Published on 08/28/2015
Human Genomics across the Lifespan
Birth Defects and Child Health
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What is the role of clinical genetics in the patient-centered medical home?: A commentary from the Medical Home Workgroup of the Heartland Regional Genetics and Newborn Screening Collaborative.
Schaefer Gerald Bradley et al. Genet. Med. 2015 Aug 20.
Cancer
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Development and Validation of a Next-Generation Sequencing Assay for BRCA1 and BRCA2 Variants for the Clinical Laboratory.
Strom Charles M et al. PLoS ONE 2015 10(8) e0136419 -
Screening Strategies for Colorectal Cancer among Patients with Non-Alcoholic Fatty Liver Disease and Family History.
Wong Martin Cs et al. Int. J. Cancer 2015 Aug 20. -
Efficacy of a web-based intelligent tutoring system for communicating genetic risk of breast cancer: a fuzzy-trace theory approach.
Wolfe Christopher R et al. Med Decis Making 2015 Jan 35(1) 46-59 -
Next-Generation Sequencing and Detection of Minimal Residual Disease in Acute Myeloid Leukemia: Ready for Clinical Practice?
Pastore Friederike et al. JAMA 2015 Aug 25. 314(8) 778-780 -
Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
Klco Jeffery M et al. JAMA 2015 Aug 25. 314(8) 811-822 -
The role of germline mutations in the BRCA1/2 and mismatch repair genes in men ascertained for early-onset and/or familial prostate cancer.
Maia Sofia et al. Fam. Cancer 2015 Aug 20. -
NCI-MATCH launch highlights new trial design in precision-medicine era.
McNeil Caroline et al. J. Natl. Cancer Inst. 2015 Jul 107(7) -
Initial medical policy and model coverage guidelines for clinical NGS in oncology, [PDF 965.34 KB]
Green Park Collaborative, Aug 17, 2015 -
Is it time to offer BRCA1 and BRCA2 testing to all Jewish women?
Metcalfe K A et al. Curr Oncol 2015 Aug 22(4) e233-6 -
Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer.
Garcia-Murillas Isaac, et al. Science translational medicine 2015 8 0. (302) 302ra133 -
Does molecular monitoring matter in early-stage breast cancer?
Sundaresan Tilak K, et al. Science translational medicine 2015 8 0. (302) 302fs35 -
New 'mutation-tracking' blood test could predict breast cancer relapse months in advance,
the Institute of Cancer Research, Aug 26, 2015 -
Women with double primary cancers of the colorectum and endometrium: do they have Lynch syndrome?
Song Taejong et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 2015 Aug 19. -
Rescreening for genetic mutations using multi-gene panel testing in patients who previously underwent non-informative genetic screening.
Frey Melissa K et al. Gynecol. Oncol. 2015 Aug 18.
Chronic Disease
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If three of my brothers have ankylosing spondylitis, why does the doctor say it is not necessarily hereditary? The meaning of risk in multiplex case families with ankylosing spondylitis.
Peláez-Ballestas Ingris et al. Chronic Illn 2015 Aug 19. -
The genomic landscape of human immune-mediated diseases.
Wu Xin et al. J. Hum. Genet. 2015 Aug 20. -
A Systematic Review on the Cost-Effectiveness of Genetic and Electrocardiogram Testing for Long QT Syndrome in Infants and Young Adults.
Gonzalez Fernando Matias et al. Value Health 2015 Jul 18(5) 700-8
Ethics/Policy/Law
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Military Health Care Dilemmas and Genetic Discrimination: A Family's Experience with Whole Exome Sequencing.
Helm Benjamin M et al. Narrat Inq Bioeth 2015 5(2) 179-86 -
Pharmacogenomics, human genetic diversity and the incorporation and rejection of color/race in Brazil.
Santos Ricardo Ventura et al. Biosocieties 2015 Mar 1. 10(1) 48-69 -
Ethical considerations in presymptomatic diagnosis of autosomal dominant spinocerebellar ataxias.
Orozco-Gutiérrez M H et al. Neurologia 2015 Aug 21. -
The Limits of FDA's Authority to Regulate Clinical Research Involving High-Throughput DNA Sequencing.
Evans Barbara J et al. Food Drug Law J 2015 70(2) 259-87, ii -
An Unfulfilled Promise: Changes Needed to the Drug Approval Process to Make Personalized Medicine a Reality.
Riley Margaret Foster et al. Food Drug Law J 2015 70(2) 289-314, ii-iii -
The gene patent controversy on Twitter: a case study of Twitter users' responses to the CHEO lawsuit against Long QT gene patents.
Du Li et al. BMC Med Ethics 2015 1655
Practice
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Pregnant patients' risk perception of prenatal test results with uncertain fetal clinical significance: ultrasound versus advanced genetic testing.
Richards Elliott G et al. Prenat. Diagn. 2015 Aug 19. -
The new world of genomic testing, families and privacy.
Wolf Susan M et al. Minn Med 2015 Jun 98(6) 32-4
Newborn Screening
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Screening for cystic fibrosis in New York State: considerations for algorithm improvements.
Kay Denise M et al. Eur. J. Pediatr. 2015 Aug 21.
Pharmacogenomics
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Physicians' opinions following pharmacogenetic testing for psychotropic medication.
Walden Lucas M et al. Psychiatry Res 2015 Aug 7. PSYD1500197
Reproductive Health
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The evolution of prenatal genetic screening.
Gross Susan et al. MLO Med Lab Obs 2015 May 47(5) 14
News/ Reviews/Comments
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Next steps in developing the Precision Medicine Initiative,
the White House, Aug 21, 2015 -
New guidelines to help payers navigate NGS testing in cancer,
by Roxanne Nelson, Medscape, Aug 19, 2015 [by free subscription only] -
Genetic testing can lead to insights - or uncertainty,
by Lauren M. Green, Cure, Aug 13, 2015 -
Biohackers gear up for genome editing,
by Heidi Ledford, Nature News, Aug 26, 2015 -
The DNA of a nation.
Marx Vivien, et al. Nature 2015 8 0. (7566) 503-5 -
Everything You Need to Know About Precision Medicine,
by Alexandra Ossola, Popular Science, Aug 27, 2015 -
The Mystery of Jimmy Carters Cancer,
the Daily Beast, Aug 20, 2015 -
New international effort to uncover schizophrenia genomics,
by Dr Philippa Brice, PHG Foundation, Aug 20, 2015 -
It's complicated: genomics, obesity and diabetes,
Genomics Education Programme, Aug 17, 2015