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Cancer PHGKB

Specific PHGKB|Cancer|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Effective August 1, 2024, this database was discontinued. All content will remain searchable and be preserved online for historical purposes only until 2029.

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The Path to Genomic Screening—Far From Simple, but the Journey Has Begun

From the article: "Today’s genomic technology introduces a multitude of assays that could be deployed in health care: diagnostic testing of patients with suspected monogenic conditions, polygenic risk prediction for common diseases, pharmacogenomic analysis for drug-gene interactions, analysis of tumors for targetable somatic sequence variations, and noninvasive screening for prenatal chromosomal disorders or occult cancer. Alongside these approaches we must also grapple with screening of the ostensibly healthy population for monogenic diseases of newborns, children, and adults with either targeted or genome-scale sequencing. "

Screening Familial Risk for Hereditary Breast and Ovarian Cancer

From the abstract: "In a large health system, how many ungenotyped patients meet family history genetic testing criteria for hereditary breast and ovarian cancer? In this cross-sectional analysis, 2.9% of patients had no evidence of prior genetic testing but had electronic health records indicating they met family history criteria. These criteria were associated with significantly increased prevalence of genetic risk variants among 38?003 genotyped patients. These findings suggest that substantial gaps exist in identifying and testing patients meeting family history criteria for hereditary breast and ovarian cancer, and other methods may be needed to close these gaps. "

Harnessing cancer genomes for precision oncology

From the abstract: "Precision oncology has just received a boost: a report on the prevalence of mutations in cancer driver genes based on whole genome sequencing of 10,000 clinical cases. The challenge ahead lies in how to explore the data to accelerate new discoveries in cancer biology while advancing precision oncology. "

Advancing Genomic Cancer Medicine in Rural and Underserved States

From the article: "In the evolving landscape of oncology, the integration of powerful genomic technologies into practice has ushered in a new era of precision cancer medicine. Complex genomic information such as mutational analyses, transcriptional signatures, and polygenic risk scores have become key diagnostics guiding therapeutic decisions and management of inherited cancer risk. However, the expertise to interpret these data for clinical decision-making remains constrained and is a significant challenge for community oncologists, especially those in rural regions and in medically underserved areas. While physical access to these tests is readily available, poor access to interpretive expertise has become the key limiting factor. "


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Hassan Youssef M, et al. Clinical and experimental medicine 2025 0 0. (1) 33
Equivocating and Deliberating on the Probability of COVID-19 Infection Serving as a Risk Factor for Lung Cancer and Common Molecular Pathways Serving as a Link. External Web Site Icon
Amara Abdelbasset, et al. Pathogens (Basel, Switzerland) 2025 0 0. (12)
IL-18 and IL-18BP: A Unique Dyad in Health and Disease. External Web Site Icon
Novick Daniela, et al. International journal of molecular sciences 2025 0 0. (24)
Longitudinal Study of SARS-CoV-2 Vaccinations and Infections in Patients with Gastrointestinal Cancer: Stabilizing Immune Responses and Neutralizing Emerging Variants with Variant-Adapted Antigen Exposures. External Web Site Icon
Gonzalez-Carmona Maria A, et al. International journal of molecular sciences 2025 0 0. (24)
SARS-CoV-2 Spike Protein Amplifies the Immunogenicity of Healthy Renal Epithelium in the Presence of Renal Cell Carcinoma. External Web Site Icon
Somova Maryna, et al. Cells 2025 0 0. (24)
SEMdag: Fast learning of Directed Acyclic Graphs via node or layer ordering. External Web Site Icon
Grassi Mario, et al. PloS one 2025 0 0. (1) e0317283
State of Knowledge About Thyroid Cancers in the Era of COVID-19-A Narrative Review. External Web Site Icon
Bronowicka-Szydelko Agnieszka, et al. Biomedicines 2025 0 0. (12)
Cardiovascular Safety of Anti-CGRP Monoclonal Antibodies in Older Adults or Adults With Disability With Migraine. External Web Site Icon
Yang Seonkyeong, et al. JAMA neurology 2025 0 0.
An automated privacy-preserving self-supervised classification of COVID-19 from lung CT scan images minimizing the requirements of large data annotation. External Web Site Icon
Chowa Sadia Sultana, et al. Scientific reports 2025 0 0. (1) 226
Recent advances in mRNA-based therapeutics for neurodegenerative diseases and brain tumors. External Web Site Icon
Yang Lizhi, et al. Nanoscale 2025 0 0.

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About Cancer PHGKB

Cancer PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the translation of genomic and other precision health discoveries into improved health care and prevention related to cancer...more

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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