Records 1 - 30
| Implementation of NUDT15 genotyping to prevent Azathioprine-induced leukopenia for patients with autoimmune disorders in Chinese population.
Clinical pharmacology and therapeutics 2022 Jul .
Wang Chuang-Wei, Chi Min-Hui, Tsai Tsen-Fang, Yu Kuang-Hui, Kao Hsiao-Wen, Chen Hsiang-Cheng, Chen Chun-Bing, Lu Chun-Wei, Chen Wei-Ti, Chang Ya-Ching, Chang Chih-Jung, Chang Yun-Ting, Jan Wu Yeong-Jian, Chang Chee-Jen, Huang Yu Huei, Ng Chau-Yee, Huang Po-Wei, Lin Yu-Jr, Hui Rosaline Chung-Yee, Chung Wen-Hung,
| ITPA and NUDT15 are Good Predictors of Clinical Outcomes in Thiopurine-Treated Chinese Patients with Inflammatory Bowel Disease.
Therapeutic drug monitoring 2022 Jan .
Luo Xuemei, Yan Simin, Jin Lu, Zhu Huaijun, Ge Weihong, Zhang Xiao
| TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India.
BMC gastroenterology 2021 Aug 21 (1): 327.
Grover Narinder, Bhatia Prateek, Kumar Antriksh, Singh Minu, Lad Deepesh, Mandavdhare Harshal S, Samanta Jayanta, Prasad Kaushal K, Dutta Usha, Sharma Vish
| Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis.
Scientific reports 2021 Apr 11 (1): 7984.
Miao Qiang, Yan Lin, Zhou Yanhong, Li Yi, Zou Yuangao, Wang Lanlan, Bai Yangjuan, Zhang Junlo
| A rare case of Azathioprine-induced leukopenia in an European woman.
Acta clinica Belgica 2020 Aug 1-5.
Séverine Wautier, Xavier De Koninck, Jean-Charles Coc
| Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohn's disease.
British journal of clinical pharmacology 2020 May .
Choi Rihwa, Lee Mi-Na, Kim Kyunga, Baek Sun-Young, Kim Tae Jun, Hong Sung Noh, Kim Young-Ho, Lee Soo-Yo
| Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice.
The pharmacogenomics journal 2020 Feb .
Anandi Prathima, Dickson Alyson L, Feng QiPing, Wei Wei-Qi, Dupont William D, Plummer Dale, Liu Ge, Octaria Rany, Barker Katherine A, Kawai Vivian K, Birdwell Kelly, Cox Nancy J, Hung Adriana, Stein C Michael, Chung Cecilia
| Predictive Value of NUDT15 Variants on Neutropenia Among Han Chinese Patients with Dermatologic Diseases: A Single-Center Observational Study.
Dermatology and therapy 2020 Feb .
Huang Po-Wei, Tseng Yu-Hsian, Tsai Tsen-Fa
| Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia.
Frontiers in pharmacology 2020 11 594262.
Burgueño-Rodríguez Gabriela, Méndez Yessika, Olano Natalia, Dabezies Agustín, Bertoni Bernardo, Souto Jorge, Castillo Luis, da Luz Julio, Soler Ana Mar
| An intronic FTO variant rs16952570 confers protection against thiopurine-induced myelotoxicities in multiethnic Asian IBD patients.
The pharmacogenomics journal 2019 Dec .
Chen Sylvia, Tan Wei Zhi, Sutiman Natalia, Lim Cindy, Lee Sze Sing, Leong Wai Fook, Tjai Madeline, Wang Chunyan, Kong Chris San Choon, Chuah Sai Wei, Schwender Brian John, Chan Webber, Shim Hang Hock, Lim Wee Chian, Khor Chiea Chuen, Ling Khoon Lin, Chowbay Balr
| Systematic review with meta-analysis: risk factors for thiopurine-induced leukopenia in IBD.
Alimentary pharmacology & therapeutics 2019 Jul .
van Gennep Sara, Konté Kadère, Meijer Berrie, Heymans Martijn W, D'Haens Geert R, Löwenberg Mark, de Boer Nanne K
| Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?
BMC cancer 2018 May 18 (1): 516.
Zhou Hong, Li Lei, Yang Peng, Yang Lin, Zheng Jin E, Zhou Ying, Han Yo
| Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease.
World journal of gastroenterology 2018 Feb 24 (8): 941-948.
Wang Hong-Hui, He Ying, Wang Hong-Xian, Liao Cheng-Ling, Peng Yu, Tao Li-Jian, Zhang Wei, Yang Hui-Xia
| Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines.
World journal of gastroenterology 2018 Jan 24 (4): 511-518.
Kojima Yuichiro, Hirotsu Yosuke, Omata Wataru, Sugimori Makoto, Takaoka Shinya, Ashizawa Hiroshi, Nakagomi Keiko, Yoshimura Dai, Hosoda Kenji, Suzuki Yoji, Mochizuki Hitoshi, Omata Mas
| NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients.
Frontiers in pharmacology 2018 9 460.
Fei Xiang, Shu Qing, Zhu Huaijun, Hua Bingzhu, Wang Shiying, Guo Ling, Fang Yun, Ge Weiho
| Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity.
