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Diabetes PHGKB

Specific PHGKB|Diabetes PHGKB|PHGKB

Last Posted: Nov 05, 2021
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Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes
DM Aly et al, Nature Genetics, November 4, 2021

We used genome-wide association and genetic risk score (GRS) analysis to compare the underlying genetic drivers. Individuals from the Swedish ANDIS (All New Diabetics In Scania) study were compared to individuals without diabetes; the Finnish DIREVA (Diabetes register in Vasa) and Botnia studies were used for replication. We show that subtypes differ with regard to family history of diabetes and association with GRS for diabetes-related traits.

Innovative new model predicts glucose levels without poking or prodding
L Wedland et al, NPJ Digital Medicine, August 20, 2021

Non-invasive glucose monitoring once seemed like an impossible challenge, but today’s technology and the incredible work of Bent et al. promise a future in which daily fingersticks are obsolete. The new challenge will be realizing that promise in an accessible and practical way that benefits all patients.

Preventing type 1 diabetes in childhood.
Dayan Colin M et al. Science (New York, N.Y.) 2021 7 (6554) 506-510

Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing ß cells of the pancreas are destroyed by T lymphocytes. Recent studies have demonstrated that monitoring for pancreatic islet autoantibodies, combined with genetic risk assessment, can identify most children who will develop T1D when they still have sufficient ß cell function to control glucose concentrations without the need for insulin.

Immunotherapy: Building a bridge to a cure for type 1 diabetes.
Bluestone Jeffrey A et al. Science (New York, N.Y.) 2021 7 (6554) 510-516

Over the past two decades, research has identified multiple immune cell types and soluble factors that destroy insulin-producing ß cells. These insights into disease pathogenesis have enabled the development of therapies to prevent and modify T1D. In this review, we highlight the key events that initiate and sustain pancreatic islet inflammation in T1D, the current state of the immunological therapies, and their advantages for the treatment of T1D.

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