Published on 03/06/2015
Human Genomics across the Lifespan
Cancer
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Health psychology and translational genomic research: Bringing innovation to cancer-related behavioral interventions.
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Development of cancer genetic services in the UK: A national consultation.
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Lynch Syndrome: A Primer for Urologists and Panel Recommendations.
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Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing.
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Triple-Modality Screening Trial for Familial Breast Cancer Underlines the Importance of Magnetic Resonance Imaging and Questions the Role of Mammography and Ultrasound Regardless of Patient Mutation Status, Age, and Breast Density.
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Family history of breast and ovarian cancer and triple negative subtype in hispanic/latina women.
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The Predictive Accuracy of PREDICT: A Personalized Decision-Making Tool for Southeast Asian Women With Breast Cancer.
Chronic Disease
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An Intervention Study of Individual, apoE Genotype-Based Dietary and Physical-Activity Advice: Impact on Health Behavior.
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Preventing tooth loss with biannual dental visits and genetic testing: Does it work?
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Interleukin 1 genetic tests provide no support for reduction of preventive dental care.
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Counterpoint: Risk factors, including genetic information, add value in stratifying patients for optimal preventive dental care.
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An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease.
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Clinical relevance of apolipoprotein E genotyping based on a family history of Alzheimer's disease.
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Clinical utility gene card for: Nemaline myopathy.
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Interactions of Lipid Genetic Risk Scores with Estimates of Metabolic Health in a Danish Population.
Justesen Johanne M, Allin Kristine H, Sandholt Camilla H, Borglykke Anders, Krarup Nikolaj T, Grarup Niels, Linneberg Allan, Jørgensen Torben, Hansen Torben, Pedersen Oluf.Circ Cardiovasc Genet 2015 Feb 24.
Ethics/Policy/Law
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Stakeholders' perspectives on biobank-based genomic research: systematic review of the literature.
Husedzinovic Alma, et al. European journal of human genetics : EJHG 2015 12 0. (12) 1607-14 -
Ethical and public policy challenges for pharmacogenomics.
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To know or not to know? Integrating ethical aspects of genomic healthcare in the education of health professionals.
Practice
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A computer-based education intervention to enhance surrogates' informed consent for genomics research.
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Closing the Gap between Knowledge and Clinical Application: Challenges for Genomic Translation.
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The Contribution of Genomic Research to Explaining Racial Disparities in Cardiovascular Disease: A Systematic Review.
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Improving Molecular Genetic Test Utilization through Order Restriction, Test Review, and Guidance.
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The Human Genome Project, and recent advances in personalized genomics.
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The Context of Collecting Family Health History: Examining Definitions of Family and Family Communication about Health among African American Women.
Pharmacogenomics
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Nurses' communication of pharmacogenetic test results as part of discharge care.
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Pharmacogenomics in diverse practice settings: implementation beyond major metropolitan areas.
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Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis.
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A patient-centered approach to the development and pilot of a warfarin pharmacogenomics patient education tool for health professionals.
Reproductive Health
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Uptake of non-invasive prenatal testing (NIPT) and impact on invasive procedures in a tertiary referral center.
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Expanded carrier screening in reproductive medicine-points to consider: a joint statement of the american college of medical genetics and genomics, american college of obstetricians and gynecologists, national society of genetic counselors, perinatal quality foundation, and society for maternal-fetal medicine.
News/ Reviews/Comments
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Whole genomes redefine the mutational landscape of pancreatic cancer.
Waddell Nicola, Pajic Marina, Patch Ann-Marie, Chang David K, Kassahn Karin S, Bailey Peter, Johns Amber L, Miller David, Nones Katia, Quek Kelly, Quinn Michael C J, Robertson Alan J, Fadlullah Muhammad Z H, Bruxner Tim J C, Christ Angelika N, Harliwong Ivon, Idrisoglu Senel, Manning Suzanne, Nourse Craig, Nourbakhsh Ehsan, Wani Shivangi, Wilson Peter J, Markham Emma, Cloonan Nicole, Anderson Matthew J, Fink J Lynn, Holmes Oliver, Kazakoff Stephen H, Leonard Conrad, Newell Felicity, Poudel Barsha, Song Sarah, Taylor Darrin, Waddell Nick, Wood Scott, Xu Qinying, Wu Jianmin, Pinese Mark, Cowley Mark J, Lee Hong C, Jones Marc D, Nagrial Adnan M, Humphris Jeremy, Chantrill Lorraine A, Chin Venessa, Steinmann Angela M, Mawson Amanda, Humphrey Emily S, Colvin Emily K, Chou Angela, Scarlett Christopher J, Pinho Andreia V, Giry-Laterriere Marc, Rooman Ilse, Samra Jaswinder S, Kench James G, Pettitt Jessica A, Merrett Neil D, Toon Christopher, Epari Krishna, Nguyen Nam Q, Barbour Andrew, Zeps Nikolajs, Jamieson Nigel B, Graham Janet S, Niclou Simone P, Bjerkvig Rolf, Grützmann Robert, Aust Daniela, Hruban Ralph H, Maitra Anirban, Iacobuzio-Donahue Christine A, Wolfgang Christopher L, Morgan Richard A, Lawlor Rita T, Corbo Vincenzo, Bassi Claudio, Falconi Massimo, Zamboni Giuseppe, Tortora Giampaolo, Tempero Margaret A, , Gill Anthony J, Eshleman James R, Pilarsky Christian, Scarpa Aldo, Musgrove Elizabeth A, Pearson John V, Biankin Andrew V, Grimmond Sean M.Nature 2015 Feb 26. (7540) 495-501 -
Excitement building for PARP inhibitors in BRCA-mutated breast cancer,
by Tony Hagen, OncLive, Feb 27 -
Making personalized medicine more affordable.
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"Personalized medicine" renamed "precision medicine",
Genome Alberta blog post, Feb 28 -
23andMe and the promise of anonymous genetic testing,
The New York Times, Mar 2 -
Separating the microbiome from the hyperbolome.
Shanahan Fergus.Genome Med 2015 (1) 17 -
When even well-posed questions are hard to answer,
by Anne Buchanan, the Mermaid's Tale blog post, Mar 2 -
Friday Feedback: Do-it-yourself genetic testing,
by Molly Walker, Medpage Today, Feb 27 -
Genetics at the heart of cardiovascular health,
by Graciela Gutierrez, Baylor College of Medicine News, Feb 26 -
Harold Varmus outlines goals for precision medicine in cancer,
Columbia University Medical Center Newsroom, Feb 26 -
Genetic pathways linked to CF disease severity pinned down,
Science Daily, Feb 23 -
Huge epigenomic map examines life's impact on our genes,
by Catherine Brahic, New Scientist, Feb 18 -
Genome sequencing: What do patients think?
Bio News, Mar 2 -
Genetic discovery may help determine effectiveness of Huntington's disease treatments,
EurekAlert, Mar 2 -
False positive screenings pose dire challenges for parents,
by Beth Daley, Genetic Literacy Project, Mar 2 -
Postmortem disclosure of genetic information to family members: active or passive?
Boers S, et al. Trends in Molecular Med 2015 21(3)148-153 -
Should doctors share gene tests after a death in the family?
By Loane Skene, the Conversation, Mar 2 -
Genomic game-changer for pancreatic cancer,
PHG Foundation, Mar 2 -
Insure people against genetic data breaches,
by Frank Pasquale, the New York Times, Mar 2 -
Meeting the challenge of rare disease diagnosis,
by Dr Philippa Brice, Feb 27 -
Proposing a new *science* of patient engagement,
e-Patient Dave