Drug metabolism and personalized therapy 2018 03 33 (1): 57-60.
Shah Swarup A V, Paradkar Minal U, Desai Devendra C, Ashavaid Tester
| Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study.
PloS one 2018 13 (4): e0195524.
Hessels Arno C, Rutgers Abraham, Sanders Jan Stephan F, Stegeman Coen
| Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients.
Pharmacogenomics 2017 Dec .
Sutiman Natalia, Chen Sylvia, Ling Khoon Lin, Chuah Sai Wei, Leong Wai Fook, Nadiger Vinayak, Tjai Madeline, Choon Kong Chris San, Schwender Brian John, Chan Webber, Shim Hang Hock, Lim Wee Chian, Khor Chiea Chuen, Cheung Yin Bun, Chowbay Balr
| Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients.
Annals of dermatology 2017 Oct 29 (5): 529-535.
Lee Minseok, Seo Jimyung, Bang Dongsik, Kim Do You
| Prevalence of thiopurine S-methyltransferase gene polymorphisms in patients with inflammatory bowel disease from the island of Crete, Greece.
European journal of gastroenterology & hepatology 2017 Aug .
Coucoutsi Constantina, Emmanouil George, Goulielmos George, Sfakianaki Ourania, Koutroubakis Ioannis E, Kouroumalis Elias
| NUDT15 p.R139C variant is common and strongly associated with azathioprine-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases.
Journal of the neurological sciences 2017 Jul 378 64-68.
Kim Sun-Young, Shin Jin-Hong, Park Jin-Sung, Kang Sa-Yoon, Nam Tai-Seung, Kim Jong Kuk, Park Ki-Jong, Huh So-Young, Oh Ji Seon, Kang Boram, Kim Dae-Seo
| Frequency of thiopurine methyltransferase mutation in patients of Mediterranean area with inflammatory bowel disease and autoimmune disorders.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2016 Dec 48 (12): 1506-1509.
Di Salvo Angela, Fabiano Carmelo, Mannara Vincenza, Dimarco Mariangela, Orlando Ambrogio, Affronti Marco, Macaluso Fabio Salvatore, Cottone Mar
| NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease.
Alimentary pharmacology & therapeutics 2016 Sep .
Zhu X, Wang X-D, Chao K, Zhi M, Zheng H, Ruan H-L, Xin S, Ding N, Hu P-J, Huang M, Gao
| NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon.
Pediatric blood & cancer 2016 Aug .
Zgheib Nathalie K, Akika Reem, Mahfouz Rami, Aridi Carol Al, Ghanem Khaled M, Saab Raya, Abboud Miguel R, Tarek Nidale, El Solh Hassan, Muwakkit Samar
| Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.
Journal of gastroenterology and hepatology 2016 Jul .
Shah Swarup A V, Paradkar Minal, Desai Devendra, Ashavaid Tester
| Influences of XDH genotype by gene-gene interactions with SUCLA2 for thiopurine-induced leukopenia in Korean patients with Crohn's disease.
Scandinavian journal of gastroenterology 2016 Jun 51 (6): 684-91.
Park Soo-Kyung, Hong Myunghee, Ye Byong Duk, Kim Kyung-Jo, Park Sang Hyoung, Yang Dong-Hoon, Hwang Sung-Wook, Kwak Min Seob, Lee Ho-Su, Song Kyuyoung, Yang Suk-Ky
| NUDT15 variant is the most common variant associated with thiopurine-induced early leukopenia and alopecia in Korean pediatric patients with Crohn's disease.
European journal of gastroenterology & hepatology 2016 Jan .
Lee Yeoun Joo, Hwang Eun Ha, Park Jae Hong, Shin Jin-Hong, Kang Boram, Kim Sun-You
| TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects.
Advances in medical sciences 2015 Dec 61 (1): 135-140.
Steponaitiene Ruta, Kupcinskas Juozas, Survilaite Santa, Varkalaite Greta, Jonaitis Laimas, Kiudelis Gediminas, Denapiene Goda, Valantinas Jonas, Skieceviciene Jurgita, Kupcinskas Lim
| A Prospective Study Evaluating Metabolic Capacity of Thiopurine and Associated Adverse Reactions in Japanese Patients with Inflammatory Bowel Disease (IBD).
PloS one 2015 10 (9): e0137798.
Odahara Shunichi, Uchiyama Kan, Kubota Takahiro, Ito Zensho, Takami Shinichiro, Kobayashi Hiroko, Saito Keisuke, Koido Shigeo, Ohkusa Toshifu
| Association Between Thiopurine S-Methyltransferase (TPMT) Genetic Variants and Infection in Pediatric Heart Transplant Recipients Treated With Azathioprine: A Multi-Institutional Analysis.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 0 23 (2): 106-110.
Green Dionna J, Duong Son Q, Burckart Gilbert J, Sissung Tristan, Price Douglas K, Figg William D, Brooks Maria M, Chinnock Richard, Canter Charles, Addonizio Linda, Bernstein Daniel, Naftel David C, Zeevi Adriana, Kirklin James K, Webber Steven A, Feingold Bri