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Infectious Disease PHGKB

Specific PHGKB|Infectious Diseases PHGKB|PHGKB
Last Posted: Dec 05, 2023
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Neighborhood Deprivation Measures and DNA Methylation Clocks-Understanding the Real Needs of Each Person.
Benjamin D Horne et al. JAMA Netw Open 2023 11 (11) e2344688 (Posted Dec 02, 2023 9AM)

From the article: " A recent study reports a unique and powerful approach for finding neighborhood factors marking risks of early death and disease.4 Measurement of racial segregation using spatial clustering methods and separating that from economic deprivation (and education) aid in clarifying the sources of health concerns. The study uses methylation patterns which can be remodeled by many factors such as smoking, physical activity, diet, infection, and stressors from the childhood environment (eg, lack of loving adult support, malnutrition), adverse living conditions (eg, noise pollution, particulate matter air pollution), and poor interactions with others (eg, emotional or physical abuse). "

A medical multimodal large language model for future pandemics
Liu et al, NPJ Digital Medicine, December 2, 2023 (Posted Dec 02, 2023 8AM)

From the paper: "With the goal of quick deployment of tools for rapid response to rare diseases, we present the medical multimodal large language model (Med-MLLM) framework. We evaluate the effectiveness of Med-MLLM using the COVID-19 pandemic “in replay”, showing that Med-MLLM is able to accomplish accurate COVID-19 decision-support tasks with limited labelled data. In contrast, existing efforts usually require thousands, or even more, labelled data to achieve similar performance. "

Notes from the Field: The National Wastewater Surveillance System's Centers of Excellence Contributions to Public Health Action During the Respiratory Virus Season - Four U.S. Jurisdictions, 2022-23.
Diana Valencia et al. MMWR Morb Mortal Wkly Rep 2023 11 (48) 1309-1312 (Posted Dec 01, 2023 7AM)

From the article: "NWSS Centers of Excellence have reported correlation between WWS data and clinical surveillance with WWS allowing localized, timely coverage, and in some situations, valuable lead time notification. In Wisconsin, WWS detected increases in influenza and RSV weeks before increases in related emergency department visits were observed. NWSS data, together with clinical surveillance data, have guided jurisdictional partner decisions regarding allocation of resources, deployment of vaccination clinics, updating clinical guidance, and sending respiratory disease notifications and alerts when trends exceed baseline thresholds. During the 2022–23 respiratory disease season, NWSS Centers of Excellence translated WWS data into real-time public health action for multiple respiratory pathogens, highlighting the contribution of WWS in monitoring disease circulation and helping guide public health response. "

'Treasure trove' of new CRISPR systems holds promise for genome editing.
Sara Reardon et al. Nature 2023 11 (Posted Nov 27, 2023 10AM)

From the paper: "CRISPR–Cas9 is best known as a laboratory tool for editing DNA, but its natural function is as part of the immune system that helps certain microorganisms to fight off viruses. Now, researchers have used an algorithm to sort through millions of genomes to find new, rare types of CRISPR system that could eventually be adapted into genome-editing tools. "


news Latest News and Publications
Breakthrough infection elicits hypermutated IGHV3-53/3-66 public antibodies with broad and potent neutralizing activity against SARS-CoV-2 variants including the emerging EG.5 lineages. External Web Site Icon
Li Ling, et al. PLoS pathogens 2023 0 0. (12) e1011856
Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86 lineages combining increased fitness and antibody evasion. External Web Site Icon
Planas Delphine, et al. bioRxiv : the preprint server for biology 2023 0 0.
Forecasting local hospital bed demand for COVID-19 using on-request simulations. External Web Site Icon
Kociurzynski Raisa, et al. Scientific reports 2023 0 0. (1) 21321
Relationships between COVID-19 healthcare outcomes and county characteristics in the U.S. for Delta (B.1.617.2) and Omicron (B.1.1.529 and BA.1.1) variants. External Web Site Icon
Bruckhaus Alexander A, et al. Frontiers in public health 2023 0 0. 1252668
Relative vaccine effectiveness of mRNA COVID-19 boosters in people aged at least 75 years during the spring-summer (monovalent vaccine) and autumn-winter (bivalent vaccine) booster campaigns: a prospective test negative case-control study, United Kingdom, 2022. External Web Site Icon
Chatzilena Anastasia, et al. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2023 0 0. (48)
SARS-CoV-2 Epidemiology and COVID-19 mRNA Vaccine Effectiveness Among Infants and Children Aged 6 Months-4 Years - New Vaccine Surveillance Network, United States, July 2022-September 2023. External Web Site Icon
Tannis Ayzsa, et al. MMWR. Morbidity and mortality weekly report 2023 0 0. (48) 1300-1306
Wastewater surveillance in the COVID-19 post-emergency pandemic period: A promising approach to monitor and predict SARS-CoV-2 surges and evolution. External Web Site Icon
Sanchez Jimenez Bryan, et al. Heliyon 2023 0 0. (11) e22356
Empowering COVID-19 detection: Optimizing performance through fine-tuned EfficientNet deep learning architecture. External Web Site Icon
Talukder Md Alamin, et al. Computers in biology and medicine 2023 0 0. 107789
Model-based analysis of the incidence trends and transmission dynamics of COVID-19 associated with the Omicron variant in representative cities in China. External Web Site Icon
Ma Yifei, et al. BMC public health 2023 0 0. (1) 2400
A medical multimodal large language model for future pandemics External Web Site Icon
Liu et al, NPJ Digital Medicine, December 2, 2023

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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