
I Am Paying for Your Expensive Medicine,
by Ezekiel J. Emanuel, New York Times, November 7, 2015 -
First precision medicine trial in cancer prevention,
by Rebecca Burbidge, PHG Foundation, November 6, 2015 -
Reproducibility and reliability of biomedical research: improving research practice,
the Academy of Medical Sciences, October 2015 -
20 Health Mistakes to Stop Making Before You Turn 40,
by Karen Pallarito, Time, October 16, 2015 -
Putting personalized medicine to the test,
University of Alabama at Birmingham, You Tube, March 11, 2015 -
US FDA sends letter to DNA4Life over consumer gene tests,
Reuters, November 10, 2015 -
Geneticist Craig Venter helped sequence the human genome. Now he wants yours,
by Carl Zimmer, Stat News, November 5, 2015